Osteoarthitis and its possible treatments

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Osteoarthitis and its possible treatments

  1. 1. Osteoarthritis and its Possible Treatments VALERIA RIVERA Biol. 3095 December, 2010
  2. 2. What is Osteoarthritis? <ul><li>It is one of the most common types of arthritis (joint degradation and inflammation). </li></ul><ul><li>It can be caused by: </li></ul><ul><ul><li>Injuries </li></ul></ul><ul><ul><li>Obesity </li></ul></ul><ul><ul><li>Inheritance </li></ul></ul><ul><ul><li>Joint malformation </li></ul></ul>
  3. 3. Who can have arthritis? <ul><li>Everyone, specially women and men over 40 </li></ul><ul><li>Also common in animals like dogs, cats and horses </li></ul><ul><li>25% to 30% of dogs suffer from arthritis and hip dysplasia (associated with abnormal joint structure) </li></ul>
  4. 4. Symptoms: <ul><li>Pain </li></ul><ul><li>Lameness (weakness) </li></ul><ul><li>Muscle atrophy (degeneration) </li></ul><ul><li>Swelling of joints (accumulation of fluids) </li></ul><ul><li>Stiffness </li></ul><ul><li>Lost of mobility </li></ul>
  5. 5. Treatments: <ul><li>The most widely used treatments are: non steroidal anti inflammatory drugs (NSAID) </li></ul><ul><li>Glucosamine/Chondroitin sulfate (nutrients) </li></ul><ul><li>Col 3 inhibition </li></ul><ul><li>Physical rehabilitation </li></ul><ul><li>Surgery </li></ul>
  6. 6. NSAID <ul><li>What it does? </li></ul><ul><ul><li>Inhibits prostaglandins (chemical found in the body, causes inflammation) </li></ul></ul><ul><ul><li>Types of NSAID </li></ul></ul><ul><ul><li>Deramaxx is used in the veterinary market to control pain and inflammation </li></ul></ul><ul><ul><li>Carprofen is one of the newest NSAID being accepted for treating dogs as well as humans </li></ul></ul>
  7. 7. Glucosamine/Chondroitin Sulfate <ul><li>Used as a treatment for dogs with Osteoarthritis </li></ul><ul><li>The research revealed positive effects from day 70 </li></ul><ul><ul><li>It inhibits degradative enzymes within the synovial fluid </li></ul></ul><ul><ul><li>Tested on 35 dogs- 16 with Glu/CS and 19 with carprofren (positive control) </li></ul></ul><ul><ul><ul><ul><li>(McCarty et al. 2006) </li></ul></ul></ul></ul>
  8. 8. Col-3 inhibition <ul><li>Col-3 I was tested with 33 client dogs (Muir P et al. 2007) </li></ul><ul><li>This test shows Col-3: </li></ul><ul><ul><li>Col-3 inhibits production of MMPs (matrix metalloproteinase; protease degrade proteins) </li></ul></ul><ul><li>Is used to ameliorate joint degradation </li></ul><ul><ul><li>Cranial cruciate ligament CCL (important ligament in the knee) </li></ul></ul>
  9. 9. Physical rehabilitation <ul><li>Involves the use of physical agents consisting of heat, cold, electricity, exercise, and water (Johnston et al.). </li></ul><ul><li>Also involves the use of: </li></ul><ul><ul><li>physioballs </li></ul></ul><ul><ul><li>PROM </li></ul></ul><ul><li>Improves: </li></ul><ul><ul><li>Circulation </li></ul></ul><ul><ul><li>Joint movement </li></ul></ul><ul><ul><li>Promotes awareness </li></ul></ul>
  10. 11. Surgery <ul><li>Arthroscopy </li></ul><ul><ul><li>cleans bone segments where inflammation occurs ( minor surgery) </li></ul></ul><ul><li>Arthroplasty </li></ul><ul><ul><li>Replaces joint with prosthetic joint implants </li></ul></ul><ul><li>Osteoplasty </li></ul><ul><ul><li>Surgical repairs deteriorating bone from joint </li></ul></ul><ul><ul><ul><ul><li>(Springhouse, 2005) </li></ul></ul></ul></ul>
  11. 12. Conclusion <ul><li>A variety of new treatments are being examined </li></ul><ul><ul><li>Pros and cons depend on side effects </li></ul></ul><ul><li>Investigations with current treatments like Glucosamine Chondroitin Sulfate are promising </li></ul><ul><li>Further research should continue in modifying the present drugs </li></ul>

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