Dengue

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Dengue

  1. 1. Enhancing surveillance for Dengue fever in Florida
  2. 2. Dengue fever <ul><li>Mosquito-borne viral disease </li></ul><ul><ul><li>4 serotypes (DEN 1,2,3,4) </li></ul></ul><ul><ul><li>Infection with one serotype confers immunity only to that serotype </li></ul></ul><ul><ul><li>Subsequent infection with another serotype increases risk of severe disease (dengue hemorrhagic fever/shock syndrome) </li></ul></ul><ul><ul><li>severe disease most common in children </li></ul></ul>
  3. 3. World Distribution of Aedes aegypti and Dengue - 1999 Areas infested with Aedes aegypti Areas with Aedes aegypti and dengue epidemic activity CDC Centers for Disease Control and Prevention
  4. 4. Symptoms <ul><li>Fever with 2 or more of: </li></ul><ul><ul><li>headache </li></ul></ul><ul><ul><li>eye pain </li></ul></ul><ul><ul><li>muscle pain </li></ul></ul><ul><ul><li>joint pain </li></ul></ul><ul><ul><li>rash </li></ul></ul><ul><ul><li>hemorrhagic symptoms </li></ul></ul>
  5. 5. Why we care about dengue in Florida <ul><li>Last epidemic: 1934-35 </li></ul><ul><ul><li>15,000 cases in Miami (135,000 pop) </li></ul></ul><ul><li>Indigenous transmission occurred in Texas in 1986 and 1995 </li></ul><ul><li>The mosquito that transmits dengue is abundant in Florida </li></ul><ul><li>Dengue is endemic in Cuba, Mexico, and elsewhere in Caribbean, central and South America </li></ul>
  6. 6. Enhanced dengue surveillance showed we have more cas es than we thought <ul><li>1987-96: mean of 1.3 cases per year reported in Florida </li></ul><ul><li>1997-98: enhanced laboratory surveillance found 18 cases </li></ul><ul><li>All imported </li></ul><ul><li>Demonstrates potential for introduction of infection </li></ul><ul><li>We have the makings for endemic dengue in Florida </li></ul>
  7. 7. Increasing surveillance in Florida <ul><li>Tampa branch laboratory offers FREE dengue testing </li></ul><ul><li>Testing is more reliable than commercial labs </li></ul><ul><li>Provides state with faster results </li></ul><ul><li>Early detection earlier control efforts </li></ul>
  8. 8. Requirements for testing <ul><li>Serum (at least 1/2 ml) </li></ul><ul><li>Need acute and convalescent (3-4 weeks apart) </li></ul><ul><li>If you have CSF, send it: it can provide some additional information, but does not replace the two sera </li></ul><ul><li>Lab performs IgM and IgG ELISA tests </li></ul>
  9. 9. Information required with samples <ul><li>Person's name </li></ul><ul><li>Onset date </li></ul><ul><li>Symptoms </li></ul><ul><li>Travel history </li></ul><ul><li>Name of person to whom results should be send </li></ul><ul><li>Contact telephone numbers </li></ul>

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