Central nervous system development

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Central nervous system development

  1. 1. 1)Neural Tube: Wall is formed by neuroepithelial cells(pseudost.epithelium) 2)Closure of neural tube: Proliferation of neuroepi.cells Form.of neuroepithelial cell layer 3)Formation of Mantle layer: Neuroepithelial cells-Neuroblasts- their cell bodies-GREY MATTER Of sp.cord 4)Formation of Marginal layer: Nerve fibres of neuroblasts-WHITE MATTER of sp.cord
  2. 2.  Basal  Alar  Roof  Floor
  3. 3.  Ventrally formed In Mantle layer  Form motor areas of sp.cord- Anterior horn  Their nerve fibres pass through the marginal layer and emerge as ventral roots of spinal nerve
  4. 4.  Form dorsal sensory areas of spinal cord  Nerve fibres penetrate marginal zone and ascend or descend for several levels to form Association neurons
  5. 5.  Between alar and basal plates
  6. 6.  Present in midline region  Contain no neuroblasts  Serve as pathways for nerve fibres from one side to the other
  7. 7.  Glioblasts are formed from neuroepithelial cells after the form.of neuroblasts has ceased  Supporting cells  Pass through all layers of spinal cord  IN MANTLE LAYER:  Differentiate to form Protoplasmic astrocytes & Fibrillar astrocytes(Nerve regeneration)  IN MARGINAL LAYER:  Differentiate to form oligodendrocytes (Myelinate ascending&descending fibres in CNS while schwann cells are responsible for myelination in PNS)
  8. 8.  Phagocytes  Formed in 2nd half of development from mesenchyme  Form ependymal cell layer after neuroblasts and glioblasts formation is over
  9. 9.  Present in T1-L3 segments of spinal cord

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