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  1. 1. Inflammation
  2. 2.  1.Function (phagocytosis)  •Phagocytic cells  –Monocytes (histiocytes, macrophages)  –PNL (particularly neutrophils)  •Non-phagocytic cells  –Lymphocytes  –Plasma cells
  3. 3.  Acute Inflammatory Cells  •PNL  Chronic Inflammatory Cells  –Macrophages –Histiocytes –Monocytes  –Lymphocytes  –Plasma cells
  4. 4. Neutrophils
  5. 5. lymphocytes
  6. 6. eosinophils
  7. 7. Basophils
  8. 8. Lymphocytic thyroditis
  9. 9. fibroblast  A fibroblast is a type of cell that synthesizes the extracellular matrix and collagen, the structural framework (stroma) for animal tissues, and plays a critical role in wound healing.
  10. 10. Fibroblast cells
  11. 11. Plasma cells  Plasma cell with distinct clear perinuclear region of the cytoplasm containing a large number of Golgi bodies
  12. 12.  Reticuloendothelial cells are phagocytic; i.e., they can engulf and destroy bacteria, viruses, and other foreign substances.  A histiocyte is an animal cell that is part of the mononuclear phagocyte system (also known as the reticuloendothelial system or lymphoreticular system). The mononuclear phagocytic system is part of the organism's immune system. The histiocyte is a tissue macrophage or a dendritic cell.
  13. 13. Giant cells/  A giant cell is a mass formed by the union of several distinct cells (usually macrophages).It can arise in response to an infection, such as from tuberculosis, herpes, or HIV, or foreign body.  Epithelioid cells Are activated macrophages resembling epithelial cells elongated, with finely granular, pale eosinophilic (pink) cytoplasm and central, ovoid nucleus (oval or elongate), which is less dense than that of a lymphocyte
  14. 14. Caseous necrosis
  15. 15. Giant cells
  16. 16. Epitheloid cells
  17. 17. Serous inflamtion
  18. 18. Pericardial thickening due to fibrinous inflammation
  19. 19. Fibrinous infammation
  20. 20. Fibrinous infammation
  21. 21. Heart: fibrinous pericarditis  This is a classic example of fibrinous inflammation involving the visceral pericardium (“bread and butter” pericarditis). Fibrinous inflammation is due to increased vessel permeability leading to the leakage of a sterile exudate with fibrin on to the surface of the heart.
  22. 22. Purulent inflammation
  23. 23. Lung Abscess  An abscess is a collection of pus that has accumulated within a tissue because of an inflammatory process in response to either an infectious process or other foreign material.
  24. 24. Mucoid or Catarrhal Inflammation  Mucoid or Catarrhal Inflammation Illustrated is an up side-down section of colon which exhibits excess secretion of mucus (M) into the colonic lumen.
  25. 25. Serous inflamation  disruption of epidermis at the basal level leaving a clear-fluid-filled bullous lesion
  26. 26. Normal lung: appears as mostly empty space. Alveoli have thin walled with a thin epithelial cell through which oxygen and carbon dioxide diffuse into the capillary lumen
  27. 27. Sub arachnoid space
  28. 28. Normal liver 3. Chronic viral hepatitis Caused by: Chronic viral hepatitis (hepatitis B virus) (Characteristic features) Chronic inflammatory infiltrate is limited to the portal area
  29. 29. Chronic inflamation
  30. 30. What is a Granuloma  A granuloma is a localized mass of granulation tissue with aggregations of chronic inflammatory cells
  31. 31. Granuloma
  32. 32. Granulation tissue