Powerpoint david healy

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De Powerpoint van de lezing van David Healy, gegeven op 15/02/'12 in Gent voor Studium Generale.

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Powerpoint david healy

  1. 1. PinelLa ManieFalretFolie circulaireBaillargerFolie a double forme
  2. 2. BELGIUM MANIC-DEPRESSIVE ILLNESS WAS 10 per million new cases per year 100 new cases per year8 Times less common than Schizophrenia
  3. 3. Articles on Mood Stabilizers 140 120 100Number 80 N 60 40 20 0 1985 1987 1989 1991 1993 1995 1997 1999 2001 2003 2005
  4. 4. Bipolar & Manic-Depressive Publications 1960-2007 Medline600500400300200100 0
  5. 5. EVIDENCE BASED MEDICINE
  6. 6. All studies of life expectancy on antipsychoticsShow a doubling of mortality ratesAnd a reduction of life expectancyAll studies of prophylaxis with mood stabilizersShow a doubling of suicidal act risk compared to placeboValproate and other mood stabilizersare among the most teratogenic drugs in medicine
  7. 7. 1870Weighing Scales1873Anorexia Nervosa1920sScales in Drugstores1920sIncrease in Eating Disorders1960sBathroom Scales1960sBulimia Nervosa
  8. 8. SuicideDivorceAlcoholismSubstance AbuseCareer Failure
  9. 9. 1997 Zyprexa MDL Documents
  10. 10. Zyprexa MDL Documents
  11. 11. Zyprexa MDL Documents
  12. 12. Zyprexa MDL Documents
  13. 13. BELGIUM MANIC-DEPRESSIVE ILLNESS WAS 10 per million new cases per year 100 new cases per year8 Times less common than Schizophrenia BIPOLAR DISORDER IS 5% + of Belgium 400,000 Belgians As common as Depression10 times commoner than Schizophrenia
  14. 14. THEODOREZIEHEN
  15. 15. Many of the mothers we interviewed remembered their baby’s excessive activity in utero. 1/ While my daughter was in the womb, she kickedso hard and often that I had very little rest… much ofthe time it felt like she was in a fight - rolling andtumbling around and then, when she was born.. shekept all the other babies up with her screaming. 2/ I too noticed signs that this was an extra-spiritedchild. In fact, while I was pregnant, I remembersaying, “Uh-oh, the baby is angry again.” His kickswould last for an hour as I doubled over in pain..3/ “At 14 weeks the sonographer and obstetricianwere unable to get a picture of Ian’s face and could notsample the amniotic fluid due toconstant, unpredictable activity.”
  16. 16. EVIDENCE BASED MEDICINE
  17. 17. J American Academy of Child & Adolescent Psychiatry 42, 1494-1503
  18. 18. Car dans la Manie,comme dans beaucoup d’autres maladies,s’il y a un artde bien administrer les médicamentes,il y a un art encore plus grandde savoir quelquefois s’en passer.Philippe Pinel 1800.
  19. 19. www.davidhealy.org www.Rxisk.org
  20. 20. www.davidhealy.org www.Rxisk.org
  21. 21. Dear Dr Healy,Thank you very much for all your hard work on thisarticle. Im afraid weve run into a legal wall with ourlibel lawyer reluctant for us to publish your piece… Iremain supportive of publication but obviously cant dothis against legal advice.Our lawyer has several questions that he wants us toaddress at this stage. He isnt ruling outpublication, but we need to reassure him about thefacts first.Best wishes,
  22. 22. UNMET NEEDSBipolar disorder 5%Under-acknowledged and under-researchedMy doc and I decided not to have antidepressantsIdentify triggers ….My feelings of persecution are really …In my most recent episode I used a mood scale ..
  23. 23. Zyprexa MDL Documents

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