Successfully reported this slideshow.
We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. You can change your ad preferences anytime.



Published on

  • Be the first to comment

  • Be the first to like this


  1. 1. 101 INVITED SEMINARS AND MEETINGS Dr. David J. Brenner Invited Speaker, International Conference on the F ratio as a Cytogenetic Marker, Hiroshima, February Invited speaker, American Statistical Society Bi-annual Conference on Radiation & Health, San Diego, June Invited Speaker, RSNA Annual Meeting, Chicago, December Invited Speaker, ASTRO Annual Meeting, Orlando, October Invited Speaker, “Transcatheter Cardiovacular Therapeutics” Washington, DC, October Dr. Gloria Calaf Invited speaker at Symposium of Physiology Research Society of Chile, Linares, Chile, April 5th, 1998 1998 Annual meeting of Radiation Research Society at Louisville, Kentucky, April. Dr. Charles Geard Microscopy and Microanalysis, Cleveland OH., August 10-14 Chemical Pathology Study Section, Chevy Chase MD, October 15-17 Maxwell Abramson Basic Science Course in Otolaryngology New York Academy of Medicine, NY, October 21 29th Annual Meeting of the Environmental Mutagen Society, Anaheim, CA, March 21- 26 National Cancer Institute Contractors Meeting Chernobyl Leukemia Study, Kiev, Ukraine, February 7-13 89th Annual Meeting of the American Association for Cancer Research, New Orleans, LA, March 28-April 1 46th Annual Meeting of the Radiation Research Society, Louisville, KY, April 25-29 NASA Johnston Space Center Facilities Review, Houston, TX, February 26-28 34th Annual Meeting of the National Council on Radiological Protection, Arlington, VA, April 1-2 NASA Space Radiation Research Workshop, Loma Linda, CA, June 14-17 Dr. Eric J. Hall Review Course, University of Tennessee at Memphis, TN July 1997 NCRP Board of Directors, Bethesda, MD, July 1997 International Microdosimetry Meeting, Oxford, UK, September 1997 Invited Seminar, Duke University, Durham, North Carolina, October 1997
  2. 2. 102 ASTRO Annual Meeting , Orlando, FL, October 1997 1997 Yuhas Lecturer, University of Pennsylvania, PA, October 1997 NCRP SC1-6 Committee Meeting, Bethesda, MD, October 1997 National Academy of Sciences, BEIR IV Meeting, November 1997 Invited Seminar, International Conference on Low Doses of Ionizing Radiation – Biological Effects of Regulatory Control, IAEA, WHO and UNSCEAR, Seville,Spain, November 1997 RSNA Annual Meeting, Chicago, IL, December 1997 NCRP Committee SC-1, San Francisco, CA, December 1997 NCRP Board of Directors, San Francisco, CA, December 1997 Tenth International Conference on Chemical Modifiers of Cancer Treatment, Clearwater, Fl, January 1998 American Board of Radiology Test Writing Committee, San Antonio, TX, February 1998 BEIR VI Committee, National Academy of Sciences, Washington, DC, January 1997 University of Florida Research Seminar Series, Gainesville & Orlando, FL, February 1997 Advances in Cardiovascular Radiation Therapy II Symposium, Washington, D.C., March 1998 1998 Lauriston S. Taylor Lecturer, Arlington, VA, April 1998 Radiation Research Society Annual Meeting, Louisville, KY, April 1998 American Radium Society Annual Meeting, Monte Carlo, France, May 1998 Invited Lecturer, Umeå University, Sweden, May 1998 Dr. Haiying Hang 46th Annual Meeting of the Radiation Research Society, Louisville, KY, April 1988 Dr. Tom K. Hei Annual meeting of the American Association for Cancer Research, New Orleans, LA., March, 1998 Annual meeting of the Radiation Research Society, Louisville, Ky., April, 1998 Invited seminar- Department of Medicine, University of Louisville, Ky., April, 1998 Invited meeting- International Workshop on Responses to Heavy Particles Irradiation. Chiba, Japan, July, 1998 Invited meeting- International Congress of the Committee on Space Research, Nagoya, Japan, July, 1998. Invited seminar- Division of Radiation Biology, Faculty of Pharmaceutical Sciences,
  3. 3. 103 Nagasaki University, Japan, July, 1998. Invited seminar-Departrnent of cell Biology, Okayama University Medical School, Okayama, Japan, July, 1998. Invited seminar- Research Institute for Radiation Biology & Medicine, Hiroshima University, Japan, July, 1998. Invited seminar- Department of Biochemistry, Chinese University of Hong Kong, August, 1998. Invited seminar- Institute of Radiation Medicine, Chinese Academy of Sciences, Beijing, China, August, 1998. Invited seminar- Laboratory of Industrial Hygiene, Beijing, China, August, 1998. Invited seminar- Laboratory of Rice Genetics, Anhui Agricultural University, Anhiu, China, August, 1998 Invited seminar- Department of Ion Beain Bioengineering, Chinese Academy of Sciences, Hefei, China, August, 1998. Dr. Howard B. Lieberman Radiation Research Society Annual Meeting Department of Energy, Environmental Management Science Program Workshop Mr. Steve Marino 46th Annual Meeting of the Radiation Research Society, Louisville, Kentucky, May 1998 Dr. Richard C. Miller Invited speaker, Dept. of Radiation Oncology, Cleveland Clinic, Cleveland, OH, 1997 Invited speaker, Dept. of Radiation Oncology, St. Barnabas Medical Center, NJ, Sept., Oct and Nov, 1997 Invited speaker, Dept. of Radiation Oncology, Univ. of Alabama, Birmingham, AL, 1998 The International Bioelectromagnetics Conference in Bologna, Italy, 1997 Annual Bioelectromagnetics Society meeting, Tampa, Florida, 1998 Radiation Research Society, Louisville, Ky, 1998 COSPAR 98, Nagoya, Japan, July, 1998 Satellite Meeting to COSPAR, Chiba, Japan, July 1998 Dr. Tej K. Pandita Invited speaker at International Symposium on Ataxia-telangiectasia and ATM: Functional, Genetic and Clinical Ramifications. Baltimore, Maryland, USA August 8-10, 1997. Invited speaker at Affymetrix, San Francisco, CA, Feb 1997
  4. 4. 104 Invited speaker at International Center for Genetic Engineering and Biotechnology, New Delhi, Delhi, 1997. Invited speaker at Regional Research Laboratory, Jammu, India, 1997. Invited speaker at The Third Meeting of the New York Human Genetics Club, New York, 1997. 1998 Annual meeting of AACR at San Diego, CA Dr. Gerhard Randers-Pehrson 46th Annual Meeting of the Radiation Research Society, Louisville, KY, April 1998 Dr. Lubomir Smilenov Annual meeting of the American Association for Cancer Research, New Orleans, LA, March 1998
  5. 5. 105 PROFESSIONAL ACTIVITIES Dr. David J. Brenner Member: Joint Taskforce on Vascular Radiation Therapy NCRP NAS BEIR VI Committee on radon risks NCRP Committee 1-6 on Risk Linearity Radiation Research Society Program Committee American Statistical Association Program Committee. Chairperson, Columbia University Radiation Safety Committee Dr. Gloria Calaf Member: The New York Academy of Sciences International Association for Breast Cancer Research American Association for Cancer Research, USA Tissue Culture Association, USA Cancer Research Society, Chile Cytology Society, Chile Experimental Biology and Medicine Society, Chile Society of Mastology of Chile Society of Biology of Chile Radiation Research Society, USA Dr. Charles Geard Member: American Society of Therapeutic Radiology and Oncology (ASTRO) Environmental Mutagen Society Radiation Research Society Advisory Committee on Radiobiology of the Brookhaven National Laboratory Associate Member of the Radiobiology Advisory Team (AMRAT) of the Armed Forces Radiobiology Research Institute (AFRRI) Columbia University, Faculty Council (Voting Member)
  6. 6. 106 Editorial Work: Editorial Board of the International Journal of Radiation Biology. Reviewer: International Journal of Radiation Oncology, Biology and Physics Radiotherapy and Oncology British Journal of Cancer Clinical Cancer Research, Mutagenesis Mutation Research Radiation Research Ad Hoc Reviewer of Grant Proposals for the American Cancer Society and the National Institutes of Health Dr. Haiying Hang Member: Radiation Research Society Dr. Eric Hall Member: American Board of Radiology Radiotherapeutic Written-Test Committee National Academy of Science: Member of BEIR VI American Society of Therapeutic Radiology and Oncology (ASTRO) Radiation Research Society International Stereotactic Radiosurgery Society: Member of the Board American Radium Society: Secretary Program Committee Chairman International Association of Radiation Research President elect Columbia University, College of Physicians & Surgeons: Cancer Center, Internal Advisory Committee/Executive Committee Columbia-Presbyterian Medical Center: Chairman, Joint Radiation Safety Committee Chairman, Radioactive Drug Research Committee
  7. 7. 107 National Council on Radiation Protection and Measurements: Member of the Board Member of Council Member, Committee 1 Member, Committee 1-6 Editorial Work: International Journal of Radiation Oncology Biology Physics International Journal of Brachytherapy Dr. Tom K. Hei Adjunct Faculty: Adjunct Faculty, Departmental of Radiological Health Sciences, Colorado State University, Fort Collins, Colorado Adjunct Professor, Department of Ion Beam Bioengineering, Chinese Academy of Sciences, Hefei, China. Member: Permanent Member, Chemical Pathology Study Section, 1998- present Chairman, Ad hoc review panel, Chemical Pathology Study Section, 1998 Radiation Research Society American Association for Cancer Research Environmental Mutagen Society Mentor: Ph.D. degree student of the Department of Ion Beam Bioengineering, Chinese Academy of Sciences, China. Master degree student of Environmental Heath Sciences, Columbia University School of Public Health. Undergraduate Internship students from Marymount College, New York. Reviewer: British Journal of Cancer Cancer Research Carcinogenesis Cancer Letters Occupational and Environmental Medicine ICRERTT Fellowship- International Union Agai st Cancer Research Grant Council- Government of Hong Kong
  8. 8. 108 NIH Molecular Biology Special Review Panel on Small Business Innovative Grants Dr. Howard B. Lieberman Chairman, NIH Radiation Study Section Reviewer: Fonds zur F”rderung der wissenschaftlichen Forschung, Vienna Biotechniques Radiation Research Member: Advisory Board, Summer Research Program for NYC Secondary School Science Teachers, Columbia University American Association for the Advancement of Science American Society for Microbiology Environmental Mutagen Society Genetics Society of America Radiation Research Society Elected Biology Councilor Sigma Xi Theobald Smith Society Dr. Richard C. Miller Member: Radiation Research Society Associate Member, American Society of Therapeutic Radiology and Oncology (ASTRO) Reviewer: Radiation Research International Journal of Radiation Biology Mutation Research Guest Scientist: Brookhaven National Laboratories (BNL), Upton, NY St. Barnabas Medical Center, Dept. of Radiation Oncology, Livingston, NJ Mr. Steve Marino Member: Columbia University Radiation Safety Committee Radiation Research Society
  9. 9. 109 Sigma Xi Guest Scientist: Brookhaven National Laboratories, Upton, NY Dr. Tej K. Pandita Member: NIH Study section American Association for the Advancement of Science. American Association of Cancer Research. Radiation Research Society The American Society for Cell Biology Reviewer: Proceedings of National Academy of Science, USA. Radiation Research Mutation Research Oncogene Clinical Cancer Research Cytogenetics and Cell Genetics Cancer Research Oncology Reports FASEB Journal
  10. 10. 110 THE COLUMBIA COLLOQUIUM AND LABORATORY SEMINARS At intervals of approximately one month during the academic year, a regular colloquium has been held to discuss ongoing research. Dr. Tej Pandita organized them and scheduled the speakers. These have been attended by the professional staff, graduate students, and senior technical staff of this Laboratory and RARAF, as well as scientists from other departments of the College of Physicians & Surgeons interested in collaborative research. Attention has focused on recent findings and future plans, with special emphasis on the inter-disciplinary nature of our research effort. During the year, we have been pleased to welcome a number of visitors who have presented formal seminars and/or spent time discussing ongoing research with various members of the Laboratory. These have included Drs. Masao S. Sasaki, Kyoto University, Kyoto, Japan, William Morgan, University of California, SF, CA, Robert Ullrich, University of Texas at Galveston, Texas, Don Chapman, Fox Chase Cancer Center, PA, Gayle Woloschak, Argonne National Laboratory, Argonne, IL, Vilhelm A. Bohr, National Institute of Health, MD, Suraj Bhat, UCLA School of Medicine, Los Angeles, CA, Andrew J. Grosovsky, University of California, (Riverside), Freddy Joel Hendler, University of Louisville, Juliana Denekamp, Umeå University, Sweden, Martin Jonas, Cambridge, University, U.K., Jai Parkash, Haverford College, Haverford, PA, Simon J. Hall, Institute of Gene Therapy and Molecular Medicine, The Mount Sinai Medical Center, NY, Harry Scherthan, University of Kaiserlautern, Germany.
  11. 11. 111 PUBLICATIONS Azziz, N., Ranogajec-Komor, M., Marino, S.A., Klemic, G.A. and Osvay, M. Fast neutron detection using aluminum oxide TLDs. In Proc. of the IRPA Regional Symposium on Radiation Protection in Neighboring Countries of Central Europe (J. Sabol, Ed.) pp. 495-497, Prague, Czech Republic (1997). Brenner D.J., Sachs RK, The mechanistic basis of the linear-quadratic formalism. Med. Phys. 25:2071-3 (1998). Brenner D.J., Zaider M, Estimating RBEs at clinical doses from microdosimetric spectra. Med. Phys.25:1055-7 (1998). Brenner, D.J., and Herbert, D. E. The use of the linear-quadratic model in clinical radiation oncology can be defended on the basis of empirical evidence and theoretical argument. Med. Phys. 24, 1245-1248 (1997) Brenner, D.J., Radiation biology in brachytherapy. J. Surg. Oncol. 65, 66-70 (1997). Brenner, D.J., Armour, E., Corry, P. and Hall, E.J., Sublethal damage repair times for a late- responding tissue relevant to brachytherapy (and external beam radiotherapy): implications for new brachytherapy protocols. Int. J. Radiat. Oncol. Biol. Phys. 41, 135-138 (1998). Brenner, D.J., Hlatky, L.R., Hahnfeldt, P.J. Huang, Y., and Sachs, R.K., The linear-quadratic and other common radiobiological models all predict similar time-dose relationships. Radiat. Res. 150, 83-91 (1998) Brenner, D.J., Lubin, J.H., and Ron, E. Moving from under the lamppost: Can epidemiologists and radiobiologists work together? Nucl. Energ. 36, 1-7 (1997) Brenner, D.J., Schiff, P.B., Huang, Y. and Hall, E.J. Pulsed dose-rate (PDR) brachytherapy: Design of convenient (daytime only) schedules. Int. J. Radiat. Oncol. Biol. Phys. 39, 809-815 (1997) Chen, C.-Z., Huang, Y., Hall, E.J., and Brenner, D.J. Pulsed brachytherapy as a substitute for continuous low dose-rate: an in vitro study with human carcinoma cells. Int. J. Radiat. Oncol. Biol. Phys. 37, 137-43 (1997). Davey, S., C.S. Han, S.A. Ramer, J.C. Klassen, A. Jacobson, A. Eisenberger, K.M. Hopkins, H.B. Lieberman, and G.A. Freyer. Fission yeast rad12+ gene regulates cell cycle checkpoint control and is homologous to the Bloom's syndrome disease gene. Mol. Cell. Biol. 18:2721-2728 (1998). Geard, C. R., Randers Pehrson, G., Hei, T. K., Jenkins, G. J., Miller, R. C., Wu, L. J., Brenner, D. J. and Hall, E. J. Microbeam mediated cellular effects: Single alpha particle induced chromosomal damage, cell cycle delay, mutation and oncogenic transformation. In: Microdosimetry, An interdisciplinary approach, Eds. Goodhead,D. T., O’Neill, P. and Menzel, H. G., pp327-330 (1997). Hall EJ, Schiff PB, Hanks GE, Brenner DJ, Russo J, Chen J, Sawant SG, Pandita TK, A preliminary report: frequency of A-T heterozygotes among prostate cancer patients with severe late responses to radiation therapy. Cancer J. Sci. Am.4:385-9 (1998).
  12. 12. 112 Hall, E. J., From chimney sweeps to astronauts: cancer risks in the work place: The 1998 Lauriston Taylor Lecture. Health Physics 75:357-366 (1998). Hall, E.J. and Brenner, D.J. Pulsed dose-rate brachytherapy (editorial). Radiotherapy & Oncology 45:1-2, 1997.Hall, E. J., Molecular mechanisms of radiation effects:Point and clastogenic mutations. Low doses of ionizing Radiation; biological and regulatory control. Proceedings of an International Conference on low doses of ionizing radiation. Internation Atomic Energy Agency, Vienna (1998). Hall, E.J. and Brenner, D.J., Pulsed dose-rate brachytherapy. Radiother. Oncol. 45, 1-2 (1997). Hall, E.J. What will molecular biology contribute to our understanding of radiation-induced cell killing and carcinogenesis? Int. J. Radiat. Biol. 71, No. 6, 667-674 (1997). Hall, E.J., In Memoriam, Gerald E. Adams (1930-1998). Radiat. Res. 150:706-707 (1998). Hang, H., S. J. Rauth, K.M. Hopkins, S.K. Davey, and H.B. Lieberman. Molecular cloning and tissue-specific expression of Mrad9, a murine orthologue of the Schizosaccharomyces pombe rad9+ checkpoint control gene. J. Cell. Physiol. 177:232-240 (1998). Hei, T.K., Liu, S.X., and Waldren, C.A., Mutagenicity of arsenic in mammalian cells: Role of reactive oxygen species. Proc. Natl. Acad Sci., 95: 8103-8107 (1998). Hei, T.K., Piao, C.Q., Wu, L.X., Willey, J.C., and Hall, E.J., Genomic instability and tumorigenic induction in immortalized human bronchial epithelial cells by heavy ions. Advances in Space Research (in press) Hei, T.K., Wu, L.J., and Piao, C.Q. Malignant transformation of immortalized human bronchial epithelial cells by asbestos fibers. Environmental Health Perspective, 105: 1085-1089 (1997). Johnson, K.L., Brenner, D.J., Nath, J., Tucker, J.D. and Geard, C.R., Radiation-induced breakpoint misrejoining in human chromosomes: random or non-random?. Int. J. Radiat. Biol. , in press Kharbanda S., Pandey P., Morris P.L., Whang Y., Xu Y., Sawant S., Zhu L., Kumar N., Yuan Z, Weichselbaum R., Sawyers C.L., Pandita T.K. and Kufe D. Functional role for the c-Abl tyrosine kinase meiosis. Oncogene 16: 1773-1777 (1998). Lindgren, A. L., Riley, E. F., Miller, R. C. and Ainsworth, J. Comparison of recovery from Go/G1 arrest in lens epithelial cells after X, neutron, and 56Fe irradiations. Submitted for publication (1997). Miller, R. C. LaNasa, P. and Hanson, W. R. Misoprostol: a potent cytotoxic and oncogenic radioprotector. Adv. Exp. Med. Biol. 400B, 861-864 (1997). Miller, R. C., Marino, S. A., Brenner, D. J., Napoli, J., Shah, H., Hall, E. J. and Geard C. R. Oncogenic transformation by low-energy neutrons. (In Press 1998). Morgan S.E., Lovly C., Pandita T.K., Shiloh Y., and Kastan M.BFragments of ATM which have dominant-negative or complementing activity. Molecular Cell Biology 17: 2020- 2029 (1997).
  13. 13. 113 Obelic, B., Srdoc, D., Djuric, P. M. and Marino, S. A. The frequency distribution of the number of ion pairs in irradiated tissue. Radiat. Res. 149, 411-415 (1998). Okayasu, R., Wu, L.J., and Hei, T.K., Biological effects of naturally occurring and manmade fibers: in vitro cytotoxicity and mutagenesis in mammalian cells. British J Cancer (in press) Pandita T.K., Benvenuto J.A., Pandita R.K., Rakovitch E., Geard C.R., Antman K.H. and Newman R.A. Effect of penclomedine (NSC-338720) on telomere fusions, chromatin blebbing, and cell viability with and without telomerase activity and abrogated p53 function. Biochem. Pharm. 53: 409-415 (1997). Rakovitch E., Mellado W., Hall E.J., Sawant S.G., Geard C.G., Newman R.N.,and Pandita T.K. Penclomedine-induced DNA fragmentation and p53 accumulation correlates with reproductive cell death in colorectal carcinoma cells with different status of p53. Oncology Reports (in press 1998). Randers-Pehrson, G. and Brenner, D.J., A practical target system for accelerator-based BNCT which may effectively double the dose rate. Med Phys. 25, 894-6. (1998). Sachs RK, Brenner D.J., Hahnfeldt PJ, Hlatky LR, A formalism for analysing large-scale clustering of radiation-induced breaks along chromosomes. Int. J. Radiat. Biol. 74:185-206 (1998). Sachs, R. K., Brenner, D. J., Chen, A. M., Hahnfeldt, P. and Hlatky, L.R. Intra-arm and interarm chromosome interchanges: tools for probing the geometry and dynamics of chromatin. Radiat. Res. 148, 330-340 (1997). Sachs, R.K., Chen, A.M., and Brenner, D.J. Review: Proximity effects in the production of chromosome aberrations by ionizing radiation. Int. J. Radiat. Biol. 71, 1-19 (1997). Sachs, R.K., Hahnfeld, P, and Brenner, D.J., The link between low-LET dose-response relations and the underlying kinetics of damage production/repair/misrepair. Int. J. Radiat. Biol. 72, 351-374 (1997) Sawant S., Antonacci R. and Pandita T.K. Determination of telomerase activity in HeLa cells after treatment with ionizing radiation by Telomerase PCR ELISA. Biochemica 4: 22- 24 (1997). Smilenov L.B., Mellado W., Roa P.H., Umbricht C.B., Sukumar S., and Pandita T.K. Cloning and chromosomal localization of Chinese hamster telomeric protein cTRF1. A potential role in chromosomal instability. Oncogene. 17 : 2137-2142 (1998). Smilenov L.B., Morgan S.E., Mellado W., Sawant S.G., Kastan M.B. and Pandita T.K., Influence of ATM function on telomere metabolism. Oncogene 15: 2659-2666 (1997). Tsui L.V., Ramagli L.S., Gao C., Pham C.D., Pandita T.K., Arlinghaus R.B. and Singh B. The biological effects of antisense mos expression in fibroblasts. International Journal Of Oncology 11:1171-1178 (1997). Waldren, C., Vannais, D., Drabek, R., Gustafson, D., Kraemer, S., Lenarczek, M., Kronenberg, A., Hei, T.K., and Ueno, A., Analysis of mutant quantity and quality in
  14. 14. 114 human hamster hybrid AL cand AL-179 cells exposed to gamma-rays and HZE-FE ions. Advances in Space Research (1997, in press). Weaver, D.A., Hei, T.K., Hukku, B., McRaven, J.A. M., and Willey, J.A., Cytogenetic and molecular genetic analysis of tumorigenic human bronchial epithelial cells induced by radon alpha particles. Carcinogenesis 18: 1251-1258, 1997. Wei-W-Z., Pauley, R., Lichlyter, D., Soule, H., Shi, W-P., Calaf, G., Russo, J., Jones, R. F. Neoplastic progression of breast epithelial cells: a molecular analysis. Br. J. Cancer 78:198-204, 1998.