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Defective Telomeres Linked To Diseases And Cancer

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Defective Telomeres Linked To Diseases And Cancer

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Defective Telomeres Linked To Diseases And Cancer

  1. 1. By: Juan Felipe González Franco Medicine student Faculty of health sciences UPB 2015
  2. 2. BIBLIOGRAPHY -Centro Nacional de Investigaciones Oncológicas (CNIO). (2015, July 15). Defective telomeres are now being linked to dozens of diseases, including many types of cancer. ScienceDaily. Retrieved august 2, 2015 from www.sciencedaily.com/releases/2015/07/ 150715130828.htm -The University of Texas Health Science Center at San Antonio. (2015, May 4). Revolutionary method of making RNAs. ScienceDaily. Retrieve august 2, 2015 from www.sciencedaily.com/releases/2015 /05/150504121041.htm MEDICAL UTILITY These researches are very important in my opinion because of the clinical application: The first one talks about investigating the telomeres and understanding these complex structures may help future medicine with new treatments for diseases like cancer. The second one Dr. Sousa thinks this new method to make RNA molecules that are chemically diverse will speed up research exponentially. In my humble opinion Dr. Sousa is too optimistic but, if he is right, biological sciences will benefit most. Until now make RNAs to develop diagnostics and therapeutics has been limited by existing technology. The interest in this is because RNAs are molecules that can be used to make therapeutics, sensors and diagnostics. GENETIC MATERIAL REPLICATION By: J. Felipe Gonzalez F. MOLECULAR BIOLOGY Teacher: Lina Martínez
  3. 3. Defective telomeres are now being linked to dozens of diseases, including many types of cancer: Telomeres are the structures that prevent the DNA strands makes chemically bonds to other strands, i.e. the chromosomes would merge and that would be lethal for the cell. The researchers are amazed about how complex is the biology of telomeres, and the high number of factors “they are finding that are essential to the preservation of telomeres and, above all, the precise coordination that is required between them all.” STUDENT OBSERVATION In my opinion what they are investigating is very important and will be will be a key issue in the future research, because they talk about topics of great interest for modern science like are cancer therapy and ageing. INTRODUTION In recent years not only their relation to ageing has been confirmed; also defective telomeres seem to be linked to a lot of diseases even with some types of cancer, this is very important for the future medicine. The importance of investigating these structures is to improve diagnoses and develop possible treatments for many diseases. Telomeres, in the opinion of these researchers, will become increasingly important in clinical studies. Different types of RNAs perform different functions, such as silencing a gene or regulating a plethora of processes in cells. The new method described by Dr. Sousa and his colleagues in Nature, which includes robotics, will speed up research exponentially. This is desirable for studies of RNA structure and function, and for design of applications that could be used to diagnose and treat diseases. This new technique allows the researcher make RNA molecules that are chemically diverse. Revolutionary method of making RNAs: Rui Sousa, Ph.D., professor of biochemistry in the School of Medicine at the Health Science Center is a co-author on the paper with colleagues from the National Institutes of Health, the University of Colorado, said that “RNAs are molecules that can be used to make therapeutics, sensors and diagnostics, for which there is a growing market”. He and his colleagues describes a new, more efficient method of making ribonucleic acids (RNAs). "This new technique allows a researcher to make RNA molecules that are chemically diverse,“ and they think this new method, will speed up research exponentially. STUDENT OBSERVATION Dr. Sousa and his collages propose a new method for making RNA in a more effective way, that will help a lot in my opinion because of what the told us at the beginning “RNAs are molecules that can be used to make therapeutics, sensors and diagnostics“.
  4. 4. INTRODUCCION  Telomeresarethe structuresthat protectthe endsof chromosomes.  The geneticinformationofDNA iscopiedinto moleculescalledmessengerRNAs,whichare basicallythe manufacturinginstructionsfor proteins.
  5. 5. Defectivetelomeres arenowbeinglinkedto dozensofdiseases, includingmanytypesof cancer: CentroNacionaldeInvestigaciones Oncológicas (CNIO). Defective telomeres are now being linked to dozens of diseases, including many types of cancer: Telomeres are the structures that prevent the DNA strands makes chemically bonds to other strands, i.e. the chromosomes would merge and that would be lethal for the cell. The researchers are amazed about how complex is the biology of telomeres, and the high number of factors “they are finding that are essential to the preservation of telomeres and, above all, the precise coordination that is required between them all.” STUDENT OBSERVATION In my opinion what they are investigating is very important and will be a key issue in the future research, because they talk about topics of great interest for modern science like are cancer therapy and ageing.
  6. 6. TELOMESRES Telomeres are the ending regions of a chromatid, their presence protects the genes before them on the chromosome from being truncated instead. Defectivetelomeres arenowbeing linkedto dozensofdiseases,including manytypesof cancer:
  7. 7. Theresearchersinvestigate telomeres, this structuresare being linkedto diseases like cancer, this show us the great importance of telomeres and their function in the prevalence of the chromosome structure.
  8. 8. telomeres havebeen tightly preserved throughout the evolution in all cell lines, that indicates its importance. Theyprevent the fusion of chromosomes and the loss of genetic information each time a cell divides.
  9. 9.  Defective telomeres are now being linked to dozens of diseases, including many types of cancer: Student observation: In my opinion what they are investigating is very important and will be a key issue in the future research, because they talk about topics of great interest for modern science like are cancer therapy and ageing.
  10. 10. Revolutionary method of making RNAs: Rui Sousa, Ph.D., professor of biochemistry in the School of Medicine at the Health Science Center is a co-author on the paper with colleagues from the National Institutes of Health, the University of Colorado, said that “RNAs are molecules that can be used to make therapeutics, sensors and diagnostics, for which there is a growing market”. He and his colleagues describes a new, more efficient method of making ribonucleic acids (RNAs). "This new technique allows a researcher to make RNA molecules that are chemically diverse,“ and they think this new method, will speed up research exponentially. STUDENT OBSERVATION Dr. Sousa and his collages propose a new method for making RNA in a more effective way, that will help a lot in my opinion because of what the told us at the beginning “RNAs are molecules that can be used to make therapeutics, sensors and diagnostics“. Revolutionary method of making RNAs:
  11. 11. Revolutionary method of making RNAs: Dr. Sousa and his colleagues talk us about a new method that includes robotics, and they think will speed up research exponentially.
  12. 12. Revolutionary method of making RNAs: Dr. Sousa mentioned this new technique and he said it allows a researcher to make RNA molecules that are chemically diverse, and can reduce the time it takes to make those molecules.
  13. 13. Revolutionary method of making RNAs: The great importance of these molecules regarding medicine, in words of Dr. Sousa is that “RNAs are molecules that can be used to make therapeutics, sensors and diagnostics”.
  14. 14.  Dr. Sousa and his collages propose a new method for making RNA in a more effective way, that will help a lot in my opinion because of what the told us at the beginning “RNAs are molecules that can be used to make therapeutics, sensors and diagnostics“. Revolutionary method of making RNAs: Student observation
  15. 15.  MEDICAL UTILITY
  16. 16. MEDICAL UTILITY Bothresearchesallowtogeneticreplication andeachonehaveamedicalapplication, howeveroneofthemewerefocusedinthe importanceoftelomereslikestructuresthat protecttheendingsofthechromatids,and theotheroneinanewmoreefficient methodtomakeRNAusingrobotics.
  17. 17. MEDICAL UTILITY The researchAbouttelomeres hasincreasing becausenowtheinvestigations areconsidering The ImportanceofThesenotvery simple structuresin topicslike conserving the genetic materialin eachchromatid.thishaveaclose relationshipWiththe mutationsand degenerationofthe genetic code, withCancer andaging.
  18. 18. MEDICAL UTILITY Until nowmakeRNAstoDevelop diagnostics andtherapeuticshas-beenlimitedbyExisting technology. As Dr.SousaSaid RNAsaremolecules thatcan beusedtomaketherapeutics, sensorsand diagnostics,forthatreasonithas anImportant clinical applicationimproving themethodto makeDNA.
  19. 19.   Centro Nacional de Investigaciones Oncológicas (CNIO). (2015, july 15). Defective telomeres are now being linked to dozens of diseases, including many types of cancer. ScienceDaily. Retrieved august 2, 2015 from www.sciencedaily.com/releases/2015/07/150715130828.htm  The University of Texas Health Science Center at San Antonio. (2015, May 4). Revolutionary method of making RNAs. ScienceDaily. Retrieve august 2, 2015 from www.sciencedaily.com/releases/2015/05/150504121041.htm  Martínez Sánchez, Lina María. Biología molecular.8.ed.Medellin: UPB. Fac. Medicina. BIBLIOGRAPHY

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