Essential

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Essential

  1. 1. NUFFIELD DEPARTMENT OF SURGICAL SCIENCES UNIVERSITY OF OXFORD ROOM 6607, LEVEL 6 JOHN RADCLIFFE HOSPITAL HEADINGTON, OXFORD, OX3 9DU Further particulars for the post of Senior Research Coordinator (NDSA/333/10) The Nuffield Department of Surgical Sciences is one of the few remaining academic surgical departments in the UK. Established in 1937, the Department was headed consecutively by four Nuffield Professors of Surgery with a variety of interests, who contributed academically and clinically to surgery at Oxford. The most prominent of these was Sir Peter Morris, who developed an internationally acclaimed unit around transplantation and vascular surgical sciences over a period of 25 years. With the recent appointment of its new head, Professor FC Hamdy, a urological oncologist, the Department is taking a new exciting direction to strengthen academic surgical oncology, as a key component of the proposed CRUK cancer centre together with Medical and Clinical Oncology, and the new Cancer Centre structure of the Oxford Radcliffe Hospitals Trust. The Department currently hosts 26 academics from every surgical discipline, including urology, ENT, colorectal surgery, transplantation, paediatrics, neurosurgery, cardiothoracic and vascular surgery, who undertake both basic and translational research projects in the department’s facilities, and employs a total of approximately 100 staff. The Department has been restructured recently with 5 committees overseeing the various activities, and an executive which meets monthly. The overarching aim is to respond to the continuing changes and demands for clinical academics in the UK, and to drive surgical sciences at Oxford to a modern internationally competitive platform of basic, translational and clinical research excellence, to ‘close the loop’, from bench to the bedside. Three basic/translational research platforms are being developed and will be embedded in high quality research environments within the best institutes at Oxford, with imminent and key joint-faculty non- clinical appointments with the Gray Institute of Radiobiology and Oncology, the Botnar Institute for Musculoskeletal Research, and the Department of Medical Oncology. Other collaborative platforms include the Ludwig Institute and the Department of Physiology and Anatomy at South Parks, as well as the strong existing Transplant Immunology Research Group. NDS research NDS is at the forefront of uro-oncology pre-clinical, phase I and Phase II research. It is currently maximising its research potential with an emphasis on increasing recruitment of patients to clinical trials and biological specimen donation [bio-banking]. An example of specimen collection is the ProMPT [Prostate Cancer: Mechanisms of Progression and Treatment] study.
  2. 2. ProMPT is a UK based, multi-centre collaborative. Its remit is to provide infrastructure to take forward translational research in prostate cancer. At its core is a collection of biological specimens [blood, urine and tissue] collected from well characterised patients. The specimens are housed in a licensed bio-repository and linked personal and clinical data is held on a dedicated and secure database. Patients participating in the ProMPT study include men with prostate cancer as well as non-prostate cancer ‘controls’. However, ProMPT is only part of the overall bio-banking ‘picture’ - additional collections from other urological cancers are expected – both utilising study specific consent and also within the framework of the Oxford Radcliffe Bio-bank [ORB]. http://wyvern.ndcls.ox.ac.uk/orb/ Underpinning research within NDS are the key principles of ICHGCP – namely, maintaining the rights/safety of trial participants and the credibility/validity of the research data. An example of current on-going specimen collection for uro-oncology within the context of the ProMPT study can be found at: http://www.promptprostate.com/ The Post Advertised The post holder will report directly to the Head of Department and will assume responsibility and take accountability for the coordination and management of clinical research and bio- banking within NDS uro-oncology. The post-holder should ensure that research activity is carried out according to national and international standards, guidelines and policies and that the opportunity for patients to enter into clinical trials/bio-banking is maximised. This involves the coordination of research activity, including ensuring that the department is ‘audit ready’ in terms of adherence to institutional and regulatory frameworks, guidelines and law. The post-holder is expected to be a source for expert advice and practical assistance to NDS researchers, senior departmental managers, as well as national and international collaborators. The post holder will also be responsible for the direct line management of a research team consisting of nursing and technical/laboratory staff. In addition, the post-holder will instigate and participate in the set up, organisation and delivery of local and national study days and training courses, in partnership with the clinical trials unit in Oxford. The post holder is expected to be actively involved in promoting NDS and the University of Oxford through presentations at meetings and conferences, as well as through media and publication. The post holder will ensure the expansion and development of the uro-oncology research portfolio by organising and chairing regular committee and working group meetings of senior managers and heads of department. The post holder is expected to participate on advisory boards including networking and developing links with other national and international institutions – including seeking research funding. The post- holder is expected to take an active role in the day to day recruitment and follow of patients and be a role model to fellow researchers. The research team are based jointly at the John Radcliffe and Churchill Hospitals, though the majority of recruitment will occur at the Churchill Hospital within the Department of Urology. JOB DESCRIPTION AND SELECTION CRITERIA The main duties of the post will include:
  3. 3. 1. Coordination: • Coordinate, facilitate and lead [with guidance from Prof Hamdy] the development of NDS uro-oncology research – maintaining the University of Oxford’s reputation as an international centre of excellence. • Overseeing the project management of multi-centre studies where Oxford is the coordinating centre. • Participate in and promote a culture of clinical research and bio-banking within the Oxford (Cancer/Urology/Surgical) Community - ensure clear and effective communication is maintained between University/ORHT staff. • Promote awareness of current studies to motivate staff with the recruitment of patients & collection of biological specimens and provide regular feedback on completeness and quality of collections made. • Ensure that research opportunity is maximised and that the uro-oncology research portfolio continues to expand by organising and chairing meetings with senior clinicians, managers and heads of department. • Active promotion of current and future research by active participation and presentations at meetings, conferences and through media and publication • Ensuring that sample collection is maximised in terms of sample ‘type’ and occasion on which it is collected, for example at biopsy, at pre-operative assessment clinic or during a surgical procedure. This involves adapting methods of identifying and tracking patients through the hospital systems – utilising NHS waiting lists and knowledge of inpatient listing procedures and coordinating specimen collection and appropriate processing. • Utilise strategies to recruit patients to studies in order to maximise the opportunity for sample collection, including liaising with staff in other departments to ensure opportunity for recruitment to clinical trials/bio-banking is maximised without compromising patient care. • Coordinate, plan and organise the availability of resources to ensure optimal research participation/bio-banking, including ensuring the involvement of other appropriate health care professionals, in-patient, out-patient and operating theatre resources.. • Plan and organise the workload of the research team in order facilitate and maximise research opportunity. • Plan and organise updates with the Chief Investigator. 2. Management: • Establish, train, supervise and line manage the research team in order to ensure ethical recruitment of patients to clinical trials and/or the donation of biological specimens for research. [the research team consist of senior and junior nurses, and the data management and bio-repository teams] • Management of resources – including adequate stock-keeping [including study medication] and budget management. • Plan the recruitment and follow-up of patients as required by each study protocol, standard operating procedures and work instructions - this includes ensuring that data/samples are collected according to specified study time-frames.
  4. 4. • Self manage flexible working patterns and prioritise workload effectively. Organise and plan time for self-development, study days, etc. • Travel to other study sites as and when required. 3. Administration/Education: • Provide expert advice and practical solutions to researchers and national/international collaborators – including, assistance with protocol, SOP/guideline writing, as well as ethics applications and the organisation and management of the Trial Master File. • Ensure that the rights and safety of patients are upheld – with particular reference to ethically approved studies, informed consent, confidentiality and data protection law in accordance with the NMC code of Professional Practice, Oxford University and Oxford Radcliffe Hospitals Trust policy, and International Conference on Harmonisation, Good Clinical Practice [ICHGCP] • Ensure that the credibility and validity of research data is upheld at all times by the research team – with reference to ICHGCP - accurate and efficient completion the required documentation, including case record forms, consent and medical records. This includes annotation of the samples with clinical and demographic information collected from the medical notes, the trust information systems and directly from the patient using the clinical management database. • Ensure that there are safe, effective and efficient systems to transfer samples from the patient to the bio-repository and the safe collection and handling of human biological samples (adhering to and developing SOPS and guidelines – with particular reference to COSHH) – including tissue collection at biopsy clinics and in the operating theatres • Assisting with the organisation, running and delivery of teaching courses [including distance learning packages] on the practical application of uro-oncology clinical trials and bio-banking. The successful candidate will have or be required to demonstrate: Essential • Qualified Nurse – with evidence of continuous professional and personal development and the delivery of evidence based practice in line with the NMC professional code of conduct • Uro–oncology experience at a senior/expert level • Senior clinical research experience – including commercial/non-commercial trials and preferably including phase I-IV trials • Trial project management experience – preferably including the writing of protocols, SOPS and the management of multi-centre trials • Senior staff management experience with an ability to independently plan ahead, motivate, supervise and manage a research team • An in-depth appreciation and understanding of NHS waiting lists and inpatient listing procedures.
  5. 5. • Knowledge and expertise on National and Regional Ethics and R&D requirements. • Excellent team player with an ability to motivate staff who are both directly and indirectly involved with NDS uro-oncology research projects. • Teaching ability – including evidence of having attended recognised teaching courses – should be skilled and have experience in the delivery of lectures, workshops and presentations. • Expert knowledge of regulatory frameworks – in particular, in relation to Good Clinical Practice as per the Institute of Clinical Research, the NHS Trust and the University. • Excellent communication skills – including multi-disciplinary collaborations, net- working and experience of communicating with senior managers and leaders. • Knowledge of Health and Safety issues (inc. COSHH). • Ability and willingness to travel to other clinical sites and to national/international conferences Desirable • Experience of bio-banking. • Experience in research and bio-banking at ORH • Expert knowledge and experience/application of the Human Tissue Act in respect of collection and storage of research samples. • Current venepuncture certification. GENERAL CONDITIONS OF APPOINTMENTS The appointment to the post of Senior Research Coordinator will be made on grade 09S of the University’s scale for Academic Related staff (salary scale £42,563 – £49,342) The person appointed will progress by annual increments from a start point, to be determined by qualifications and experience, to the maximum of the scale. Salaries are adjusted periodically on the basis of national salary settlements for university staff. The selected candidate will be asked to complete a brief and straightforward medical questionnaire, acceptance of which, by the University Occupational Health Physician, is required prior to appointment. The appointment, commencing as soon as possible, is for a period of 3 years in the first instance, subject to satisfactory completion of a six-month probationary period (or other such period agreed at the time of appointment). A full-time appointment is envisaged. The post is pensionable and the post-holder eligible for membership of the Universities Superannuation Scheme /Oxford Staff Pension Scheme (or, if already a member of, remaining in the NHS Pension Scheme). Subject to the Statement of Pensions Policy which will be issued to the successful candidates, an appointee will be deemed to be in membership of the this pension scheme until such time as he or she gives notice in writing to exercise the right not to be a member of the scheme.
  6. 6. The post holder will be entitled to 30 days annual leave (excluding public holidays) pro rata. The actual distribution of annual holidays is subject to agreement. In the case of fixed-term appointments, holiday entitlement must be taken within the contract period. Information on sick pay, maternity leave, nursery provision, etc., is available on request. Applicants who would need a work visa if appointed to the post are asked to note that under the UK’s new points-based migration system they will need to demonstrate that they have sufficient points, and in particular that: (i) they have sufficient English language skills (evidenced by having passed a test in basic English, or coming from a majority English-speaking country, or having taken a degree taught in English). (ii) that they have sufficient funds to maintain themselves and any dependents until they receive their first salary payment. Further information is available at: http://www.ukba.homeoffice.gov.uk/workingintheuk/tier2/generalarrangements/eligibility/ APPLICATION PROCEDURE Informal enquiries about the post may be made to Professor Freddie Hamdy, Head of the Nuffield Department of Surgical Sciences, Nuffield Department of Surgical Sciences, Level 6, John Radcliffe Hospital, Oxford via Mrs Brenda Carter, Senior PA to Professor Hamdy: brenda.carter@nds.ox.ac.uk To apply for this post, please complete the application form, attaching i) a curriculum vitae and ii) a covering letter which clearly sets out how you meet the selection criteria for the post (as detailed above). Please complete all of the sections on the application form in full, do not cross reference to your curriculum vitae. Applications should reach: The Assistant Administrator, Nuffield Department of Surgical Sciences, Administration Office, Level 6, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, by not later than 5.00 pm on Friday 1st October 2010. Applicants should quote reference NDSA/333/10. The department does not accept applications by email or fax. PLEASE DO NOT STAPLE ANY PARTS OF YOUR APPLICATION, USE PAPER CLIPS IF NECESSARY. ENSURE THAT YOUR NAME IS ON ALL PAGES. You should include the names, addresses and contact details of two referees. Those named as referees should have direct experience of your work, either as a manager or through a sustained period of professional interaction, and ideally at least one should be a formal line manager at the current or most recent employer. If a first job application, a teacher or course tutor would be appropriate. Where an applicant has insufficient work references available, then a reference from a person of good standing in the community, or who has a reasonable period of knowledge and professional interaction with the applicant, may be acceptable in some circumstances. Your application should indicate the capacity in which the referees have gained knowledge of your
  7. 7. work. We will assume that we are free to approach referees at any stage unless the application stipulates otherwise. Candidates who wish a referee or referees to be approached only with their specific permission and/or if they are being called for interview on the final short list or are in receipt of a conditional offer are asked to state such requirements explicitly alongside the details of the relevant referee(s). If at all possible, please avoid nominating referees who cannot be approached. Prior to an offer of employment being made in the case of candidates internal to the University of Oxford, a reference will be sought from the Head of Department or Administrator of the previous employing department, even where the head or administrator has not been cited as a referee. POLICY STATEMENTS The policy and practice of the University of Oxford require that entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria, which are related to the duties of each particular post and the relevant salary structure. Subject to statutory provisions, no applicant or member of staff will be treated less favourably than another because of his or her sex, marital status, racial group or disability. In all cases, ability to perform the job will be the primary consideration. All data supplied by applicants will be used only for the purposes of determining their suitability for the post and will be held in accordance with the principles of the Data Protection Act 1998 and the University's Data Protection Policy.

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