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Originally isolated in glioblastoma, Gli1 binds to the DNA consensus sequence 5'-GACCACCCA-3'. The Gli proteins are effectors of Hedgehog (Hh) signalling, and play a role in cell fate determination. proliferation and organ cell patterning during embryo development. In the developing spinal cord the target genes of Gli proteins, that are themselves transcription factors, are arranged into a complex gene regulatory network that translates the extracellular concentration gradient of Sonic hedgehog into different cell fates along the dorsoventral axis.
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