Abstract. The research project MEDICO aims at developing an intelligent, robust and scalable semantic search engine for medical images and is designated for diﬀerent kinds of users, such as medical doctors, medical IT professionals, patients and citizens, and policy makers. Since semantic search results are not always self-explanatory various kinds of explanation are necessary to satisfy diﬀerent user goals. Our prime concern is to provide intuitive justiﬁcations for inexperienced users in the medical domain using semantic networks as form of depiction. In addition, we provide several interaction styles enabling a deeper insight into the medical knowledge.