Why Teach Heart Development to Cardiologists?


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Why should those who care for patients with congenital heart disease understand developmental biology? How will this help patients? See and find out.

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  • Why Teach Heart Development to Cardiologists?

    1. 1. Why teach heart development to cardiologists? Fraz Ahmed Ismat, MD Clinical Associate in Pediatrics The Children's Hospital of Philadelphia
    2. 2. Congenital heart disease deaths doubled childhood cancer deaths in 2005… Congenital heart disease Childhood cancer AHA website; Cancer Facts & Figures 2005
    3. 3. … but our improvements have stagnated Welke, et al., 2009
    4. 4. Why are we failing our patients?
    5. 5. Is our technology not cool enough? flickr.com/people/thedayhascome
    6. 6. Do we not care enough? flickr.com/people/30367663@N02
    7. 7. What are we missing? flickr.com/people/30367663@N02
    8. 8. It’s how we think about heart disease. flickr.com/people/rainerebert
    9. 9. How we think now…
    10. 10. How we think now… “obstruction” “hole”
    11. 11. www.oatey.com
    12. 12. Congenital heart disease is not just a plumbing problem… www.oatey.com
    13. 13. It’s a complex genetic problem…
    14. 14. …that we know a lot more about it than we used to, and…
    15. 15. ‘‘ When asked: Would you like to learn more about ’’ cardiac developmental biology and genetics?
    16. 16. When asked: ‘‘ Would you like to learn more about ’’ cardiac developmental biology and genetics? Yes! …clinicians No Not sure… want to bit.ly/DevCardio_Survey_1 learn it!
    17. 17. How we need to think…
    18. 18. How we need to think… Tbx1 Zic3 Tbx1 Jag1
    19. 19. But how does this help our patients?
    20. 20. Genetic changes don’t just affect the heart cells… flickr.com/people/arboreus
    21. 21. Genetic changes affect the entire developing body Ed Uthman, MD
    22. 22. How I study heart development… flickr.com/people/casperonline
    23. 23. Nf1 mutations lead to congenital heart disease… e normal f g Nf1 mutants i j k Gitler et al., 2003
    24. 24. Fatal blood vessel obstruction with Nf1 mutation Kanter et al., 2006
    25. 25. The right treatment can prevent these problems. flickr.com/people/jdvolcan
    26. 26. Blood vessel blockage in Nf1 mice can be prevented. Nf1 mutant normal Nf1 mutant + treatment Xu, Ismat, et al., 2008
    27. 27. He’ll thank you for it. flickr.com/people/partsnpieces
    28. 28. References Congenital Cardiovascular Defects: Statistics. http://www.americanheart.org/presenter.jhtml?identifier=4576. Cancer Facts and Figures 2005. American Cancer Society. Welke KF, Diggs BS, Karamlou T, Ungerleider RM. Ann Thorac Surg. 2009;87(1): 216-222. Kanter RJ, Graham M, Fairbrother D, Smith SV. J Pediatr. 2006;149(5):718-20. Gitler AD*, Zhu Y*, Ismat FA, Lu MM,Yamauchi Y, Parada LF, Epstein JA. Nat Genet. 2003;33(1):75-9. Xu J*, Ismat FA*, Wang T,Yang J, Epstein JA. Circulation. 2007 Nov 6;116(19):2148-56. Cardiac Developmental Biology & Genetics - Initial Survey http://bit.ly/DevCardio_Survey_1 flickr.com/people/partsnpieces