Kāwili Lā‘auSpring 2012 • Volume 4, Issue 3One who mixes ingredients, drugs or medications: a pharmacistTMUNIVERSITYO F H A WAI‘IATHILOCOLLEGE OF PHARMACYINSIDE• CoP is host to hundreds of natural products scientists and researchers at 50th annual PSNA conference• Research at CoP garners technology agreement• CoP achieves national ranking in fifth year
In this issue, we report the 50th Anniversary Meeting of thePhytochemical Society of North America that was held inWaikoloa last December. The College of Pharmacy was honoredserve as the local host. No quote is more apropos than the onegenerally attributed to Isaac Newton: “If I have seen further it isby standing on the shoulders of Giants.” No scientific discoveryis the result of one laboratory, and the statement attributed toNewton aptly describes the caliber of researchers who attendedthis meeting. The names may not mean much to people outsideof the natural products field, but they are truly giants in the field.The research and discovery presented and discussed at thismeeting have the potential of improving treatments of disastrous illnesses.But more than the impressive list of attendees and speakers, we should be proud of ourown faculty, postdoctoral associates and students. Their contributions, through thorough andprofessional presentations of their research, showed this international group of scientists that, in amere five years, UH Hilo College of Pharmacy is a force to be reckoned with that can affect healththroughout the world. I hope that the stories and photos in this issue reflect the magnitude of thisimpressive event, another milestone in our existence.The May 12 commencement of our second class of PharmD’s also represents a milestone inour development, one that we will document in a future edition of Kawili La‘au. The Class of 2012are the first to graduate since we have become fully accredited. It is my sincere wish that theycontinue to stay connected and active in the evolution of the college they were so instrumental informing.Yet another milestone in our development is making the list of pharmacy schools ranked byexperts in the field in U.S. News and World Reports for the first time. Considering all of the newschools opened since 2000, we were ranked among the top five. This is concrete evidence of ourprogress, and gives me renewed confidence in our trajectory to reach the top 25.That goal, of course, is dependent on providing a permanent building from which to work,study and learn. I will be sharing more news about the potential of constructing this facility in thenear future, but I would like to send my deepest gratitude to all who have supported us on thisodyssey. We will succeed.Dean’s MessageJohn M. PezzutoProfessor and Dean
Spring, 2012 Volume 4, Issue 3AdministrationJohn M. Pezzuto Founding DeanRobert Borris Associate Dean for ResearchEdward Fisher Associate Dean for Academic AffairsAndré S. Bachmann Chair, Pharmaceutical SciencesLiz Heffernan Director, Student ServicesKaren Pellegrin Director, Strategic Planning and Continuing EducationKāwili Lā‘au EditorMaggie MorrisProduction, PrintingUH Hilo Graphic ServicesPublished by theCollege of PharmacyUniversity of Hawai‘i at Hilo200 W. Kāwili St. Hilo, Hawai‘i 96720Phone: 808-933-2909Fax: 808-933-2974http://pharmacy.uhh.Hawai‘i.eduPharmacy@Hawai‘i.eduKāwili Lā‘au is the magazine for the onlyCollege of Pharmacy in the Pacific region,the University of Hawai‘i at HiloTMUNIVERSITYO F H A WAI‘IATHILOCOLLEGE OF PHARMACYKāwili Lā‘auContentsPhytochemical Society of North Americadiscovers aloha at 50th annual meetingon Kohala Coast 2CoP presents research during PSNA meeting 6Research at CoP:Bachmann labs focus on new medicines forpediatric cancer 8Retail lab adds to first-year student experiences 10CoP attracts noted engineer on sabbatical 12Beacon funding helpscommunity projects 14UH Hilo College of Pharmacy earns spot inU.S. News & World Report rankings 16College of Pharmacy Extended‘Ohana:Meet Kathy Borris 17CoP equipment comes to the aid ofFirst Responder Training 18College of Pharmacy namesDean’s List for Fall 2011 24Regular FeaturesFaculty Briefs 19Preceptor Spotlight 20Student Activities 21Alumna Update 24Rotation Report IBON THE COVER –Dean John Pezzuto (right to left) and Judith Fox-Goldstein, Director of UH Hilo ConferenceCenter joined Hawaii County Mayor William “Billy” Kenoi at the PSNA conference as hepresented a lei to Her Royal Highness Dr. Chulabhorn Mahidol, princess of Thailand, whospoke at the conference.
Phytochemical Society of North Americadiscovers aloha at 50th annual meetingon Kohala Coast2 KĀWILI LĀ‘AU | Spring 2012More than 500 researchers,scientists, faculty and studentscame to the Island of Hawaiiin December to attend the 50th AnnualMeeting of the Phytochemical Societyof North America, hosted by UH HiloCollege of Pharmacy (CoP) Dean JohnPezzuto.The program included 13general symposia exploring the useof natural products in a multitudeof topics, including metabolism,agriculture, drug discovery and cancerchemoprevention. Two separateevenings of poster sessions featuredresearch from several UH Hilo CoP labs.“We attracted scholars from atleast 18 countries and 32 states, someof whom have never visited the BigIsland and were able to see firsthandwhy we are called a living laboratory,”Dean John Pezzuto said.“Their researchwill change global health care, andthe importance of their contributionscannot be overstated. But my sincerehope is that they left knowing aboutthe aloha in Hawai‘i as well.” The meeting was organized bythe UH Hilo Conference Center. MayorWilliam“Billy”Kenoi was an honoredguest who welcomed the group in thefirst plenary session.Dean Pezzuto, who is credited forthe discovery of anticancer activity ofresveratrol in red grapes and grapeproducts such as red wine, was one ofthe featured speakers. His work alsowas presented in nine poster sessions.Also speaking at the plenarysession included Her Royal HighnessChulabhorn Mahidol, princess ofThailand and president of ChulabhornGraduate Institute, who has adoctorate in science from MahidolUniversity in Thailand. During a privateaudience with the princess and herstaff beforehand with Thai TV cameraspresent, Dean Pezzuto delivered a giftfrom UH Hilo of a handmade koa bowl.Other prestigious speakersincluded Professor Mansukh C.Wani, co-discoverer of Taxol andcamptothecin, two anti-cancer drugsconsidered standard in the treatmentto fight ovarian, breast, lung and coloncancers. Dr. Wani gave a personalhistory of the history of the discoveryand development of taxol as ananticancer agent, which benefittedmillions of people all over the world.“In the development of taxol, andfirst camptothecin, there were so manyobstacles in its development that taxolParticipants gathered at the Fairmont Orchid Hotel on the Kohala Coast for a group photo at the 50th Annual Meeting of the Phytochemical Society of North America.
KĀWILI LĀ‘AU | Spring 2012 3almost wentback to theforest fromwhere it cameon numerousoccasions.What mystory will tellyou is thatpersistenceand patiencepays off,”he told the group.Research on recognizableproducts such as blueberries, ginseng,ginger, tomatoes and teas waspresented, along with less commonsubstances blue Anigozanthos rootculture and liverworts. Other researchdelved into studying biosynthesis andbioactive compounds. “It’s an honor to associateParticipants in the concurrent sessions on chemoprevention included: Top row (left to right): A.-N. Tony Kong, Ernest Mario School of Pharmacy, RutgersUniversity; Karen Liby, Department of Medicine, Dartmouth Medical School; Clarissa Gerhaeuser, Deutsches Krebsforschungszentrum (DKFZ) - GermanCancer Research Center; Nanjoo Suh, (Co-organizer), Ernest Mario School of Pharmacy, Rutgers University; Kathryn A. Gold, Department of Thoracic/Head and Neck Medical Oncology, M. D. Anderson Cancer Center, The University of Texas; Nancy H. Colburn, Center for Cancer Research, National CancerInstitute-Frederick; Albena T. Dinkova-Kostova, Division of Cancer Research, Medical Research Institute, University of Dundee, United Kingdom; Scott M.Lippman, Anderson Cancer Center, Department of Thoracic/Head and Neck Medical Oncology, University of Texas.Bottom row (left to right): Allan H. Conney, Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario Schoolof Pharmacy, Rutgers University; Michael B. Sporn, MD, Dept. of Pharmacology, Dartmouth Medical School; Young-Joon SURH, Tumor MicroenvironmentResearch Center, College of Pharmacy, Seoul National University; Gary Stoner, Department of Medicine, Medical College of Wisconsin; Chung S. Yang,Department of Chemical Biology and Director, Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers University; John M.Pezzuto, (Co-organizer), College of Pharmacy, University of Hawaii at Hilo; Thomas W Kensler, Johns Hopkins Bloomberg School of Public Health, JohnsHopkins School of Medicine, and University of Pittsburgh; Jed W. Fahey, Dept of Pharmacology & Molecular Sciences, Johns Hopkins University School ofMedicine. NOT SHOWN: Hasan Mukhtar, Department of Dermatology, University of Wisconsinwith these dedicatedresearchers, who worklong days and nights allin the name of science,”Pezzuto said.“Much of thework presented here hasone goal, and that is helppeople and their familiesavoid the disastrousdomino effect of diseasessuch as cancer anddiabetes.” The PhytochemicalSociety of NorthAmerica has a missionto encourage and stimulate researchin the chemistry and biochemistryof plant constituents, their effectsupon plant and animal physiologyand pathology, and their industrialimportance and utilization.Mansukh C. WaniChemoprevention sessions attract distinguishedresearchers from prestigious institutionsDean John Pezzuto presented a gift of ahandmade koa bowl from UH Hilo to HerRoyal Highness Chulabhorn Mahidol, princessof Thailand and president of ChulabhornGraduate Institute.
4 KĀWILI LĀ‘AU | Spring 2012PSNA Conference 2012(top to bottom)Dignitaries included Hawai`i Mayor William“Billy” Kenoi (center) and Her Royal HighnessChulabhorn Mahidol, princess of Thailand.Dr. André Bachmann discusses the conferencewith Dr. Leng Chee Chang, both from UH Hilo.Dr. Eun Jung “Amy” Park spoke to one of thebreakout groups.Her Royal Highness Chulabhorn Mahidol (left)had dinner with Mrs. Mimi Pezzuto and DeanJohn Pezzuto.
KĀWILI LĀ‘AU | Spring 2012 5The conference gave participants opportunities toexchange ideas over meals and at buffets during theposter sessions.
CoP presents research duringPSNA meetingJulie Adrian, DVM, assistant professor, Department ofPharmacy Practice, presented a poster session on“Analysisof Guava as a Forage - Organic Constituents”with coauthorsNorman Q. Arancon, PhD; Bruce Mathews, PhD; JamesR. Carpenter, PhD. Dr. Adrian also received the PSNA USNational Science Foundation Sponsored Travel Award, whichwas recognized at the banquet with a certificate.CoP Associate Dean for Research Robert Borris’grouppresented 3 posters:1) “Pigment Analysis of Spathes in Anthurium Species.”Benjamin R. Clark,Jon. Y. Suzuki,Barbara J. Bliss,andRobert P. Borris.Project supported in part by the NSFHawaii EPSCoR Program under National ScienceFoundation award EPS-0903833.2) “Quantitative Analysis of Curcumin and RelatedCompounds in Curcuma Longa by HPLC and LC-MS.”Kwang Jin Lee, Kathie Pomeroy, Swapan Pramanick,Robert P. Borris. Program under National ScienceFoundation award EPS-09038333) “Phytochemical Study of the Native Hawaiian Plant,Metrosideros Polymorpha.” Swapan Pramanick, Benjamin R. Clark, Norman Q.Aranconand Robert P. Borris. Program under National Science Foundation awardEPS-0903833.Daniela Gundisch, assistant professor, Department ofPharmaceutical Sciences, and her group presented a posterentitled“Development of potential CNS therapeutics derivedfrom the alkaloid cytisine”along with her group, formerpost-doctoral associate Christoph Eibl, current post-doctoralassociate Isabelle Tomassoli and Matthias Wolf, who was inher lab on a research rotation and is now back in Germany.Dianqing Sun, assistant professor, Department ofPharmaceutical Sciences, presented three poster sessions::1) “Inhibitory effect of a callophycin A derivative on iNOSexpression in lipopolysaccharide-stimulated RAW 264.7cells.”With Dean Pezzuto’s lab coauthors E.-J. Park, and T.P. Kondratyuk and L. Shen.2) “Syntheses of Novel Macrocyclic Engelhardione Analogsas Potential Antituberculosis Agents.”With co-author L.Shen.3) D. Sun, J. G. Hurdle, R. E. Lee, L. Shen, T. P. Kondratyuk,R. E. Lee, M. Cushman, J. M. Pezzuto, AntimicrobialEvaluation of a Focused Naringenin and ResveratrolChemical Library.Ghee Tan, assistant professor, Department ofPharmaceutical Sciences, presented a poster session on“The cytotoxic constituents of Stemphylium solani, a fungalendophyte of Morinda citrifolia L. (noni)”with co-authorsCrispin D. Sesaazi, Anthony D. Wright, Sisay Girmay, ChadHiga, Fred M. Sebisubi, Jasper Ogwal-Okeng and Brian Perry.Anthony Wright, associate professor, Department ofPharmaceutical Sciences, gave an oral presentation entitled:“Correlation between tea leaf age and chemical content andshade levels” with co-authors Ran Song, Dovi Kelman, andKimberley Johns.Dovi Kelman, postdoctoral associate, gave an oralpresentation entitled:“Antioxidant activity of HawaiianMacro-algae” with co-authors Ellen Kromkowski Posner,Karla J. McDermid, and Anthony D. Wright. Also, Dr. Kelmanreceived the PSNA Postdoctoral Travel Award to attend themeeting.The Wright research group presented the followingposters:“Antioxidant activity of Hawaiian lichens”, with co-authorsDovi Kelman, Kimberley Johns, Patrick R. Wright, Nicole K.Tabandera, and Kehau A. Hagiwara. Kehau Hagiwara wona student travel award to present the poster. They alsopresented“The antioxidative and antimicrobial roles ofassociated fungi of the lichen Usnea australis from Hawaii”with co-authors Dovi Kelman, and Jonathan D. Awaya.Dean Pezzuto’s research group presented the followingposter sessions:1) “Resveratrol derivative (E)-4(3,5-Dimethoxystryl)Anilineis a novel inhibitor of cancer cell invations.”Authors:Tamara P. Kondratyuk, Eun-Jung Park, Tyler Hirokawa,Ethyn Leong, Mark Cushman and John M. Pezzuto/2) “Suppression of 12-O-Tetradecanolyphorbol-13-Acetate-induced ornithine decarboxylase activity byresveratrol derivatives.”Authors: Suaib Luqman, Tamara P.Kondratyuk, Mark Cushman, John M. Pezzuto.3) “Inhibitory effect of a callophycin A derivative on iNOSexpression in lipopolysaccharide-stimulated RAW 264.7cells.”Authors: Eun-Jung Park, Li Shen, Dianqing Sun,Tamara P. Kondratyuk, and John M. Pezzuto4) “Suppression of cyclooxygenase-2 and induciblenitric oxide synthase expression by 4-[(2’-O-acetyl-α-lrhamnosyloxy)benzyl]isothiocyanate in LPS-stimulatedRAW 264.7 cells.”Authors: Eun-Jung Park, SarotCheenpracha, Leng Chee Chang, Tamara P. Kondratyukand John M. Pezzuto.6 KĀWILI LĀ‘AU | Spring 2012
apoptosis in HL-60 human leukemia cells by natural product-based 3-amino-6-(3-aminopropyl)-5,6-dihydro-5,11-dioxo-11H-indeno[1,2-C]isoquinoline dihydrochloride.”Supakit Wongwiwatthananukit, associate professor,Department of Pharmacy Practice, and Leng Chee Chang,assistant professor, Department of Pharmaceutical Sciences,presented the following poster sessions at the PSNAconference:1) “Biologically active constituents from flower of Vernoniacinerea.”Presented by postdoctoral associate Dr. UiJoung Youn with co-authors Dean Pezzuto and hisgroup.2) “Evaluation of Smoking Cessation Agents from NaturalProducts.”Presented by Leng Chee Chang. Co-authors Dr. Anthony Otsuka, Instructor, Department ofPharmaceutical Sciences and Dr. David Montgomerie,Instructor, Department of Biology.5) “Inhibition of lipopolysaccharide-inducedcyclooxygenase-2 and inducible nitric oxide synthase byepimuqubilin A in RAW 264.7 cells.”Authors: Eun-JungPark, Sarot Cheenpracha, Leng Chee Chang, Tamara P.Kondratyuk and John M. Pezzuto.6) “Antimicrobial evaluation of a focused naringeninand resveratrol chemical library.”Authors: DianqingSun, Julian G Hurdle, Robin E Lee, Li Shen, Tamara PKondratyuk, Richard E Lee, Mark Cushman, John MPezzuto.7) “Thiazole and thiadiazole derivatives of resveratrol asinducers of quinone reductase 1.”Authors: Laura Marler,Abdelrahman S. Mayhoub, Mark Cushman, and JohnPezzuto.Dr. Eun-Jung Park, post-doctoral associate, gave anoral presentation to PSNA conference participants on thepotential cancer chemopreventive activities of AM6-36,with the title“Induction of RXR transcriptional activity andKĀWILI LĀ‘AU | Spring 2012 7Poster Session and Oral Session Abstracts from the 50th Annual Meeting of the Phytochemical Society of NorthAmerica are now online and can be viewed for FREE. To access the abstracts please go to the PharmaceuticalBiology website at http://informahealthcare.com/toc/phb/current. Pharmaceutical Biology is published byInforma Healthcare and is indexed on MedLine.(left to right)Dr. Leng CheeChang explainsher research toUH Hilo CoP PhDstudent TalysaOgas Hoover.Dr. DanielaGundisch talksabout herresearch withparticipant atone of the postersessions.(left to right)Dr. Julie Ann LuizAdrian preparesto explain herresearch at aposter session.Dr. Eun-Jung“Amy” Park (left)and Dr. DianqingSun (center)discuss researchwith a participant.
8 KĀWILI LĀ‘AU | Spring 2012Dr. André Bachmann, DepartmentChair and Associate Professor ofPharmaceutical Sciences at UH HiloCollege of Pharmacy, has focusedmuch of the past 10 years onbiological studies of neuroblastoma(NB), a pediatric cancer of thenervous system. In more recentyears, his work also involved thetranslational application of hisresearch towards the clinic, andin 2010 the first Phase I clinicaltrial with relapsed and refractoryNB patients commenced in fourChildren’s hospitals in the US. Hisefforts to move the drug DFMO(Eflornithine) from bench to bedsidewere recognized in 2010 with theInaugural Weinman InnovatorAward for Translational Research.Neuroblastoma, or NB, whichoccurs primarily in infants andyoung children, is a cancerthat develops in the tissues of thesympathetic nervous system and is themost common tumor in children lessthan 1 year of age. Each year there areapproximately 650 new cases in theUnited States, of which 40% to 50%have high-risk disease. Patients thatrelapse after initial treatment stand avery dismal chance for survival. Ourgoal is to develop new medicines thattarget the relapsed patient populationand those that are resistant toconventional treatment.NB has received national attention,in great parts due to the hard workof private NB and pediatric cancerorganizations and their parentadvocates. In the 2012 Department ofDefense (DOD) bill, $50 million wereprovided for the DOD Peer ReviewedMedical Research Program. Thanksto the great lobbying efforts by oneparent (Gavin Lindberg), NB has beenlisted for the 4th year as a diseaseeligible to compete for funding underthis program (one of only 22 diseases),clearly demonstrating the importanceof this childhood disease. A new trend that is nowbecoming increasingly popular (bothin academia and the pharmaceuticalindustry) is the“repurposing orrepositioning”of well-establishedor old drugs. If we can find a newpurpose for an old drug, or a drugcurrently in use for another disease, itsaves both time and money, becausethese medicines have already gonethrough comprehensive testing andclinical trials in humans in order toreceive market approval.In 2002, I applied this trainof thought when I decided torepurpose DFMO for NB, a drugsuccessfully used today by the WorldHealth Organization (WHO) to treatWest African Sleeping Sickness(tryponosomiasis). Spurred by ourbasic research findings, I begancollaboration with a pediatriconcologist (Dr. Giselle Sholler, M.D.),now at the Helen DeVos Children’sHospital in Grand Rapids, Michigan.Within less than two years, Dr. Sholleropened the first clinical study withDFMO/etoposide in relapsed/refractoryNB. I have been very fortunate to serveas a co-investigator on this clinicalstudy that is headed by Dr. Sholler. Asour phase I study is nearing the end,we have already prepared a phase IItrial to further study this repurposeddrug DFMO.While the repurposing of olddrugs is undoubtedly a promisingendeavor, there continues to be anurgent need for the discovery anddevelopment of entirely new drugmolecules with specific biologictargets. Moreover, more targeted drugdelivery via the development of novelnanocarrier systems is also neededto improve the directed delivery ofdrugs to tumor sites without affectingadjacent healthy tissues that leads tounwanted side-effects.My laboratory works on bothaspects. In one project, we identifiedBachmann labs focus on newmedicines for pediatric cancerR E S E A R C H A T C o P :By André Bachmann
KĀWILI LĀ‘AU | Spring 2012 9a new class of proteasome inhibitormolecules that has shown greatpromise in the treatment of multiplemyeloma and other cancer typesincluding NB.The second project is carried outin collaboration with pharmaceuticalsciences faculty member Dr. MahavirChougule, who devised novelnanocarrier systems that carry ourdrugs directly to the NB tumors.Both projects were protectedearly on through patents thatwere executed by the UH Office ofTechnology Transfer and EconomicDevelopment (OTTED). Based on themerits of these inventions, local start-up company Pono Pharma (http://www.ponocorp.com/ponopharma/)was founded with the goal to furtherdevelop these novel technologies intoviable drug therapeutics.All these exciting researchdevelopments including multi-centerclinical trials and pharmaceuticalentrepreneurship are testament tothe commitment and progressivedevelopment of the College ofPharmacy that is well on its way tobecoming a top-rated U.S. Collegeby providing excellent education toPharmD students as well as cutting-edge research opportunities to ourPharmD and PhD students from Hilo,Honolulu, and from around the world.(From UH System Reports)Three technologies developed by the University ofHawai‘i are now owned by Honolulu-based PonoCorporation under an agreement that will allowUH to realize the value of the technologies sooner thanit would with a traditional licensing deal due to longdrug development timelines.Under the terms of a technology commercializationagreement signed by the university’s Office ofTechnology Transfer and Economic Developmentwith Pono, the university receives equity stake in thecompany and is now a shareholder in Pono in exchangefor an assignment of the technologies.“We are evolving our technology transfer processto speed commercialization of early-stage technologiesdeveloped at the University of Hawai‘i,”said UHPresident M.R.C. Greenwood.“The agreement withPono will allow the university to participate side-by-side with other Pono shareholders and founders astechnology developed at the University of Hawai‘i iscommercialized.”The agreement gives Pono ownership of threeUH-developed technologies, including a proteasomeinhibitor drug, humanized cobra venom factor, and ahybrid nanocarrier drug delivery system.“Pono is honored to have the opportunity tobuild on the work done at the University of Hawai‘i bymoving forward with the commercialization of thesetechnologies,”said Kaleo Taft, Pono’s chief technologyofficer.Pono will work to develop the technologies underthe agreement with a focus on moving them throughthe regulatory approval process.“We are looking forward to this promisingopportunity to work with the company towards theclinical development of our novel anti-cancer drugs,”said André S. Bachmann, associate professor andchairman of the Department of Pharmaceutical Sciencesat the UH Hilo College of Pharmacy.Bachmann is one of the inventors of theproteasome inhibitor discovery and a co-inventor ofthe nanocarrier drug delivery system with MahavirChougule, assistant professor at the UH Hilo College ofPharmacy.The proteasome inhibitors discovered byBachmann and his collaborators are a new class ofcompounds potentially useful for anti-cancer and othertherapeutic uses. The proprietary nanocarrier systemdeveloped by Bachmann and Chougule aims to provideimproved cancer treatment through targeted, tumor-specific delivery of chemotherapeutic drugs.CoP technologyreceives patentagreementAndré Bachmann Mahavir Chougule
By Lara Gomez, PharmD, Director ofClinical Education,Department of Pharmacy PracticeBeginning this summer semester2012, first-year students willparticipate in a four-weeksummer retail rotation as part oftheir Introductory Pharmacy PracticeExperiences (IPPE). The students havebeen participating in an orientationsession this semester.In the past, students wereexposed to retail pharmacy byspending approximately two morningsa week for six weeks during either thefall or spring semester of their firstyear. This rotation allowed studentsto observe the daily operations ofcommunity pharmacy, but limitedtheir actual hands-on experiences.We want to ensure our studentshave the full retail experience beforethey graduate, so we created andimplemented the first-year summerretail rotation, which lasts four weeksand provide 160 IPPE hours. Thestudents will not only observe, but alsoactually gain hands on experience andbe part of the daily operations at thepharmacies, which is truly invaluable.With the placement of thisrotation in the summer, most first-yearstudents will have their Hawai’i internlicense, allowing them to participatein many experiences for which theycould not do without an intern license.To prepare the first-year students,the Experiential Office needed tocreate an orientation for them toprovide some basic backgroundknowledge of pharmacy practicein the community setting. Dr.Leslie Rodriguez, Clinical EducationCoordinator, who joined the COP inOctober and Jennifer Aguiar, AssistantClinical Education Coordinator, tookthe lead in developing the orientation.The orientation, which spannedover four weeks, included a three-hour lecture on Tuesdays devoted tovarious topics including pharmacy lawfollowed by a two-hour“simulationhands-on lab”held in the pharmacypractice lab on either a Wednesday orThursday.Aided by CoP faculty membersMrs. Mimi Pezzuto, Dr. Forrest Batz andMrs. Pat Jusczak, the team developedthe structure and content of theorientation material. This effort helpedto reinforce skills learned in othercourses taken the first-year.During the hands-on lab, studentsparticipated in simulated activitiesRetail lab adds to first-yearstudent experiencesOrder entry: First year student pharmacists Franklin Liu and Jennie Lim prepare drugs in CoP’s retail lab, whileLynn Nguyen (in the background) works on something else. (Photo by Justin Arias, Student Pharmacist, Classof 2012)We covered a wide variety of retailpharmacy concepts in a short amount oftime. I feel the hands-on time was key tothe retention of the skills.– Dr. Leslie Rodriguez“”10 KĀWILI LĀ‘AU | Spring 2012
KĀWILI LĀ‘AU | Spring 2012 11Patient Pickup: Josen Ho and Eric Ngo, first-year student pharmacists, practice role play experiential training inthe retail lab at CoP. (Photo by P4 Justin Arias, Student Pharmacist, Class of 2012)such as receiving a prescriptiondropped off by a patient, order entry,filling a prescription, and selling aprescription to a patient. Students alsolearned to take verbal prescriptionsover the phone from a physician,transfer prescriptions with anotherpharmacy, as well as assist a patientwho called in a prescription refill,focusing on developing professionalcommunication skills.Examples of activities includedrole-play exercises by Class of 2012students Justin Arias and KelseyAtebara, who are on academic rotationand Wendy Yamasaki-Herring, whois on a hospital elective rotation. Thefourth-year students and I acted as thephysician and provided feedback tothe first-year students on how they didwith their physician calls.Another activity involved theutilization of drug informationresources pertinent to communitypharmacy, including the Orange Bookfor generic substitution and variousinformation sources, to support thedevelopment of professional judgmentand drug information skills. Studentswere given an OTC drug informationpatient question and returned the nextday in lab to discuss how they wouldanswer the patient question and whatresources they used.Faculty andstaff were a hugehelp as they actedout the parts ofpatients; withoutthem, simulating the patientinteraction would not have beenpossible. Thank you to Dr. Ed Fisher,Mrs. Mimi Pezzuto, Dr. Peyton Wong,Ms. Amy Knehans, Dr. Paula Zeszotarski,Ms. Ana Barrenechea, Ms. KristyNakamura, Ms. Cara Suefuji, Mr. DarylMasanda, Ms. Char Cockette, Ms. LizHeffernan and Mr. Robert Moore.“We covered a wide variety ofretail pharmacy concepts in a shortamount of time. I feel the hands-ontime was key to the retention of theskills. Our volunteer patients made thelearning experiences informational,fun and memorable. Mrs. Pezzutochallenged the students by trying topass off a forged narcotic prescription,creating a distraction with comicalconversation with Dr. Fisher, who wasalso a volunteer patient at the time,all while shoplifting our OTC coughsyrups,”Dr. Rodriguez said.First-year students will begin thisnewly formatted retail rotation thissummer, and are scheduled in eitherthe first or second session, startingMay 21 or July 18, respectively. Byhaving this rotation occur during thesummer months, students can beplaced at pharmacies throughoutthe state of Hawaii, enabling CoP toexpand our resources, involve manymore preceptors and offer a widervariety of retail pharmacy practice sitesin the experiential education of ourstudents.“We would like to thank all thecommunity pharmacies that haveopened their doors to help ourstudents in this first-time endeavor,”Ms. Aguiar said.“This experience hasbeen an invaluable addition to theireducation.”
Dr. Rajesh Davé from the New JerseyInstitute of Technology became thefirst professor to choose to spend alarge portion of his sabbatical yearof research at UH Hilo College ofPharmacy.An engineer in the truestsense of the word, ProfessorRaj Davé is a builder. He hasbuilt award-winning research onenhancing bioavailability of drugsand pharmaceutical engineering, andhas built an internationally acclaimedreputation as an expert in engineeringparticulates.“Most engineers fail to build fromthe opportunities they have,”said Dr.Davé, who has been on the faculty atNew Jersey Institute of Technology(NJIT) since 1985 and is DistinguishedProfessor in the Department ofChemical, Biologicaland PharmaceuticalEngineering. He is alsothe Site-Leader, ThrustLeader and a Test-bed Leader, NationalScience FoundationEngineering ResearchCenter on StructuredOrganic ParticulateSystems (NSF ERC-SOPS), a Rutgers(lead), Purdue, NJIT andUPRM partnership. Inaddition, he is the founding Directorof New Jersey Center for EngineeredParticulates, an R&D Excellence Centerengaged in research for applicationssuch as pharmaceutical, food,electronic and energetic materials.“Ilike to build things that matter.”Since last July, he hasbeen building on internationalcollaborations through work duringhis sabbatical year away from theNew Jersey Institute of Technology(NJIT). With an eye towards identifyingplaces“that matter,”Dr. Davé chose fivelocations to expand different areas ofhis research interests.“My goals for this sabbatical wereto strengthen research capabilities,expand collaborations and rechargeand catch up on writing papers,”Dr.Davé said.“One place couldn’t meet allthose objectives.”Dr. Davé looked for newcollaborations at the School ofPharmacy of the University ofWisconsin-Madison, as well as theIndian Institute of Technology inBombay and the University of NewSouth Wales in Sydney, Australia.He chose two other universities tostrengthen existing collaborations:Osaka Prefecture University in Japan,and the University of Hawaii at HiloCollege of Pharmacy (UH Hilo CoP).“The other schools had beenestablished longer, but I had visited UHHilo a few times, and was impressedwith the rate of growth at CoP,including making it into the nationalrankings for pharmacy schools,”Dr.Davé said.“I like to look at the bigpicture, and I believe Dean JohnPezzuto to be a man of vision who alsolooks at the big picture.”He began his quest using RutgersUniversity in New Jersey as a base.When it’s all over by the end of June,he will have spent two weeks workingin Wisconsin, two weeks in India, fiveweeks in Australia, a month in Japanand more than two months in Hawaii.CoP attracts notedengineer on sabbaticalDr. Ken Morris (right to left) and Dr. Raj Davé work with CoP PhD student Micah Glasgow on x-ray diffraction in Dr. Morris’ lab onUH Hilo campus.12 KĀWILI LĀ‘AU | Spring 2012
KĀWILI LĀ‘AU | Spring 2012 13His collaborator at UH Hilois Professor Ken Morris in theDepartment of PharmaceuticalSciences. They had previously workedtogether for many years on a projectwith the National Science FoundationEngineering Research Center onStructured Organic Particulate Systems(NSF-ERC-SOPS) when Dr. Morris wason faculty at Purdue University. Uponmoving to UH Hilo, Dr. Morris againcollaborated with Dr. Davé to make UHHilo an ERC outreach partner.“Involvement with the NSF-ERC-SOPS is absolutely critical to helpingour students understand the value ofpharmaceutical research and be a partof an interdisciplinary national effortto improve the way pharmaceuticalsare manufactured,”Dr. Morris said.“I’mgrateful to Raj Davé for his perpetualenergy and consummate expertise aswell as his belief and support.”Bringing Dr. Morris back into anactive role with the ERC was key to Dr.Davé’s plan to come to Hilo.“I considerKen Morris not only as a good friendbut to be someone from whom Ican learn new things,”Dr. Davé said.“Through him, I have been introducedto bright young faculty at UH Hilo suchas Mazen Hamad in chemistry andMahavir Chougule in pharmacy. I’mlooking forward to forming many morepositive working relationships in thefuture.”In addition to researchcollaboration, Dr. Davé will helpmentor CoP PhD student, MicahGlasgow, who is partially funded by ascholarship from the NSF-ERC-SOPS.Glasgow is one of the first studentswho started a PhD in PharmaceuticalSciences at UH Hilo in the fall of 2011.He originally began his undergraduateeducation in chemical engineeringat the University of Missouri, but hecompleted his bachelor’s degree inbiology with a cell and molecular trackat UH Hilo.“Micah may be the only nativeHawaiian working at any ERC site inthe entire country, which is a valuabledistinction considering the personalexperiences he can bring to thetable,”Dr. Davé said.“He will help usto expand the ERC footprint in Hiloand in general help to give other PhDstudents exposure to engineering.”Through this association, Glasgowwill have opportunities to meet otherPhD students throughout the countryand attend industrial advisory boardmeetings in several locations on themainland U.S.Glasgow said he was inspiredat the professional developmentworkshop Dr. Davé held at CoP, wherehe explained how to be a moreeffective person and to focus on thebig picture.“The ERC support has allowedme to combine the knowledge ofpharmaceutical science with themechanisms of engineering, and I’mready to take it on and see where it cango,”Glasgow said. “It’s an exciting newpath and I would like to say‘mahalo’toall of ERC for this unique opportunity.”In addition to his work sustainingthe NSF-ERC-SOPS while on sabbatical,Dr. Davé hopes to contribute to thenew engineering initiative at UH Hilo,and wants to explore the possibility ofa new multi-university research centerwhere NJIT has a prominent role. This,he recognized, will take time.“Sabbaticals are investments, likesowing seeds,”he said.“It’s not overwhen it’s over. It takes years to realizethe full benefit of a sabbatical.”– Dr. Rajesh DavéSabbaticals areinvestments, likesowing seeds,”Professor Davésaid. “It’s not overwhen it’s over.It takes yearsto realize thefull benefit of asabbatical.“”
[Parts of the following were supplied by the Coalition for a Tobacco-Free Hawai‘iin East Hawai‘i and the Hawai‘i Island Beacon Community]The Hawai‘i Island Beacon Community (HIBC) selectedcommunity-based projects for its Healthy Eating andActive Living (HEAL) Program, including four projectsin UH Hilo’s College of Pharmacy.HEAL aims to effect positive changes in eating, physicalactivity and tobacco use habits of the public. Supported byapproximately $300,000 of HIBC’s federal funding, the HEALProjects will run through February 2013 and directly reachmore than 15,000 Hawai‘i Island residents in all regions, ofall ages, from diverse ethnic groups, including those most atrisk.The $16 million Beacon Community grant was awardedto a consortium led by the College of Pharmacy (CoP) in2010. Hawai’i County was one of 15 communities acrossthe nation chosen to serve as pilot communities to developwide-scale use of electronic medical records through thisprogram. CoP Director of Stategic Planning and ContinuingEducation, and Director of the Center for Rural HealthSciences Karen Pellegrin served as principal investigatorof the grant that was awarded through President Obama’s“Beacon Communities”program.“Hawaii Island Beacon Community is the only Beacon inthe nation to put significant funds towards local community-based wellness programs outside of the healthcare system,”Pellegrin said.“The healthcare system is hard-wired to treatdisease; it is not designed to prevent disease. Wellness anddisease originate, not in the healthcare system, but in homes,schools, churches, businesses, and neighborhoods. So this iswhere dollars should be spent for prevention.”The HEAL Program began with a mandatory healthliteracy training day on March 15, 2012 for the leadersfrom all HEAL Projects. Throughout the year, updates andtestimonials will be posted at hibeacon.org.The CoP HEAL Projects are:Environmental Tobacco Smoke: UH Hilo CoP PharmDstudents will be working with the Coalition for a Tobacco-Free Hawaii in East Hawai`i (TFEH). TFEH plans to implementthe What About Tobacco (WAT) Youth Prevention Project intargeted East Hawaii elementary schools to educate fourth-grade students about tobacco use. The overall goal is toeducate 1,200 fourth graders in 15 elementary schools incommunities where tobacco use is highest among adultseither in targeted populations or socio-economic status.The larger objective is to increase children’s knowledgeregarding tobacco uses that are predisposed to smokingaddiction and to increase their decision to choose not tostart smoking.The WAT Youth Prevention Project will train fourthgraders in: the harmful effects of tobacco use on the body;how to avoid smoking initiation; understand tobaccoaddiction; how to speak to a family member about theirtobacco use and how it affects them.The WAT Youth Prevention project will be funded fromMarch 2012-February 2013.Marshallese Mobile Screening Clinic (MMSC): UHHilo College of Pharmacy at the University of Hawai‘i at Hilowill provide health screenings, health education and accessto affordable health care for Marshallese families, adults andyouth.“The Marshallese Mobile Screening Clinic is a studentpharmacist led initiative that focuses on reaching outto underserved, Pacific Islander populations on the BigIsland. With the help of interpreters, we hope to provide freediabetes, blood pressure, and cholesterol screenings alongwith healthy eating and exercise education. In the process,we also hope to overcome cultural and language barriers,so we are able to educate our peers on how to effectivelytreat these culturally sensitive populations. We are excited toprovide this service to our community and hope that it willempower them to engage in healthier lifestyles,”said ShaneleShimabuku, Student Pharmacist, Class of 2013.Volunteer Counseling and Health Screenings:National Community Pharmacists Association (NCPA)Student Chapter at the College of Pharmacy at the Universityof Hawai‘i at Hilo Free counseling on diet/lifestyle changesand health screenings provided by student pharmacists forcommunity members to better manage chronic diseasessuch as diabetes, hypertension and hyperlipidemia.Miloli‘i Health Fair: The members of the Gamma ThetaChapter of the Phi Delta Chi Fraternatiy will host a health fairin Miloli’i, in the district of South Kona. Through estabilishedhealth partners the fair will provide an opportunity forresidents to implement long term plans around healthyeating, physical activity, and smoking cessation.Other projects funded by Beacon include:• Big Island Babes Junior Roller Derby Paradise RollerGirls Introduction to roller derby with safety equipmentprovided• Building a Garden and Doing Physical Activities to ImproveHealthy Eating and Physical Fitness Hawai‘i CountyEconomic Opportunity Council (HCEOC) Six-week summerprogram for students in grades 3-6 and their families• Eat-Think-Grow: Nutritional Education for School GardenTeachers on Hawai‘i Island The Kohala Center, Inc.Workshops and courses for teachers, education events andfood festivalsBeacon funding helpscommunity projects14 KĀWILI LĀ‘AU | Spring 2012
KĀWILI LĀ‘AU | Spring 2012 15• Get Fit Hawai‘i 2012 Five Mountains Hawai‘i Ten-week,team-based Take It Off Hawaii program modified for teens• Hana Ka Lima Social Sciences Department at theUniversity of Hawai‘i at Hilo Seminars, classes, workshops,tours and fitness activities for at-risk and low- incometeens from the Hilo High School Lanakila Learning Center• Healthy Families/Healthy Children Neighborhood Placeof Puna Education, home visits and hands-on projectsto prevent child abuse/neglect and encourage healthyeating• The HHDC Healthy Abundance Project Hilo-HamakuaDevelopment Corporation (HHDC) Community educationto facilitate local food production• Huli Ka Lima Ilalo Kū I Ka Pono After-school gardeningprogram for students and their families• Ka‘Ohana Mahi‘ai Maku‘u Farmers Association Workshopsto increase fresh fruit and vegetable consumption byfamilies in the Maku‘u Homestead area of Puna• Keeping Keiki Kicking Kaho‘omiki Program to increase thephysical activity of elementary school students• Mahi A‘Ai Cultivate Health and Wellness Project Mahi A‘Ai,LLC Ten-week, hands-on course to teach at-risk teens howto grow and cook healthy food while incorporating moreexercise into their lives• Mothers on the Move (MOM) Family Support Hawai‘iProgram to promote appropriate physical activity forlow-income pregnant and new mothers and their youngchildren• Sowing Seeds Na‘alehu Elementary School Hands-on projects, gardening and other activities to teachelementary school students the skills and judgment tomake healthier eating choices(Provided by Hawai‘i Island Beacon Community)Hilo, Hawai‘i (January 11, 2012)—Hawai‘i IslandBeacon Community (HIBC) has awarded a$680,000 contract to North Hawai‘i CommunityHospital (NHCH) to implement a Health InformationExchange (HIE) system throughout the North Hawai‘iregion, impacting more than 32,000 patients andmarking the first step toward an island-wide HIE.Implementation has begun and will continue through2012.NHCH’s existing vendor partner Wellogic® hasalready laid the technical foundation for the HIE,connecting information systems from NHCH; affiliatedphysician groups; two statewide labs; all pharmacies,radiology and imaging centers in the region; a nationaldatabase of dispensed prescriptions; and a FederallyQualified Health Center (FQHC).“We are pleased to support the groundbreakinginitiatives of NHCH to help providers in the NorthHawai‘i region adopt and benefit from the latesttechnology in health care,”said Susan B. Hunt, M.H.A.,project director and CEO of HIBC.“NHCH has pioneeredthe use of Electronic Health Records (EHR) by NorthHawai‘i providers and helped to achieve a nearly 95percent adoption rate—one of the highest for anycommunity nationwide. The region is more than readyto take the next step, and both patients and providerswill benefit from the streamlined operations that asecure HIE system makes possible.”“It’s an exciting breakthrough for health care inNorth Hawai‘i,”said William Park, M.D., chief medicalofficer and general surgeon at NHCH, who haschampioned the region’s HIE since the project’sinception.“Our partnership with Wellogic® has been verysuccessful, and we have built up to a smooth launch.Through access to comprehensive, up-to-date patientinformation for providers and, eventually, patientsthemselves, care will be more efficient, more easilycoordinated and more holistic.” Wellogic® staff will beconducting training for all North Hawai‘i providers. Inaddition, HIBC staff, in partnership with staff from theHawai‘i Pacific Regional Extension Center (REC), willcontinue ongoing support related to the adoption anduse of EHR.In addition to supporting and assisting with EHRand HIE implementation, HIBC is working to effectclinical transformation, particularly in terms of greatercoordination of and access to care for patients whoare most at-risk for chronic diseases, and conductingoutreach by awarding $300,000 to the community inthe form of Healthy Eating and Active Living (HEAL)Grants.North Hawai‘i Community HospitalReceives $680,000 Contract
Dean John Pezzuto spoke to Big Island PressClub members at their annual dinner March3, held at Hilo Yacht Club. He told the groupabout some of the research being done atCoP, and spoke about the bill pending in thelegislature to provide $33 million for the firstphase of permanent facilities. Dean Pezzutoalso gave a rundown of how the college wentfrom zero to 100 in five years.16 KĀWILI LĀ‘AU | Spring 2012Dean Pezzutomeets the pressUH Hilo College of Pharmacy earns spot inU.S. News & World Report rankingsThe University of Hawaii at Hilo College of Pharmacy(UHH CoP) has earned national ranking as one of thetop five new schools of pharmacy in the U.S. News& World Report according to a rankings released Monday,March 13. In its first year of eligibility since admitting theinaugural class in 2007, the College ranked 74 out of 135schools of pharmacy in the United States. Of the 42 newpharmacyprograms established in or after 2000, only threeprograms ranked higher. “These rankings are based on expert opinions aboutprogram excellence, so to garner attention at all at this stageof our development is good recognition of our progress,”saidDean John M. Pezzuto.“But our goal is to achieve rankingin the top-ranked 25, and we are confident in our ability toachieve this goal once we are housed in our permanentCollege of Pharmacy facility.” Each year, U.S. News and World Report ranksprofessional school programs in business, education,engineering, law, and medicine, though the magazine doesnot rank all programs every year. Pharmacy schools were lastranked in 2009. The data come from surveys of administrators at morethan 1,200 programs and nearly 15,000 academics andprofessionals, conducted during the fall of 2011 and early2012. As has been the case for many years, the Universityof California-- San Francisco was ranked the number onepharmacy school in the nation. “This is the first time a UH Hilo graduate program hasbeen identified in the U.S. News & World Report, so we areindeed proud and optimistic that we will be able to continuean upward trend,”Dean Pezzuto said.“This is tangible proofthat students graduate from our program with a top-notcheducation in a unique environment.” The only fully accredited school of pharmacy inthe Pacific region, UH Hilo CoP also offers a PhD inpharmaceutical sciences, a Bachelor of Arts in PharmacyStudies (BAPS), a Masters in Clinical Psychopharmacology(MSCP) for members of the armed forces, and a residencyprogram in community pharmacy. For more information onthe college, please visit http://pharmacy.uhh.hawaii.edu/.
Work is painful for a lot ofpeople who dread goinginto the office. Not so forKathy Borris. She says she has “the bestjob in the world.”As a sixth grade teacher at St.Joseph Elementary School in Hilo,Mrs. Borris says she likes what shedoes because she can spend all hertime with children and fuel theirexcitement. Married to CoP AssociateDean for Research Dr. Robert“Bob”Borris, she moved to Hilo five years agofrom New Jersey.“Moving to Hilo was difficult atfirst,”she admits.“We were establishedin New Jersey, lived in the same placefor 23 years, I had my two childrenthere. But I told myself moving toHawaii was fabulous, and discovered itreally is.”When they moved to Hilo in2007, their daughter Anna, nowin law school at the University ofWashington, had just started collegeat the University of Hawaii at Manoa.Son Christian was starting 8thgrade atSt. Joseph Elementary School, and thisyear is graduating from St. Joseph HighSchool.With a bachelor’s degree inelementary education from theUniversity of Illinois, graduate workat Northwestern and Rutgers, andwith more than 15 years teachingexperience, it seemed a logical fitwhen Mrs. Borris started teaching mathand science part time at St. JosephElementary School four years ago. Shemoved on to a full-time position theretwo years ago as the primary teacherin sixth grade teaching math, science,language arts and religion.One of 19 schools in the state, St.Joseph School is part of the“Schoolsof the Future”program. The teachingphilosophy, funded by a grant fromthe Hawai‘i Association of IndependentSchools, promotes solving open-ended problems and the use oftechnology in the learning experience.Mrs. Borris is the elementary chair ofthe Schools of the Future committee,and says she tries to use technology asmuch as possible.“I always find new ways to usetechnology, and sometimes mystudents show me a thing I don’tknow, which is great,”Mrs. Borris says.A member of the Keaukahacanoe club, paddling has given her anew outlet for physical fitness and anexperience in Hawaiian culture. Shesays paddling is a chance to be partof a team and release the tensions ofteaching.She enjoys education thatexpands outside of the traditionallearning environment. At the end ofMarch, she accompanied her class to atwo-day overnight excursion to KilaueaMilitary Camp in Volcano NationalPark, where they were surrounded byscience lessons mixed with guidedhikes and nature.Her students seem to havecaptured her enthusiasm. Eleven-year-old Elisabeth Pezzuto says sixthgrade has been a turning point in hereducational life.“Mrs. Borris is teaching us topicswe never knew about before,”MissPezzuto says.“I really liked learningabout Greek and Roman history. Wehad a festival and everyone took partby representing a different topic in theAncient Roman and Greek times. It wasreally fun.”Eleven-year-old Gracie Rogersbecomes animated and her eyessparkle when she talks about school.“Every day I learn 70 things,sometimes more,”Miss Rogers says.“Mrs. Borris has a way about her thatmakes learning fun.”College of PharmacyExtended ‘Ohana:Meet Kathy BorrisSt. Joseph ElementarySchool Teacher Mrs.Kathy Borris helpssixth grader NagahiroOhashi with socialstudies research usingthe Internet.KĀWILI LĀ‘AU | Spring 2012 17Mrs. Kathy Borris and her sixth grade class at St. Joseph Elementary School.
Hawaii FireDepartment helda “First ResponderRefresher Training” at theCollege of Pharmacy onMarch 29 with one of thepatient simulators used byPharmD students. Directorof Clinical Education LaraGomez helped organizethe event for CoP, alongwith Fire Medical SpecialistChris Honda of the HawaiiFire Department’s EMSBureau. CoP PatientSimulation SpecialistRobert Moore maintainedthe simulators.Welcometo CoPDean Pezzuto (center) welcomedCara Suefuji (left), academicsupport specialist in the Officeof Student Services and PeytonWong, associate specialist in theDepartment of Pharmacy PracticeJan. 31 at a Chancellor’s SpringGathering. The event recognizednew faculty and staff at UH Hilocampus center.CoP equipment comes to the aid ofFirst Responder Training18 KĀWILI LĀ‘AU | Spring 2012
André Bachmann, associateProfessor and Chair, Department ofPharmaceutical Sciences, College ofPharmacy, was a co-author on a paperthat was published in InternationalJournal of Cancer entitled“PEA15 impairscell migration and correlates with clinicalfeatures predicting good prognosis inneuroblastoma.”Dr. Bachmann was an invited speaker onthe clinical use of DFMO in relapsed neuroblastoma at theMemorial Sloan Kettering Cancer Center in New York Cityon February 9, and he started an elective course in“CancerPrevention”for which 102 students signed up, which he saidwas a record for an elective course.Ben Chavez, assistant professor,Department of Pharmacy Practice,published two articles in the journalCurrents in Pharmacy Teaching andLearning, a quarterly publication of high-quality, peer-reviewed articles relevantto all areas of pharmacy education. Thetitles are“The use of short downloadablelectures to supplement didactic lectures”and“Populargameshows as educational tools in the pharmacy classroom.”He also was an invited speaker for a webinar for AmericanAssociation of College of Pharmacy titled“Gaming inEducation.”Spring 2012Faculty BriefsMahavir Chougule, assistantprofessor, Department of PharmaceuticalSciences, was a recipient of the 2012The American Association for CancerResearch (AACR) Minority-ServingInstitution Faculty Scholar in CancerResearch award. The award is given tofull-time faculty members of Minority-Serving Institutions, including Native Hawaiian-ServingInstitutions, as defined by the US Department of Education.The purposes of this award program are to increase thescientific knowledge base of faculty members at Minority-Serving Institutions, and to encourage them and theirstudents to pursue careers in cancer research. AACR honoredDr. Chougule at the AACR 103rd Annual Meeting in Chicago.Dr. Chougule also co-wrote an article published inPLoS ONE, an international, peer-reviewed high impactfactor journal in the field of pharmaceutical sciences,entitled“Enhanced anticancer activity of Gemcitabinein combination with Noscapine via antiangiogenic andapoptotic pathway against Non-Small Cell Lung Cancer.”Deborah Juarez, assistantprofessor, Department of PharmacyPractice, published: 1)“The Relationshipof Hospital Quality and Cost Per Casein Hawaii”in Inquiry (in press, Spring2012 issue). Co-authors were Ashby J,Sibley P, Berthiaume J, and Chung R; 2)”Prevalence of Comorbid Conditions withAging Among Patients with Diabetes and CardiovascularDisease”in Hawaii Med J (October 2011). Co-authors wereDavis J and Chung RS; 3)“Prevalence of Coronary HeartDisease and Its Risk Factors Related to Age in Asian, PacificIslanders, and Caucasians in Hawai‘i”in Journal of Healthcarefor the Poor and Underserved (in press). Co-authors wereDavis JW, Brady SK, and Chung RS. She was also appointedby Governor Abercrombie to the State Health PlanningCouncil.Eugene A. Konorev, assistantprofessor, Department of PharmaceuticalSciences, co-wrote an article publishedin PLoS ONE, an international, peer-reviewed high impact factor journal inthe field of pharmaceutical sciences,entitled“Stretch-Induced HypertrophyActivates NFkB-Mediated VEGF Secretionin Adult Cardiomyocytes.”Russell Molyneux, affiliatefaculty and associate editor, Journalof Agricultural and Food Chemistry,co-wrote an article published in FoodAdditives and Contaminants entitled“Pyrrolizidine alkaloid toxicity in livestock:a paradigm for human poisoning?” aswell as another article entitled“Pyrrolizidine alkaloids infood: a spectrum of potential health consequences.”Other– continued on next pageKĀWILI LĀ‘AU | Spring 2012 19Leng Chee Chang, assistant professor, Departmentof Pharmaceutical Sciences, was invited to Mae FahLuang University in Chiang Rai, Thailand to supervise aPhD student. The trip, which took place from Jan. 28-Feb.3, was funded by the Royal Golden Jubilee-PhD grant.While there, she introduced students and faculty to thePhD program in pharmaceutical sciences in the Collegeof Pharmacy at UH Hilo.
Preceptor Spotlight:Sheryl Itamura, PharmD, BCPS,Kaiser Permanente MoanaluaMedical Center InpatientPharmacySheryl Itamura, Supervisor ofSterile IV Compounding Servicesat Kaiser Permanente MoanaluaMedical Center Inpatient Pharmacy, began her role as apreceptor to UH Hilo CoP pharmacy students enrolled inAdvanced Pharmacy Practice Experience (APPE) in 2010.Kaiser Permanente recently awarded her their Preceptorof the Year Award for 2011.In the words of Wes Sumida, PharmD, BCPS,Director of Pharmaceutical Services,“Sheryl hasestablished herself as a leader of the IV room and USP797 SME. Sheryl’s students benefitted not only from herspecialty knowledge about sterile compounding, butalso her ability to role model what a new leader shouldbe.” “What I appreciate about Sheryl is her ongoingcommitment to continuously improve herself as apharmacist, leader, and preceptor”, says Jeani Jow,PharmD, Manager of Pharmacy HR, Learning &Development, Preceptor, Residency & Intern Programsfor Kaiser. Sheryl states that the best part of being a preceptoris being able to see the students develop over the sixweeks. “Being a preceptor was something new to me,but ever since I started doing it, I have learned so muchabout myself. I have also learned that each student isvery different and that you have to adjust to each oneslearning styles. At Kaiser we are so fortunate to have anutrition support team and I think having the studentsparticipate in this during their rotation has been avaluable learning experience for them. Total parenteralnutrition, or TPN, and nutrition support is somethingthat takes practice beyond learning in the classroom.I think giving the students hands on experience inmonitoring and ordering of TPN gives them a greaterunderstanding of this area of pharmacy.”APPE students who have been given theopportunity to work with Sheryl have noted:“Iappreciated that Sheryl included me in her daily TPNrounds and in her daily activities. She would always giveme opportunities to learn which is all I could ask for”and“She was very knowledgeable, and facilitated theexpansion of my pharmacy-related knowledge throughteaching and enforcing self-directed learning.”CoP is grateful for Dr. Itamura’s dedication to theeducation of our pharmacy students.papers he co-authored include: 1)“Loss of msnA, a putativestress regulatory gene, in Aspergillus parasiticus and Aspergillusflavus increased production of conidia, aflatoxins and kojic acid”in Toxins; 2)“Detection of high levels of pyrrolizidine-N-oxidesin the endangered plant Cryptantha crassipes (Terlingua CreekCat’s-eye) using HPLC-ESI-MS”in Phytochemical Analysis; and 3)“Quantitation of Sensory-Active and Bioactive Constituents ofFood: A Journal of Agricultural and Food Chemistry Perspective”in the Journal of Agricultural and Food Chemistry.Dianqing Sun, assistant professor,Department of Pharmaceutical Sciences,presented research entitled“Discoveryand Design of 2-Phenylindole-based NitricOxide Synthesis Inhibitors as PotentialAntiinflammatory and ChemopreventiveAgents”at the 243rd American ChemicalSociety National Meeting held March 25-29,2012 in San Diego. The other coauthors are X. Yu E.-J. Park, T. P.Kondratyuk, and J. M. Pezzuto.Dr. Sun also presented a poster entitled“Synthesis andAntibacterial Evaluation of Novel Macrocyclic EngelhardioneAnalogs”at Gordon Research Conference on New AntibacterialDiscovery & Development held April 15-20, 2012, in Lucca, Italy.Anthony Wright, associate professor,Department of Pharmaceutical Sciences,co-wrote an article published in MarineDrugs , a journal on the research,development and production of drugsfrom the sea, including marine naturalproduct chemistry published onlinequarterly, entitled“A New Diketopiperazine,Cyclo-(4-S-hydroxy-R-proline-R-isoleucine), from an AustralianSpecimen of the Sponge Stelletta sp.”He also co-wrote a paperthat is in press at The Journal of Marine Science: Research andDevelopment entitled“Correlation Between Natural ProductsProduction and Pressure from Local Environmental Stressors.”Dovi Kelman, postdoctoral associate, published thefollowing two papers:“Correlation between leaf age, shadelevels, and characteristic beneficial natural constituents of tea(Camellia sinensis) grown in Hawaii”with co-authors R. Song,K. Johns and A.D. Wright in Food Chemistry; and“Antioxidantactivity of Hawaiian marine algae”with co-authors E. KromkowskiPosner, K.J. McDermid Smith, N.K. Tabandera, P.R. Wright and A.D.Wright in Marine Drugs.Buddhini Samarasinghe, postdoctoral associate,presented a poster of his research on“Heat-shock andAutophagy in cancer: Novel role for DGK iota” AACR (AmericanAssociation of Cancer Research) Annual Meeting in Chicago. Co-authors are Christina Wales and Dr. Aaron Jacobs.continued –20 KĀWILI LĀ‘AU | Spring 2012Postdoc Briefs
Student PharmacistsCelebrate Blood DonorMonthSupplied by Jack FernandezStudent pharmacists from the University of HawaiiCollege of Pharmacy held a community blood drive onJanuary 23 at the UH Hilo campus. The day-long blooddrive saw a solid-booked day of 200 appointments, with 144participants successfully donating blood. Approximately 17percent of these participants were first-time donors.Hawaii County Mayor William“Billy”Kenoi helped setthe stage for this year’s drive by proclaiming January 2012as Blood Donor Month.“Each January, Blood Bank of Hawaiijoins other blood donation centers across the nation incelebrating National Blood Donor Month to encouragehealthy citizens to make a donation,”said Kenoi in his publicproclamation.“We are very grateful for the outpouring of support fromour Mayor’s office, community members, as well as my fellowstudent pharmacists in helping to replenish the state’s bloodsupplies,”said Jack Fernandez, coordinator for this year’sblood drive, and himself a committed blood donor.“Whenwe have such a high first-time-donor rate, this is an inspiringreflection of our team’s education and recruitment efforts.Every pint of blood brings us ever closer to meeting theneeds of Hawaii’s patients.”S T U D E N T A C T I V I T I E S :This year marks the third annual blood drive sponsoredby the College of Pharmacy. According to the Blood Bankof Hawaii, up to 60 percent of people in Hawaii will needblood sometime in their lives, but only two percent donate.Members of the American Pharmacists Association (APhA)and National Community Pharmacists Association (NCPA)student chapters donated food and funds for the event.KĀWILI LĀ‘AU | Spring 2012 21Student pharmacists participatein Ocean DayThe National Community Pharmacists Association (NCPA) Hilo Chapter and the Collegeof Pharmacy participated in the community’s annual Ocean Day Malama KanaloaFestival in Keaukaha in Hilo on Feb. 22. Open to the public, this free event attractedthousands of people even in the rain.“It’s our first year here,”says Nicole Tabandera, NCPA President and booth coordinator.“Wedidn’t expect to have 2100-plus customers. Of course we ran out of supplies.”The chapter offered both kids and adults the chance to learn about compoundingby making either slime or Spirulina soap bars in the shape of seashells and sea animals inrepresentation of the festival.“The festival had a great turnout,“ says Ericson Ganotisi, a first-year student pharmacistparticipant.“It’s by far the biggest event NCPA has been a part of as well as the college itself.”When asked if NCPA would conduct another compounding for kids event for next year’sfestival, Nicole laughed and said,“Not by ourselves. Definitely not by ourselves.”From left: Third-year student pharmacists who participated in the 2012 BloodDrive are (left to right) Flora Kim, Margaret Kang, Jack Fernandez and ChristineLucas.Stephanie Ogle, a P2 studentpharmacist, displays how much funmaking soap can be.
By Steven NishimotoStudent Pharmacist, Class of 2014 Iwanted to thank everyone for your hard work at makingRelay for Life a success. With all of your efforts, our CoPteam raised over $3500. As an added bonus, we were thetop contributing team among UH Hilo. Overall, the wholeUH Hilo system raised over $29,000.The CoP booth also won first place for the MissionActivities Booth. CoP focused on Nutrition, emphasizingthat healthy eating and exercise will go a long way in cancerprevention.I wanted to personally thank third-year studentpharmacist Christine Lucas for being co-captain and taking alarge part of this program. We wouldn’t have raised as muchmoney without her efforts. I also wanted to thank those whotook their time to relay and make monetary donations. Our contribution to Relay for Life will aid the AmericanCancer Society (ACS) fight back by building volunteerprograms, funding research, promoting education andawareness, and other services; our hard efforts will help ACSsave lives. As ACS puts it,“we aren’t just fighting one typeof cancer – we’re fighting for every birthday threatened byevery cancer in every community.” CoP students want to add a special thank you to Nora fromTwo Ladies Kitchen for donating mochi to NCPA to sell inefforts to help raise funds for Relay for Life. Also, the UH HiloStudents Association (UHHSA) gave NCPA funds to purchasethe mochi. All of the proceeds raised were donated to Relayfor Life on behalf of the CoP team from NCPAMahalo22 KĀWILI LĀ‘AU | Spring 2012UH Hilo students help educate legislatorson 2012 opening daySeveral UH Hilo students traveled to Oahu for the statelegislature’s opening day day Jan. 18 to advocate fundingthe College of Pharmacy’s (CoP) permanent building and totalk about other concerns on campus.The legislature is considering a bill for an act for capitalimprovements, H.B. 2818, included funding for the first phase ofthe permanent building for the College of Pharmacy.The group included students from the University of Hawaiiat Hilo Student Association (UHHSA) along with leaders fromchartered student organizations Student Activity Council, BreakThru Adventures and the Campus Center Fee Board.“The students worked very hard to network and arrangeappointments with state senate and house members, and Iwanted to thank them for their efforts and support of CoP,”saidstudent pharmacist Anqi Liu, Class of 2013, who is a graduatesenator with the UH Hilo Student Association (UHHSA).Students met with state representatives including JerryChang, Clift Tsuji and senators including Josh Green, chair of thesenate health committee.“Many CoP students have since taken part in letting the legislature know how important the new building is, includingReece Uyeno from the class of 2013, who is the current senator for UHHSA,”Ms. Liu said.“He wasn’t able to make it to the thattrip but did go on a seperate occasion recently to also advocate for funding.”UH Hilo students who visited the state legislature on opening day were:Back row: Lyssa Waren-Dale, Rachel Nazara, Melequini Gaisoa, MarvinMathew, Keahi Tajon. Front row: Anqi Liu, Robyn Taniguchi, Kanoe Elvenia,Senator Josh Green, Kuulei Bezilla and Mike Sado. I personally took on Relay for Life because my familyand friends have been affected by cancer and experiencedthe devastating consequences this group of diseases caused.It really touches me to know that other people care aboutthis deeply. I hope this will become a tradition and the CoPteam will continue to be dedicated to this important causein the years to come. Thank you for your support.CoP team makes animpression on communityat Relay for Life 2012
KĀWILI LĀ‘AU | Spring 2012 23The National Community Pharmacists Association(NCPA) Hilo Chapter hosted its first event forcommunity pharmacies on the Big Island. Co-sponsoring with Mina Pharmacy, the event attracted morethan 50 pharmacists, pharmacy technicians, employees andeven student pharmacists from 15 different pharmaciesacross the island.“For the pharmacists from Kona who couldn’t makeit in person, we had ourwebmaster Chris Aysonstream the presentationlive so that they also couldparticipate,”said Keshia Mahi-Leopoldino, coordinator ofthe event and NCPA vicepresident.Mr. Keith Kamita, DeputyDirector for the Departmentof Public Safety and FormerChief of the NED, gave athorough and excitingpresentation on ControlledSubstances. The presentationinvolved a review on StateNational Community Pharmacists Association teamswith Mina Pharmacy for educational eventand Federal Law and updates on changes with the law andnew controlled substances. He stressed the importance offollowing the law and calling the NED if anything about apatient is suspicious.“We’d rather have you call us no matter what yourquestions are versus having the NED come to your frontdoor,”he stated, illiciting laughter from the audience.Kerri Okamura, Director of Pharmacy at KTA and anattendee says,“If you everwant to draw a crowd, he’s agood person to have.”Although thispresentation wasn’t an actualCE event and the attendeesdidn’t receive any credit, thesuccess of it was bigger thanexpected.“We’re very proud ofhow it turned out and lookforward to hosting moreevents with NCPA in thefuture,”says Mike Hoskins,Pharmacy Manager at MinaPharmacy.UH Hilo CoP’s Hawaii Student Society of Health-SystemPharmacists (HSSHP) collaborated with Hilo MedicalCenter (HMC) to hold blood glucose screening for thecommunity at the 2012 Hilo Heart Walk. Student volunteersfrom the first-, second- and third-year in pharmacy activelyparticipated in patient education on diabetes and glucosetesting for the public.The American Pharmacists Association (APhA) andAcademy of Managed Care (AMCP) collaborated in a healthfair booth at the Hilo Heart Walk health fair. The volunteersfrom APhA offered blood pressure screening and strokerisk assessment to the public. AMCP displayed a hearthealth education poster ranged from smoking cessation,obesity, exercise, diet, lifestyle and sunscreen protection andanswered questions from the community.Students conduct wellnessscreenings at 2012 HiloHeart Walk Health FairKeith Kamita, (center) Deputy Director for the Department of Public Safety, metwith student Pharmacists Ericson Ganotisi (left to right), Anqi Lu,Keshia Mahi-Leopoldino and Nicole Tabandera.Student Pharmacists Jack Goldsberry, Trina Tran, Faculty Supervising PharmacistDr. Yaw Owusu, Yan Lin, Margaret Kang, Stephanie Sumner, and StephanieGregorio came out despite the rain for the Hilo Heart Walk.By Keshia K. Mahi-Leopoldino, NCPA HI Chapter Vice President, UHH College of Pharmacy, Student Pharmacist, Class of 2014
The following University ofHawai‘i at Hilo College ofPharmacy students haveachieved a GPA of at least 3.5 and havebeen named to the Dean’s List for the2011 fall semester. The class of 2012is performing clinical rotations andtherefore this designation does notapply. Class of 2013:Kurt Adkins, Christopher Ayson, GinaChan, Phuongquynh Doan, WilliamEngen, Jackwayne Fernandez, RyanGaspar, Nargis Hassan, Byoung HakJun, Christopher Kamei, Margaret Kang,Flora Kim, Alison Kobayashi, MarcusKouma, Diem Le, Elizabeth Lee, JamesLee, Victor Lin, Cheryl Lopez, Shih-ChiaLu, Daniel Lupas, Brynn Macumber,Tina Marrie Mcdonald, Tasha Medeiros,Mathew Mullahy, Ahmad Musheinesh,Jason Okazaki, Chanel Opunui, StevenOsgood, Kaylene Peric, Mylan Phan,Tyler Prescott, Rosa Quan, MatthewSasaki, Nicole Schauer, Prabu Segaran,Jordan Shibata, Takeshi Shikuma,Shanele Shimabuku, Michael Tsuji,Reece Uyeno, Irving Veilleux, WilliamWalker, Melissa Yoneda, ModanietYoung, May Yu.Class of 2014:Miho Aoki, Maurina Bartlett, JoanneDaproza, Jizan-Anne Evangelista, JohnFujita, Jack Goldsberry, Brianne Gustilo,Jaymie Kanda, Mariko Katagiri, DanielKim, Kyle Kumashiro, RomelynneLamosao, Andy-Long Le, Yan FengLin, Janine Masri, Janelle Matsukawa,Tiffany Mizo, Tracy Nakama, KennethNavarrete, Steven Nishimoto,Naoto Oki, John Opoku-Ansah, KeriOyadomari, Thao Phan, BehnamRostami, Jed Sana, Caroline Sousa,Koon Ting, Hana Tran, Ann Txakeeyang,Dayna Michelle Wong, James Yi. Class of 2015:Brianne Blakesley, Jasmine MichelleBradfish, Andrea Brauer, Chao Cox,Jeremy Daube, Le Du, Jozelle Gabriel,Ericson Ganotisi, Davis Hanai, DanielHasegawa, Ryan Himes, Bryan Huynh,Kelly Ishizuka, Brian John, MadisonKarr, Tiffany Khan, Traci Kusaka, DanielLeong, Jennie Lim, Wei Lin, Kristina Lo,Tracy Ng, Eric Ngo, Kristi Anne Nishek,Darian Oshiro, Alysia Osugi, Jin BaeCollege of Pharmacy namesDean’s List for Fall 2011Pak, Jessica Parker, Jarred Prudencio,Latasha Riddick, Natalie Savona,Lindsey Takara, Trina Tran, AntonioVerduzco, Jill Anne Villarosa, JillianWewers, Nichole Wilson, Edward Wong,Allison Yamashita, Akio Yanagisawa,Nicole Young.ALUMNA Update: Dr. Jill GelviroClass of 2011 alum Rovigel “Jill” Gelviro was selected to be the Aide-de-Camp to Rear Admiral (RADM)Scott F. Giberson during the 2012 Indian Health Service Southwestern Regional Pharmacy meetingin Scottsdale, Arizona. An Aide-de-Camp is a confidential assistant to a high-ranking officer. RADMGiberson currently holds the positions of U.S. Assistant Surgeon General and Chief Pharmacy Officerfor the U.S. Public Health Service Commissioned Corps and Director of the Commissioned CorpsPersonnel. Dr. Gelviro is a commissioned officer in the U.S. Public Health Service and is near completionof a PGY-1 Pharmacy Residency at Phoenix Indian Medical Center, Phoenix, Arizona. She is also a priorenlisted Air Force Veteran who served in Texas, Mississippi, Guam, Bahrain, Saudi Arabia and Iraq. Shesaid, “It was an honor to have been selected as RADM Giberson’s Aide-de-Camp during his visit toArizona. The time spent with the Admiral was an inspiring and motivating experience. I hope he canone day visit UH Hilo CoP. He would be an inspiration to all.”Kawili La‘au readers want to hear from all alumni. Please e-mail firstname.lastname@example.org with your stories.24 KĀWILI LĀ‘AU | Spring 2012
Anthony Thai, Class of 2012Walgreen Specialty Pharmacyin San FranciscoAfter half a year of doingrotations away from home,I finally returned to SanFrancisco in January to completemy sixth block. My rotation was at aWalgreens Specialty Pharmacy withDr. Jeffrey Wong. I wanted to sharewhat I learned and the experience thatI had since I know that a few P3s willbe rotating there this following year.Before I go on, I would like to thankNancy Huang, the Walgreens DistrictPharmacy Supervisor in Hawaii, forrecommending Dr. Wong’s rotation.Previously, I had worked as a pharmacytechnician for Walgreens and alsointern with them over the summers, soNancy thought it would be beneficial ifI did a rotation at a specialty clinic.The pharmacy I worked atspecialized in diabetes and vaccines.The actual pharmacy was locatedwithin the California Pacific MedicalRotation Report:Anthony ThaiCenter (CPMC), which meant thatit also received a lot of dischargemedications. I learned a great dealfrom Dr. Wong during my time here. Tolist a few things: I learned how to useinsulin pens, nebulizers, glucometers,MDI, DPI etc. And that is just the tipof the iceberg of what I learned. Iappreciate the time that Dr. Wongspent showing me these devices andthen providing me the opportunity tocounsel patients on how to use them.In addition, almost on a dailybasis, Dr. Wong and I would havediscussions on topics such as vaccines,OTC products, law, HIV meds, OCs, anddiabetes. All this was done after hoursin the pharmacy. I was impressed bythe commitment and dedication thatDr. Wong made to make sure that a)the rotation was going to be tailoredto my interests and b) we are goingto cover topics that I am not toofamiliar with to help prepare me forthe NAPLEX. As some of us fourth-yearpharmacy students may already know,and many of you third-year pharmacystudents will too, its makes a bigdifference if you have a preceptor whois willing to teach and is interested inyour learning.Furthermore, I reinforced my skillsregarding vaccinations and I after thefirst couple of days, I was vaccinatinganybody that came through thedoor. There were a variety of vaccinesthat I administered from influenza,pneumococcal, Hep B, Hep A , Tdap,varicella etc. It definitely helpedbuild my confidence in providingvaccinations in the future.The unique thing about thissite is that the staff is familiar withpharmacy students rotating throughthe store. They receive many studentsfrom nearby pharmacy schools suchas UCSF, Touro, UOP, and other out-of-state schools. The staff was very helpfulto me and made sure too keep an eyeout for any patients started on newmedications so that I would have thechance to counsel them before theyleave. From the technicians to thepharmacists everybody gave me theirinput on ways to improve.The most important thing I tookaway from this learning experienceis that it strengthened my beliefthat retail pharmacists play a vitalrole in a patient’s health. There aremany opportunities for pharmaciststo counsel patients on proper useof drugs, whether it has to do withinhaler technique, timing of dose etc.Also I can start to see a change inretail pharmacy meshing the worldof dispensing pharmacy and clinicalpharmacy. A specialty pharmacyprovides patients with anotherresource for education on their diseasestate and medications.Lastly, I would like to say that Dr.Wong is really a great preceptor. Hewas an ideal model on how and whata pharmacist should be. Not only didhe take the time to teach his studentsbut he is also very easy going andapproachable. He cares about makingthe rotation a learning experience forthe student and definitely caters totheir interests. I was glad to have hadthe opportunity to meet Dr. Wongand this would be an excellent site forfuture rotations.