Healthy heart


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Healthy heart

  1. 1. Healthy Heart – An Ayurvedic ApproachUnder the Guidance of, By,Dr.Ashalatha.M. Dr.Tanmaya.K.AcharyaH.O.D., Dept of P.G.Studies inDravyaguna, II M.D., Dept of DravyagunaG.A.M.C., Bengaluru G.A.M.C., Bengaluru
  2. 2. Introduction• India has the largest Cardio-vascular Disease rate in the world.• Ganas mentioned specifically in Charaka and Sushrutha Samhita for Hrdya karma and Hrd roga• Hrdya gana, Parushakadi gana, Bruhatyadi gana, Utpaladi gana, Balya dashemani, Lekhaneeya dashemani.
  3. 3. • Charaka Hrdya Gana: Amra Amrataka Likucha Karamarda Vrkshamla Amlavetasa Kuvala Badara Dadima Matulunga• Sushruta Vargas:• Bruhatyadi : Bruhati Kantakari Kutajaphala Patha Madhuka
  4. 4. • Parushakadi varga: Parushaka Draksha Katphala Dadima Rajadana Katakaphala Sakaphala Triphala• Utpaladi varga: Utpala Raktotpala Kumuda Saugandhika Kuvalaya Pundarika Madhuka
  5. 5. Amra :Mangifera indicaPhytoconstituents ActivityMangiferin : Poly Alteration of Cardiacphenol mitochondrial energy metabolism
  6. 6. Karamarda :Carrisa carandasPhytoconstituents ActivityTriterpene: Carissol Ia Cardio tonic activity Carissic Ib
  7. 7. Bruhati :Solanum indicumPhytoconstituents ActivityChlorogenic acid Blood pressure lowering effects
  8. 8. Madhuka :Madhuca indicaPhytoconstituents ActivityMadhucosides A & B Significant inhibitoryProtobassic acid effects superoxide release from polymorphonuclear cells.
  9. 9. Draksha :Vitis viniferaPhytoconstituents ActivityProcyanidins Supplementation makes the heart less susceptible to ischemia/reperfusion damage.
  10. 10. Kamala :Nelumbo nuciferaPhytoconstituents ActivityDaurisoline Antiarrhythmic effectNeferine Hypotensive effect
  11. 11. Brahmi :Bacopa monnieriPhytoconstituents ActivitySterol glycoside : AntihypertensivesBacosterol-3-0-beta-D- VasodilatorsglucopyrosideBacopa saponnin-C,Bacopaside-1, BacopasideII
  12. 12. Chitraka :Plumbago zeylanicaPhytoconstituents ActivityPlumbagin Regression of Atheroma Reduces serum cholesterol, LDL cholesterol
  13. 13. Arka :Calatropis proceraPhytoconstituents ActivityCalotropagenin Inhibitors of Na(+) /K(+) - ATPase to regulate heart contractions
  14. 14. Conclusion• Various approach towards cardio-protective activity: • Protective: Amra, Madhuka, Draksha • Anti-hypertensives: Bruhati, Brahmi • Inotropic activity : Karamarda • Chronotropic activity : Kamala, Arka • Anti-cholesterol : Chitraka• The need to fill the lacuna between Literature Research Implementation• Rediscover the connection between ‘Plant’ and ‘Health’
  15. 15. References• Effect of mangiferin on mitochondrial energy production in experimentally induced myocardial infarcted rats. Department of Biochemistry, University of Madras, A.C. Tech., Guindy campus, Chennai-600 025, India.• BIOSYNTHESIS OF CAR1SSOL AND CARISSIC ACID. Department of Chemistry, University of Karachi, Karachi-75270, Pakistan.• Solanum indicum ssp. distichum extract is effective against L-NAME-induced hypertension in rats. Department of Pharmacology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.• Madhucosides A and B, protobassic acid glycosides from Madhuca indica with inhibitory activity on free radical release from phagocytes. Department of Natural Products, National Institute of Pharmaceutical Education and Research, Sector 67, SAS Nagar, Punjab 160062, India.• Diet enriched with procyanidins enhances antioxidant activity and reduces myocardial post- ischaemic damage in rats. Istituto Chimico Farmaceutico Tossicologico, University of Milan, Italy.• Effects of neferine on transmembrane potentials of guinea pig myocardium. Li GR, Li XG, Lü FH• Bacopa monnieri and its constituents is hypotensive in anaesthetized rats and vasodilator in various artery types. Department of Physiology, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, Thailand.• Hypolipidaemic and antiatherosclerotic effects of plumbagin in rabbits. Department of Zoology, University of Rajasthan, Jaipur.• Rapid identification of calotropagenin glycosides using high-performance liquid chromatography electrospray ionisation tandem mass spectrometry. Sophisticated Analytical Instrument Facility, Central Drug Research Institute, Lucknow, 226001,