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The Heat Shock Protein Response in the Skeletal Muscle of  Untrained Individuals<br />Shaun Guest<br />San Diego State Uni...
Modified from Noble, 2008<br />
INTRODUCTION<br />Magnitude of heat shock response to exercise: <br />Individual characteristics <br /> Training status<br...
INTRODUCTION<br />Exercise training with trained individuals:<br />Maximum volume workloads induces the largest HSP change...
PURPOSE<br />Based on results from acute exercise bouts and training programs, determine whether exercise training in untr...
FINDING THE LITERATURE<br />Data base search:<br />PubMed/Medline (via EBSCO)<br />Biosis Previews<br />SPORTDiscus<br />W...
DISCUSSION<br />With exercise training:<br />Number of physiological adaptations in human skeletal muscle.<br />Ex:  fat ...
CONCLUSIONS<br />Based on results from acute exercise bouts and training programs, it remains unclear whether exercise tra...
FUTURE RESEARCH<br />Examine of role of HSP induction with performance.<br />Continue to use non-damaging exercise protoco...
Questions???<br />
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Heat Shock Protein Response

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Directed Readings Project for completion of Masters Degree from SDSU

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Heat Shock Protein Response

  1. 1. The Heat Shock Protein Response in the Skeletal Muscle of Untrained Individuals<br />Shaun Guest<br />San Diego State University<br />School of Exercise and Nutritional Sciences<br />December 1st, 2009<br />
  2. 2. Modified from Noble, 2008<br />
  3. 3. INTRODUCTION<br />Magnitude of heat shock response to exercise: <br />Individual characteristics <br /> Training status<br /> Age<br /> Sex<br />Absolute workload <br />Intensity <br />Duration<br />Novelty of exercise stress<br /> Noble, 2008<br />
  4. 4. INTRODUCTION<br />Exercise training with trained individuals:<br />Maximum volume workloads induces the largest HSP changes (Liu, 1999).<br />Highest levels of HSP with high intensities <br /> (Liu 1999, 2000). <br />High-intensity resistance exercise and low-intensity endurance exercise<br />Blunted/abolished stress responses (Nething, 2003). <br />HSP response due to increased baseline levels of HSPs pre-exercise (Morton, 2009).<br />
  5. 5. PURPOSE<br />Based on results from acute exercise bouts and training programs, determine whether exercise training in untrained individuals will lead to an attenuated heat shock protein response.<br />
  6. 6. FINDING THE LITERATURE<br />Data base search:<br />PubMed/Medline (via EBSCO)<br />Biosis Previews<br />SPORTDiscus<br />Web of Science<br />Google Scholar<br />Search topics: <br />Heat shock proteins<br />HSP72<br />Skeletal Muscle<br />PEDro Scale.<br />Quality of Evidence Score of 5 (Maher et al, 2003)<br />Inclusion criteria:<br />Male subjects<br />Avg Age: 18-35 yrs<br />Exclusion criteria:<br />Female subjects<br />Age > 35 yrs<br />Musculoskeletal abnormality<br />Neurologic disease<br />
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  12. 12. DISCUSSION<br />With exercise training:<br />Number of physiological adaptations in human skeletal muscle.<br />Ex:  fat oxidation, LA, muscle remodeling<br />The magnitude of the heat shock response is dependent upon: <br />Individual characteristics<br />Exercise Type<br />Frequency<br />Intensity<br />Duration <br />
  13. 13. CONCLUSIONS<br />Based on results from acute exercise bouts and training programs, it remains unclear whether exercise training will lead to an attenuated response in untrained individuals.<br />HSP response shown to be vary greatly between individuals.<br />HSP results reflect genetic variability of skeletal muscle to recover, remodel, and/or adapt to exercise specific stress. <br />
  14. 14. FUTURE RESEARCH<br />Examine of role of HSP induction with performance.<br />Continue to use non-damaging exercise protocols  ‘clean’ results.<br />Compare HSP response with training program in untrained and trained individuals. <br />
  15. 15. Questions???<br />

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