Lowering the Histamine Burden Oct 2012 Mastocytosis Conference

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This presentation shares how we lowered our young son's histamine burden. This was necessary to help his system calm down from having persistent and dangerous reactions, related to mast cell activation disorder. The strategies would potentially help anyone dealing with allergies, and many other histamine mediated disorders.

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  • Does your son have adenoids? As my son has big ones, I wonder if it is because of mast cells, as he is not actually allergic, but reacts to fruit and fermented food.
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  • Great info! Thanks much.
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  • Type Location Function H 1 histamine receptor Found on smooth muscle , endothelium , and central nervous system tissue Causes, bronchoconstriction , bronchial smooth muscle contraction, vasodilation , separation of endothelial cells (responsible for hives ), and pain and itching due to insect stings; the primary receptors involved in allergic rhinitis symptoms and motion sickness ; sleep and appetite suppression. H 2 histamine receptor Located on parietal cells and vascular smooth muscle cells Primarily involved in vasodilation. Also stimulate gastric acid secretion H 3 histamine receptor Found on central nervous system and to a lesser extent peripheral nervous system tissue Decreased neurotransmitter release: histamine, acetylcholine, norepinephrine, serotonin H 4 histamine receptor Found primarily in the basophils and in the bone marrow. It is also found on thymus, small intestine, spleen, and colon. Plays a role in chemotaxis.
  • Lowering the Histamine Burden Oct 2012 Mastocytosis Conference

    1. 1. Lowering the Histamine BurdenMethods we used to lower our young son’s histamine burden,to reduce the frequency and intensity of dangerous and painful histamine mediated reactions. The Mastocytosis Society Annual Conference October 2012 Copyright Tiffany Blackden 2012 All Rights Reserved
    2. 2. Copyright Tiffany Blackden 2012All Rights Reserved
    3. 3. Max’s Daily MCAD SymptomsHives, dermatographia, flushing, swelling, stomach aches, headaches, leg pain, itching, anaphylaxis from: Food (too many to name!) Friction Heat Cold Change in temp Animals Chemicals Synthetic Fabrics Skin Contact With Plants/Grass Etc…??? Copyright Tiffany Blackden 2012 All Rights Reserved
    4. 4. A few of his reactions: Really angry reaction from playing with a scratchy rope. This was after it was calm, we nearly went to the hospital, it covered a lot of his torso and most of his arm. Rolled around on synthetic rug…taken after the hives calmed down a bit.Blisters on both lower legs Copyright Tiffany Blackden 2012 All Rights Reservedafter consuming olive oil.
    5. 5. Max’s Health Team: Naturopathic Doctors Nationally Certified Nutritionists Acupuncturist - BioSet Practitioner Chinese Medicine Practitioner Osteopathic Doctor Chiropractor MD Homeopath Biomedical MD His Mommy, Daddy and Sister, Ellie  Copyright Tiffany Blackden 2012 All Rights Reserved
    6. 6. What’s in a mast cell? Preformed mediators : (from granules) -Serine proteases -Tryptase -Histamine -Serotonin -Proteoglycans-mainly heparin Newly formed Lipid Mediators: (eicosanoids) -Thromboxane -Prostoglandins -Leukotreines -Platelet Activating Factor -CytokinesArt by: Angela Canada Hopkinshttp://www.canadahopkins.com/ Today we are focusing on HISTAMINE… Copyright Tiffany Blackden 2012 All Rights Reserved
    7. 7. Histamine is a protective part of ourbody’s natural responses… Local Immune Response for Injury Protective Mechanism in ‘Boundary’ Tissues Regulates Smooth Muscle Contraction Neurotransmitter Copyright Tiffany Blackden 2012 All Rights Reserved
    8. 8. Histamine Affects Every System of the Body Neurological Cardiovascular Musculoskeletal Gastrointestinal Reproductive Respiratory CutaneousIt is produced in mast cells, basophils, platelets, neutrophils and some neurons…and stored intracellularly, thenCopyright Tiffanywhen stimulated. released Blackden 2012 All Rights Reserved
    9. 9. Histamine Receptors:H1: Smooth Muscle, Endothelium, Central Nervous System TissueH2: Gastrointestinal, Vascular Smooth Muscle TissueH3:Central Nervous System and Some Peripheral Nervous SystemH4 (Just discovered in 2000): Bone Marrow, Basophils, Thymus, Small Intestine, Spleen, Colon Copyright Tiffany Blackden 2012 All Rights Reserved
    10. 10. Copyright Tiffany Blackden 2012 All Rights ReservedDtsch Arztebl 2006; 103(51–52):A 3477–83.
    11. 11. Histamine Burden iscumulative over thecourse of a day(sometimes more, ifthe burden is high).Control what youCAN, to keep thecup from overflowingwith all the factorsnot in your control. Copyright Tiffany Blackden 2012 All Rights Reserved
    12. 12. Histamine Overload…Chicken Leftover in Fridge Hot Day Ragweed Cat Dander Histamine for Digestion Pineapple Sodium Benzoate in Soda Copyright Tiffany Blackden 2012 All Rights Reserved
    13. 13. Sources of Histamine:Normal Metabolic Function Throughout BodyDietary HistamineFoods That Release Histamine From Mast CellsIgE (Allergy) Mast Cell Degranulation Non-IgE (Trigger)Mast Cell DegranulationBacteria Copyright Tiffany Blackden 2012 All Rights Reserved
    14. 14. Avoiding High Histamine Pitfalls:Fermented FoodsCured FoodsDyesPreservatives/AdditivesSulphitesRefrigerated Leftovers (freeze them)AlcoholHigh Histamine FoodsHistamine Releasing FoodsDAO Inhibiting Chemicals Copyright Tiffany Blackden 2012 All Rights Reserved
    15. 15. How Does Histamine *EXIT* Our Bodies? Copyright Tiffany Blackden 2012 All Rights Reserved
    16. 16. Deactivation AND Liver Metabolism Enzymes that BREAK DOWN Histamine: o DAO (Diamine Oxidase) o HMT (Histamine Methyltransferase) o MAO A (Monoamine Oxidase A) Phase I & II Liver Detoxification o Methylation o Sulfation o Oxidation Copyright Tiffany Blackden 2012 All Rights Reserved
    17. 17. Histamine Liberating or DAO Inhibiting MedicationsSubstance class Some Active agents Radiological Contrast media Muscle relaxants Pancuronium, Alcuronium, D-Tubocurarin Narcotics Thiopental Analgesics Morphine, pethidine, NSAR, ASS, metamizole Local anesthetics Prilocaine Antihistamines Dyphenhydramine Antihypotensives Dobutamine Antihypertensives Verapamil, alprenolol, dihydralazine Antiarrhythmics Propafenon Diuretics Amiloride Motility agents Metoclopramide Antibiotics Cefuroxime, cefotiam, isoniazid,pentamidine, clavulanic acid, chloroquine Mucolytics Acetylcysteine, ambroxol Broncholytics Aminophylline H2 receptor antagonists Cimetidine Cytostatics Cyclophosphamide Copyright Tiffany Blackden 2012 Antidepressants All Rights Reserved Amitriptylline
    18. 18. Ways to Help the Liver Flush Histamine Reduce overall chemical load. Move lymph in our bodies. Lower your stress level. Drink lots of clean water. Get adequate nutrients for detoxification. Copyright Tiffany Blackden 2012 All Rights Reserved
    19. 19. Some doctors in Europe treat DAO deficiency as a progressing disease process… Mastocytosis MCAD Hypersensitivity Disorder Histaminosis Histamine Intolerance Copyright Tiffany Blackden 2012 All Rights Reserved
    20. 20. Our Low Histamine Strategies Copyright Tiffany Blackden 2012 All Rights Reserved
    21. 21. Mast Cell – Histamine DiariesFoods (Sensitivities/Histamine/Glycemic Index)Beverages (Hydration Level/Dyes/Sweeteners)Exposures (Pollen/Stores/Chemicals/Smells)Reactions (Type/Duration/Medication)Sleep (Amount/Quality)Emotional State (Anxious/Depressed/Happy/Stressed) Copyright Tiffany Blackden 2012 All Rights Reserved
    22. 22. Our High Quality NutritionDrink plenty of good quality water every day.Low Histamine/Tyramine, Organic Whole Foods (locally grown when possible)Rotate FoodsNo Gluten/Dairy/Soy/Eggs/Nuts/Citrus/Dyes/Additives Preservatives/Polyunsaturated FatsOnly grass fed beef and wild caught fishGood quality fats daily(No PUFAs)Digestive EnzymesSources of Trace Minerals (Pink Himalayan Salt, Dulse Flakes, Superdupermineralpackedwheatgrass juice)Some High Quality SupplementsRaw Leafy Greens (methylation support) Copyright Tiffany Blackden 2012 All Rights Reserved
    23. 23. Daily Health SupportHydration, Hydration, HydrationDense NutritionEpsom Salt Baths Daily (Additional Magnesium Chloride Spray as Needed)Moderate Exercise-Play, Mini TrampolineClean AirGood Quality SleepLimit All Man-made Chemical Exposure PossibleAyurvedic-Style Meal Preparation12 Hour Night FastLow Stress Copyright Tiffany Blackden 2012 All Rights Reserved
    24. 24. Get in touch, get support… Tiffany Blackden on Facebook or Twitter Tiffany@YogaDeepCreek.com Join Facebook Group: “Mastocytosis – Holistic Approach” Our FB page for our medical journey & research: www.Facebook.com/blackdenfamily Copyright Tiffany Blackden 2012 All Rights Reserved

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