Cytopathology Conference 9/08/05 - Case 1

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Cytopathology Conference 9/08/05 - Case 1

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Cytopathology Conference 9/08/05 - Case 1

  1. 1. Cytopathology 09/08/05
  2. 2. <ul><li>Peritoneal fluid from a 77 year old female. </li></ul>
  3. 5. Diagnosis?
  4. 8. Diagnosis?
  5. 9. Metastatic Lobular Carcinoma of the Breast
  6. 10. Lobular Carcinoma of the Breast <ul><li>Arises from terminal ductules of the TDLUs </li></ul><ul><li>Types: classic, alveolar, solid, pleomorphic </li></ul><ul><li>Incidence: 1-20% of invasive breast cancers </li></ul><ul><li>Pure ILC does not involve nipple </li></ul><ul><li>Tendency to be multicentric and bilateral </li></ul>
  7. 11. Lobular Carcinoma of the Breast <ul><li>Cytology: </li></ul><ul><ul><li>May see separate dyshesive cells or groups of cells </li></ul></ul><ul><ul><li>Well defined borders </li></ul></ul><ul><ul><li>May see Indian filing </li></ul></ul><ul><ul><li>May see intracytoplasmic vacuoles </li></ul></ul>
  8. 12. Diff-Quick Stain Papanicolaou Stain
  9. 13. Stains (diff-quick)
  10. 15. Wright Stain <ul><li>“ Romanovsky-type” stain </li></ul><ul><ul><li>A.K.A. Wright-Giemsa; utilized in peripheral blood smears. </li></ul></ul><ul><ul><li>Contains mixtures of methylene blue, azure, and eosin. </li></ul></ul><ul><ul><li>Metachromasia: property of methylene blue and toluidine blue dyes. </li></ul></ul><ul><ul><ul><li>Cell components stain a different color than the dye itself. </li></ul></ul></ul><ul><ul><ul><ul><li>Mast cell granules, cartilage, and mucin will stain purple. </li></ul></ul></ul></ul>
  11. 16. James Homer Wright Determination of the cellular lineage of multiple myeloma. Demonstration of spirochetes in syphilitic aneurysms of the aorta. Identification of the megakaryocyte as the cell of origin of blood platelets. Co-authored a book with Frank Mallory: “Patholgical Technique”, which was the staple laboratory manual for over 40 years. (1869-1928)
  12. 17. Pap Smear from a 71-year-old Female
  13. 21. Diagnosis?
  14. 22. Atrophic Vaginitis
  15. 23. Atrophy
  16. 24. Atrophy
  17. 31. <ul><li>64-year-old female with history of left breast mass </li></ul>
  18. 36. Mucocele with an associated Intraductal Papilloma
  19. 37. Comparison: Colloid Carcinoma
  20. 39. Comparison: Colloid Carcinoma

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