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Infeksi Jamur pada Paru                          1
COCCIDIOIDOMYCOSIS
COCCIDIOIDOMYCOSISIt may occur as either an acute, benign, self-limited disease or a chronic, malignantdisseminated diseas...
Coccidioidomycosis: Valley Fever• Coccidioides immitis - causes coccidioidomycosis• Distinctive morphology – blocklike art...
PORTAL OF ENTRYINHALATIONINOCULATION     (Rare)
Pulmonary Symptoms•   Anorexia•   Shortness of breath•   Weight loss•   Productive cough•   Night sweats•   Arthralgia•   ...
ECOLOGICAL ASSOCIATION• Desert soil   Archeological middens   Pottery   Rodent burrows   Cotton   Construction sites
SOIL____________               ARTHROCONIDIA  ANIMAL               ENDOSPORES  HUMAN                   SPHERULE
CLINICAL SPECIMENS        Sputum           Pus    Gastric washings           CSF   Bronchial washings     Biopsy material
SEROLOGICAL TESTS•   Complement fixation•   Immunodiffusion•   Slide agglutination•   EIA
DRUGS OF CHOICE• Fluconazole      (mild infection)• Itraconazole     (mild infection)• Amphotericin B    (severe infections)
Infeksi jamur pada paru 3
Infeksi jamur pada paru 3
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Infeksi jamur pada paru 3

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Infeksi jamur pada paru 3

  1. 1. Infeksi Jamur pada Paru 1
  2. 2. COCCIDIOIDOMYCOSIS
  3. 3. COCCIDIOIDOMYCOSISIt may occur as either an acute, benign, self-limited disease or a chronic, malignantdisseminated disease involving thecutaneous, subcutaneous, visceral or osseoustissue.
  4. 4. Coccidioidomycosis: Valley Fever• Coccidioides immitis - causes coccidioidomycosis• Distinctive morphology – blocklike arthroconidia in the free-living stage and spherules containing endospores in the lungs• Lives in alkaline soils in semiarid, hot climates and is endemic to southwestern U.S.• Arthrospores inhaled from dust, creates spherules and nodules in the lungs• Amphotericin B treatment 4
  5. 5. PORTAL OF ENTRYINHALATIONINOCULATION (Rare)
  6. 6. Pulmonary Symptoms• Anorexia• Shortness of breath• Weight loss• Productive cough• Night sweats• Arthralgia• Erythema multiforme
  7. 7. ECOLOGICAL ASSOCIATION• Desert soil Archeological middens Pottery Rodent burrows Cotton Construction sites
  8. 8. SOIL____________ ARTHROCONIDIA ANIMAL ENDOSPORES HUMAN SPHERULE
  9. 9. CLINICAL SPECIMENS Sputum Pus Gastric washings CSF Bronchial washings Biopsy material
  10. 10. SEROLOGICAL TESTS• Complement fixation• Immunodiffusion• Slide agglutination• EIA
  11. 11. DRUGS OF CHOICE• Fluconazole (mild infection)• Itraconazole (mild infection)• Amphotericin B (severe infections)

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