NUFFIELD DEPARTMENT OF SURGICAL SCIENCES
UNIVERSITY OF OXFORD
ROOM 6607, LEVEL 6
JOHN RADCLIFFE HOSPITAL
HEADINGTON, OXFORD, OX3 9DU
Further particulars for the post of Senior Research Coordinator (NDSA/333/10)
The Nuffield Department of Surgical Sciences is one of the few remaining academic surgical
departments in the UK. Established in 1937, the Department was headed consecutively by four
Nuffield Professors of Surgery with a variety of interests, who contributed academically and
clinically to surgery at Oxford. The most prominent of these was Sir Peter Morris, who
developed an internationally acclaimed unit around transplantation and vascular surgical sciences
over a period of 25 years. With the recent appointment of its new head, Professor FC Hamdy, a
urological oncologist, the Department is taking a new exciting direction to strengthen academic
surgical oncology, as a key component of the proposed CRUK cancer centre together with
Medical and Clinical Oncology, and the new Cancer Centre structure of the Oxford Radcliffe
Hospitals Trust. The Department currently hosts 26 academics from every surgical discipline,
including urology, ENT, colorectal surgery, transplantation, paediatrics, neurosurgery,
cardiothoracic and vascular surgery, who undertake both basic and translational research projects
in the department’s facilities, and employs a total of approximately 100 staff.
The Department has been restructured recently with 5 committees overseeing the various
activities, and an executive which meets monthly. The overarching aim is to respond to the
continuing changes and demands for clinical academics in the UK, and to drive surgical sciences
at Oxford to a modern internationally competitive platform of basic, translational and clinical
research excellence, to ‘close the loop’, from bench to the bedside. Three basic/translational
research platforms are being developed and will be embedded in high quality research
environments within the best institutes at Oxford, with imminent and key joint-faculty non-
clinical appointments with the Gray Institute of Radiobiology and Oncology, the Botnar Institute
for Musculoskeletal Research, and the Department of Medical Oncology. Other collaborative
platforms include the Ludwig Institute and the Department of Physiology and Anatomy at South
Parks, as well as the strong existing Transplant Immunology Research Group.
NDS is at the forefront of uro-oncology pre-clinical, phase I and Phase II research. It is currently
maximising its research potential with an emphasis on increasing recruitment of patients to
clinical trials and biological specimen donation [bio-banking]. An example of specimen
collection is the ProMPT [Prostate Cancer: Mechanisms of Progression and Treatment] study.
ProMPT is a UK based, multi-centre collaborative. Its remit is to provide infrastructure to take
forward translational research in prostate cancer. At its core is a collection of biological
specimens [blood, urine and tissue] collected from well characterised patients. The specimens
are housed in a licensed bio-repository and linked personal and clinical data is held on a
dedicated and secure database. Patients participating in the ProMPT study include men with
prostate cancer as well as non-prostate cancer ‘controls’. However, ProMPT is only part of the
overall bio-banking ‘picture’ - additional collections from other urological cancers are expected
– both utilising study specific consent and also within the framework of the Oxford Radcliffe
Bio-bank [ORB]. http://wyvern.ndcls.ox.ac.uk/orb/
Underpinning research within NDS are the key principles of ICHGCP – namely, maintaining the
rights/safety of trial participants and the credibility/validity of the research data.
An example of current on-going specimen collection for uro-oncology within the context of the
ProMPT study can be found at: http://www.promptprostate.com/
The Post Advertised
The post holder will report directly to the Head of Department and will assume responsibility
and take accountability for the coordination and management of clinical research and bio-
banking within NDS uro-oncology. The post-holder should ensure that research activity is
carried out according to national and international standards, guidelines and policies and that the
opportunity for patients to enter into clinical trials/bio-banking is maximised. This involves the
coordination of research activity, including ensuring that the department is ‘audit ready’ in terms
of adherence to institutional and regulatory frameworks, guidelines and law. The post-holder is
expected to be a source for expert advice and practical assistance to NDS researchers, senior
departmental managers, as well as national and international collaborators. The post holder will
also be responsible for the direct line management of a research team consisting of nursing and
technical/laboratory staff. In addition, the post-holder will instigate and participate in the set up,
organisation and delivery of local and national study days and training courses, in partnership
with the clinical trials unit in Oxford. The post holder is expected to be actively involved in
promoting NDS and the University of Oxford through presentations at meetings and conferences,
as well as through media and publication. The post holder will ensure the expansion and
development of the uro-oncology research portfolio by organising and chairing regular
committee and working group meetings of senior managers and heads of department. The post
holder is expected to participate on advisory boards including networking and developing links
with other national and international institutions – including seeking research funding. The post-
holder is expected to take an active role in the day to day recruitment and follow of patients and
be a role model to fellow researchers.
The research team are based jointly at the John Radcliffe and Churchill Hospitals, though the
majority of recruitment will occur at the Churchill Hospital within the Department of Urology.
JOB DESCRIPTION AND SELECTION CRITERIA
The main duties of the post will include:
• Coordinate, facilitate and lead [with guidance from Prof Hamdy] the development of
NDS uro-oncology research – maintaining the University of Oxford’s reputation as an
international centre of excellence.
• Overseeing the project management of multi-centre studies where Oxford is the
• Participate in and promote a culture of clinical research and bio-banking within the
Oxford (Cancer/Urology/Surgical) Community - ensure clear and effective
communication is maintained between University/ORHT staff.
• Promote awareness of current studies to motivate staff with the recruitment of patients &
collection of biological specimens and provide regular feedback on completeness and
quality of collections made.
• Ensure that research opportunity is maximised and that the uro-oncology research
portfolio continues to expand by organising and chairing meetings with senior clinicians,
managers and heads of department.
• Active promotion of current and future research by active participation and presentations
at meetings, conferences and through media and publication
• Ensuring that sample collection is maximised in terms of sample ‘type’ and occasion on
which it is collected, for example at biopsy, at pre-operative assessment clinic or during a
surgical procedure. This involves adapting methods of identifying and tracking patients
through the hospital systems – utilising NHS waiting lists and knowledge of inpatient
listing procedures and coordinating specimen collection and appropriate processing.
• Utilise strategies to recruit patients to studies in order to maximise the opportunity for
sample collection, including liaising with staff in other departments to ensure opportunity
for recruitment to clinical trials/bio-banking is maximised without compromising patient
• Coordinate, plan and organise the availability of resources to ensure optimal research
participation/bio-banking, including ensuring the involvement of other appropriate health
care professionals, in-patient, out-patient and operating theatre resources..
• Plan and organise the workload of the research team in order facilitate and maximise
• Plan and organise updates with the Chief Investigator.
• Establish, train, supervise and line manage the research team in order to ensure ethical
recruitment of patients to clinical trials and/or the donation of biological specimens for
research. [the research team consist of senior and junior nurses, and the data
management and bio-repository teams]
• Management of resources – including adequate stock-keeping [including study
medication] and budget management.
• Plan the recruitment and follow-up of patients as required by each study protocol,
standard operating procedures and work instructions - this includes ensuring that
data/samples are collected according to specified study time-frames.
• Self manage flexible working patterns and prioritise workload effectively. Organise and
plan time for self-development, study days, etc.
• Travel to other study sites as and when required.
• Provide expert advice and practical solutions to researchers and national/international
collaborators – including, assistance with protocol, SOP/guideline writing, as well as
ethics applications and the organisation and management of the Trial Master File.
• Ensure that the rights and safety of patients are upheld – with particular reference to
ethically approved studies, informed consent, confidentiality and data protection law in
accordance with the NMC code of Professional Practice, Oxford University and Oxford
Radcliffe Hospitals Trust policy, and International Conference on Harmonisation, Good
Clinical Practice [ICHGCP]
• Ensure that the credibility and validity of research data is upheld at all times by the
research team – with reference to ICHGCP - accurate and efficient completion the
required documentation, including case record forms, consent and medical records. This
includes annotation of the samples with clinical and demographic information collected
from the medical notes, the trust information systems and directly from the patient using
the clinical management database.
• Ensure that there are safe, effective and efficient systems to transfer samples from the
patient to the bio-repository and the safe collection and handling of human biological
samples (adhering to and developing SOPS and guidelines – with particular reference to
COSHH) – including tissue collection at biopsy clinics and in the operating theatres
• Assisting with the organisation, running and delivery of teaching courses [including
distance learning packages] on the practical application of uro-oncology clinical trials
The successful candidate will have or be required to demonstrate:
• Qualified Nurse – with evidence of continuous professional and personal development
and the delivery of evidence based practice in line with the NMC professional code of
• Uro–oncology experience at a senior/expert level
• Senior clinical research experience – including commercial/non-commercial trials and
preferably including phase I-IV trials
• Trial project management experience – preferably including the writing of protocols,
SOPS and the management of multi-centre trials
• Senior staff management experience with an ability to independently plan ahead,
motivate, supervise and manage a research team
• An in-depth appreciation and understanding of NHS waiting lists and inpatient listing
• Knowledge and expertise on National and Regional Ethics and R&D requirements.
• Excellent team player with an ability to motivate staff who are both directly and
indirectly involved with NDS uro-oncology research projects.
• Teaching ability – including evidence of having attended recognised teaching courses –
should be skilled and have experience in the delivery of lectures, workshops and
• Expert knowledge of regulatory frameworks – in particular, in relation to Good Clinical
Practice as per the Institute of Clinical Research, the NHS Trust and the University.
• Excellent communication skills – including multi-disciplinary collaborations, net-
working and experience of communicating with senior managers and leaders.
• Knowledge of Health and Safety issues (inc. COSHH).
• Ability and willingness to travel to other clinical sites and to national/international
• Experience of bio-banking.
• Experience in research and bio-banking at ORH
• Expert knowledge and experience/application of the Human Tissue Act in respect of
collection and storage of research samples.
• Current venepuncture certification.
GENERAL CONDITIONS OF APPOINTMENTS
The appointment to the post of Senior Research Coordinator will be made on grade 09S of the
University’s scale for Academic Related staff (salary scale £42,563 – £49,342) The person
appointed will progress by annual increments from a start point, to be determined by
qualifications and experience, to the maximum of the scale. Salaries are adjusted periodically on
the basis of national salary settlements for university staff.
The selected candidate will be asked to complete a brief and straightforward medical
questionnaire, acceptance of which, by the University Occupational Health Physician, is required
prior to appointment.
The appointment, commencing as soon as possible, is for a period of 3 years in the first instance,
subject to satisfactory completion of a six-month probationary period (or other such period
agreed at the time of appointment). A full-time appointment is envisaged.
The post is pensionable and the post-holder eligible for membership of the Universities
Superannuation Scheme /Oxford Staff Pension Scheme (or, if already a member of, remaining in
the NHS Pension Scheme). Subject to the Statement of Pensions Policy which will be issued to
the successful candidates, an appointee will be deemed to be in membership of the this pension
scheme until such time as he or she gives notice in writing to exercise the right not to be a
member of the scheme.
The post holder will be entitled to 30 days annual leave (excluding public holidays) pro rata. The
actual distribution of annual holidays is subject to agreement. In the case of fixed-term
appointments, holiday entitlement must be taken within the contract period. Information on sick
pay, maternity leave, nursery provision, etc., is available on request.
Applicants who would need a work visa if appointed to the post are asked to note that under the
UK’s new points-based migration system they will need to demonstrate that they have sufficient
points, and in particular that:
(i) they have sufficient English language skills (evidenced by having passed a test in basic
English, or coming from a majority English-speaking country, or having taken a degree taught in
(ii) that they have sufficient funds to maintain themselves and any dependents until they receive
their first salary payment.
Further information is available at:
Informal enquiries about the post may be made to Professor Freddie Hamdy, Head of the
Nuffield Department of Surgical Sciences, Nuffield Department of Surgical Sciences, Level 6,
John Radcliffe Hospital, Oxford via Mrs Brenda Carter, Senior PA to Professor Hamdy:
To apply for this post, please complete the application form, attaching i) a curriculum vitae
and ii) a covering letter which clearly sets out how you meet the selection criteria for the
post (as detailed above). Please complete all of the sections on the application form in full, do
not cross reference to your curriculum vitae.
Applications should reach: The Assistant Administrator, Nuffield Department of Surgical
Sciences, Administration Office, Level 6, John Radcliffe Hospital, Headington, Oxford, OX3
9DU, by not later than 5.00 pm on Friday 1st
October 2010. Applicants should quote reference
The department does not accept applications by email or fax.
PLEASE DO NOT STAPLE ANY PARTS OF YOUR APPLICATION, USE PAPER CLIPS
IF NECESSARY. ENSURE THAT YOUR NAME IS ON ALL PAGES.
You should include the names, addresses and contact details of two referees. Those named as
referees should have direct experience of your work, either as a manager or through a sustained
period of professional interaction, and ideally at least one should be a formal line manager at the
current or most recent employer. If a first job application, a teacher or course tutor would be
appropriate. Where an applicant has insufficient work references available, then a reference from
a person of good standing in the community, or who has a reasonable period of knowledge and
professional interaction with the applicant, may be acceptable in some circumstances. Your
application should indicate the capacity in which the referees have gained knowledge of your
work. We will assume that we are free to approach referees at any stage unless the application
stipulates otherwise. Candidates who wish a referee or referees to be approached only with their
specific permission and/or if they are being called for interview on the final short list or are in
receipt of a conditional offer are asked to state such requirements explicitly alongside the details
of the relevant referee(s). If at all possible, please avoid nominating referees who cannot be
approached. Prior to an offer of employment being made in the case of candidates internal to the
University of Oxford, a reference will be sought from the Head of Department or Administrator
of the previous employing department, even where the head or administrator has not been cited
as a referee.
The policy and practice of the University of Oxford require that entry into employment with the
University and progression within employment will be determined only by personal merit and
the application of criteria, which are related to the duties of each particular post and the relevant
salary structure. Subject to statutory provisions, no applicant or member of staff will be treated
less favourably than another because of his or her sex, marital status, racial group or disability. In
all cases, ability to perform the job will be the primary consideration.
All data supplied by applicants will be used only for the purposes of determining their suitability
for the post and will be held in accordance with the principles of the Data Protection Act 1998
and the University's Data Protection Policy.