To add or subtract fractions with different denominators: 1) Find the least common denominator (LCD) of the fractions, which is the smallest number that is a multiple of all the denominators. 2) Convert the fractions to equivalent fractions with the LCD as the denominator by multiplying the numerators and denominators by the same number. 3) Add or subtract the new numerators, keeping the common denominator, to obtain the final answer in simplest form.