IN-1
Oncologic Drugs Advisory Committee
Bethesda, Maryland
January 31, 2002
C
IN-2
Introduction
Burkhard Daldrup, PhD
Global Head, Drug Regulatory Affairs
Oncology Business Unit
Novartis Pharmaceutica...
IN-3C
ZOMETA®
Overview
 ZOMETA belongs to a new class of highly potent
bisphosphonates
 Treatment of hypercalcemia of ma...
IN-4C
ZOMETA®
in Bone Metastases
Proposed Indication
ZOMETA (zoledronic acid) is
indicated for the treatment of
osteolytic...
IN-5C
ZOMETA®
in Bone Metastases
Phase III Trials
ZOMETA
4 mg and 8 mg Patient
Trial N versus populationDuration
010 1,648...
IN-6C
ZOMETA®
in Bone Metastases
Clinical Profile (1)
 ZOMETA is bone specific, not tumor specific;
effective in a broad ...
IN-7C
ZOMETA®
in Bone Metastases
Clinical Profile (2)
 First bisphosphonate shown to be effective
across a wide variety o...
IN-8C
Agenda
Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . Burkhard Daldrup, PhD
Pathophysiology of M...
IN-9C
Questions and Answers
Novartis Oncology
Clinical Research and Development . . John Seaman, PharmD
Consultants
Statis...
IN-9C
Questions and Answers
Novartis Oncology
Clinical Research and Development . . John Seaman, PharmD
Consultants
Statis...
Upcoming SlideShare
Loading in …5
×

ppt

764 views

Published on

0 Comments
0 Likes
Statistics
Notes
  • Be the first to comment

  • Be the first to like this

No Downloads
Views
Total views
764
On SlideShare
0
From Embeds
0
Number of Embeds
4
Actions
Shares
0
Downloads
16
Comments
0
Likes
0
Embeds 0
No embeds

No notes for slide

ppt

  1. 1. IN-1 Oncologic Drugs Advisory Committee Bethesda, Maryland January 31, 2002 C
  2. 2. IN-2 Introduction Burkhard Daldrup, PhD Global Head, Drug Regulatory Affairs Oncology Business Unit Novartis Pharmaceuticals Corporation C
  3. 3. IN-3C ZOMETA® Overview  ZOMETA belongs to a new class of highly potent bisphosphonates  Treatment of hypercalcemia of malignancy – Approved by FDA in August 2001 – Approved in over 60 countries  Treatment of bone metastases – Filed July 2001 in EU and August 2001 in US and other major countries – Dose: Zoledronic acid 4 mg infused over 15 min q 3 to 4 wk  Non-oncologic uses under evaluation – Paget’s disease, osteoporosis, rheumatoid arthritis
  4. 4. IN-4C ZOMETA® in Bone Metastases Proposed Indication ZOMETA (zoledronic acid) is indicated for the treatment of osteolytic, osteoblastic, and mixed bone metastases of solid tumors and osteolytic lesions of multiple myeloma, in conjunction with standard antineoplastic therapy
  5. 5. IN-5C ZOMETA® in Bone Metastases Phase III Trials ZOMETA 4 mg and 8 mg Patient Trial N versus populationDuration 010 1,648 Pamidronate Multiple myeloma 13 mo Breast cancer 039 643 Placebo Prostate cancer 15 mo 011 773 Placebo Other solid tumors 9 mo Three randomized, international, parallel, double-blind trials
  6. 6. IN-6C ZOMETA® in Bone Metastases Clinical Profile (1)  ZOMETA is bone specific, not tumor specific; effective in a broad variety of tumor types studied – Breast cancer and multiple myeloma – Prostate and other solid tumors • Other bisphosphonates have not demonstrated efficacy in these tumor types
  7. 7. IN-7C ZOMETA® in Bone Metastases Clinical Profile (2)  First bisphosphonate shown to be effective across a wide variety of solid tumor types in treatment of bone metastases  Safety is comparable with that of i.v. pamidronate – Overall safety profile is supported by data from over 3,000 patients treated with ZOMETA
  8. 8. IN-8C Agenda Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . Burkhard Daldrup, PhD Pathophysiology of Metastatic Bone Disease and the Role of Bisphosphonates . . . . . . . . . . Prof. Robert Coleman, MD, FRCP ZOMETA® in Breast Cancer and Multiple Myeloma . . . . . . . . . . . . . . . . . . . . . James Berenson, MD, Paul Gallo, PhD ZOMETA® in Prostate Cancer and Solid Tumors Other Than Prostate Cancer and Breast Cancer . . . . . . . . . . . . . . . . . . . . . . . . . Matthew Smith, MD Prof. Robert Coleman, MD, FRCP Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . David Parkinson, MD
  9. 9. IN-9C Questions and Answers Novartis Oncology Clinical Research and Development . . John Seaman, PharmD Consultants Statistics . . . . . . . . . . . . . . . . . . . . . . . . . . Richard J. Cook, PhD Thomas R. Fleming, PhD Clinical Experts Lung and Other Cancers . . . . . . . Pierre P. Major, MD, FRCPC Radiologic Analysis . . . . . . . . . Joseph F. Simeone, MD, FACR Renal Advisory Board . . . . . . . . . . Raimund R. Hirschberg, MD
  10. 10. IN-9C Questions and Answers Novartis Oncology Clinical Research and Development . . John Seaman, PharmD Consultants Statistics . . . . . . . . . . . . . . . . . . . . . . . . . . Richard J. Cook, PhD Thomas R. Fleming, PhD Clinical Experts Lung and Other Cancers . . . . . . . Pierre P. Major, MD, FRCPC Radiologic Analysis . . . . . . . . . Joseph F. Simeone, MD, FACR Renal Advisory Board . . . . . . . . . . Raimund R. Hirschberg, MD

×