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Neonatal Cold Injury Syndrome (sclerema neonatorum)
Objectives What will I learn? Etiologies and pathophysiology Symptoms Diagnosis Treatment
Definition --  mainly caused by  cold stress --the clinical features are  low body  temperature and scleredema   --serious...
Etiology and pathophysiology Characteristics of temperature regulation  and subcutaneous fatty composition in  newborn ●  ...
●   limited storage of energy, heat production  mainly by brown fatty metabolism,  lacking  shivery thermogenesis ●   more...
Distribution of neonatal brown fat
Cold injury ●   Cold environment increase heat loss, low body temperature causes constriction of peripheral blood vessels,...
Other  Factors ●   severe infection, ●   premature, ●   asphyxia,  ICH, ●   erythroblastosis
Imbalance between heat production and loss Heat production  Non-enough intake √ √ √ cold √ asphyxia infection
Imbalance between heat production and loss Heat loss  cold √ relative larger surface √ cold √ immature of temperature center
immature of temperature center relative larger surface  cold 、 non-enough intake infection 、 asphyxia   heat production  o...
Anoxia,  acidosis coagulation of subcutaneous fat constriction of  skin vessels anoxia of tissue  hardening of skin  Slowl...
●   usually occur in cold season ●   during  first 3 days or any time in preterm infants ●   Low body temperature ●   Scle...
●   feature:  skin and subcutaneous tissue  become indurated, woody, non-pitting,  cold to touch, involved area may with  ...
Neonatal scleredema
 
multiple organ dysfunction ●   bradycardia, dyspnea,  ●   microcirculation disturbance,  ●   shock,  DIC , ●   acute renal...
Evaluation of body surface area Head and neck  20% Upper limbs  18% Anterior part of trunk  14% Posterior part of trunk  1...
Degrees of NCIS Body temperature(℃)  involved area  change of organic anus T  axil – anus T  (% 、 color)  function I 0  ≥ ...
nonspecific examination for diagnosis.  blood gas analysis, CT, PT,  blood glucose level, platelet,  electrolytes, BUN, fi...
Differential diagnosis <ul><li>Neonatal edema </li></ul><ul><li>●   Localized edema </li></ul><ul><li>●   Premature infant...
Neonatal  edema
Differential diagnosis <ul><li>Subcutaneous gangrene </li></ul><ul><li>-  staphylococcus aureus </li></ul><ul><li>-compres...
Neonatal Subcutaneous Gangrene
treatment Heat loss Heat production Correction of organ dysfunction normal  body temperature organs function
Treatment ●   Restoration of body temperature ●   Energy supply and fluid infusion ●   Correction of organ dysfunction ·  ...
Treatment <ul><li>Rewarming </li></ul><ul><li>●   T R  >30 ℃, TA-R≥0 </li></ul><ul><li>--Placed in a neutral thermal  </li...
Treatment <ul><li>●   T R  < 30 ℃,  TA-R<0 </li></ul><ul><li>Placed in a incubator where environmental temperature higher ...
Treatment Ways of re-warming ●   Incubator ●   Open radiant warmer bed ●   Others water bath, electric blanket ,  Kangaroo...
Incubator
 
Open radiant warmer bed
Huge omphalocele( 巨大脐膨出)
 
 
 
 
 
kangaroo care
Prevention ●   Neonatal care:  warm environment,  enough clothes ●   Encourage early breast feeding ●   Prevent high risk ...
 
Conclusion and Review ●   How to diagnose neonatal sepsis? ●   Which marker can indicate neonatal  infection? ●   How many...
Thank You
Mini case discussion
Clinical case presentation <ul><li>Patient1:10.09.06 </li></ul><ul><li>Sex: male </li></ul><ul><li>GA:32 +2 W </li></ul><u...
 PROM  of 2days intrapartum ampicillin because of PROM( pre-rupture of membrane )  and maternal elevation of CRP  Admitt...
<ul><li>Frequent apnea 2 hrs after birth, </li></ul><ul><li>aminophyllin and CPAP ( continuous positive airway pressure ) ...
<ul><li>The general condition was stable after D 3  except poor enteral feeding. </li></ul><ul><li>On postnatal D 13 , he ...
05/26/10
Questions <ul><li>What kinds of diseases did the baby suffer? Predisposing factor? </li></ul><ul><li>What kinds of Lab tes...
Septic work-ups <ul><li>Complete Blood Count </li></ul><ul><li>Blood & Urine cultures </li></ul><ul><li>Lumbar Puncture </...
 
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Neonatal cold injury syndrome

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Neonatal cold injury syndrome

  1. 1. Neonatal Cold Injury Syndrome (sclerema neonatorum)
  2. 2. Objectives What will I learn? Etiologies and pathophysiology Symptoms Diagnosis Treatment
  3. 3. Definition -- mainly caused by cold stress --the clinical features are low body temperature and scleredema --serious one may appear multiple organ dysfunction. Scleredema --- hardening of the skin and subcutaneous tissue
  4. 4. Etiology and pathophysiology Characteristics of temperature regulation and subcutaneous fatty composition in newborn ● immaturity of temperature regulation center ● relative large surface area and rich blood flow cause poor thermal insulation
  5. 5. ● limited storage of energy, heat production mainly by brown fatty metabolism, lacking shivery thermogenesis ● more quantity of saturated fatty acid with higher melting point Imbalance between heat production and loss
  6. 6. Distribution of neonatal brown fat
  7. 7. Cold injury ● Cold environment increase heat loss, low body temperature causes constriction of peripheral blood vessels, dysfunction of microcirculation ● Low body temperature and cold environment cause anoxia , metabolic disturbance and acidosis even multiple organ dysfunction ( MOD )
  8. 8. Other Factors ● severe infection, ● premature, ● asphyxia, ICH, ● erythroblastosis
  9. 9. Imbalance between heat production and loss Heat production Non-enough intake √ √ √ cold √ asphyxia infection
  10. 10. Imbalance between heat production and loss Heat loss cold √ relative larger surface √ cold √ immature of temperature center
  11. 11. immature of temperature center relative larger surface cold 、 non-enough intake infection 、 asphyxia heat production of brown fat↓ anoxia, acidosis higher saturated fatty acid higher melt point body temperature ↓ coagulation of subcutaneous fat Pathogenesis of Neonatal Scleredema
  12. 12. Anoxia, acidosis coagulation of subcutaneous fat constriction of skin vessels anoxia of tissue hardening of skin Slowly blood flow disturbance of microcirculation capillary permeability ↑ edema circulating volume↓ shock multiple organs dysfunction DIC
  13. 13. ● usually occur in cold season ● during first 3 days or any time in preterm infants ● Low body temperature ● Scleredema ● MOD in severe case Clinical Manifestations
  14. 14. ● feature: skin and subcutaneous tissue become indurated, woody, non-pitting, cold to touch, involved area may with edema, redness, cyanosis; symmetrical ● Sequence : calves->thighs->low extremities->buttock->cheeks->upper extremities->whole body Scleredema
  15. 15. Neonatal scleredema
  16. 17. multiple organ dysfunction ● bradycardia, dyspnea, ● microcirculation disturbance, ● shock, DIC , ● acute renal failure, ● pulmonary hemorrhage
  17. 18. Evaluation of body surface area Head and neck 20% Upper limbs 18% Anterior part of trunk 14% Posterior part of trunk 14% Buttock 8% Lower limbs 26% 20% 9% 9% 14% 14% 8% 13% 13%
  18. 19. Degrees of NCIS Body temperature(℃) involved area change of organic anus T axil – anus T (% 、 color) function I 0 ≥ 35 positive < 20 no change (mild) pale II 0 < 35 0 or positive 20 ~ 50 poor reaction (moderate) dark red bradycardia III 0 < 35 negative > 50 shock 、 DIC 、 (severe) or < 30 cyanotic PH or ARF
  19. 20. nonspecific examination for diagnosis. blood gas analysis, CT, PT, blood glucose level, platelet, electrolytes, BUN, fibrogen, etc. EKG, X - ray Laboratory Examination
  20. 21. Differential diagnosis <ul><li>Neonatal edema </li></ul><ul><li>● Localized edema </li></ul><ul><li>● Premature infant edema </li></ul><ul><li>-- hypoalbuminemia, hyponatremia </li></ul><ul><li>● Hemolytic disease of newborns </li></ul><ul><li>- anemia, splenohepatomegaly or Jaundice </li></ul><ul><li>● Congenital nephrosis </li></ul><ul><li>- abnormal in urine </li></ul>
  21. 22. Neonatal edema
  22. 23. Differential diagnosis <ul><li>Subcutaneous gangrene </li></ul><ul><li>- staphylococcus aureus </li></ul><ul><li>-compressive site or impaired site </li></ul><ul><li>-swelling, blush, hard </li></ul><ul><li>-darkening, bleed, ulcer </li></ul><ul><li>-obscure boundary </li></ul>
  23. 24. Neonatal Subcutaneous Gangrene
  24. 25. treatment Heat loss Heat production Correction of organ dysfunction normal body temperature organs function
  25. 26. Treatment ● Restoration of body temperature ● Energy supply and fluid infusion ● Correction of organ dysfunction · correction of acidosis and volume expansion · treatment of pulmonary hemorrhage · arrangement of ARF and DIC ● Others: antibiotics, symtomatic therapy
  26. 27. Treatment <ul><li>Rewarming </li></ul><ul><li>● T R >30 ℃, TA-R≥0 </li></ul><ul><li>--Placed in a neutral thermal </li></ul><ul><li>environment </li></ul><ul><li>--Returned to normal temperature </li></ul><ul><li>during 6~12 hours </li></ul>
  27. 28. Treatment <ul><li>● T R < 30 ℃, TA-R<0 </li></ul><ul><li>Placed in a incubator where environmental temperature higher 1~2 ℃ than body temperature( 0.5-1℃/h ) </li></ul><ul><li>Kept in a neutral thermal environment when T R ≥ 35 ℃ </li></ul><ul><li>Returned to normal temperature during 12~24 hours </li></ul>
  28. 29. Treatment Ways of re-warming ● Incubator ● Open radiant warmer bed ● Others water bath, electric blanket , Kangaroo Care, etc
  29. 30. Incubator
  30. 32. Open radiant warmer bed
  31. 33. Huge omphalocele( 巨大脐膨出)
  32. 39. kangaroo care
  33. 40. Prevention ● Neonatal care: warm environment, enough clothes ● Encourage early breast feeding ● Prevent high risk factors: premature, infection, asphyxia
  34. 42. Conclusion and Review ● How to diagnose neonatal sepsis? ● Which marker can indicate neonatal infection? ● How many factors can cause NCIS? ● Which complication is caused by NCIS? ● State the clinic S/S and degrees of NCIS.
  35. 43. Thank You
  36. 44. Mini case discussion
  37. 45. Clinical case presentation <ul><li>Patient1:10.09.06 </li></ul><ul><li>Sex: male </li></ul><ul><li>GA:32 +2 W </li></ul><ul><li>BW:1240g </li></ul><ul><li>Vaginal delivery Apgar:8-10-10 </li></ul><ul><li>Umbilical pH:7.22 </li></ul>
  38. 46.  PROM of 2days intrapartum ampicillin because of PROM( pre-rupture of membrane ) and maternal elevation of CRP  Admitted to NICU duo to prematurity  General condition is unstable
  39. 47. <ul><li>Frequent apnea 2 hrs after birth, </li></ul><ul><li>aminophyllin and CPAP ( continuous positive airway pressure ) was given for 3 days and apnea disappeared. </li></ul><ul><li>Because of VLBW, umbilical venous catheterization was performed on D 1 and the catheter was removed on D 7 . PICC ( peri-intravenous central-line catheterization ) was inserted on D 7 . </li></ul>
  40. 48. <ul><li>The general condition was stable after D 3 except poor enteral feeding. </li></ul><ul><li>On postnatal D 13 , he was getting worse : tachypnea, tachycardia, pale, grunting , abdominal distention, cyanosis, low BP and hypothemia. </li></ul><ul><li>-- antibiotics , IVIG, CPAP was given . </li></ul>
  41. 49. 05/26/10
  42. 50. Questions <ul><li>What kinds of diseases did the baby suffer? Predisposing factor? </li></ul><ul><li>What kinds of Lab tests would you order? </li></ul><ul><li>How can you save his life? </li></ul><ul><li>How about his prognosis? </li></ul>
  43. 51. Septic work-ups <ul><li>Complete Blood Count </li></ul><ul><li>Blood & Urine cultures </li></ul><ul><li>Lumbar Puncture </li></ul><ul><li>Chest X-Ray </li></ul><ul><li>Line cultures </li></ul>

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