The “MODMED” Diet
Based on the traditional Mediterranean
diet, this presentation is where the
“MODMED” diet was conceived
...
The Modern Mediterranean Diet

A diet for people on the move…..
Albert Zumbé & Adam Lee
Natraceutical S.A.
May 2004
Autovi...
Fact: the importance of nutrition
 Nutrition is a recognised key health
determinant1
 Poor diets are directly related to...
The North American/Western Diet
 The typical North American/Western diet is
characterised by2,3,4,5
High intakes

Low int...
Recommended and actual daily
dietary intake in the US3
Recommended
intake

Actual intake

Fats, oils, sweets

Use sparingl...
“America has become the land of
the obese6”
 Obesity has become pandemic in the United
States:








61% of Americ...
The consequences of obesity and
physical inactivity
“Modern times may be characterised as a ‘feast’
environment, the conse...
Environmental & “lifestyle” factors
in the development of obesity
“Obesity is a multifactorial disease in which
environmen...
The urgent need to reduce obesity
& obesity related disorders
 “The public would benefit from increased
availability of f...
How to achieve a healthy diet & weight:
Recommendations of the American Heart
Association19
The AHA recommends consumption...
Which healthy diet can fulfil the
recommendations of the American Heart
Association?








Help achieve a healthy...
The Mediterranean Diet
“A proven cultural model for healthy
eating”20

20

Willett et al (1995) Am. J. Clin. Nutr. 61; (Su...
The Mediterranean basin: more than
20 countries border the Mediterranean
Spain
France
Italy
Greece
Turkey
Lebanon
Syria
Is...
Some characteristics of the
Mediterranean diet20,21
 Based on food patterns typical of Crete, most
of Greece & Southern I...
Composition of the Mediterranean
Diet22
 High consumption of olive oil & low
consumption of animal fats
 High consumptio...
The Mediterranean Diet Pyramid20

20

Willett et al (1995) Am. J. Clin. Nutr. 61; (Suppl 6): 1402S-1406S
The Mediterranean Diet
Health benefits
The Mediterranean diet and
coronary heart disease (CHD)
 Reduces the overall risk of CHD23,24
 Protects against CHD in T...
Cancer & Mediterranean dietary
traditions
“Approximately up to 25% of the incidence
of colorectal cancer, 15% of breast ca...
The Mediterranean diet and
cancer: clinical studies results
“Greater adherence to the Mediterranean diet is
associated wit...
Other health benefits of the
Mediterranean diet
 Reduces serum low density lipoprotein (LDL) &
increases serum high densi...
The Mediterranean diet is
compatible with “Low Carb” foods

Serum glucose

Serum glucose

Low carb and/or low net carb = l...
The importance of antioxidants:
“oxidative stress” and disease39,40
 Reactive oxygen species (ROS) or “free
radicals” pla...
Diets rich in antioxidants prevent
organic deterioration caused by
excessive oxidative stress41
 Key Mediterranean foods ...
Choose the right type of fats:
prevent atherosclerosis42
 The main sources of fat in the Mediterranean
diet are olive oil...
Alkalinizing effect of fruits & vegetables
in the Mediterranean diet43,44
 Fruits & vegetables in the Mediterranean diet
...
The big question: can the
Mediterranean diet help weight loss?
 Results of clinical studies in which obese
subjects consu...
Evolution of the Mediterranean
diet
A highly adaptable & constantly
evolving diet
Evolution of the Mediterranean diet
 The virtues of the Mediterranean diet were
promoted as early as 161448
 Now defined...
The Mediterranean diet incorporates foods
from many non-Mediterranean sources49
 Grapes (Vitis vinifera)

Central & South...
Further adaptation of the
Mediterranean diet for a modern
Western lifestyle
 Although healthy, the traditional Mediterran...
The Modern Mediterranean Diet
The “MODMED” diet
A diet for people on the move…..
The “MODMED” diet: incorporates
traditional Mediterranean foods
 Incorporates the key healthy ingredients
of the traditio...
The “MODMED” diet: incorporates
novel functional foods
 Incorporates novel, key, functional food
ingredients and function...
Functional “MODMED” food
ingredients from Natraceutical S.A.

Chocolate sponge cake

Olive bread

Ingredient: Cocoa Bean P...
Functional “MODMED” food
ingredients from Natraceutical S.A.
Ingredient: Nopal Powder
Claims: Made from the “prickly pear”...
Functional “MODMED” consumer
products from Natraceutical S.A.
Product: Chocolate spread/sauce
Claims: Made with chocolate ...
Functional “MODMED” consumer
products from Natraceutical S.A.
Product: Olive Sauce
Claims: Made with Mediterranean ingredi...
Summary:
 Obesity & it’s co-morbidities are pandemic in
Western societies
 The Mediterranean diet is a proven cultural m...
For more information see:
 www.olivepowder.com
 www.wholecocoabeanpowder.com
 www.chocolatepowder.com
 www.natraceutic...
“Let food be our first medicine”
Hippocrates (400 BC)

Autovia A-3. Salida 343
Cami de Torrent, s/n 46930
Quart de Poblet
...
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  • Reference:
    1 Kafatos A (2003) Why we need a European Nutrition policy. EGEA, International Conference on Health Benefits of the Mediterranean Diet. Abstract book, 1st Edition.
  • References:
    2 Frazao E & Allshouse J (2003) Strategies for intervention: commentary and debate. Journal of Nutrition 133: 844S-847S.
    3 Kantor L (1988) A dietary assessement of the U.S. food supply: comparing per capita food consumption with food guide pyramid servings recommendations. Agricultural Economic Report No. 772, U.S. Department of Agriculture, Economic Research Service, Washington D.C.
    4 Economic Research Service (2002) Food Consumption (per capita) System. http://www.ers.usda.gov.data/foodconsumption
    5 Howarth NC, Saltzman E & Roberts SB (2001) Dietary fibre and weight regulation. Nutrition Reviews, 59: 129-139.
  • Reference:
    3 Kantor L (1988) A dietary assessement of the U.S. food supply: comparing per capita food consumption with food guide pyramid servings recommendations. Agricultural Economic Report No. 772, U.S. Department of Agriculture, Economic Research Service, Washington D.C.
  • References:
    6 Moore BJ (2003) Supersized America: help your patients regain control of their weight. Cleve. Clin. J. Med. 70: 237-240
    7 Montague MC (2003) The physiology of obesity. ABNF J. 14: 56-60.
    8 Bray GA & Champagne CM (2004) Obesity and Metabolic Symdrome: implications for dietetics practitioners. J. Am. Diet. Assoc. 104: 86-89.
    9 Manson JE, Skerrett PJ, Greenland P, VanItallie TB (2004) The escalating pandemics of obesity and sedentary lifestyle. A call to action for clinicians. Arch. Intern. Med. 164: 249-258.
  • References:
    10 Wargovich MJ & Cunningham JE (2003) Diet, individual responsiveness and cancer prevention. J. Nutr. 133: (Suppl 7): 2400S-2403S.
    11 Dubbert PM, Carithers T, Sumner AE, Barbour KA, Clark BL, Hall JE, Crook ED (2002) Obesity, physical inactivity, and risk for cardiovascular disease. Am. J. Med. Sci. 324: 116-126.
    12 Sowers JR (2003) Obesity as a cardiovascular risk factor. Am. J. Med. 115: Suppl 8A: 37S-41S.
    13 Giovannucci E (2003) Diet, body weight, and colorectal cancer: a summary of the epidemiologic evidence. J. Womens Health (Larchmt) 12: 173-182.
  • References:
    2 Frazao E & Allshouse J (2003) Strategies for intervention: commentary and debate. Journal of Nutrition 133: 844S-847S.
    9 Manson JE, Skerrett PJ, Greenland P, VanItallie TB (2004) The escalating pandemics of obesity and sedentary lifestyle. A call to action for clinicians. Arch. Intern. Med. 164: 249-258.
    12 Sowers JR (2003) Obesity as a cardiovascular risk factor. Am. J. Med. 115: Suppl 8A: 37S-41S.
    14 Clement K, Boutin P, Froguel P. Genetics of obesity (2002) Am. J. Pharmacogenomics 2: 177-187.
    15 Bellisle F (2003) Why should we study human food intake behaviour? Nutr. Metab. Cardiovasc. Dis. 13: 189-193.
    16 Jeffery RW & Utter J (2003) The changing environment and population obesity in the United States. Obes. Res. 11: Suppl: 12S-22S.
  • References:
    17 U.S. Dept. of Health and Human Services (1988) The Surgeon General’s Report on Nutrition and Health. DHSS (PHS) publication No. 88-50211, Washington, D.C.
    18 Barringer TA (2001) Mediterranean diets and cardiovascular disease. Curr. Atheroscler. Rep. 3: 437-445.
  • Reference:
    19 Kris-Etherton PM, Etherton TD, Carlson J, Gardner C (2002) Recent discoveries in inclusive food-based approaches and dietary patterns for reduction in risk for cardiovascular disease. Curr. Opin. Lipidol. 13:397-407.
  • Metabolic syndrome, a consequence of obesity, is a lethal combination of:
    Obesity
    Hypertension
    Insulin resistance
    Type 2 diabetes
    Atherosclerosis (hardening of the arteries)
  • Reference:
    20 Willett WC, Sacks F, Trichopoulou A, Drescher G, Ferro-Luzzi A, Helsing E, Trichopoulos D (1995) Am. J. Clin. Nutr. 61; (Suppl 6): 1402S-1406S.
  • References:
    20 Willett WC, Sacks F, Trichopoulou A, Drescher G, Ferro-Luzzi A, Helsing E, Trichopoulos D (1995) Am. J. Clin. Nutr. 61; (Suppl 6): 1402S-1406S.
    21 Nestle M (1995) Mediterranean diets: historical and research overview. Am. J. Clin. Nutr. 61; (Suppl 6): 1313S-1320S.
  • Reference:
    22 Naska A (2003) The Mediterranean diet at present. EGEA, International Conference on Health Benefits of the Mediterranean Diet. Abstract book, 1st Edition.
  • Reference:
    20 Willett WC, Sacks F, Trichopoulou A, Drescher G, Ferro-Luzzi A, Helsing E, Trichopoulos D (1995) Am. J. Clin. Nutr. 61; (Suppl 6): 1402S-1406S.
  • References:
    23 Kok FJ & Kromhout D (2004) Atherosclerosis epidemiological studies on the health effects of a Mediterranean diet. Eur. J. Nutr. 43; (Suppl 1): I2-I5.
    24 Srinath Reddy K & Katan MB (2004) Diet, nutrition and the prevention of hypertension and cardiovascular diseases. Public Health Nutr. 7 (1A): 167-186.
    25 Toobert DJ, Glasgow RE, Stryker LA, Barrera M Jr, Radcliffe JL, Wander RC, Bagdade JD (2003) Biologic and quality-of-life outcomes from the Mediterranean lifestyle program: a randomized clinical trial. Diabetes Care 26: 2288-2293.
    26 Pitsavos C, Panagiotakos DB, Chrysohoou C, Papaioannou I, Papadimitriou L, Tousoulis D, Stefanadis C, Toutouzas P (2003) The adoption of Mediterranean diet attenuates the development of acute coronary syndromes in people with the metabolic syndrome. Nutr. J. 19: 1-7.
    27 von Schacky C (2003) Secondary prevention of coronary heart disease. MMW Fortschr. Med. 145 (13): 28, 30, 32-33.
    28 Martin-Du Pan R (2003) Rev. Med. Suisse Romande 123: 183-189.
  • Reference:
    29 Trichopoulou A, Lagiou P, Kuper H, Trichopoulos D (2000) Cancer and Mediterranean dietary traditions. Cancer Epidemiol. Biomarkers Prev. 9: 869-873.
  • References:
    30 Trichopoulou A, Costacou T, Bamia C, Trichopoulos D (2003) Adherance to a Mediterranean diet and survival in a Greek population. N. Engl. J. Med. 348: 2599-2608.
    31 Bosetti C, Gallus S, Trichopoulou A, Talamini R, Franceschi S, Negri E, La Vecchia C (2003) Influence of the Mediterranean diet on the risk of cancers of the upper aerodigestive tract. Cancer Epidemiol. Biomarkers Prev. 12: 1091-1094.
    32 Fortes C, Forastiere F, Farchi S, Mallone S, Trequattrinni T, Anatra F, Schmid G, Perucci CA (2003) The protective effect of the Mediterranean diet on lung cancer. Nutr. Cancer 46: 30-37.
    33 Riboli E & Norat T (2003) Consumption of fruit and vegetables and prevention of cancers of the digestive tract: results from EPIC aand other studies. EGEA, International Conference on Health Benefits of the Mediterranean Diet. Abstract book, 1st Edition.
    34 Adderley-Kelly B & Williams-Stephens E (2003) The relationship between obesity and breast cancer. ABNF J. 14: 61-65.
  • References:
    25 Toobert DJ, Glasgow RE, Stryker LA, Barrera M Jr, Radcliffe JL, Wander RC, Bagdade JD (2003) Biologic and quality-of-life outcomes from the Mediterranean lifestyle program: a randomized clinical trial. Diabetes Care 26: 2288-2293.
    35 Haban P, Klvanova J, Zidekova E, Nagyova A (2004) Dietary supplementation with olive oil leads to improved lipoprotein spectrum and lower n-6 PUFAs in elderly subjects. Med. Sci. Monit. 10: PI49-PI54.
    36 Panagiotakos DB, Pitsavos CH, Chrysohoou C, Skoumas J, Papadimitriou L, Stefanadis C, Toutouzas PK (2003) Status and management of hypertension in Greece: role of the adoption of a Mediterranean diet: the Attica study. J. Hypertens. 21: 1483-1489.
    37 Panagiotakos DB, Pitsavos CH, Chrysohoou C, Skoumas J, Stefanadis C (2004) Status and management of blood lipids in Greek adults and their relation to socio-demographic, lifestyle and dietary factors: the ATTICA Study; blood lipids distribution in Greece. Atherosclerosis 173: 351-359.
    38 Visioli F & Galli C (2001) The role of antioxidants in the Mediterranean diet. Lipids 36; Suppl: S49-S56.
  • Free radicals are normally generated in the body’s cells by metabolic processes. However, these free radicals may be generated in excess due to poor diet, smoking and environmental stress. Thus, free radicals may accumulate in the body and cause damage to the body’s cells. This type of damage is implicated in the development of several diseases including cardiovascular disease, hypertension, diabetes and cancer. Free radicals are implicated in cardiovascular disease because they oxidise serum cholesterol which then builds up on the walls of arteries causing atherosclerosis and coronary heart disease. Antioxidants play a vital role in preventing tissue damage due to free radicals because they “quench” or neutralise the oxidising effect of free radicals, thus preventing development of several important diseases.
    References:
    39 Castronovo V (2003) Nutrition and Cancer. Rev.Med. Liege. 58: 231-239.
    40 Taniyama Y & Griendling KK (2003) Reactive oxygen species in the vasculature: molecular and cellular mechanisms.
  • References:
    41 Elejalde Guerra JI (2001) Oxidative stress, diseases and antioxidant treatment. An. Med. Interna. 18: 326-335.
  • Reference:
    42 Moreno JA & Mitjavila MT (2003) The degree of unsaturation of dietary fatty acids and the development of atherosclerosis (review). J. Nutr. Biochem. 14: 182-195.
  • References:
    43 Remesy C & Demigne C (2003) Alkalinizing effects of fruits, vegetables and potatoes. EGEA, International Conference on Health Benefits of the Mediterranean Diet. Abstract book, 1st Edition.
    44 Weisburger JH (2000) Eat to live, not live to eat. Nutrition 16: 767-773.
  • References:
    45 Castagnetta L, Granata OM, Cusimano R, Ravazzolo B, Liquori M, Polito L, Miele M, Di Cristina A, Hamel P, Traina A (2002) The Mediet Project. Ann. N. Y. Acad. Sci. 963: 282-289.
    46 Bautista-Castano I, Molina-Cabrillana J, Montoya-Alonso JA, Serra-Majem L (2003) Med. Clin. (Barc) 121: 485-491.
    47 McManus K, Antinoro L, Sacks F (2001) A randomised controlled trial of a moderate-fat, low-energy diet compared with a low fat, low-energy diet for weight loss in overweight adults. Int. J. Obes. Relat. Metab. Disord. 25: 1503-1511.
  • References:
    22 Naska A (2003) The Mediterranean diet at present. EGEA, International Conference on Health Benefits of the Mediterranean Diet. Abstract book, 1st Edition.
    48 Haber B (1997) The Mediterranean diet: a view from history. Am. J. Clin. Nutr. 66; (Suppl 4): 1053S-1057S.
  • Reference:
    49 Smartt J (1995) Evolution of crop plants, 2nd Edition. Blackwell, Oxford.
  • Mod med diet

    1. 1. The “MODMED” Diet Based on the traditional Mediterranean diet, this presentation is where the “MODMED” diet was conceived Albert Zumbé & Adam Lee © Natraceutical UK 1st of March 2004 For more information: Info@natrauk.com
    2. 2. The Modern Mediterranean Diet A diet for people on the move….. Albert Zumbé & Adam Lee Natraceutical S.A. May 2004 Autovia A-3. Salida 343 Cami de Torrent, s/n 46930 Quart de Poblet Valencia, Spain
    3. 3. Fact: the importance of nutrition  Nutrition is a recognised key health determinant1  Poor diets are directly related to the increasing burden of chronic diseases in Western populations, notably:     Cardiovascular disease Obesity & its co-morbidities (diabetes) Various cancers Osteoporosis 1 Kafatos (2003) EGEA, International Conference on Health Benefits of the Mediterranean Diet
    4. 4. The North American/Western Diet  The typical North American/Western diet is characterised by2,3,4,5 High intakes Low intakes Sugars Fresh fruits Refined carbohydrate Fresh vegetables Saturated fats Dietary fibre Red meat Some micronutrients Frazao & Allshouse (2003) J. Nutr. 133: 844S-847S Kantor (1998) USDA Report No. 772 4 ERS (2002) www.ers.usda.gov/data/foodconsumption 5 Howarth et al (2001) Nutr. Rev. 59: 129-139 2 3
    5. 5. Recommended and actual daily dietary intake in the US3 Recommended intake Actual intake Fats, oils, sweets Use sparingly 34 tsp. added sugars & 64 g added fats Meat, poultry, fish, beans, eggs, nuts 2 – 3 servings 2 – 5 servings Fruit 2 – 4 servings 1.4 servings Vegetables 3 – 5 servings 4 servings 3 Kantor (1998) USDA Report No. 772
    6. 6. “America has become the land of the obese6”  Obesity has become pandemic in the United States:      61% of Americans >20 years are overweight or obese7 At least 25% of Americans are clinically obese7 24% of the population has metabolic syndrome8 Obesity leads to 300,000 premature deaths every year9 Obesity costs $90 billion in direct health care costs annually in the USA alone9 Moore (2003) Cleve. Clin. J. Med. 70: 237-240 Montague (2003) ABNF J. 14: 56-60 8 Bray & Champagne (2004) J. Am. Diet. Assoc. 104: 86-89 9 Manson et al (2004) Arch. Intern. Med. 164: 249-258 6 7
    7. 7. The consequences of obesity and physical inactivity “Modern times may be characterised as a ‘feast’ environment, the consequences being an increase in risk for several diseases”10 Cardiovascular disease11  Hypertension12  Type 2 diabetes12  Insulin resistance12  Cancer13  Wargovioch & Cunningham (2003) J. Nutr. 133: 2400S-2403S Dubbert et al (2002) Am. J. Med. Sci. 324: 116-126 12 Sowers (2003) Am. J. Med. 115: Suppl 8A; 37S-41S 13 Giovannucci (2003) J. Womens Health 12: 173-182 10 11
    8. 8. Environmental & “lifestyle” factors in the development of obesity “Obesity is a multifactorial disease in which environmental and genetic factors interact”14 Some environmental factors: Poor palatability of alternative diets2 Poor nutrition knowledge2 Sedentary lifestyle9 Excess energy intake12 Increased portion sizes15 Increased availability of convenience food16 Busy lifestyle/time constraints16 Frazao & Allshouse (2003) J. Nutr. 133: 844S-847S 9 Manson et al (2004) Arch. Intern. Med. 164: 249-258 12 Sowers (2003) Am. J. Med. 115: Suppl 8A; 37S-41S 2 Clement et al (2002) Am. J. Pharmacogenomics 2: 177-187 Bellisle (2003) Nutr. Metab. Cardiovasc. Dis. 13: 189-193 16 Jeffery & Utter (2003) Obes. Res. 11: 12S-22S 14 15
    9. 9. The urgent need to reduce obesity & obesity related disorders  “The public would benefit from increased availability of foods and food products low in calories and total fat”17  “Epidemiologic data and clinical trials suggest that the beneficial impact of specific dietary and lifestyle changes on cardiac event rates could be greater than that achieved by any of the drug or revascularisation trials to date” 18 17 18 The Surgeon General’s report on Nutrition & Health (1988) U.S. Dept. of Health & Human Services Barringer TA (2001) Curr. Atheroscler. Rep. 3: 437-445
    10. 10. How to achieve a healthy diet & weight: Recommendations of the American Heart Association19 The AHA recommends consumption of:  Fruits & vegetables  Grains & wholegrains  Fish  Lean meat  Poultry  Fat-free products  Low-fat dairy products  Legumes  Soluble fibre  Plant sterols  Less saturated fat 19 Kris-Etherton et al (2002) Curr. Opin. Lipidol. 13: 397-407
    11. 11. Which healthy diet can fulfil the recommendations of the American Heart Association?        Help achieve a healthy weight Promote heart-health Promote desirable lipid levels Promote desirable blood pressure Reduce risk of diabetes & metabolic syndrome Reduce cholesterol levels Is varied & pleasurable to consume
    12. 12. The Mediterranean Diet “A proven cultural model for healthy eating”20 20 Willett et al (1995) Am. J. Clin. Nutr. 61; (Suppl 6): 1402S-1406S
    13. 13. The Mediterranean basin: more than 20 countries border the Mediterranean Spain France Italy Greece Turkey Lebanon Syria Israel Egypt Libya Morocco
    14. 14. Some characteristics of the Mediterranean diet20,21  Based on food patterns typical of Crete, most of Greece & Southern Italy in the early 1960’s  Adult life expectancy amongst the highest in the World  Rates of heart disease, cancers & diet related diseases amongst the lowest in the World  Lifestyle included regular physical activity  Attractive, varied dietary pattern  Highly palatable & enjoyable 20 21 Willett et al (1995) Am. J. Clin. Nutr. 61; (Suppl 6): 1402S-1406S Nestle M (1995) Am. J. Clin. Nutr. 61; (Suppl 6): 1313S-1320S
    15. 15. Composition of the Mediterranean Diet22  High consumption of olive oil & low consumption of animal fats  High consumption of fruit & vegetables  High consumption of legumes  High consumption of grains & whole grains  Moderate to high consumption of oily fish  Moderate consumption of dairy products  Moderate wine consumption  Low consumption of meat & meat products 22 Naska (2003) EGEA, International Conference on Health Benefits of the Mediterranean Diet
    16. 16. The Mediterranean Diet Pyramid20 20 Willett et al (1995) Am. J. Clin. Nutr. 61; (Suppl 6): 1402S-1406S
    17. 17. The Mediterranean Diet Health benefits
    18. 18. The Mediterranean diet and coronary heart disease (CHD)  Reduces the overall risk of CHD23,24  Protects against CHD in Type II diabetics25  Protects against CHD in subjects with metabolic syndrome (35% reduced risk)26  Protects against further cardiac events in CHD patients27,28 Kok & Kromhout (2004) Eur. J. Nutr. 43; (Suppl 1): I2-I5 Srinath Reddy & Katan (2004) Public Health Nutr. 7 (1A): 167-186 25 Toobert et al (2003) Diabetes Care 26: 2288-2293 26 Pitsavos et al (2003) Rev. Med. Suisse Romande 123: 183-189 27 von Schacky (2003) MMW Fortschr. Med. 145 (13): 28, 30, 32-33 28 Martin-Du Pan (2003) Rev. Suisse Romande 123: 183-189 23 24
    19. 19. Cancer & Mediterranean dietary traditions “Approximately up to 25% of the incidence of colorectal cancer, 15% of breast cancer and 10% of the incidence of prostate, pancreas and endometrial cancer could be prevented if the populations of developed Western countries could shift to the traditional healthy Mediterranean diet” 29 29 Trichopoulou et al (2000) Cancer Epidemiol. Biomarkers Prev. 9: 869873
    20. 20. The Mediterranean diet and cancer: clinical studies results “Greater adherence to the Mediterranean diet is associated with a significant reduction in mortality due to cancer”30 The Mediterranean diet significantly reduces the risk of:  Cancers of the upper aerodigestive tract 31  lung cancer32  Colorectal cancer33  Breast cancer34 Trichopoulou et al (2003) N. Engl. J. Med. 348: 2599-2608 30 Bosetti et al (2003) Cancer Epidemiol Biomarkers Prev. 12: 1091-1094 Fortes et al (2003) Nutr. Cancer (2003) 46: 30-37 33 Riboli & Norat (2003) EGEA 34 Adderley-Kelly & Williams-Stephens (2003) ABNF J. 14: 61-65 31 32
    21. 21. Other health benefits of the Mediterranean diet  Reduces serum low density lipoprotein (LDL) & increases serum high density lipoprotein (HDL)35  Reduces hypertension & controls blood pressure36  Reduces serum lipids37  Improves glycemic control25  Rich in antioxidants38 Toobert et al (2003) Diabetes Care 26: 2288-2293 25 Haban et al (2004) Med. Sci. Monit. 10: PI49-PI54 Panagiotakos et al (2003) J. Hypertens. 21: 1483-1489 37 Panagiotakos et al (2004) Atherosclerosis 173: 351-359 38 Visioli & Galli (2001) Lipids 36; Suppl: S49-S56 35 36
    22. 22. The Mediterranean diet is compatible with “Low Carb” foods Serum glucose Serum glucose Low carb and/or low net carb = low Glycemic Index (GI) Time after meal (hours) Time after meal (hours) High carbohydrate ingredient Low carbohydrate Mediterranean ingredient
    23. 23. The importance of antioxidants: “oxidative stress” and disease39,40  Reactive oxygen species (ROS) or “free radicals” play a major role in the development of:      Oxidative stress states Cardiovascular disease Hypertension Diabetes Cancer 39 40 Castronova (2003) Rev. Med. Liege 58: 231-239 Taniyama & Griendling (2003) Hypertension 42: 1075-1081
    24. 24. Diets rich in antioxidants prevent organic deterioration caused by excessive oxidative stress41  Key Mediterranean foods with high antioxidant activity:      Olives & olive oil (hydroxytyrosol, oleuropein) Tomatoes (lycopene) Red wine (procyanidins) Fruits & vegetables (various polyphenols) Cocoa derivatives (flavonoids) 41 Elejalde Guerra (2001) An. Med. Interna. 18: 326-335
    25. 25. Choose the right type of fats: prevent atherosclerosis42  The main sources of fat in the Mediterranean diet are olive oil & oily fish:      Rich in unsaturated fatty acids Reduces low density lipoprotein concentrations Increases high density lipoprotein concentrations Helps prevent atherosclerosis & cardiovascular disease Helps prevent coronary heart disease 42 Moreno & Mitjavila (2003) J. Nutr. Biochem. 14: 182-195
    26. 26. Alkalinizing effect of fruits & vegetables in the Mediterranean diet43,44  Fruits & vegetables in the Mediterranean diet are rich in K+ ions  These neutralise “fixed acidity” which reflects metabolism of dietary proteins  High K+ fruits & vegetables and Ca2+ from dairy products must be consumed with high protein diets to prevent metabolic acidosis and deleterious effects on Ca2+ status 43 44 Remesy & Demigne (2003) EGEA, International Conference on Health Benefits of the Mediterranean Diet Weisburger (2000) Nutrition 16: 767-773
    27. 27. The big question: can the Mediterranean diet help weight loss?  Results of clinical studies in which obese subjects consumed a prescribed Mediterranean diet show:    Weight loss & strong reduction in cholesterol levels45 Weight loss & beneficial effects on blood pressure46 Significant weight loss & superior long-term adherence to the prescribed diet47 Castagnetta et al (2002) Ann. N. Y. Acad. Sci. 963: 282-289 Bautista-Castano et al (2003) Med. Clin. (Barc) 121: 485-491 47 McManus et al (2001) Int. J. Obes. Relat. Metab. Disord. 25: 1503-1511 45 46
    28. 28. Evolution of the Mediterranean diet A highly adaptable & constantly evolving diet
    29. 29. Evolution of the Mediterranean diet  The virtues of the Mediterranean diet were promoted as early as 161448  Now defined on the basis of dietary patterns found in the region in the 1950’s and early 1960’s 22  Evolved over many years & still evolving  Incorporates non-native foods from many other continents and countries  Great variation but with common characteristics 22 48 Naska (2003) EGEA, International Conference on Health Benefits of the Mediterranean Diet Haber (1997) Am. J. Clin. Nutr. 66; (Suppl 4): 1053S-1057S
    30. 30. The Mediterranean diet incorporates foods from many non-Mediterranean sources49  Grapes (Vitis vinifera) Central & South East Asia South East Asia & India South America  Citrus fruit (Citrus sp.)  Tomatoes (Lycopersicon sp.)  Peppers & chillis (Capsicum sp.)  Cocoa (Theobroma cacao) 49 Central & South America Central & South America Smartt (1995) Evolution of crop plants, 2 nd Ed.
    31. 31. Further adaptation of the Mediterranean diet for a modern Western lifestyle  Although healthy, the traditional Mediterranean diet needs to be adapted for modern Western societies  Modern Western societies are:     Highly mobile but sedentary Increasingly busy but without hard physical labour May not have the time needed to source & prepare Mediterranean foods Have an urgent need for convenient healthy food choices
    32. 32. The Modern Mediterranean Diet The “MODMED” diet A diet for people on the move…..
    33. 33. The “MODMED” diet: incorporates traditional Mediterranean foods  Incorporates the key healthy ingredients of the traditional Mediterranean diet      Olives & olive oil Fruits & vegetables Cereals & whole grains Oily fish Red wine
    34. 34. The “MODMED” diet: incorporates novel functional foods  Incorporates novel, key, functional food ingredients and functional consumer products         Olive Powder Cocoa Bean Powder Nopal Powder Tomato Powder Low fat chocolate sauce/spread Low fat olive spread Low fat tomato sauce Low fat olive sauce
    35. 35. Functional “MODMED” food ingredients from Natraceutical S.A. Chocolate sponge cake Olive bread Ingredient: Cocoa Bean Powder Claims: Made from whole cocoa beans High in dietary fibre Low fat product High in natural antioxidants Natural cocoa taste Ingredient: Olive Powder Claims: Made from fresh olives High dietary fibre High in natural antioxidants Improves shelf life Natural olive taste
    36. 36. Functional “MODMED” food ingredients from Natraceutical S.A. Ingredient: Nopal Powder Claims: Made from the “prickly pear” Reduces glycemic index of foods High in soluble dietary fibre Low fat product Ingredient: Tomato Powder Claims: High in dietary fibre Low fat product High in natural antioxidants
    37. 37. Functional “MODMED” consumer products from Natraceutical S.A. Product: Chocolate spread/sauce Claims: Made with chocolate flakes Low fat product Cholesterol free Trans fatty acids free High in natural antioxidants Product: Olive Light Claims: Made with olive oil Low fat product Cholesterol free Trans fatty acids free High in natural antioxidants
    38. 38. Functional “MODMED” consumer products from Natraceutical S.A. Product: Olive Sauce Claims: Made with Mediterranean ingredients Low fat product Cholesterol free Trans fatty acids free High in natural antioxidants Product: Tomato Sauce Claims: Made with Mediterranean ingredients Low fat product Cholesterol free Trans fatty acids free High in natural antioxidants
    39. 39. Summary:  Obesity & it’s co-morbidities are pandemic in Western societies  The Mediterranean diet is a proven cultural model for healthy eating  The Mediterranean diet can be adapted to suit busy Western societies  Functional food ingredients & consumer products can be incorporated into the Mediterranean diet to give the “MODMED” diet  The “MODMED” diet could help management of obesity and associated diseases
    40. 40. For more information see:  www.olivepowder.com  www.wholecocoabeanpowder.com  www.chocolatepowder.com  www.natraceuticaluk.com
    41. 41. “Let food be our first medicine” Hippocrates (400 BC) Autovia A-3. Salida 343 Cami de Torrent, s/n 46930 Quart de Poblet Valencia, Spain www.natraceuticals.com info@natraceuticals.com

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