Neuropathology Conference 12/01/05 - Case 2

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Neuropathology Conference 12/01/05 - Case 2

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Neuropathology Conference 12/01/05 - Case 2

  1. 1. Neuropathology Case Conference 12/02/2005
  2. 2. Case 2: 62 y/o Female, Progressive left upper extremity numbness, S/P liver transplant
  3. 4. Differential Diagnosis <ul><li>Malignant Melanoma </li></ul><ul><li>Foreign Body Type Reaction </li></ul><ul><li>Glial Neoplasm </li></ul><ul><li>Phaeohyphomycosis </li></ul>
  4. 5. Cerebral Phaeohyphomycosis <ul><li>Dematiaceous fungi (darkly pigmented fungi) </li></ul><ul><li>Phaeohyphomycosis (CNS cases: Cladophialophora bantiana ) </li></ul><ul><li>Chromoblastomycosis (CNS cases: Fonsecaea pedrosoi ) </li></ul><ul><li>Dark, thick-walled muriform cells ( sclerotic bodies ) </li></ul><ul><li>High mortality (70% in C. bantiana ) and morbidity </li></ul><ul><li>Fungi identified on frozen section/ touch prep </li></ul>

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