Neuropathology Conference 12/01/05 - Case 1

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Neuropathology Conference 12/01/05 - Case 1

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Neuropathology Conference 12/01/05 - Case 1

  1. 1. Neuropathology Case Conference 12/02/2005
  2. 2. Case 1: 40 y/o Male, intermittent generalized headache
  3. 5. Differential Diagnosis <ul><li>Rathke’s Cleft Cyst </li></ul><ul><li>Dermoid Cyst </li></ul><ul><li>Colloid Cyst </li></ul><ul><li>Epidermoid Cyst </li></ul><ul><li>Craniopharyngioma </li></ul>
  4. 6. Colloid cyst of third ventricle <ul><li>Origin: neuroepithelial? vs. primitive foregut endoderm? </li></ul><ul><li>Intermittent generalized headache (rare “classical history”), “colloid cyst apoplexy”, sudden death </li></ul><ul><li>Gross: gray pultaceous material or soft cartilage-like hyaline substance slipping out like a marble. </li></ul><ul><li>Micro: cuboidal, columnar cells, goblet cells, ciliated columnar cells </li></ul><ul><li>IHC: low- and high-molecular CK, EMA: Positive, GFAP: Negativet </li></ul>

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