ACCORD Glucose (Action to ControlCardiovascular Risk in Diabetes —Glucose-lowering arm)
ACCORD Glucose (Action to Control CardiovascularRisk in Diabetes — Glucose-lowering arm)National Heart, Lung, and Blood In...
ACCORD Glucose: Results• The median A1c level achieved in the intensive-treatment group was 6.4%, vs  7.5% in the standard...
ACCORD Glucose: Commentary*"The simple and honest answer is that we have done extensive analyses and notidentified a cause...
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ACCORD Glucose trial - Summary & Results

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A study on Action to Control Cardiovascular Risk in Diabetes (ACCORD Glucose) to test whether an intensive strategy that targets HbA1c levels <6.0% reduces the rate of CV events more than a standard strategy that targets an HbA1c of 7.0% to 7.9%

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ACCORD Glucose trial - Summary & Results

  1. 1. ACCORD Glucose (Action to ControlCardiovascular Risk in Diabetes —Glucose-lowering arm)
  2. 2. ACCORD Glucose (Action to Control CardiovascularRisk in Diabetes — Glucose-lowering arm)National Heart, Lung, and Blood InstituteACCORD telebriefing prepared remarks; February 6, 2008• Goal: To test whether an intensive strategy that targets HbA1c levels <6.0% reduces the rate of CV events more than a standard strategy that targets an HbA1c of 7.0% to 7.9%• Population and treatment: 10 000 patients with type 2 diabetes and either heart disease or two risk factors for heart disease Randomly assigned to intensive blood sugar lowering or to standard blood sugar lowering• Primary outcome: A composite of fatal and nonfatal major CV events
  3. 3. ACCORD Glucose: Results• The median A1c level achieved in the intensive-treatment group was 6.4%, vs 7.5% in the standard group• The trial was stopped early because of an excess of three deaths per 1000 participants per year in the intensive group vs the standard group, over an average of four years of treatmentDeaths in the two treatment groups at four years Standard glycemic control Intensive glycemic controlDeaths, n 203 (11/1000/y) 257 (14/1000/y)
  4. 4. ACCORD Glucose: Commentary*"The simple and honest answer is that we have done extensive analyses and notidentified a cause for the increased mortality." - Dr William Friedewald (Chair of the ACCORD steering committee)"My key message is that the ACCORD result is not a reason to panic. The kind ofpatients enrolled in this study are a minority in terms of diabetes patients, and thetreatment given was exceptionally intensive, so the average diabetic patient need notworry about these results." - Dr John Buse (ACCORD steering committee member)"This result really does defy conventional wisdom." - Dr Steve Nissen*All comments from The day after: Experts puzzled over increased death rate in ACCORD(http://www.theheart.org/article/842297.do)
  5. 5. Become a member of http://www.theheart.org Become a fan on Facebook: http://www.facebook.com/theheartorg Follow us on Twitter: http://www.twitter.com/theheartorgtheheart.org is the leading online source of independent cardiology news.We are the top provider of news and opinions for over 100 000 physicians.

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