Dr. Dane Goede - Update on Porcine Epidemic Diarrhea Virus Studies

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Update on Porcine Epidemic Diarrhea Virus Studies - Dr. Dane Goede, University of Minnesota, Veterinary Medicine , from the 2013 Allen D. Leman Swine Conference, September 14-17, 2013, St. Paul, Minnesota, USA.

More presentations at http://www.swinecast.com/2013-leman-swine-conference-material

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Dr. Dane Goede - Update on Porcine Epidemic Diarrhea Virus Studies

  1. 1. Update on Porcine Epidemic Diarrhea Virus Studies Dane Goede, Bob Morrison
  2. 2. Outline • Lateral Spread – Index cases & nearest neighbors – Cluster analyses • Production Impact • Time-to-Stability • Swine Health Monitoring Project
  3. 3. National Pork Board Project LATERAL SPREAD STUDY
  4. 4. Two Approaches Incidence in Neighboring Herds • Index cases in negative areas identified • Questionnaire administered to record potential sources of risk to infect neighbors • Neighbors identified, given similar questionnaires, and monitored for infection Cluster Analysis • 268 premises participating • PEDv spread fast in Oklahoma panhandle • Aerosol? Transportation? Pests? • Spatial analysis for pattern of movement
  5. 5. Progress • Both retrospective & prospective cohorts • 22 case farms identified • 19 of which verbally agreed to participate • 14 of which have enrolled officially
  6. 6. Progress % Negative • 5 fully-completed index case & neighbor questionnaire sets Weeks after index case became infected
  7. 7. PRODUCTION IMPACT STUDY
  8. 8. Methods • Breeding herds undergoing exposure programs • Baseline production parameters identified – Piglets weaned per week – 26 weeks of data prior to infection – Shewhart control chart • Time-to-Baseline Production • Loss (piglets/1000 sows)
  9. 9. Production Impact N = 18 herds % Baseline Production Avg TTBP = 5.9 wks 95% CI = 4.2-7.6 Loss: 1688 pigs/1000 sows 95% CI = 1077-2299 3.9 wks production 95% CI = 2.0-5.8 Weeks Post-Infection
  10. 10. TIME-TO-STABILITY STUDY
  11. 11. Methods • Breeding herds undergoing exposure programs • Criteria for Stability – Free of clinical signs – 4 samples PCR negative at weekly intervals • • • • At least 30 litters from farrowing 1 swab/swiffer per litter Pools of 5 litters Bias sample collection towards any diarrhea and/or younger sow parity
  12. 12. Time-to-Stability Progress • 4 sites enrolled and actively testing • 1 site has reached stability at 18 wks post-infection
  13. 13. SWINE HEALTH MONITORING PROJECT & REPORT
  14. 14. Swine Health Monitoring Project • What will be the next pathogen to cross the border into the US? • Infrastructure • VDL release agreement – Premises ID – Linked to VDL results – Linked to GPS coordinates in National Repository
  15. 15. Swine Health Monitoring Report
  16. 16. Visual History of PED Prevalence
  17. 17. Most Recent: 9/13/2013
  18. 18. Thank You! • Study participants & SHMP supporters • Dane Goede (goed0051@umn.edu) to receive report
  19. 19. Acknowledgments • Funding from – National Pork Board – Swine Disease Eradication Center – Leman China scholarship fund • Drs. Rossow, Rovira & Tousignant & U of M VDL • ISU, KSU, SDSU VDLs & NAHLN • USDA APHIS Centers of Epidemiology & Animal Health • • • • • AASV Bob Morrison Peter Davies Montse Torremorell U of MN Graduate Students
  20. 20. QUESTIONS?

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