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Mycoplasma hyopneumoniae
“Infection Chain”

Eduardo Fano DVM MS PhD
BIVI
Swine Technical Manager Americas
What is the current Mhyo infection picture?
• Clinically Mhyo associated respiratory disease in growingfinishing units
• I...
Correlation of prevalence at weaning with severity of the
disease in vaccinated finishing pigs

C2

Average Lung Lesion Sc...
Mycoplasma hyopneumoniae “Infection Chain”
Level 1
Replacement animals

External
-Gilts
+Gilts

Horizontal
transmission
La...
Level 1
Replacement animals
Persistence of infection/shedding
“The key factor”
Level 2
Sow herd
•Incoming gilts exposure/protection status
•Incoming gilts shedding status

•Sow herd instability
Sow herd instability
Consequence of sow herd instability:
• More sow to piglet transmission (prevalence at weaning)
• Variability between group...
Transfer of disease from sow to piglet

Level 2
Sow herd
Vertical
transmission
Level 3
Wean to finish pigs
Consequence of vertical transmission:
• Higher the prevalence at weaning higher the clinical impact of Mhyo
in finishing p...
Level 3

Wean to finish pigs
•Prevalence at weaning
•Horizontal transmission rate downstream
•Pig flow and W to F manageme...
The infection chain
• Clinically Mhyo associated respiratory disease in
growing- finishing units
• Nursery piglets exposur...
Dr. Eduardo Fano - "Cadena de Infección" de Mycoplasma hyopneumoniae, en Español
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Dr. Eduardo Fano - "Cadena de Infección" de Mycoplasma hyopneumoniae, en Español

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En Español, "Cadena de Infección" de Mycoplasma hyopneumoniae - Dr. Eduardo Fano, Swine Technical Manager Americas, Boehringer Ingelheim, de la World Pork Expo 2013, Junio 5 - 7, 2013, Des Moines, IA, USA.

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Dr. Eduardo Fano - "Cadena de Infección" de Mycoplasma hyopneumoniae, en Español

  1. 1. Mycoplasma hyopneumoniae “Infection Chain” Eduardo Fano DVM MS PhD BIVI Swine Technical Manager Americas
  2. 2. What is the current Mhyo infection picture? • Clinically Mhyo associated respiratory disease in growingfinishing units • In some cases there is a perception of lack of efficacy of vaccination protocols • Are we over focusing the strategy just in the piglet? • Are we looking at the “ whole herd’ infection picture of the disease? Are we understanding the “root’ of the problem?
  3. 3. Correlation of prevalence at weaning with severity of the disease in vaccinated finishing pigs C2 Average Lung Lesion Score 15 10 5 C1 0 0 20 40 60 Prevalence at weaning (N-PCR, Nasal) R-squared= 0.5304, P-Value= 0.0009 * Fano et al., 2007
  4. 4. Mycoplasma hyopneumoniae “Infection Chain” Level 1 Replacement animals External -Gilts +Gilts Horizontal transmission Lateral Level 2 spread Sow herd Vertical transmission Level 3 Wean to finish pigs Horizontal transmission Local Replacement Fano et al., 2007
  5. 5. Level 1 Replacement animals
  6. 6. Persistence of infection/shedding “The key factor”
  7. 7. Level 2 Sow herd •Incoming gilts exposure/protection status •Incoming gilts shedding status •Sow herd instability
  8. 8. Sow herd instability
  9. 9. Consequence of sow herd instability: • More sow to piglet transmission (prevalence at weaning) • Variability between groups 60 Prevalence (%) 50 40 30 20 1 0 0 1 2 3 4 5 6 7 Groups 8 9 10 11 Average
  10. 10. Transfer of disease from sow to piglet Level 2 Sow herd Vertical transmission Level 3 Wean to finish pigs
  11. 11. Consequence of vertical transmission: • Higher the prevalence at weaning higher the clinical impact of Mhyo in finishing pigs C2 Average Lung Lesion Score 15 10 5 C1 0 0 20 40 60 Prevalence at weaning (N-PCR, Nasal) R-squared= 0.5304, P-Value= 0.0009 * Fano et al., 2007
  12. 12. Level 3 Wean to finish pigs •Prevalence at weaning •Horizontal transmission rate downstream •Pig flow and W to F management •Piglet immunization •Piglet medication
  13. 13. The infection chain • Clinically Mhyo associated respiratory disease in growing- finishing units • Nursery piglets exposure • Prevalence at weaning • Sow herd instability/Vertical transmission • Gilt Mhyo management

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