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  1. 1. RBV: GREATER MANCHESTER CANCER PROGRAMME Agarwala SS, Kirkwood JM, Gore M, Dreno B, Thatcher N, Czarnetski B, Atkins M, Buzaid A, Skarlos D, Rankin EM. Temozolomide for the treatment of brain metastases associated with metastatic melanoma: A phase II study. Journal of Clinical Oncology. 2004; 22 (11): 2101-2107 Ahmad T, Farnie G, Bundred NJ, Anderson NG. The mitogenic action of insulin-like growth factor I in normal human mammary epithelial cells requires the epidermal growth factor receptor tyrosine kinase. Journal of Biological Chemistry. 2004; 279 (3): 1713-1719 Baka S, Lorigan P, Thatcher N. Palliative treatment. Hematology-Oncology Clinics of North America. 2004; 18 (2): 417 Banks E, Reeves G, Beral V, Bull D, Crossley B, Simmonds M, Hilton E, Bailey S, Barrett N, Briers P, English R, Jackson A, Kutt E, Lavelle J, Rockall L, Wallis MG, Wilson M, Patnick J. Influence of personal characteristics of individual women on sensitivity and specificity of mammography in the Million Women Study: cohort study. BMJ. 2004; 329 (7464): 477-479 Banks, E; Reeves, G; Beral, V; Bull, D; Crossley, B; Simmonds, M; Hilton, E; Bailey, S; Barrett, N; Briers, P; English, R; Jackson, A; Kutt, E; Lavelle, J; Rockall, L; Wallis, MG; Wilson, M; Patnick, J. Impact of use of hormone replacement therapy on false positive recall in the NHS breast screening programme: results from the million women study. BMJ. 2004; 328(7451): 1291-1292 Barvaux VA, Ranson M, Brown R, McElhinney RS, McMurry TBH, Margison GP. Dual repair modulation reverses Temozolomide resistance in vitro. Molecular Cancer Therapeutics. 2004; 3 (2): 123-127 Barvaux VA, Lorigan P, Ranson M, Gillum AM, McElhinney RS, McMurry TBH, Margison GP. Sensitization of a human ovarian cancer cell line to temozolomide by simultaneous attenuation of the Bcl-2 antiapoptotic protein and DNA repair by O-6-alkylguanine-DNA alkyltransferase. Molecular Cancer Therapeutics. 2004; 3 (10): 1215-1220 Bell J.K., Laasch H-U., Wilbraham L., England R.E., Morris J.A., Martin D.F. Bispectral index monitoring for conscious sedation in intervention: better, safer, faster. Clinical Radiology. 2004; 59: 1106-1113 Boland GP, Butt IS, Prasad R, Knox WF, Bundred NJ. COX-2 expression is associated with an aggressive phenotype in ductal carcinoma in situ. British Journal of Cancer. 2004; 90 (2): 423-429 Borjesson, L.; Willen, R.; Haboubi, N.; Duff, S. E.; Hulten, L. The risk of dysplasia and cancer in the ileal pouch mucosa after restorative proctocolectomy for ulcerative proctocolitis is low: A long-term term follow-up study. Colorectal Disease. 2004; 6(6):494-498 Bundred NJ, Turner LE. Postmenopausal hormone therapy before and after breast cancer: clinical experiences. Maturitas. 2004; 49 (1): S22-S31 Clayton AJ, Danson S, Jolly S, Ryder WDJ, Burt PA, Stewart AL, Wilkinson PM, Welch RS, Magee B, Wilson G, Howell A, Wardley AM. Incidence of cerebral metastases in patients treated with trastuzumab for metastatic breast cancer. British Journal of Cancer. 2004; 91 (4): 639-643 1
  2. 2. Costello B, Chenggang LG, Duff S, Butterworth D, Khan A, Perkins M, Owens S, Al- Mowallad AF, O'Dwyer S, Kumar S. Perfusion of Tc-99(m)-labeled CD105 Mab into kidneys from patients with renal carcinoma suggests that CD105 is a promising vascular target. International Journal of Cancer. 2004; 109 (3): 436-441 Coyne JD; Dervan PA; Barr L. High-grade carcinomas of the breast showing patterns of mixed ductal and myoepithelial differentiation (including myoepithelial cell-rich carcinoma of the breast) Histopathology 2004; 44 (6): 580-584 Davies L, Laasch H-U, Wilbraham L, Marriott A, England R.E, Martin D.F. The consent process in interventional radiology: the role of specialist nurses. Clinical Radiology. 2004; 59: 246-252 Duff, S; Wood, C; McCredie, V; Levine, E; Saunders, M; O'Dwyer, S. Waiting times for treatment of rectal cancer in North West England. Journal of the Royal Society of Medicine. 2004; 97(3):117-118 Evans DGR, Eccles DM, Rahman N, Young K, Bulman M, Amir E, Shenton A, Howell A, Lalloo F. A new scoring system for the chances of identifying a BRCA1/2 mutation outperforms existing models including BRCAPRO. Journal of Medical Genetics. 2004; 41 (6): 474-480 Eyden, B., Radford, J., Shalet, S.M. Thomas, N., Brison, D.R., Lieberman, B.A. Ultrastructural preservation of ovarian cortical tissue cryopreserved in dimethylsulfoxide for subsequent transplantation into young female cancer patients. Ultrastructural Pathology. 2004; 28:239-245. Fallowfield, L; Cella, D; Cuzick, J; Francis, S; Locker, G; Howell, A. Quality of Life of Postmenopausal Women in the Arimidex, Tamoxifen, Alone or in Combination (ATAC) Adjuvant Breast Cancer Trial. Journal of Clinical Oncology. 2004; 22(21): 4261-4271 Gridelli C, Ardizzoni A, Le Chevalier T, Manegold C, Perrone F, Thatcher N, van Zandwijk N, Di Maio M, Martelli O, De Marinis F. Treatment of advanced non-small-cell lung cancer patients with ECOG performance status 2: results of a European Experts Panel. Annals of Oncology. 2004;15 (3): 419-426 Gullipalli, R.; Woodcock, S.; Galloway, S.; McLWelch, I. Staging computed tomography and laparoscopy for oesophagogastric adenocarcinoma: a 2-year experience in South Manchester. British Journal of Surgery - Supplement. 2004; 91 (Supplement 1):68-69 Hancock BW, Wheatley K, Harris S, Ives N, Harrison G, Horsman JM, Middleton MR, Thatcher N, Lorigan PC, Marsden JR, Burrows L, Gore M. Adjuvant interferon in high-risk melanoma: The AIM HIGH study-United Kingdom Coordinating Committee on cancer research randomized study of adjuvant low-dose extended-duration interferon alfa-2a in high-risk resected malignant melanoma. Journal of Clinical Oncology. 2004; 22 (1): 53-61 Harvie MN, Campbell IT, Baildam A, Howell A. Energy balance in early breast cancer patients receiving adjuvant chemotherapy. Breast Cancer Research and Treatment 2004; 83: 201-210. Howell, A; Robertson, J. F.R.; Abram, P; Lichinitser, M R.; Elledge, R; Bajetta, E; Watanabe, T; Morris, C; Webster, A; Dimery, I; Osborne, C K. Comparison of Fulvestrant Versus Tamoxifen for the Treatment of Advanced Breast Cancer in Postmenopausal Women Previously Untreated With Endocrine Therapy: A Multinational, Double-Blind, Randomized Trial. Journal of Clinical Oncology. 2004; 22(9): 1605-1613 2
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  4. 4. Sis B; Sagol O; Kupelioglu A; Sokmen S; Terzi C; Fuzun M; Ozer E; Bishop P. Prognostic significance of matrix metalloproteinase-2, cathepsin D, and tenascin-C expression in colorectal carcinoma. Pathology Research and Practice. 2004; 200 (5): 379-387 Slack, H.; Woodcock, S.; Welch, I. McL; Martin, D.; Galloway, S. The decreasing demand for open common bile duct exploration in South Manchester. British Journal of Surgery - Supplement. 2004; 91 (Supplement 1):29 Smith IE, A'Hern RP, Coombes GA, Howell A, Ebbs SR, Hickish TF, O'Brien MER, Mansi JL, Wilson CB, Robinson AC, Murray PA, Price CGA, Perren TJ, Laing RW, Bliss JM. A novel continuous infusional 5-fluorouracil-based chemotherapy regimen compared with conventional chemotherapy in the neo-adjuvant treatment of early breast cancer: 5 year results of the TOPIC trial. Annals of Oncology. 2004; 15 (5): 751-758 Thatcher N. Management of small cell lung cancer. EJC Supplements. 2004; 2 (4): 40-43 Warren, R; Harvie, M; Howell, A. Strategies for Managing Breast Cancer Risk after the Menopause. Treatments in Endocrinology. 2004; 3(5): 289-307 Zwiggelaar R, Astley SM, Boggis CRM, Taylor CJ. Linear structures in mammographic images: Detection and classification. IEEE Transactions on Medical Imaging. 2004; 23 (9): 1077-1086 Collaborators’ Publications Anderson, E; Clarke, RB. Steroid Receptors and Cell Cycle in Normal Mammary Epithelium. Journal of Mammary Gland Biology & Neoplasia. 2004; 9(1):3-13 Baser ME, Kuramoto L, Joe H, Friedman JM, Wallace AJ, Gillespie JE, Ramsden RT, Evans DGR. Genotype-phenotype correlations for nervous system tumors in neurofibromatosis 2: A population-based study. American Journal of Human Genetics. 2004;75 (2): 231-239 Brennan KR, Brown AMC. Wnt proteins in mammary development and cancer. Journal of Mammary Gland Biology and Neoplasia. 2004; 9 (2): 119-131 Brennan, K; Gonzalez-Sancho, J M; Castelo-Soccio, LA; Howe, LR; Brown, AMC. Truncated mutants of the putative Wnt receptor LRP6/Arrow can stabilize [beta]-catenin independently of Frizzled proteins. Oncogene. 2004;23(28):4873-4884 Ditchfield, C; Keen, N; Taylor, SS. The Ipl1/Aurora Kinase Family: methods of inhibition and functional analysis in mammalian cells. Methods Mol Biol. 2004; 296: 371-82 Dowling AJ; Daborn PJ; Waterfield NR; Wang P; Streuli CH; ffrench-Constant RH. The insecticidal toxin Makes caterpillars floppy (Mcf) promotes apoptosis in mammalian cells. Cellular Microbiology. 2004; 6 (4): 345-353 Evans DGR, Neuhausen SL, Bulman M, Young K, Gokhale D, Lalloo F. Haplotype and cancer risk analysis of two common mutations, BRCA1 4184del4 and BRCA2 2157delG, in high risk northwest England breast/ovarian families. Journal of Medical Genetics. 2004; 41 (2) Foster C, Evans DGR, Eeles R, Eccles D, Ashley S, Brooks L, Cole T, Cook J, Davidson R, Gregory H, Mackay J, Morrison PJ, Watson M. Non-uptake of predictive genetic testing for 4
  5. 5. BRCA1/2 among relatives of known carriers: Attributes, cancer worry, and barriers to testing in a multicenter clinical cohort. Genetic Testing. 2004; 8 (1): 23-29 González-Sancho, JM; Brennan, KR; Castelo-Soccio, LA; Brown, AMC. Wnt Proteins Induce Dishevelled Phosphorylation via an LRP5/6- Independent Mechanism, Irrespective of Their Ability To Stabilize β-Catenin. Mol Cell Biol. 2004; 24(11): 4757–4768 Green KA; Naylor MJ; Lowe ET; Wang PB; Marshman E; Streuli CH. Caspase-mediated cleavage of insulin receptor substrate. Journal of Biological Chemistry. 2004; 279 (24): 25149-25156 Green KA; Streuli CH. Apoptosis regulation in the mammary gland. Cellular and Molecular Life Sciences. 2004; 61: 1867-1883 Hayward, DG; Clarke, RB; Faragher, AJ; Pillai, MR; Hagan, IM; Fry, AM. The centrosomal kinase Nek2 displays elevated levels of protein expression in human breast cancer. Cancer Res. 2004; 64 (20): 7370-6 Johnson, VL; Scott, MI; Holt, SV; Hussein, D; Taylor, SS. Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression. J Cell Sci. 2004; 117: 1577-89 Keen, N; Taylor, S. Aurora-kinases as anti-cancer agents. Nature Reviews – Cancer. 2004; 4: 927-936 Taylor, SS; Scott, MI; Holland, AJ. The spindle checkpoint: a quality control mechanism which ensures accurate chromosome segregation. Chromosome Res. 2004; 12: 599-616 Tighe, A; Johnson, VL; Taylor, SS. Truncating APC mutations have dominant effects on proliferation, spindle checkpoint control, survival and chromosome stability. J Cell Sci. 2004; 117: 6339-6353 Tsilchorozidou T, Menko FH, Lalloo F, Kidd A, De Silva R, Thomas H, Smith P, Malcolmson A, Dore J, Madan K, Brown A, Yovos JG, Tsaligopoulos M, Vogiatzis N, Baser ME, Wallace AJ, Evans DGR. Constitutional rearrangements of chromosome 22 as a cause of neurofibromatosis 2. Journal of Medical Genetics. 2004; 41 (7): 529-534 Wang PB; Gilmore AP; Streuli CH. Bim is an apoptosis sensor that responds to loss of survival signals delivered by epidermal growth factor but not those provided by Integrins. Journal of Biological Chemistry. 2004; 279 (40): 41280-41285 Watson M, Foster C, Eeles R, Eccles D, Ashley S, Davidson R, Mackay J, Morrison PJ, Hopwood P, Evans DGR. Psychosocial impact of breast/ovarian (BRCA 1/2) cancer- predictive genetic testing in a UK multi-centre clinical cohort. British Journal of Cancer. 2004;91 (10): 1787-1794 Zoubiane GS; Valentijn A; Lowe ET; Akhtar N; Bagley S; Gilmore AP; Streuli CH. A role for the cytoskeleton in prolactin-dependent mammary epithelial cell differentiation. Journal of Cell Science. 2004; 117(2): 271-280 5
  6. 6. RM2: A PROGRAMMED INVESTIGATION OF OBSTRUCTIVE AND PARENCHYMAL LUNG DISEASE Al-Mousawi MSH, Lovel H, Behbehani N, Arifhodzic N, Woodcock A, Custovic A. Asthma and sensitization in a community with low indoor allergen levels and low pet-keeping frequency. J Allergy Clin Immunol 2004; 114: 1389-1394 Andersen CB, Christiansen L, Tan Q, Haagerup A, Vestbo J, Kruse TA. Possible gene dosage effect of glutathione-S-transferases on atopic asthma using real-time PCR for quantification of GSTM1 and GSTT1 gene copy numbers. Hum Mut 2004; 24: 208-214. Asher I, Baena-Cagnani C, Boner A, Canonica GW, Chuchalin A, Custovic A, Dagli E, Haahtela T, Haus M, Lemmo-Hoten M, Holgate S, Holloway J, Holt P, Host A, Iikura Y, Johansson SG, Kaplan A, Kowalski ML, Lockey RF, Naspitz C, Odhiambo J, Ring J, Sastre J, Venables K, Vichyanond P, Volovitz B, Wahn U, Warner J, Weiss K, Zhong NS; World Allergy Organization.. World Allergy Organization guidelines for prevention of allergy and allergic asthma. Int Arch Allergy Immunol. 2004 Sep;135(1):83-92. Bakirci, N; Niven, R; Tumerdem, N. Health effects of cotton dust and byssinosis. Turk. J . Public Health. 2004; 2: 123-125 Barber, PV. Martin, J. O'Donnell, PNS. The development of the first nurse-led bronchoscopy post in the United Kingdom. Respiratory Medicine. 2004, 98 (6), 504-508 Bhowmick B, Niven R. Unilateral vocal cord palsy: a non-psychogenic cause of vocal cord dysfunction. Respiratory Medicine. 2004; 98 (7): 677-678 Bieger-Farhan AK; Chadha NK; Camilleri AE; Stone P; McGuinness K. Portable method for the determination of snoring site by sound analysis. Journal of Laryngology and Otology. 2004; 118 (2): 135-138 Booth, S., Wade, R., Johnson, M., Kite, S., Swanwick, M., Anderson, H. The use of oxygen in the palliation of breathlessness. A report of the expert working group of the scientific committee of the association of palliative medicine. Respiratory Medicine. 2004; 98 (1): 66-77 Bornehag CG, Sundell J, Bonini S, Custovic A, Malmberg P, Skerfving S, Sigsgaard T, Verhoeff A. Dampness in buildings as a risk factor for health effects, EUROEXPO: a multidisciplinary review of the literature (1998-2000) on dampness and mite exposure in buildings and health effects. Indoor Air 2004;14: 243-257 Celli BR, MacNee W, Agusti A, Anzueto A, Berg B, Buist AS, Calverley PMA, Chavannes N, Dillard T, Fahy B, Fein A, Heffner J, Lareau S, Meek P, Martinez F, McNicholas W, Muris J, Austegard E, Pauwels R, Rennard S, Rossi A, Siafakas N, Tiep B, Vestbo J, Wouters E, ZuWallack R. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. Eur Respir J 2004 23: 932-946. Custovic A, Simpson A, Woodcock A. Manchester Cohort. Pediatric Pulmonol 2004 (Suppl 26): 12-13 Custovic A, Simpson A. Environmental allergen exposure, sensitisation and asthma: from whole population to individuals at risk. Thorax 2004; 59: 825-827 6
  7. 7. Cystic Fibrosis Trust Control of Infection Group. Pseudomonas aeruginosa infection in people with cystic fibrosis: suggestions for prevention and infection control. Cystic Fibrosis Trust, 2004 - revised 2nd edition. Cystic Fibrosis Trust Control of Infection Group. The Burkholderia cepacia complex: suggestions for prevention and infection control. Cystic Fibrosis Trust, 2004. Dalsgarð OJ, Hansen NC, Søes-Petersen U, Evald T, Høegholm A, Barber J, Vestbo J. A multicenter, randomized, double-blind, placebo-controlled, 6-month trial of bupropion hydrochloride sustained-release tablets as an aid to smoking cessation in hospital employees. Nicotine and Tobacco Research 2004; 6: 55-61. Frank PI, Frank TL, Hazell ML, Hirsch S. Changes in smoking habits. A longitudinal population study. Family Practice 2004; 21(1):33-38 Frank TL, Cropper JA, Hazell ML, Frank PI, Hannaford PC. Childhood Asthma: Healthcare resource utilisation in those with and without a diagnosis of the condition. Respiratory Medicine 2004; 98: 454-463 Gore C, Custovic A. Can we prevent allergy? Allergy 2004; 59: 151-161 Gore C, Custovic A. Protective parasites and medicinal microbes? The case for the hygiene hypothesis. Primary Care Respiratory Journal 2004; 13: 68-75 Gore C, Custovic A. Response to “No clinical evidence base to support the hygiene hypothesis” by C.P. van Schayck and J.A. Knottnerus. Primary Care Respiratory Journal 2004; 13: 80-82 Gore C, Johnson RJ, Caress AL, Woodcock A, Custovic, A. The information needs and preferred roles in treatment decision-making of parents caring for infants with atopic dermatitis: a qualitative study. Allergy 2004 (in press) Grønbæk M, Johansen D, Becker U, Hein HO, Schnohr P, Jensen G, Vestbo J, Sørensen TIA. Changes in alcohol intake and mortality: A longitudinal population-based study. Epidemiology 2004; 15: 222-228. Haworth CS, Jones AM, Adams JE, Selby Pl, Webb AK. Inflammatory related changes in bone mineral content in adults with cystic fibrosis. Thorax. 2004; 59: 613-617 Haworth C, Jones AM, Adams JE, Selby PL, Webb AK. Randomised double-blind placebo controlled trial investigating the effect of calcium and vitamin D supplementation on bone mineral density and bone metabolism in adults with cystic fibrosis. Journal of Cystic Fibrosis, 2004; 233-236. Hirsch S, Frank TL, Shapiro JL, Hazell ML, Frank PI. Development of a questionnaire weighted scoring system to target diagnostic examinations for asthma in adults: a modelling study. BMC Family Practice 2004, 5:30. Houghton CM, Woodcock A, and Singh SD. A comparison of lung function methods for assessing the dose response effects of Salbutamol. British Journal of Clinical Pharmacology 2004; 58.2:134-141 Houghton CM, Langley SJ, Singh SD, Holden J, Preti Monici P, Acerbi, Poli G. Woodcock A. Comparison of bronchoprotective and broncholdilator effects if a single dose of formoterol delivered by hydrofluoroalkane and chlorofluorocarbon aerosols and dry powder in a double 7
  8. 8. blind, placebo controlled, crossover study. British Journal Clinical Pharmacology. 2004; 58:359-366 Houghton CM; Raghuram A; Sullivan PJ; O'Driscoll R. Pre-medication for bronchoscopy: a randomised double blind trial comparing alfentanil with midazolam. Respiratory Medicine 2004; 98 (11): 1102-1107 Jones AM, Dodd ME, Govan JRW, Barcus V, Doherty CJ, Morris J, Webb AK. Burkholderia cenocepacia, and Burkholderia multivorans:influence on survival in cystic fibrosis. Thorax. 2004; 59: 948-951 Jones AM, Dodd ME, Govan JR, Doherty CJ, Smith CM, Isalska BJ, Webb AK. Prospective surveillance for Pseudomonas aeruginosa cross infection at a cystic fibrosis centre. Am J Respir Crit Care Med. 2004; 171: 257-260 Jones, AM. Transmissible Pseudomonas aeruginosa strains and their consequences. In: Colomycin - new insights and practical issues. Royal Soc Med Press, 2004. Lewis SJ; Cherry NM; Niven RM; Barber PV; Povey AC. Associations between smoking, GST genotypes and N7-methylguanine levels in DNA extracted from bronchial lavage cells. Mutation Research-Genetic Toxicology and Environmental Mutagenesis. 2004; 559, (1-2): 11-18 Lowe L, Murray CS, Martin L, Deas J, Cashin E, Poletti G, Simpson A, Woodcock A, Custovic A. Reported versus confirmed wheeze and lung function in early life. Arch Dis Child 2004; 89: 540-3 Lowe L, Custovic A, Woodcock A. Childhood asthma. Curr Allergy Asthma Rep 2004; 4: 159-65 Lowe LA, Woodcock A, Murray CS, Morris J, Simpson A, Custovic A. Lung function at age 3 years: effect of pet ownership and exposure to indoor allergens. Arch Ped Adolesc Med 2004; 158: 996-1001 Moorcroft AJ, Dodd ME, Morris J, Webb AK. Individualised unsupervised exercise training in adults with cystic fibrosis: a 1-year randomised controlled trial. Thorax. 2004; 59: 1074-1080 Murray CS, Woodcock A, Smillie FI, Cain G, Kissen P, Custovic A. Tobacco smoke exposure, wheeze and atopy. Pediatr Pulmonol 2004; 37: 492-498 Murray CS, Simpson A, Custovic A. Allergens, Viruses, and Asthma Exacerbations. Proc Am Thoracic Soc 2004; 1: 99-104 Nicholson AG; Addis BJ; Bharucha H; Clelland CA; Corrin B; Gibbs AR; Hasleton PS; Kerr KM; Ibrahim NBN; Stewart S; Wallace WAH; Wells AU. Inter-observer variation between pathologists in diffuse parenchymal lung disease. Thorax. 2004; 59 (6): 500-505 Pillai SG, Cousens DJ, Barnes AA, Buckley PT, Chiano MN, Hosking LK, Cameron LA, Fling ME, Foley JJ, Green A, Sarau HM, Schmidt DB, Sprankle CS, Blumenthal MN, Vestbo J, Kennedy-Wilson K, Wixted WE, Wagner MJ, Anderson WH, Ignar DM; Investigators of the GAIN Network. A coding polymorphism in the CYSLT2 receptor with reduced affinity to LTD4 is associated with asthma. Pharmacogenetics 2004; 14: 627-33. Redfern J; Webb AK. Benefits of a dedicated cystic fibrosis pharmacist. Journal of the Royal Society of Medicine. 2004; 97: 2-7 8
  9. 9. Simler NR; Brenchley PE; Horrocks AW; Greaves SM; Hasleton PS; Egan JJ. Angiogenic cytokines in patients with idiopathic interstitial pneumonia. Thorax. 2004; 59 (7): 581-585 Simpson A, Custovic A. Allergen avoidance in the primary prevention of asthma. Curr Opin Allergy Clin Immunol 2004; 4: 45-51 Simpson A, Custovic A. The role of allergen avoidance in primary and secondary prevention. Pediatric Pulmonol 2004 (Suppl 26): 225-228 Simpson A, Custovic A. Exposure to domestic pets: effect on sensitisation and asthma. Airways J 2004; 2: 39-42 Smith, CM, Jones AM. Living with cystic fibrosis: preparing a patient for lung transplantation. Airways 2004; 2: 156-160. Stipic-Markovic A, Pevec B, Radulovic Pevec M, Custovic A, Predovic J. Allergic diseases in relationship with environmental factors in a population of school children in Zagreb, Croatia. Arh Hig Rada Toksikol. 2004; 55(2-3): 221-8. Thornton J, Dodd ME, Webb AK, Tully R. Long-term clinical outcome of home and hospital intravenous antibiotic treatment in adults with cystic fibrosis. Thorax. 2004; 59: 242-246 The TORCH Study Group. The TORCH (TOwards a Revolution in COPD Health) Survival Study protocol. Eur Respir J 2004; 24: 206-210. Vestbo J, Soriano JB, Anderson JA, Calverley P, Pauwels R, Jones P, on behalf of the TRISTAN study group. Gender does not influence the response to the combination of salmeterol and fluticasone propionate in COPD. Respir Med 2004; 98: 1045-50. Vestbo J. COPD in the ECRHS? Thorax 2004; 59: 89-90. Vestbo J. What is an exacerbation? Eur Respir Rev 2004; 13: 6-13. Vestbo J. Outpatient management of COPD (CME paper). Clin Med 2004; 4: 220-4. Vestbo J. Chronic bronchitis – should it worry us? Chron Respir Dis 2004; 1: 173-6. Watson L, Vestbo J, Postma DS, Decramer M, Rennard S, Kiri VA, Vermeire PA, Soriano JB. Gender differences in the management and experience of Chronic Obstructive Pulmonary Disease. Respir Med 2004; 98: 1207-13. Woodcock A, Lowe LA, Murray CS, Simpson BM, Pipis SD, Kissen P, Simpson A, Custovic A. Early life environmental control: effect on symptoms, sensitization and lung function at age 3 years. Am J Respir Crit Care Med 2004; 170: 433-9 Youg SL, Simon MA, Baird MA, Tannock GW, Bibiloni R, Spencley K, Lane JM, Fitzharris P, Crane J, Town I, Addo-Yobbo E, Murray CS, Woodcock A (2004) Bifidobacterial species differentially affect expression of cell surface Markers and cytokines of dendritic cells harvested from cord blood. Clinical and Diagnostic Laboratory Immunology 2004; 11:686-690 9
  10. 10. Collaborators’ Publications Houghton CM, Raghuram A, Sullivan PJ, O'Driscoll R. Pre-medication for bronchoscopy: a randomised double blind trial comparing alfentanil with midazolam. Respiratory Medicine. 2004; 98 (11): 1102-1107 Vijayanand P, Wilkins E, Woodhead M. Severe acute respiratory syndrome (SARS): a review. Clin Med. 2004 Mar-Apr;4(2):152-60 Woodhead M. Community-acquired pneumonia: severity of illness evaluation. Infect Dis Clin North Am. 2004 Dec;18(4):791-807; viii. Wilkinson M, Woodhead MA. Guidelines for community-acquired pneumonia in the ICU. Curr Opin Crit Care. 2004 Feb;10(1):59-64 10
  11. 11. RM2: ARTERIAL AND VENOUS DISEASES, THROMBOSIS, COAGULATION AND BLOOD TRANSFUSION Bhutta A, Nasim A. Left arm pain 22 years after repair of aortic coarctation. Journal of the Royal Society of Medicine. 2004; 97 (6): 283-284 Calderwood, R, Halka, T, Haji-Michael, P, Welch, M. Ruptured Abdominal Aortic Aneurysm: Is It Possible to Predict Outcome? International Angiology; 2004; 23(1):47-53. Calderwood, R, Welch, M. Screening Men for Aortic Aneurysm. International Angiology. 2004; 23(2):185-8. Chant H, Ashleigh R, McCollum C. Thrombectomy for acute internal carotid thrombosis: Five thrombectomy devices compared. European Journal of Vascular and Endovascular Surgery. 2004; 27 (4): 403-408 Dennis MW, Downey C, Bruffato N, Nesheim ME, Stevenson KJ, Toh CH. Prothrombinase enhancement through quantitative and qualitative changes affecting very low density lipoprotein in complex with C-reactive protein. Thromb Haemost 2004; 91:522-530 England, A; Butterfield, J S; Jones, N; McCollum, C N.; Nasim, A; Welch, M; Ashleigh, R J. Device Migration after Endovascular Abdominal Aortic Aneurysm Repair: Experience with a Talent Stent-Graft. Journal of Vascular & Interventional Radiology. 2004; 15(12): 1399-1405 Nataraj, V.,Mortimer, AJ. Endovascular abdominal aortic aneurysm repair. Continuing Education in Anaesthesia, Critical Care & Pain. 2004; 4(3): 91-94 Nirmalan, M. Niranjan, M, Willard T, Edwards, JD, Little, RA and Dark, PM. Estimation of errors in determining intrathoracic blood volume using thermal dilution in pigs with acute lung injury and haemorrhage. BJA Advance Access published on July 26, 2004 Simon, DA; Dix, FP; McCollum, CN. Management of venous leg ulcers. BMJ. 2004; 328(7452): 1358-1362 Stevenson KJ, Craig S, Goodman L, Kanyike FB. No deterioration after thirteen years in a stability study of a rabbit brain, plain, thromboplastin, RBT1010, in rubber-stoppered ampoules. Br J Haematol 2004; 125:240-242 11
  12. 12. RM2: MULTIDISCIPLINARY RESEARCH ON CORONARY ARTERY DISEASE, STROKE, PARADOXICAL EMBOLI AND CEREBRAL INJURY Bridgewater, B, Grayson, A.D. Au, J. Hassan, R, Dihmis, W.C. Munsch, C, Waterworth, P. Improving mortality of coronary surgery over first four years of independent practice: retrospective examination of prospectively collected data from 15 surgeons. BMJ. 2004; 329: 421. Coyne JD; Banerjee SS; Bromley M; Mills S; Diss TC; Harris M. Post-transplant T-cell lymphoproliferative disorder/T-cell lymphoma: a report of three cases of T-anaplastic large- cell lymphoma with cutaneous presentation and a review of the literature. Histopathology 2004; 44 (4): 387-393 Deaton C, Bennett J, Riegel B. Cardiac Nurses and Older Adults: State of the Science for Care of Older Adults with Heart Disease. Nursing Clinics of North America. 2004; 39(3): 495-528. Deaton C, Grady K. State of the Science for Cardiovascular Nursing Outcomes: Heart Failure. Journal of Cardiovascular Nursing. 2004; 19(5): 329-338. Deaton C, Namasavayam S. Nursing Outcomes in Coronary Heart Disease. Journal of Cardiovascular Nursing. 2004; 19(5): 308-315 Deaton C. Observations and Outcomes. Journal of Cardiovascular Nursing. 2004; 19(2): 142-144 Densem CG; Bennett DH; Davidson NC. Fusion of permanent pacing leads. EUROPACE 2004; 6 (1): 77-78 Densem CG; Mutlak ASM; Pravica V; Brooks NH; Yonan N; Hutchinson L. A novel polymorphism of the gene encoding furin, a TGF-beta 1 activator, and the influence on cardiac allograft vasculopathy formation. Transplant Immunology. 2004; 13 (3):185-190 Densem CG; Hutchinson IV; Yonan N; Brooks NH. Donor and recipient transforming growth factor-beta 1 polymorphism and cardiac transplant-related coronary artery disease. Transplant Immunology. 2004; 13 (3): 211-217 Densem CG; Hutchinson IV; Yonan N; Brooks NH. Influence of IFN-gamma polymorphism on the development of coronary vasculopathy after cardiac transplantation. Annals of Thoracic Surgery. 2004; 77 (3): 875-880 Densem CG, Wassel J, Cooper A, Yonan N, Brooks NH, Keevil B. Haptoglobin phenotype correlates with development of cardiac transplant vasculopathy. J Heart Lung Transplant. 2004; 23: 43-9 Devine, C; McCollum, C. The North West Femoro-Popliteal Trial Participants Heparin- bonded Dacron or polytetrafluorethylene for femoropopliteal bypass: Five-year results of a prospective randomized multicenter clinical trial. Journal of Vascular Surgery. 2004; 40(5): 924-931 Gandhi NM; Bennett DH. Malignant vasovagal syndrome in two patients with Wolff- Parkinson-White syndrome. Heart. 2004; 90 (4): e19 Gandhi NM; Greaves M; Brooks NH. Rare case of heart failure caused by compression of the left atrium by a thoracic aortic aneurysm. Heart. 2004; 90 (2): e9 12
  13. 13. Karthik, S, Srinivasan, A.K, Grayson, A.D, Jackson, M, Sharpe, DAC, Keenan, DJM, Bridgewater, B, Fabri, B.M. Limitations of additive EuroSCORE for measuring risk stratified mortality in combined coronary and valve surgery. Eur. J. Cardiothorac. Surg. 2004; 26: 318 - 322. Macnab, A, Jenkins, NP, Ewington,I, Bridgewater, B J M, Hooper, TL, Greenhalgh, DL, Patrick, MR, Ray, SG. A method for the morphological analysis of the regurgitant mitral valve using three-dimensional echocardiography. Heart. 2004; 90: 771 - 776. MacNab A, Jenkins NP, Bridgewater B, Hooper TL, Greenhalgh D, Patrick M, Ray SG. Three dimensional echocardiography is superior to multiplane transoesophageal echo in the pre-operative assessment of mitral valve morphology. Eur J Echocardiography. 2004; 5: 212-222. McCollum C N, O'Neill P A, Welsh S J. Urgent carotid surgery for acute stroke. Protocol - the Cochrane Library Issue 2 2004 McDowell G, Gupta S, Dellerba M, Coppinger T, Levy RD, Keevil BG. Plasma concentrations of tumour dimeric pyruvate kinase are increased in patients with cardiac failure. Ann Clin Biochem 2004; 41(6): 491-3 Naoumova RP, Neuwirth C, Lee P, Miller JP, Taylor KG, Soutar AK. Autosomal recessive hypercholesterolaemia: long-term follow up and response to treatment. Atherosclerosis. 2004; 174 (1): 165-172 Neil, H A W ; Seagroatt, V ; Betteridge, D J ; Cooper, M P ; Durrington, P N ; Miller, J P ; Seed, M ; Naoumova, R P ; Thompson, G R ; Huxley, R ; Humphries, S E. Established and emerging coronary risk factors in patients with heterozygous familial hypercholesterolaemia. Heart. 2004; 90 (12): 1431-1437 Prendergast BD. Diagnostic criteria and problems in infective endocarditis. Heart 2004; 90: 611-613. Prendergast BD. Palpitations: Investigation and Management. British Heart Foundation Factfile 2004. Prendergast BD. Anticoagulation for patients with prosthetic heart valves during non- cardiac surgery. ESC e-journal of Cardiology 2004. Riding, G.; Daly, K.; Hutchinson, S.; Rao, S.; Lovell, M.; McCollum, C. Paradoxical cerebral embolisation: An Explanation for Fat Embolism Syndrome. Journal of Bone & Joint Surgery - British Volume. 2004; 86-B(1):95-98 Seriki DM, Abidia A, Butterfield JS, Ashleigh RJ, McCollum CN. Endovascular stent graft: Treatment of pseudoaneurysm of the superior mesenteric artery. Cardiovascular and Interventional Radiology. 2004; 27 (3): 271-273 Walker AH, Fildes JE, Leonard CT, Yonan N. The influence of donor age on transplant coronary artery disease and survival post heart transplantation: is it safe to extend donor age? Transplant Proc. 2004; 36(10): 3139-41. Welsh, S, Mead, G, Chant, H, Picton, A, O'Neill, PA, McCollum, CN. Early carotid surgery in acute stroke: A multicentre pilot study. Cerebrovascular Diseases 2004; 18: 200-205 13
  14. 14. RM2: BURN, PLASTIC AND RECONSTRUCTIVE SURGERY Bayat A, Arscott G, Ollier WER, Ferguson MWJ, Mc Grouther DA. Description of site- specific morphology of keloid phenotypes in an Afrocaribbean population. British Journal of Plastic Surgery. 2004; 57 (2): 122-133 Bayat A. Bock, O. Mrowietz, U. Ollier, WER. Ferguson, MWJ. Genetic susceptibility to keloid disease: Transforming growth factor beta receptor gene polymorphisms are not associated with keloid disease. Experimental Dermatology. 2004; 13 (2): 120-124 Birchall M, Idowu B, Murison P, Jones A, Burt R, Ayling S, Stokes C, Pope L, Terenghi G. Laryngeal abductor muscle reinnervation in a pig model. Acta Oto-Laryngologica. 2004; 124 (7): 839-846 Bisson MA; Mudera V; McGrouther A; Grobbelaar AO. The contractile properties and responses to tensional loading of Dupuytren's disease-derived fibroblasts are altered: A cause of the contracture? Plastic and Reconstructive Surgery. 2004; 113 (2): 611-621 Cano SJ, Browne JP, Lamping DL, Roberts AHN, McGrouther DA, Black NA. The patient outcomes of surgery-hand/arm (POS-Hand/Arm): A new patient-based outcome measure. Journal of Hand Surgery-British and European Volume. 2004; 29B (5): 477-485 Dunn K; Edwards-Jones V. The role of Acticoat (TM) with nanocrystalline silver in the management of burns. Burns. 2004; 30: S1-S9 Edwards J. Scar management: what are the available options? Nursing in Practice, 2004; 16:69-71 Edwards-Jones V, Buck R, Shawcross SG, Dawson MM, Dunn K. The effect of essential oils on methicillin-resistant Staphylococcus aureus using a dressing model. Burns 2004 30(8):772-777 Greenbaum AR, Donne J, Wilson D, Dunn KW. Intentional burn injury: an evidence-based, clinical and forensic review. Burns. 2004; 30(7):628-42. Hart AM, Wilson ADH, Montovani C, Smith C, Johnson M, Terenghi G, Youle M. Acetyl-L- carnitine: a pathogenesis based treatment for HIV-associated antiretroviral toxic neuropathy. Aids. 2004;18 (11): 1549-1560 Hart, AM; Terenghi, G. Frozen-section fluorescence microscopy and stereology in the quantification of neuronal death within dorsal root ganglia. Journal of Molecular Histology. 2004; 35(6): 565-580 Hart AM, Terenghi G, Kellerth JO, Wiberg M. Sensory neuroprotection, mitochondrial preservation, and therapeutic potential of N-acetyl-cysteine after nerve injury. Neuroscience. 2004; 125 (1): 91-101 Katerinaki E, Chakrabarty KH. Distally based dorsal metacarpal flaps: a review of a series of patients treated in a 6-month period. Injury-International Journal of the Care of the Injured. 2004; 35 (11): 1176-1181 Peck, FH, Kennedy, SM, Watson, JS, Lees VC. An evaluation of the influence of practitioner led hand clinics on rupture rates following primary tendon repair in the hand. British Journal of Plastic Surgery, 2004; 57 (1): 45-49 14
  15. 15. Price RD; Das-Gupta V; Harris PA; Leigh IM; Navsaria HA. The role of allogenic fibroblasts in an acute wound healing model. Plastic and Reconstructive Surgery. 2004; 113 (6): 1719-1729 Shaaban H; Giakas G; Bolton M; Williams R; Scheker LR; Lees VC. The distal radioulnar joint as a load-bearing mechanism - A biomechanical study. Journal of Hand Surgery- American Volume. 2004; 29A (1): 85-95 Sutton DN, Lewis BRK, Pate M, Cawood JI. Changes in facial form relative to progressive atrophy of the edentulous jaws. International Journal of Oral And Maxillofacial Surgery. 2004; 33 (7): 676-682 Tohill MP, Mann DJ, Mantovani CM, Wiberg M, Terenghi G. Green fluorescent protein is a stable morphological marker for Schwann cell transplants in bioengineered nerve conduits. Tissue Engineering. 2004; 10 (9-10): 1359-1367 Tohill M, Mantovani C, Wiberg M, Terenghi G. Rat bone marrow mesenchymal stem cells express glial markers and stimulate nerve regeneration. Neuroscience Letters. 2004; 362 (3): 200-203 Tympanidis P, Casula MA, Yiangou Y, Terenghi G, Dowd P, Anand P. Increased vanilloid receptor VR1 innervation in vulvodynia. European Journal of Pain. 2004; 8 (2): 129-133 Zhang CG, Ma JJ, Terenghi G, Mantovani C, Wiberg M. Phrenic nerve transfer in the treatment of brachial plexus avulsion: An experimental study of nerve regeneration and muscle morphology in rats. Microsurgery. 2004; 24 (3): 232-240 Collaborators’ Publications Birtles A, Virgincar N, Sheppard CL, Walker RA, Johnson AP, Warner M, Edwards-Jones V, George RC. Antimicrobial resistance of invasive Streptococcus pneumoniae isolates in a British district general hospital: the international connection. J Med Microbiol. 2004 53(12):1241-1246 Blakytny R, Ludlow A, Martin GEM, Ireland G, Lund LR, Ferguson MWJ, Brunner G. Latent TGF-beta 1 activation by platelets. Journal of Cellular Physiology. 199 (1): 67-76 APR 2004 Ferguson MWJ, O'Kane S. Scar-free healing: from embryonic mechanisms to adult therapeutic intervention. Philosophical Transactions of the Royal Society of London Series B- Biological Sciences. 2004; 359 (1445): 839-850 15
  16. 16. RM2: INVASIVE FUNGAL DISEASES Boyd AE, Modi S, Howard S, Moore CB, Keevil BG, Denning DW. Adverse reactions to high concentrations of voriconazole. Clin Infect Dis. 2004; 39:1241-4 Birch M, Denning DW, Robson GD. A comparison of extracellular phospholipase activities in clinical and environmental isolates of Aspergillus isolates. Medical Mycology. 2004; 42: 81-86. Denning DW. Antifungal drugs – where are we headed. Drug Plus International. 2004:11-13. Denning DW. Caspofungin for severe fungal infections. Drugs & Ther Bull. 2004; 42: 5-8. Denning DW. Aspergillosis in "non-immunocompromised" critically ill patients in intensive care. Am J Resp Med Crit Care. 2004; 170:580-1 Dodgson AR, Dodgson KJ, Pujol C, Pfaller MA, Soll DR. Clade-specific flucytosine resistance is due to a single nucleotide change in the FUR1 gene of Candida albicans. Antimicrob Agents Chemother. 2004; 48 (6): 2223-7. Fahad B, McKellar M, Armstrong M, Denning D, Tullo A. Aspergillus keratitis following corneal foreign body in the United Kingdom. Br J Ophthmol. 2004; 88: 847-8. Hope WW, Denning DW. Invasive aspergillosis: the current and future challenges in diagnosis and therapy. Clin Microbiol Infect. 2004; 10: 2-4. Hope WW, Padwell A, Guiver M, Denning DW. Invasive pulmonary aspergillosis with spontaneous resolution and the diagnostic utility of PCR from tissue specimens. J Infection. 2004; 49: 136-40. Hope WW, Denning DW. Optimising antifungal therapy for individual patients (Editorial). Intern Med J. 2004; 34:147-9. Hope WW, Denning DW. Antifungal therapy. MIMS Advances. 2004; 8-11. Hope WW, Tabernero L, Denning DW, Anderson MJ. Insights into the molecular mechanisms of primary resistance to 5-fluorocytosine (5FC) in Candida albicans. Antimicrob Ag Chemother. 2004; 48: 4377-86 Hope WW, Morton AP, Looke DF, Schooneveldt JM, Nimmo GR. A PCR method for the identification of methicillin-resistant Staphylococcus aureus (MRSA) from screening swabs. Pathology. 2004; 36 (3): 265-8. Hwan Do J, Anderson MJ, Denning DW, Bornberg-Bauer E. Inference of Aspergillus fumigatus pathways by computational genome analysis; Tricarboxylic acid cycle (TCA) and glyoxylate shunt. J Microbial Biotechnol. 2004; 14: 74-80. Kamran M, Calcagno AM, Findon H, Bignell E, Jones MD, Warn PA, Hopkins P, Denning DW, Butler G, Rogers TR, Mühlschlegel F, Haynes K. Inactivation of the ACE2 transcription factor gene in the fungal pathogen Candida glabrata results in hypervirulence. Eucaryotic Cell. 2004; 3: 546-552. Keevil B, Newman, Lockhart S, Moore CB, Howard S, Denning DW. Validation of an assay for voriconazole in serum samples using liquid chromatography- tandem mass spectrometry. Ther Drug Monit. 2004; 26: 650-657 16
  17. 17. Mabey JE, Anderson MJ, Giles P, Miller C, Attwood TK, Paton N, Bornberg-Bauer E, Robson GD, Oliver S, Denning DW. CADRE: the Central Aspergillus Data Repository. Nucleic Acids Research. 2004; 32: D401-5. Maertens J, Raad I, Petrikkos G, Boogaerts M, Selleslag D, Petersen FB, Sable C, Kartsonis N, Ngai A, Taylor A, Patterson T, Denning DW, Walsh TJ. A multicenter, open, noncomparative study to estimate the safety, tolerability and efficacy of caspofungin (MK-0991) in the treatment of invasive Aspergillus infections in adults who are refractory to or intolerant of amphotericin B, lipid formulations of amphotericin B or azoles. Clin Infect Dis. 2004; 39: 1563-71 Pain A, Woodward J, Quail MA, Anderson MJ, Clark R, Collins M, Fosker N, Fraser A, Harris D, Larke N, Murphy L, Humphray S, O'Neil S, Pertea M, Price C, Rabbinowitsch E, Rajandream MA, Salzberg S, Saunders D, Seeger K, Sharp S, Warren T, Denning DW, Barrell B, Hall N. An insight into the genome of the most abundant opportunist human pathogen: analysis of 922 kb fragment of chromosome VIII of Aspergillus fumigatus. Fung Genet Biol. 2004; 41: 443-53. Sari-Kouzel H, Chadwick P, Denning DW, Muir LTSW, Herrick A . Case report: Mycobacterium chelonae finger infection in a patient with Raynaud’s phenomenon and anticardolipin antibody syndrome. Ann Rheumat Dis. 2004; 63: 1178-9. Warn PA, Sharp A, Guinea J, Denning DW. Effect of hypoxic conditions on in vitro susceptibility testing of amphotericin B, itraconazole and micafungin against Aspergillus and Candida. J Antimicrob Chemother. 2004; 53: 743-9. Zaspel U, Denning DW, Lemke AJ, Greene R, Schurmann D, Maschmeyer G, Ruhnke M, Herbrecht R, Ribaud P, Lortholary O, Zonderland H, Rabe KF, Rottgen R, Bittner R, Neumann K, Oestmann JW. Diagnosis of IPA in HIV: Role of chest-X-ray and radiologist. Eur Radiol. 2004;14: 2030-7 17
  18. 18. RM2: MEDICAL EDUCATION Boggis, CRM. Management of the expansion of clinical placements for medical students in a teaching hospital. Clinician in Management. 2004; 12(2):69-75 Bundy C. Changing behaviour: using motivational interviewing techniques. Journal of the Royal Society of Medicine. 2004; 97: 43-47 Suppl. 44 Clark, E. Action learning with young carers. Action Learning: Research and Practice. 2004. 1 (1):109-116. Dornan, T; Bundy, C. What can experience add to early medical education? Consensus survey. BMJ. 2004; 329(7470):834 Dornan T, Boshuizen H, Cordingley L, Hider S, Hadfield J, Scherpbier A. Evaluation of self- directed clinical education: validation of an instrument. Medical Education. 2004; 38 (6): 670-678 Furber C, Hickie J, Lee K, McLoughlin A, Boggis C, Sutton A, Cooke S, Wakefield A. Interprofessional education in a midwifery curriculum: the learning through the exploration of the professional task project (LEAPT). Midwifery. 2004; 20 (4):358-66 Gray, J, Jackson, C. The Development & Introduction of an 'On-Line Drug Calculations Quiz.' Nursing Times. 2004; 100 (4): 40 Kirshbaum, M., Beaver, K., Luker, K.A. Perspectives of breast care nurses on research dissemination and utilisation. Clinical Effectiveness in Nursing. 2004; 8: 47-58 Schroter S, Morris J, Chaudhry S, Smith R, Barratt H. Does the type of competing interest statement affect readers' perceptions of the credibility of research? Randomised trial. British Medical Journal. 2004; 328 (7442): 742-743 Wass V, van der Vleuten C. The long case. Medical Education. 2004; 38 (11): 1176-1180 Wass, V; O'Neill, P. What the educators are saying. BMJ. 2004; 328(7433):210 Wass, V. What the educators are saying. BMJ. 2004; 329(7461):335 18
  19. 19. RM2: MEDICINES MANAGEMENT Ashcroft DM, Millson D. Naratriptan for the treatment of acute migraine: meta-analysis of randomised controlled trials. Pharmacoepidemiology and Drug Safety 2004; 13: 73-82. Breen E. Does Supplier Development benefit Hospital Pharmacy? Pharmacy Management 2004; 20(3): 10-17 Chen LC, Elliott RA, Ashcroft DM. Systematic review of the analgesic efficacy and tolerability of Cox-2 inhibitors in post-operative pain control. Journal of Clinical Pharmacy and Therapeutics 2004; 29: 215-229. Child D, Cantrill J, Cooke J. The effectiveness of hospital pharmacy in the UK: methodology for finding the evidence. Pharmacy World & Science. 2004; 26 (1): 44-51 Cooke J. The role of the hospital pharmacist in combating antimicrobial resistance. European Journal of Hospital Pharmacy 2004;10:30 Cooke J. Infectious diseases – the need for new antibiotics. Hospital Pharmacist. 2004;11:265-268. El-Beik S, Banfield S. Implementing the Medicines Information Service Strategy - The Challenge. Pharmacy Management 2004; 20(4): 5-8 El-Beik S et al. Community Pharmacists have a need for better access to medicines information. Pharmacy in Practice. 2004; 91-94 Farooq V, Hegarty J, Chandrasekar T, Lamerton EH, Mitra S, Houghton JB, Kalra PA, Waldek S, O'Donoghue DJ, Wood GN. Serious adverse incidents with the usage of low molecular weight heparins in patients with chronic kidney disease. Am J Kidney Dis 2004; 43(3): 531-537 Mason A, Drummond M, Towse A, Cooke J. Influencing prescribing in English primary care: the views of primary care organisations. Journal of Health Services Research & Policy. 2004;9:153-158 Redfern J , Webb AK. Benefits of a dedicated cystic fibrosis pharmacist. J R Soc Med 2004; 97(Suppl 44):2-7 Reeves P; Cooke J; Lloyd A; Hutchings A. An economic evaluation of the costs and benefits of heparin rationalisation in a hospital pharmacy. Pharmacy World & Science. 2004; 26 (3): 160-168 Rooney A, Carrington I. A new approach is needed to manage type 2 diabetes dyslipidaemia. Pharmacy in Practice 2004;14:170-173 Smith GM, Cantrill JA, Tully MP. Exploring the effect of the electronic patient record on hospital pharmacies: developing a case study approach. Health Services Research and Pharmacy Practice Conference, Volume of Abstracts. King’s College, London. March 2004, p19. Smith GM, Cantrill JA, Tully MP. NHS information technology: the views of hospital pharmacists and technicians. Int. J. Pharm. Pract. 2004; 12 (suppl): R29. 19
  20. 20. Smith GE, Smith S, Heatlie H, Bashford JNR, Hawker J, Ashcroft D, Millson D, Verlander NQ, Warren R. What has happened to antimicrobial usage in primary care in the United Kingdom since the SMAC report? Description of trends in antimicrobial usage using the General Practice Research Database. Journal of Public Health 2004; 26(4): 359-364. Tully MP. Prescribing errors and medication histories. Pharm. World Sci. 2004; 26(6): A101 Tully MP. Prescribing errors at different stages of hospital admission. Pharm. World Sci. 2004; 26(6): A100 Tully MP, Tung P, Maybury J, Lepp E. The impact of prescribing documentation in the medical record on the content of the discharge summary. Int. J. Pharm. Pract. 2004; 12 (suppl): R33 20
  21. 21. RM3: STUDIES OF THE GASTROINTESTINAL TRACT IN HEALTH AND DISEASE Atkinson W, Sheldon T, Shaath N, Whorwell PJ. Food elimination based on IgG antibodies in irritable bowel syndrome: a randomised controlled trial. Gut 2004;69:254-61. Calvert EL, Whorwell PJ, Houghton LA. Inter-digestive and post-prandial antro-pyloro- duodenal motor activities in humans: effect of 5-hydroxytryptamine 1 receptor agonism. Aliment Pharmacol Ther 2004;19:805-15. Evans BW, Clark W, Moore D, Whorwell PJ. Tegasterod for the treatment of irritable bowel syndrome. Cochrane database Syst Rev 2004;1:CD003960. Gonsalkorale W, Toner B, Whorwell PJ. Cognitive change in patients undergoing hypnotherapy for irritable bowel syndrome. Journal of Psychosomatic Research 2004;56:271-278. Harris RP, Daly KJ, Jones LS, Kiff ES. Stoma formation for functional bowel disease. Colorectal Dis. 2004; 6: 280-4 Houghton LA, Whorwell PJ. Functional bowel disorders: recent advances. Part I. London: Biggs & Co; 2004. Houghton LA, Whorwell PJ. Functional bowel disorders: recent advances. Part II. London: Biggs & Co; 2004. Lea R, Whorwell PJ. Benefit-risk assessment of tegaserod in irritable bowel syndrome. Drug Safety 2004;27:229-42. Lea R, Whorwell P. Dietary treatment of the irritable bowel syndrome. Current treatment options in gastroenterology 2004;7:307-316. Lea R. Whorwell PJ. Psychological features of irritable syndrome. Minerva Medicine 2004;95:443-50. Lea R, Hopkins VL, Whorwell PJ. Diagnostic criteria for IBS: utility and applicability in clinical practice. Digestion 2004; 70: 210-3. Lea R, Bancroft, Whorwell PJ. Irritable bowel syndrome, pelvic inflammatory disease and endometriosis - a comparison of symptomatology. European Journal of Gastroenterology and Hepatology 2004;16:1269-72. Marriott P, Laasch H-U, Wilbraham L, Marriott A, England R.E, Martin D.F. Conscious sedation for endoscopic and non-endoscopic interventional gastrointestinal procedures: meeting patients' expectations, missing the standard. Clinical Radiology. 2004; 59: 180-185 Miller V, Whittaker K, Morris JA, Whorwell PJ. Gender and irritable bowel syndrome: the male connection. J Clinical Gastroenterology 2004;38:558-60. Miller V, Hopkins VL, Whorwell PJ. Suicidal ideation in patients with irritable bowel syndrome? Clinical Gastroenterology and Hepatology 2004;2:1064-8. Newton Ede MP, Kiff ES. A “simple” cholecystectomy: the value of the pre-operative assessment. J R Army Med Corps. 2004; 150: 122-3 21
  22. 22. Sarkar S; Thompson DG; Woolf CJ; Hobson AR; Millane T; Aziz Q. Patients with chest pain and occult gastroesophageal reflux demonstrate visceral pain hypersensitivity which may be partially responsive to acid suppression. American Journal of Gastroenterology. 2004; 99 (10):1998-2006 Simren M, Brazier J, Coremans G, Dapoigny M, Muller-Lissner SA, Pace F, Smout AJ, Stockbrugger RW, Vatn MH, Whorwell PJ. Quality of life and illness costs in irritable bowel syndrome. Digestion 2004;69:254-61. Smout AJ, Azpiroz F, Brummer RJ, Coremans G, Dapoigny M, Muller-Lissner SA, Pcae F, Stockbrugger RM, Vatn M, Whorwell PJ. Technologies in the evaluation of irritable bowel syndrome. Digestion 2004;69:158-65. Telford KJ, Faulkner G, Hosker GL, Kiff ES, Hill J. The strength duration test: a novel tool in the identification of occult neuropathy in women with pelvic floor dysfunction. Colorectal Dis. 2004; 6: 442-5 Telford KJ, Ali AS, Lymer K, Hosker GL, Kiff ES, Hill J. Fatigability of the external anal sphincter in anal incontinence. Dis Colon Rectum. 2004; 47 (5): 746-52 Whorwell PJ. Management of irritable bowel syndrome with constipation. Medscape 2004. Available at: 22
  23. 23. RW3: CLINICAL DIABETES AND ENDOCRINOLOGY Attanasio, A.F., Shavrikova, E., Blum, W.F., Cromer, M., Child, C.J., Paskova, M., Lebl, J., Chipman, J.J., The Hypopituitary Developmental Outcome Study Group and Shalet, S.M. Continued growth hormone (GH) treatment after final height is necessary to complete somatic development in childhood-onset GH-deficient patients. The Journal of Clinical Endocrinology & Metabolism. 2004; 89(10):4857-4862. Chatterjee, D.; Eccles, M.; Rowe, R.; Venning, M. One year retrospective study of screening for nephropathy and prioritization of referral to nephrologists in diabetes annual review clinic. Diabetic Medicine Supplement. 2004; 21 Supplement 2:23 Gleeson, H.K., Gattamaneni, H.R., Smethurst, L., Brennan, B.M. and Shalet, S.M. Reassessment of growth hormone status is required at final height in children treated with growth hormone replacement after radiation therapy. The Journal of Clinical Endocrinology & Metabolism. 2004; 89: 662-666. Lawson, VL; Bundy, C; Lyne, PA; Harvey, JN. Using the IPQ and PMDI to predict regular diabetes care-seeking among patients with Type 1 diabetes. British Journal of Health Psychology. 2004; 9(2): 241-252 Limdi, J.K.; Crampton, J.R. Hereditary haemochromatosis. Qjm. 2004; 97(6):315-324 Mukherjee, A., Murray, R.D., Teasdale, G.M. and Shalet, S.M. Acquired prolactin deficiency (APD) after treatment for Cushing’s disease is a reliable marker of irreversible severe GHD but does not reflect disease status. Clinical Endocrinology. 2004; 60:476-483. Murray, R.D., Columb, B., Adams, J.E. and Shalet, S.M. Low bone mass is an infrequent feature of the adult growth hormone deficiency syndrome in middle-age adults and the elderly. The Journal of clinical Endocrinology & Metabolism. 2004; 89:1124-1130. Murray, R.D., Adams, J.E. and Shalet, S.M. Adults with partial growth hormone deficiency have an adverse body composition. The Journal of Clinical Endocrinology & Metabolism. 2004; 89;1586-1591. Paisley AN, Trainer PJ, Drake WM. The place of pegvisomant in the acromegaly treatment algorithm. Growth Hormone & IGF Research. 2004; 14: S101-S106 Suppl. A Paisley AN, Trainer P, Drake W. Pegvisomant: a novel pharmacotherapy for the treatment of acromegaly. Expert Opinion on Biological Therapy. 2004; 4 (3): 421-425 Parkinson C, Flyvbjerg A, Trainer PJ. High levels of 150-kDa insulin-like growth factor binding protein three ternary complex in patients with acromegaly and the effect of pegvisomant-induced serum IGF-I normalization. Growth Hormone & IGF Research. 2004; 14 (1): 59-65 Pokrajac-Simeunovic A, Trainer PJ. Pitfalls in the diagnosis of acromegaly. Hormone Research. 2004; 62: 74-78 Suppl. 3 Randeva, H.S., Lewandowski, K.C., Komorowski, J., Murray, R.D., O’Callaghan, C.J., Hillhouse, E.W., Stepien, H. and Shalet, S.M. Growth hormone replacement decreases plasma levels of matrix metalloproteinases (2 and 9) and vascular endothelial growth factor in growth hormone-deficient individuals. Circulation. 2004; 109:2405-2410. 23
  24. 24. Renehan, A.G., Zwahlen, M., Minder, C., O'Dwyer, S.T., Shalet, S.M. and Egger, M. Insulin- like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis. Lancet. 2004; 363(9418):1346-53 Van Schie CHM, Carrington AL, Vermigli C, Boulton A. Muscle weakness and foot deformities in diabetes. Diabetes Care. 2004; 27 (7): 1668-1673 24
  25. 25. RW 3: REHABILITATION AND AGEING Burgess, L. Addressing the palliative care needs of people with dementia. Nursing Times. 2004; 100 (19): 36 Greco KE, Deaton C, Kutner M, Schnelle JF, Ouslander J. Psychoactive medications and actigraphically scored sleep quality in frail nursing home patients. Journal of American Medical Directors Association. 2004; 5: 223–227. Pal, B. Inflammatory rheumatic disorders. Annals of the Rheumatic Diseases. 2004; 63(5):611 Purandare N, Burns A, Challis D, Morris J. Perceived mental health needs and adequacy of service provision to older people in care homes in the UK: a national survey. Int J of Ger Psych. 2004; 19: 549-53 Ryan-Woolley B, Caress A-L, Wilson K. User and carer perspectives on the impact and value of services received from a community rehabilitation team Disability and Rehabilitation. 2004; 26 (13): 817-826 Smith MG; Dunkow P; Lang DM. Treatment of osteoporosis: missed opportunities in the hospital fracture clinic. Annals of the Royal College of Surgeons of England 2004; 86 (5): 344-346 Twiste, M. Rithalia, SVS. Kenney, L. A cam-displacement transducer device for measuring bi-plane prosthetic motion. Medical Engineering and Physics. 2004; 26 (4): 335-40 Walshe C, Caress A-L, Chew-Graham C, Todd C. Case study: a research strategy appropriate for palliative care? Palliative Medicine. 2004; 18: 677-684 25
  26. 26. RW3: SERVICE DELIVERY AND MANAGEMENT RESEARCH Booker J, Eardley A, Cowan R, Logue J, Wylie J, Caress A-L. Telephone first post- intervention follow-up for men who have had radical radiotherapy to the prostate: evaluation of a novel service delivery approach European Journal of Oncology Nursing. 2004; 8: 325-333 Kirshbaum, M.; Booth, K.; Luker, K. The changing face of cancer care in the UK: can nurses help to structure new services? European Journal of Cancer Care. 2004; 13(3):246-253 Mellor, F; Foley, T; Connolly, M; Mercer, V; Spanswick, M. Role of a clinical facilitator in introducing an integrated care pathway for the care of the dying. International Journal of Palliative Nursing. 2004; 10 (10): 497 - 501 Vick, D, Whyatt, H. Tackling work-related stress in a National Health Service Trust. Action Learning: Research and Practice. 2004; 1 (1): 101-107 26
  27. 27. PUBLICATIONS OUTSIDE RESEARCH PROGRAMMES Allaf, N; Dunkow, P; Lovell, M. A technique for reduction and casting of closed tibial fractures. Annals of the Royal College of Surgeons of England. 2004; 86(5):382-383 Allaf N; Lovell M. Annual review of fractured neck of femur mortality rates: is this a true picture? Annals of the Royal College of Surgeons of England 2004; 86 (5): 347-348 Balmer P, Falconer M, McDonald P, Andrews N, Fuller E, Riley C, Kaczmarski E, Borrow R. Immune response to meningococcal serogroup C conjugate vaccine in asplenic individuals. Infection and Immunity. 2004; 72 (1): 332-337 Campbell IT. Water and electrolyte disturbances. Handbook of Clinical Anaesthesia, 2nd edition. Ed BJ Pollard, Churchill Livingstone, Edinburgh, 2004. pp 624-628. Campbell IT. Porphyria. In: Handbook of Clinical Anaesthesia, 2nd Edition. Ed: BJ Pollard, Churchill Livingstone, Edinburgh, 2004, pp179-181. Campbell IT. Glycogen storage disease. In: Handbook of Clinical Anaesthesia, 2nd Edition. Ed: BJ Pollard. Churchill Livingstone, Edinburgh, 2004, pp284-286. Campbell IT. Osmolarity and partitioning of fluids. Anaesthesia and Intensive Care Medicine 2003; 4: 423- 425. Campbell IT, Little RA. And the metabolic response to trauma. Wylie and Churchill Davidson’s A Practice of Anaesthesia. Ed Healy TEJ and Knight PR. Arnold, London 2003, pp 1049-1061. Campbell IT. Osmolarity and partitioning of fluids. Surgery 2004; 22: 48c-48e. Campbell IT. Macronutrients, minerals vitamins and energy. Anaesthesia and Intensive Care Medicine 2004; 5: 136-141. Campbell IT. Intermediary metabolism. Anaesthesia and Intensive Care Medicine 2004: 5: 142-143. Campbell IT. Cell biology and gene expression. Anaesthesia and Intensive Care Medicine 2004; 5: 169-173. Campbell IT. Starvation, exercise, injury and obesity. Anaesthesia and Intensive Care Medicine 2004; 5: 243-248. Camorcia M, Capogna G, Lyons G, Columb M. Epidural test dose with levobupivacaine and ropivacaine: Determination of the ED50 for motor block after spinal administration. British Journal of Anaesthesia 2004; 92 (6): 850-3. Camorcia M, Capogna G, Lyons G, Columb M. The relative motor blocking potencies of intrathecal ropivacaine: Effects of concentration. Anesthesia & Analgesia 2004; 98 (6): 1779-82. Chau SK, Columb MO, Lyons G. Thrombocytopenia, thromboelastography and pregnancy, an invitro model. Anesthesiology 2004; 100 (suppl 1): A1 27
  28. 28. Chow K; Dixon J; Gilpin S; Kavanagh JP; Rao PN. Citrate inhibits growth of residual fragments in an in vitro model of calcium oxalate renal stones. Kidney International. 2004; 65 (5): 1724-1730 Chow K; Dixon J; Gilpin S; Kavanagh JP; Rao PN. A stone farm: development of a method for simultaneous production of multiple calcium oxalate stones in vitro. Urological Research 2004; 32 (1): 55-60 Clarke, SFJ; Arepalli, N; Armstrong, C; Dargan, PI. Duodenal perforation after ibuprofen overdose. Journal of Toxicology: Clinical Toxicology. 2004; 42 (7): 983 Cullen MM, Trail A, Robinson M, Keaney M, Chadwick PR: Serratia marcescens outbreak in a neonatal intensive care unit prompting review of decontamination of laryngoscopes, Journal of Hospital Infection. 2004; (59) 1:68-70. Davison, K L; Andrews, N; White, J M; Ramsay, M E; Crowcroft, N S; Rushdy, A A; Kaczmarski, E B; Monk, P N; Stuart, J M. Clusters of meningococcal disease in school and preschool settings in England and Wales: what is the risk? Archives of Disease in Childhood. 2004; 89(3):256-260 Doran DA, Jones SP, Lagathu C, Evans L, Campbell IT, Stokes DJ, Yates AP, Caron M, Pirmohamed M, Black DJ, Khoo SH, Maclaren DP. Mechanisms of insulin resistance in HIV- seronergative individuals acutely treated with ritinavir boosted indinavir and atazanavir regimens. Antiviral Therapy 2004; 9: L6 Dunkow PD, Jatti M, Muddu BN. A comparison of open and percutaneous techniques in the surgical treatment of tennis elbow. Journal of Bone and Joint Surgery-British Volume. 2004; 86B (5): 701-704 Esteban A, Anzueto A, Frutos-Vivar F, Alia I, Ely EW, Brochard L, Stewart T E, Apezteguia C, Tobin MJ, Nightingale P, Matamis D, Pimentel J, Abroug F. Mechanical Ventilation International Study Group. Outcome of older patients receiving mechanical ventilation. Intensive Care Med, 2004; 30(4): 639-46. Gupta, S; Gandhi, NM; Ferguson, J. Cutaneous vasculitis secondary to ramipril. Journal of Drugs in Dermatology. 2004; 3 (1): 81 Jones AM, Wilkerson DP, Campbell IT. Nitric oxide synthase inhibition with L-NAME reduces maximal oxygen uptake but not gas exchange threshold during incremental cycle exercise in man. Journal of Physiology 2004; 560: 329-338. Jones AM, Wilkerson DP, Wilmshurst S, Campbell IT. Influence of L-NAME on pulmonary O2 uptake kinetics during heavy-intensity cycle exercise. Journal of Applied Physiology 2004; 96: 1033-1038. Jones AM, Campbell IT, Pringle SMP. Influence of muscle fibre type and pedal rate on the VO2 – work rate slope during ramp exercise. European Journal of Applied Physiology 2004; 91: 238-245. Jones AM, Koppo K, Wilkerson DP, Wilmshurst S, Campbell IT. Dichloroacetate does not speed phase II pulmonary VO2 kinetics following the onset of heavy intensity cycle exercise. European Journal of Applied Physiology 2004; 447: 867-874. 28
  29. 29. Kaushik V, Malik TH, Bishop PW, Jones PH. Histiocytic necrotising lymphadenitis (Kikuchi's disease): A rare cause of cervical lymphadenopathy. Surgeon-Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland. 2004; 2 (3): 179-182 Kirby A, Chapman C, Hassan I, Burnie J. The diagnosis of hepatosplenic candidiasis by DNA analysis of tissue biopsy and serum. Journal of Clinical Pathology. 2004; 57 (7): 764-765 Koppo K, Wilkerson DP, Bouckaert J, Wilmshurst S, Campbell IT, Jones AM. Influence of DCA on pulmonary VO2 kinetics during moderate intensity cycle exercise. Medicine and |Science in Sports and Exercise 2004, 36: 1159-1164. Malik H; Lovell M. Soft tissue neck symptoms following high-energy road traffic accidents. Spine 2004; 29 (15): E315-E317 McGrath B, Columb M. Renal replacement therapy causing ECG artefact mimicking atrial flutter: Case report, discussion and recommendations. British Journal of Intensive Care Medicine 2004; 14 (2): 49-50 Nirmalan M, Dark PM, Nightingale P, Harris J. Editorial IV: physical and pharmacological restraint of critically ill patients: clinical facts and ethical considerations. Br J Anaesth. 2004; 92(6):789-92 Reid CL, Campbell IT, Little RA. Muscle wasting and energy balance in critical illness. Clinical Nutrition 2004; 23: 273-280. Reid CL, Campbell IT. Metabolic physiology. Current Anaesthesia and Intensive Care 2004; 15: 209-217. Reid CL, Campbell IT. Nutrition and metabolism in critical illness. Current Anaesthesia and Intensive Care 2004; 15: 336-349. Siddiqui F, Kirkman RJ, Chandiok S. Re-audit of referral compliance of chlamydia-positive women from a family planning clinic. Journal of Family Planning and Reproductive Health Care. 2004; 30 (2): 86-87 Singh, SD; Alexander, J; Owen, A; Rustom, R; Bone, M; Hammad, A; Roberts, N; Park, BK; Pirmohamed, M. Cyclosporin Resistance in Stable Renal Transplant Patients; Inhibition Of Cell Proliferation In Whole Blood Ex-Vivo Is Related To The Expression Of P-Glycoprotein. Transplantation. 2004; 77 Trotter CL, Andrews NJ, Kaczmarski EB, Miller E, Ramsay ME. Effectiveness of meningococcal serogroup C conjugate vaccine 4 years after introduction. Lancet. 2004; 364 (9431): 365-367 Whitaker IS, Rao J, Izadi D, Butler PE. Historical Article: Hirudo medicinalis: ancient origins of, and trends in the use of medicinal, leeches throughout history. British Journal of Oral & Maxillofacial Surgery. 2004; 42 (2): 133-137 Wilkerson DP, Campbell IT, Jones AM. Influe3nce of nitric oxide synthase inhibition on pulmonary O2 uptake kinetics during supra-maximal exercise in humans. Journal of Physiology 2004; 561: 623-535. 29