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Summers imeko 2011

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Summers imeko 2011

  1. 1. Progress on Measurement in Biology & Medicine: Multiscale Systems Engineering Ron SummersDept Electronic & Electrical Engineering, Loughborough University, UK R.Summers@lboro.ac.uk http://www-staff.lboro.ac.uk/~lsrs1
  2. 2. Outline• Introduction to the Team• Multiscale Modelling Anatomic Level of Analysis Cellular Level of Analysis Protein Level of Analysis Genome Level of Analysis• Future Work
  3. 3. International Team
  4. 4. Multiscale Modelling Context
  5. 5. Engineering Dimension“…multiscale modelling is the field of solving physical problems which have important features at multiple scales, particularly multiple spatial and (or) temporal scales”. Wikipedia, accessed 2010
  6. 6. Scales of Measurement Hunter P, Robbins P, Noble D (2002) The IUPS human physiome project. Eur J Physiol 445 1-9
  7. 7. Medical Dimension• Why is it important to better understand congenital heart defects ?• What is the Tetralogy of Fallot from an anatomical standpoint ?• Which embryological processes are involved in the formation of the Tetralogy of Fallot ?
  8. 8. Why is it important to know more about the congenitalheart defect and particularly about the Tetralogy of Fallot ?The prevalence of congenital heart defects,the most common congenital anomalyobserved in newborns, has been reported tobe 5-10 per 1000 births 10% of the childhood mortalityTetralogy of Fallot is the most common formof cyanotic congenital heart disease.It affects 9%-15% of all infants and childrenwith congenital heart disease (CHD) whichrepresents 55%-70% of all cyanoticcongenital malformationsWe need to improve our knowledge aboutthis abnormality
  9. 9. Multiscale Modelling Anatomic Level
  10. 10. Aorta Pulmonary arteryRightVentricle Anterior view Posterior view
  11. 11. Anatomy of the Normal Human Heart
  12. 12. Tetralogy of Fallot desaturationPulmonary StenosisVentricular Septal Defect bymalalignmentDextroposition of the Aorta(aortic overriding)Right ventricular hypertrophy
  13. 13. Normal Anatomic Development Membranous Septum Muscular Septum Nature
  14. 14. Multiscale Modelling Cellular Level
  15. 15. Scales of Measurement Hunter P, Robbins P, Noble D (2002) The IUPS human physiome project. Eur J Physiol 445 1-9
  16. 16. Epithelial to Mesenchymal Transition Notch Delta
  17. 17. EMT Simulations
  18. 18. In vitro EMTWildtype Notch1 BMP2 L. Luna-zurita et al. “Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation,” The Journal of Clinical Investigation, vol. 120, 2010.
  19. 19. Multiscale Modelling Protein Level
  20. 20. Multiscale Modelling Genome Level
  21. 21. Which embryological processes are involved in the formation of the Tetralogy of Fallot ? Scale of tissue and cells
  22. 22. Which embryological processes are involved in the formation of the Tetralogy of Fallot ? Scale of gene regulation
  23. 23. Future Work
  24. 24. A lot of work remains…• Information Issues • Scale-linking • Biological Networks• Methodological Issues • Multiscale Model Process • Multiscale Model Validation • Multiscale Visualization• Software Issues • Multiscale Software Programming• Patho-physiological Issues • Anatomic Definition of Tetralogy of Fallot
  25. 25. Thank you for your attention
  26. 26. Biophotonics Imaging SystemOptical Physiological Tomography: Concepts Electronic sub system ency W High USB Frequ Hz (4 00 avel 6–9 – 9 en 00 gth nm ) Oxygen level Oxygen level Micro- Micro- O2% electronics Fast digital Low Camera Multi- Multi- wavelength illuminator Photonics sub system Comprises biomedical photonics, microelectronics engineering, systems engineering, applied signal and image processing, and multiscale modelling/simulation

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