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COTI-2 | A Potential Breakthrough
Therapy for Many Cancers

June 11, 2013
About COTI-2

Late preclinical
drug candidate
discovered using
CHEMSAS®
- the company’s
proprietary, artificial
intelligen...
COTI-2 highlights

1

Potential breakthrough therapy for
many cancers

2

Active against many cancers with
mutations of th...
Why p53 is important?

p53 is a tumour
suppressing
gene

If mutated, cancers
can develop & grow
without control

A mutatio...
The future of cancer treatments

COTI-2 targets and
primarily destroys
tumor cells
Traditional chemotherapy
kills growing ...
COTI-2 development progress

Easily synthesized oral formulation with no
stability issues

Effective alone or in combinati...
Disclaimer
When used anywhere in this presentation, whether oral or written, the words
potential, expects, believes, antic...
COTI-2 | A Potential Breakthrough
Therapy for Many Cancers
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Potential Breakthrough Therapy for Many Cancers

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Brief presentation about Critical Outcome Technologies' lead cancer drug candidate, COTI-2. COTI-2 has a major mechanism of action that is dependent on p53 gene mutation status in human cancer cells. This is important as drug treatment for p53 mutations represents a novel therapy and would be a first in class treatment for the drug company bringing COTI-2 to market. - See more at: http://www.criticaloutcomeblog.com/blog-posts.html#sthash.gt8VdlWx.dpuf

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Potential Breakthrough Therapy for Many Cancers

  1. 1. COTI-2 | A Potential Breakthrough Therapy for Many Cancers June 11, 2013
  2. 2. About COTI-2 Late preclinical drug candidate discovered using CHEMSAS® - the company’s proprietary, artificial intelligence-based drug discovery technology 2
  3. 3. COTI-2 highlights 1 Potential breakthrough therapy for many cancers 2 Active against many cancers with mutations of the p53 gene 3 > 50% of all human cancers have a p53 mutation 3
  4. 4. Why p53 is important? p53 is a tumour suppressing gene If mutated, cancers can develop & grow without control A mutation of the p53 gene is the most common mutation found in human cancer cells 4
  5. 5. The future of cancer treatments COTI-2 targets and primarily destroys tumor cells Traditional chemotherapy kills growing & dividing cells, cancer or healthy COTI-2 would treat genetic mutations common in many types of cancer Most current treatments are organ specific (i.e. treatment for lung cancer, colon cancer, etc.) 5
  6. 6. COTI-2 development progress Easily synthesized oral formulation with no stability issues Effective alone or in combination with approved cancer drugs In final two-species toxicity studies prior to FDA filing enabling human trials 6
  7. 7. Disclaimer When used anywhere in this presentation, whether oral or written, the words potential, expects, believes, anticipates, estimates and similar expressions are intended to identify forward-looking statements. Forward-looking statements may include statements addressing future financial and operating results of Critical Outcome Technologies Inc. (COTI). COTI bases these forward-looking statements on its current expectations about future events. Such statements are subject to risks and uncertainties including, but not limited to, the successful implementation of COTI’s strategic plans, the acceptance of new products, the obsolescence of existing products, the resolution of potential patent issues, competition, changes in economic conditions, and other risks described in COTI’s public documents such as press releases and filings with the Toronto Stock Exchange and the Ontario Securities Commission. All forward-looking statements are qualified in their entirety by the cautionary statements included in this document and such filings. These risks and uncertainties could cause actual results to differ materially from results expressed or implied by forward-looking statements contained in this presentation. These forward-looking statements speak only as of the date of this presentation. 7
  8. 8. COTI-2 | A Potential Breakthrough Therapy for Many Cancers

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