Dr.Sivarama Prasad Kethamakka, M.A.(Astro),M.D.(Ay)(Osm).Reader, Post Graduation And Research Center,Shree D.G.M.Ayurvedic Medical College,GADAG, 582 103, Karnataka, INDIA.Tel :- 08372-38014. ABSTRACT “ APPRAISAL OF VAMANA - AN ENDOTOXIN EXPULSION THERAPY” Vamana is an effective exclusive eliminative therapy of dosha from oral orifice. It isindicated for the doshas, kapha and Pitta from Amashaya. In Amashaya Kapha have madhura,lavana rasa and Pitta amlarasa under the influence of Samana vata. This expulsion therapy givesstress and strain for the patients, thus it is not applied in the western patients ( They are strong byphysic but psychologically delicate). With their qualities of Ushna, Teekshana, Sukshma,Vyavayee, Vikashi and Urdhvabhaga prabhava it induces anupravana in srotases and movesliquified doshas from there to Amashaya and eliminates. Anupravana action of vamana continueseven in pakwashaya and results into Virechana. This process even through indicated for KaphajaVyadhis, it is widely used for Tamaka swasa and Kusta. The apakwa Kapha in amashaya as its seat is urdhwa amashaya in normal will have theinfluence of vitiated Bodhaka, Kledaka kapha in abnormality. It can be claimed as heavy metalslike Lead and Mercury excretion in saliva and nitrogenous end products of digestion collected inamashaya as an action of Anupravana. The second dosha, Pitta seated in adhoamashaya withamla rasa considered normal and subjected to the vitiation under the influence of Samana vata.The modern science explains the secretions from fundas of stomach apart from mucin are VIP,GRP, substance P and Somatostatin; out of GRP and Somatostatin increases Gastrin secretion andrest inhibits under motor and secretory neuron control, and also above said influence motility ofstomach referred as pachaka pitta and samana vata respectively. Like wise in antrum of stomachGlucagon which regulates the glucose concentration in blood levels have an indirect influence onmadhurayata of kapha in vriddhi state. Chiefly the electrolytes exchange in to free fluid form in stomach from interstitialcompartment are Na , K , Cl , HPO , SO , H O along with Nitrogenous end productscauses the depletion in electrolytes and also water in the body. In observations patients are subjected to loss of Na, Cl and K in vomit’s along with largequantities of mucin and water. They were subjected for stress and strain along with heaviness inabdomen in the process of Vamana. Almost all the patients had the virechana after the vamanaeven through they had proper pittanta vamana according to samyak yoga lakshana. The patientswith kusta (psoriasis) had a tremendous relief with the madanaphala yoga vamana, as a repeatedsodhana for an interval of 21 days. Only one patient of Tamaka swasa had blood stain in thevomits. Thus Vamana is an effective therapy especially for the disorders of skin and a palliativefor Asthmatics.