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THUỐC ĐIỀU TRỊ ĐÁI THÁO ĐƯỜNG

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NỘI TIẾT

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THUỐC ĐIỀU TRỊ ĐÁI THÁO ĐƯỜNG

  1. 1. TỤY TẠNG NỘI TiẾT-ĐÁI THÁO ĐƯỜNG-THUỐC DÙNG TRONG ĐÁI THÁO ĐƯỜNG
  2. 2. TỤY TẠNG & INSULIN
  3. 3. INSULIN&GLUCAGON 2 THÀNH PHẦN PHẢN ĐiỀU HÒA
  4. 4. THỤ THỂ GLUCAGON
  5. 5. GLUCOSE TRANSPORTER 
  6. 6. YẾU TỐ ĐiỀU BiẾN INSULIN
  7. 7. exendin-4
  8. 8. TASTE RECEPTOR IN INCRETINS SECRETION
  9. 9. INCRETINS GIP, glucose-dependent insulinotropic polypeptide; GLP-1, glucagon-like peptide-1.
  10. 10. PHYSIOLOGICAL ROLE OF INCRETINS Physiology of GLP-1 secretion and action on GLP-1 receptors in different organs and tissues. GLP-1 is produced postprandially by intestinal L-cells. Through activation of insulin receptors on beta-cells GLP-1 (like GIP) stimulates insulin biosynthesis and secretion and inhibits glucagon secretion in the pancreas, which in turn reduces hepatic gluconeogenesis. GLP-1 release also exerts protective effects on heart and brain. Insulin sensitivity in the periphery is increased by improved insulin signaling and reduced gluconeogenesis. Figure modified with permission from Cell Metabolism [3]
  11. 11. PHYSIOLOGICAL ROLE OF INCRETINS
  12. 12. TÁC ĐỘNG CỦA GLP-1 TRÊN TẾ BÀO  ĐẢO TỤY
  13. 13. ADIPOSE TISSUE: FIRST MODULATOR
  14. 14. TẾ BÀO MỠ
  15. 15. DIABETES TYPE II: PATHOGENESIS MODULATOR & TREATMENT WITH SULFONYLUREAS- THIAZOLIDINEDIONE-METFORMIN- INCRETINS AGONISTS-DIPEPTIDYL PEPTIDASE-4 INHIBITORS
  16. 16. INSULIN & BLOOD GLUCOSE
  17. 17. LỘ TRÌNH TÍN HiỆU CỦA INSULN
  18. 18. TZDs ACTIVATE PPARγ
  19. 19. THIAZOLIDINEDIONE GÂY PHÓNG THÍCH INSULIN QUA CHOLESTEROL EFFLUX
  20. 20. TZDs INDUCED OSTEOPOROSIS
  21. 21. GLP-1 & AGONISTS
  22. 22. AMPK TARGET OF METFORMIN +
  23. 23. AMPK NHIBITED Acetyl-CoA Carboxylase
  24. 24. ROLE OF METFORMIN IN CARDIAC PROTECTION GLUT: Glucose transporter; PFK, phosphofructokinase; ACC, Acetyl-CoA carboxylase; CPT1, carnitine palmitoyltransferase 1; and MCD, malonyl-CoA decarboxylase.
  25. 25. CẢM ƠN SỰ QUAN TÂM THEO DÕI
  • jeniferloze

    Oct. 7, 2020
  • NguyenducLong8

    May. 22, 2020
  • HngLu8

    Sep. 5, 2019

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