4. Risk factors
Risk factorsinclude
• cigarettesmoking
• exposure to industrial
chemicals or toxinsin
the environment
• a diet high in fat, meat,
or both
• Pancreaticcancer is
also associated with
diabetes mellitus,
chronic pancreatitis,
and hereditary
pancreatitis.
4
SWATILEKHA DAS
5. Clinical
Manifestations
• Pain, jaundice, or both are present
in more than 80% of patients and,
along with weight loss
• Rapid, profound,and progressive
weight loss.
• Vague upper- or midabdominal pain
or discomfort unrelated to any GI
function; radiates as a boring pain in
the mid back Symptoms of insulin
deficiency (diabetes: glucosuria,
hyper-glycemia, and abnormal
glucose tolerance) may be an early
sign of carcinoma.
5
SWATILEKHA DAS
6. CLINICAL
MANIFESTATIONS
• Meals often aggravateepigastric pain.
• Malabsorption of nutrients and fat-soluble
vitamins, anorexia and malaise, and clay-colored
stools and dark urine are common
SWATILEKHA DAS 6
7. Assessment
and
Diagnostic
Methods
• Spiral (helical) CT
• MRI scan
• endoscopic retrograde
cholangiopancreatography
(ERCP)
• GI x-rays, percutaneous fine-
needle biopsy,
• percutaneous transhepatic
cholangiography (PTC), angiog-
raphy, laparoscopy, or
intraoperative ultrasonography
• Glucose tolerance test
7
SWATILEKHA DAS
13. Medical
Management
• Radiation and chemotherapy may
be used; intraoperative radiation
therapy (IORT) or interstitial
implantation of radioactive
sources may be used for pain
relief.
13
SWATILEKHA DAS
14. Medical Management
SWATILEKHA
DAS
• Diet high in protein with pancreatic enzymes, adequate
hydration, vitamin K, and treatment of anemia with blood
components and total Parenteral Nutrition may be instituted
before surgery when indicated.
14