Successful Star R01 to R01Investigators Panel


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Successful Star R01 to R01Investigators Panel

  1. 1. Successful Star R01 to R01Investigators Panel Kathleen A. Cooney, M.D. Chief, Division of Hematology/Oncology Department of Internal Medicine University of Michigan Medical School
  2. 2. My Research Career: Part 1 • Chose to work in molecular coagulation research lab – Selected based on scientific environment – Reputation of PI for training physician scientists – Available project • Successful early grants: – Individual NRSA – VA Career Development Award – K08 from NHLBI
  3. 3. After 4 years… • Several high profile publications • Getting good job offers in hematology but… • My clinical interests were focused in care of cancer patients not general hematology • Having difficult time balancing clinical/research interests as well as work/life balance
  4. 4. My Research Career: Part 2 • I had strong training in molecular genetics • Selected a cancer which had evidence for inherited predisposition • Established a research program focused on molecular basis for inherited prostate cancer susceptibility • Terminated my K08 from NHLBI
  5. 5. Funding for my second research program • SPORE Career Development Award • Submitted ~ same grant to: – VA Merit: funded first time – ACS: funded on resubmission – NIH R01: funded on resubmission • Other grants: – DOD, ICPCG consortium, SPORE, etc
  6. 6. Some thoughts about transitioning to becoming an independent investigator • Study something you are passionate about… • Do your homework about your scientific topic – Go to national meetings to understand the current state of research in your field – Use NIH tools and resources to see what grants are funded in your area or related areas
  7. 7. Planning your first R01 • Draft your ideal Specific Aims well before you actually write your grant • Outline the required preliminary data and work toward this while drafting the grant • A conservative strategy may be a safer strategy for a young investigator • Enlist some key mentors/advisors to help you along the way
  8. 8. The final draft • Get this done WELL BEFORE the due date and out to advisors with enough time for review/comments • Address key criticisms in your grant – Experimentally – In problems and pitfalls section • Consider letters of collaboration – Internal letters show you have local support – External letters • Validate significance of your research • Demonstrates that you know your field
  9. 9. The final draft (continued) • PRESENTAION IS IMPORTANT • Use figures and diagrams in strategic fashion • Be sure final draft is easy to read and visually-appealing • PROOF READ CAREFULLY!
  10. 10. Understand the NIH Grant Review Process • Visit the Center for Scientific Review website • Look at the make up of study sections that might receive your grant • Contact individuals that you know on study sections for advice • Learn the instructions for reviewers and address review criteria: – Significance – Investigator(s) – Innovation – Approach
  11. 11. Final thoughts • Step back and look at your application objectively – Is your hypothesis important? – What will be accomplished if you get the grant? – How will your research lead to progress in your field? • Prepare for the long haul – Most grants are not funded the first time – Starting generating additional data to support your proposal if it is not funded right away – Consider other agencies, foundations, etc.