Acne

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Acne

  1. 1. WELCOME3/9/2012 Dept of Dravyaguna,GAMC,Bangalore 1
  2. 2. RESEARCH UPDATES ON DRUGS IN  MUKHADOOSHIKA(ACNE VULGARIS)Under the guidelines ofDr. Ashalatha MProfessor and HODDept of DravyagunaGAMCBangalore- 09 By Dr. Thriveni D.P. Final year MD Dept. of Dravyaguna GAMC Bangalore-09 3/9/2012 Dept of Dravyaguna,GAMC,Bangalore 2
  3. 3. Content  Introduction  Acne treatment modalities and kind of drugs  Ayurvedic perspective  Bioactive compounds in Acne  Researches  Few herbal drugs  Conclusion3/9/2012 Dept of Dravyaguna,GAMC,Bangalore 3
  4. 4. Introduction3/9/2012 Dept of Dravyaguna,GAMC,Bangalore 4
  5. 5. Classical references  ‘Kshudra Rogas’ (SU.Ni.13)  Kshudraroga pratisheda (A.H.U.31,32)  Varnya, Vayasthapana (Ch.Su.4/8).  Shasti Upkramas (SU.Chi.1/68- 78).  Kshudraroga chikitsa-Chakradata  Sarangdhara Samhita - certain special Lepas3/9/2012 Dept of Dravyaguna,GAMC,Bangalore 5
  6. 6. Kind of drugs useful in MUKHADOOSHIKA Varnya gana Shothahara Pandukarana Mrudukarana Darunikarana Avasadana Utsadana Vranaropana3/9/2012 Dept of Dravyaguna,GAMC,Bangalore 6
  7. 7. Treatment modality of Acne vulgaris1.   To counteract excess sebum and androgen‐ ‐ Sebostatics, Antiandrogen2.   To get rid of P.acne ‐ Antibiotics3.   To treat lesion                 ‐ Comedolytics, Anti‐inflammatory4. For regenerative               ‐ Steroid Antioxidants 3/9/2012 Dept of Dravyaguna,GAMC,Bangalore 7
  8. 8. Bioactive compounds Glycoside Antioxidant, Antibiotic, Anti-(Phenolic,Flavonoids) inflammatoryTannin(hydrosible) -Antimicrobial, Anti- inflammatory, Antipruritic effectsCondensed tannin(Isoflavones) -Anti-cellulite , Viscoelastic propertiesFatty acids (Omega-3& omega-6) optimizes permeability in the skinVolatile oil -Antibacterial, increases the permiabillity, healingTerpenoid -Anti-inflammatorySesquiterpene -AntimicrobialVitamin A Sebostatic, Anti-inflammatoryVitamin E Antioxidant 3/9/2012 Dept of Dravyaguna,GAMC,Bangalore 8
  9. 9. Researches Rathod Suresh- The study of Shalmali w.s.r.to its efficacy on Mukhadooshika 2002, Tilaka Ayurveda College Pune. Agravat H.P - Yuvan Pidaka and role of Lodhradi Lepa there in (Acne ) Sandeep Sagare - Comparative study on Vachadi Lepa and Mruttika Lepa in Mukhadooshika with special reference to Acne Vulgaris.3/9/2012 Dept of Dravyaguna,GAMC,Bangalore 9
  10. 10. Lodhra- Symplocos racemosa Part used ‐ Stembark Action‐ vranaropana,grahi Constituents Action Phenolic glycoside- Anti-inflammatory symploracemoside Alkaloid- Antiseptic, loturine,collutrine Antioxidant (Ref‐Kerala Ayurveda vaidyam)3/9/2012 Dept of Dravyaguna,GAMC,Bangalore 10
  11. 11. Vacha- Acorus calamus Part used‐ Rhizome Action‐ lekhanaConstituent ActionMonoterpene Anti‐Terpineol inflammatory (Ref;Birla Institute of technology and  science,Pharmacy group)3/9/2012 Dept of Dravyaguna,GAMC,Bangalore 11
  12. 12. Yasti – Glycirrhiza glabra Part used- root Action- vranaropana, raktadoshahara Constituent Action Gycyrrhizin Anti‐inflammatory Glabridin Hinders   Liquiritin melanogenesis(Ref;Birla Institute of technology and science,Pharmacygroup) 3/9/2012 Dept of Dravyaguna,GAMC,Bangalore 12
  13. 13. Manjista- Rubia cordifolia Part used- root Action- varnya,raktaprasadanaConstituents ActionManjistin Anti-inflammtoryAnthroquinone Antibacterial Antioxidant(Ref; Review of Articles on Ayurveda and natural products )3/9/2012 Dept of Dravyaguna,GAMC,Bangalore 13
  14. 14. Shalmali- Bombax ceiba Part used- spines Action – grahi,pittasranashana Constituent Action Shamimin ‐Antimicrobial Oxalate ‐Disintegrates  hard tissue (Ref‐ Himalaya drug company,Bangalore) 3/9/2012 Dept of Dravyaguna,GAMC,Bangalore 14
  15. 15. Kola- Zizyphus jujuba Part used‐ Fruitpulp Action – grahi, Constituent Action Triterpinoid Anti‐ inflammatory Flavaonoid Antioxidant Saponin Enhances the  penetration  Essential oil Healing (Ref;Kerala Ayurveda vaidyam)3/9/2012 Dept of Dravyaguna,GAMC,Bangalore 15
  16. 16. Conclusion Ayurveda also given importance to  cosmetics with therapeutics There are lot of researches done and carrying out on  Mukhadooshika to find still more effficient one. Further there is a scope for studying these dravyas in  more detail  with respect to pharmacokinetics.3/9/2012 Dept of Dravyaguna,GAMC,Bangalore 16
  17. 17. THANKING                 YOU3/9/2012 Dept of Dravyaguna,GAMC,Bangalore 17

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