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In Course PresentationYogyakarta, May 2th, 2012Tenri A.W.Musketeers Course 2012
MAJOR CONCEPT
“The BIG IDEA”
MAJOR CONCEPT
WHAT IS DENDRITIC CELL?DENDRITIC CELL (DC)IS AN ANTIGEN PRESENTING CELL (APC)DC IS EXPRESSING SEVERAL PATTERN-RECOGNITION ...
MAJOR CONCEPT
ROLE DENDRITIC CELL IN IMMUNITYDC IN TLR-MEDIATEDANTIGENRECOGNITIONDC IN ACTIVATIONAND MIGRATIONDC IN ANTIGENPRESENTATION ...
ROLE DENDRITIC CELL IN IMMUNITYDC IN TLR-MEDIATEDANTIGENRECOGNITIONDC IN ACTIVATIONAND MIGRATIONDC IN ANTIGENPRESENTATION ...
TOLL-LIKE RECEPTOR
TLR, LIGAND, AND ADJUVANT                   (DUIN ET AL., 2006)
ROLE DENDRITIC CELL IN IMMUNITYDC IN TLR-MEDIATEDANTIGENRECOGNITIONDC IN ACTIVATIONAND MIGRATIONDC IN ANTIGENPRESENTATION ...
TLR SIGNALING PATHWAY                 SIGNALING                 MOLECULE                  TLRCYTOKINESECRETION     SIGNALI...
TLR SIGNALING PATHWAY (CONT)
TLR SIGNALING INDUCE  CCR7 EXPRESSION
TLR SIGNALING UPREGULATE MHC II AND CO-STIMULATORY MOLECULE
ROLE DENDRITIC CELL IN IMMUNITYDC IN TLR-MEDIATEDANTIGENRECOGNITIONDC IN ACTIVATIONAND MIGRATIONDC IN ANTIGENPRESENTATION ...
DC PRESENT ANTIGEN  TO NAÏVE T CELL
DC INDUCE BOTH CD 4 & CD 8     T CELL ACTIVATION
DC INDUCE CD 4 T-CELL               DIFFERENTIATIONIN MOST CASE, VIA TLR ACTIVATION, INDUCEDEVELOPING T HELPER 1      RESP...
TH 1 CELL in INTRACELLULAR DEFENSE                  TH 1 INDUCE Ig G, NK                  CELL, MACROPHAGE AND OTHER CELL ...
MAJOR CONCEPT
VACCINE IN INFECTIOUS DISEASE
MYCOBACTERIUM BCG VACCINE• BCG VACCINE IS USING TLR 2 AND TLR 4 – MYD88 PATHWAY
TLR 2 - TLR 4 – MYD88 PATHWAY
VACCINE IN MELANOMA CANCER•   MELANOMA CANCER VACCINE IS DNA VACCINE, USING TLR 9 – MYD88 PATHWAY
PRINCIPLE OF TLR SIGNALING
THANK YOU TO THESE GUYS
MAJOR CONCEPT
SUMMARY
TLR Signalling Pathway-based Vaccination
TLR Signalling Pathway-based Vaccination
TLR Signalling Pathway-based Vaccination
TLR Signalling Pathway-based Vaccination
TLR Signalling Pathway-based Vaccination
TLR Signalling Pathway-based Vaccination
TLR Signalling Pathway-based Vaccination
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TLR Signalling Pathway-based Vaccination

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Musketeers Course: Course in Immunology Batch 2012 | Yogyakarta, Indonesia | 2 May 2012.

Published in: Technology, Health & Medicine
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TLR Signalling Pathway-based Vaccination

  1. 1. In Course PresentationYogyakarta, May 2th, 2012Tenri A.W.Musketeers Course 2012
  2. 2. MAJOR CONCEPT
  3. 3. “The BIG IDEA”
  4. 4. MAJOR CONCEPT
  5. 5. WHAT IS DENDRITIC CELL?DENDRITIC CELL (DC)IS AN ANTIGEN PRESENTING CELL (APC)DC IS EXPRESSING SEVERAL PATTERN-RECOGNITION RECEPTOR(PRR), INCLUDING TOLL-LIKE RECEPTOR (TLR)
  6. 6. MAJOR CONCEPT
  7. 7. ROLE DENDRITIC CELL IN IMMUNITYDC IN TLR-MEDIATEDANTIGENRECOGNITIONDC IN ACTIVATIONAND MIGRATIONDC IN ANTIGENPRESENTATION ANDADAPTIVEIMMUNITYACTIVATION
  8. 8. ROLE DENDRITIC CELL IN IMMUNITYDC IN TLR-MEDIATEDANTIGENRECOGNITIONDC IN ACTIVATIONAND MIGRATIONDC IN ANTIGENPRESENTATION ANDADAPTIVEIMMUNITYACTIVATION
  9. 9. TOLL-LIKE RECEPTOR
  10. 10. TLR, LIGAND, AND ADJUVANT (DUIN ET AL., 2006)
  11. 11. ROLE DENDRITIC CELL IN IMMUNITYDC IN TLR-MEDIATEDANTIGENRECOGNITIONDC IN ACTIVATIONAND MIGRATIONDC IN ANTIGENPRESENTATION ANDADAPTIVEIMMUNITYACTIVATION
  12. 12. TLR SIGNALING PATHWAY SIGNALING MOLECULE TLRCYTOKINESECRETION SIGNALING PHOSPORILATION CASCADE PATHWAY TRANSCRIPTION FACTOR ACTIVATION
  13. 13. TLR SIGNALING PATHWAY (CONT)
  14. 14. TLR SIGNALING INDUCE CCR7 EXPRESSION
  15. 15. TLR SIGNALING UPREGULATE MHC II AND CO-STIMULATORY MOLECULE
  16. 16. ROLE DENDRITIC CELL IN IMMUNITYDC IN TLR-MEDIATEDANTIGENRECOGNITIONDC IN ACTIVATIONAND MIGRATIONDC IN ANTIGENPRESENTATION ANDADAPTIVEIMMUNITYACTIVATION
  17. 17. DC PRESENT ANTIGEN TO NAÏVE T CELL
  18. 18. DC INDUCE BOTH CD 4 & CD 8 T CELL ACTIVATION
  19. 19. DC INDUCE CD 4 T-CELL DIFFERENTIATIONIN MOST CASE, VIA TLR ACTIVATION, INDUCEDEVELOPING T HELPER 1 RESPONSE (TRINCHIERY, 2003)
  20. 20. TH 1 CELL in INTRACELLULAR DEFENSE TH 1 INDUCE Ig G, NK CELL, MACROPHAGE AND OTHER CELL ACTIVATION IN INTRACELLULAR DEFENSE MECHANISM
  21. 21. MAJOR CONCEPT
  22. 22. VACCINE IN INFECTIOUS DISEASE
  23. 23. MYCOBACTERIUM BCG VACCINE• BCG VACCINE IS USING TLR 2 AND TLR 4 – MYD88 PATHWAY
  24. 24. TLR 2 - TLR 4 – MYD88 PATHWAY
  25. 25. VACCINE IN MELANOMA CANCER• MELANOMA CANCER VACCINE IS DNA VACCINE, USING TLR 9 – MYD88 PATHWAY
  26. 26. PRINCIPLE OF TLR SIGNALING
  27. 27. THANK YOU TO THESE GUYS
  28. 28. MAJOR CONCEPT
  29. 29. SUMMARY

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