What is the Brain?
A Grey Pulpy Gruesome Device?
Brain as Behavioral-Cognitive Reflex Apparatus
(Sherrington, Cognitive Neuroscience)
Stimulus-induced activity :
Complete and exclusive
determination by the stimulus
Brain itself has No SAY in what
happens in the brain!
Brain as Active Player in its Neuronal Activity
(Brown, Lashley, Llinas, Shulman, Panksepp)
Stimulus-induced activity : Result
of Rest-Stimulus Interaction
Brain itself has a Strong SAY in
what happens in the brain!
Is the Brain's Resting State Activity Relevant?
For the Brain’s Function in Depression
Supported by: CRC, CIHR, Michael Smith Foundation, DFG,
DAAD, BMBF, SNF, Krupp-Stiftung, Salus-Stiftung, GebertRüf Stiftung, Astra Zeneca, Lilly, Goldberg Foundation, Hope
of Depression Research Foundation (HDRF/ISAN)
How is the abnormally high resting state activity in
depression related to gaba- and glutamat-ergic
receptors? A translational approach
Deactivation (Negative BOLD Response) in
depression: Baseline > Emotional perception in
Healthy subjects >
Decreased deactivation or negative BOLD response
(NBR) during emotional perception in ventromedial
prefrontal cortex (VMPFC) in depression
Grimm, Neuropsychopharmacology, 2009