Prospect of CSC-targeting Therapy - SeigiOshima

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Prospect of CSC-targeting Therapy - SeigiOshima

  1. 1. Prospect of CSC-targeting TherapyKyoto Univ. Faculty of Medicine (1) Seigi Oshima
  2. 2. Outline 1. Cancer stem cells (CSCs) 2. Previous studies on CSC-targeting therapy 3. My suggestion on the novel therapy 4. Conclusion
  3. 3. What’s a Cancer Stem Cell (CSC)?CSC…. This figure is cited from http://www.childrenshospital.org/gallery/index.cfm?G=67
  4. 4. Normal anticancer drugs targetonly nCSCs…. nCSC CSC relapse
  5. 5. CSC-targeting Therapy1. Differentiation therapy2.CSC niche targeting therapy3. Direct reprogramming
  6. 6. What’s directreprogramming?
  7. 7. What’s Direct Reprogramming? differentiation iPS cells Cells you likeSomatic cells Cells you like
  8. 8. Previous Studies Yamanaka factors Cancer cells iPS cells
  9. 9. Suggestion• If direct reprogramming can be applied to CSCs, then this method is novel cancer treatment. certain transcription factorsCancer Stem Cells Normal cells
  10. 10. Hurdles toward my suggestion1. Possibility of developing cancer2. Extraction of pure CSCs from tumors3. Drug delivery system
  11. 11. The Future Prospect• CSC Drug Discovery of Victory over CSC-targeting markers Screening drug cancer

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