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ProfessorProfessorAbdur-Rab KhanAbdur-Rab KhanMRCP- FRCP (UK)MRCP- FRCP (UK)Ayub Medical College AbbottabadAyub Medical Co...
Diagnosis of AsthmaDiagnosis of Asthma
HistoryHistory
Peak Expiratory Flow RatePeak Expiratory Flow Rate(PEFR)(PEFR) Measures how fast a person can exhale air Requires a peak...
PEFR VariabilityPEFR VariabilityAsthma Diagnostic Clues:• PEF Variability > 20%(basis: home monitoring 2-4x/dayfor 1-2 wee...
SpirometrySpirometry Recommended for the initial assessment of allasthma suspects!
> 15% increase in FEV1.0after ß-2 inhalationHallmark of Asthma: Reversibility!Spirometry
Types of FlowVolume CurvesNormal ObstructiveLiterspersecondConcavityAsthmaConcavitypre-bronchodilatorImprovedpost-bronchod...
Good MeasurementsGood Measurementsare Essential!are Essential!AcceptableLoopUnacceptableLoop
Is it Asthma?Determine that the patient isexperiencing episodic symptomsof airflow obstructionDemonstrate that theobstruct...
AsthmawheezingLung Disease OverlapChronicBronchitiscough+sputumEmphysemabreathlessnessAirway Remodeling inAsthmaDenudation...
Classifying Severity:BASED ON SYMPTOMS & LUNG FUNCTIONDaytimeSymptomsExacerbations Nightattacks11223344IntermittentIntermi...
THANK YOUTHANK YOU
Asthma diagnosis
Asthma diagnosis
Asthma diagnosis
Asthma diagnosis
Asthma diagnosis
Asthma diagnosis
Asthma diagnosis
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Asthma diagnosis

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Asthma diagnosis

  1. 1. ProfessorProfessorAbdur-Rab KhanAbdur-Rab KhanMRCP- FRCP (UK)MRCP- FRCP (UK)Ayub Medical College AbbottabadAyub Medical College Abbottabad
  2. 2. Diagnosis of AsthmaDiagnosis of Asthma
  3. 3. HistoryHistory
  4. 4. Peak Expiratory Flow RatePeak Expiratory Flow Rate(PEFR)(PEFR) Measures how fast a person can exhale air Requires a peak expiratory flow monitorOmronMini-Wright AM2 Plus
  5. 5. PEFR VariabilityPEFR VariabilityAsthma Diagnostic Clues:• PEF Variability > 20%(basis: home monitoring 2-4x/dayfor 1-2 weeks)• Improvement in baseline PEF by20% after a 2-week therapeutictrialPEFmax - PEFminPEFave(pm, post-bd) (am, pre-bd)% Variability = X 1000501001502002503003501 2 3 4 5 6 7DaysPEFR(L/min)pm PEFRam PEFR
  6. 6. SpirometrySpirometry Recommended for the initial assessment of allasthma suspects!
  7. 7. > 15% increase in FEV1.0after ß-2 inhalationHallmark of Asthma: Reversibility!Spirometry
  8. 8. Types of FlowVolume CurvesNormal ObstructiveLiterspersecondConcavityAsthmaConcavitypre-bronchodilatorImprovedpost-bronchodilator
  9. 9. Good MeasurementsGood Measurementsare Essential!are Essential!AcceptableLoopUnacceptableLoop
  10. 10. Is it Asthma?Determine that the patient isexperiencing episodic symptomsof airflow obstructionDemonstrate that theobstruction is at least partiallyreversibleExclude alternate diagnoses
  11. 11. AsthmawheezingLung Disease OverlapChronicBronchitiscough+sputumEmphysemabreathlessnessAirway Remodeling inAsthmaDenudation of the airwayepitheliumCollagen depositionbeneath the basementmembraneEdemaMast cell activationInflammatory cellinfiltrationCOPD
  12. 12. Classifying Severity:BASED ON SYMPTOMS & LUNG FUNCTIONDaytimeSymptomsExacerbations Nightattacks11223344IntermittentIntermittent• <1x a week • BriefMildMildpersistentpersistent• >1x a weekbut < 1x/day• May affectactivity &sleepModerateModeratepersistentpersistent• Daily • May affectactivity &sleepSevereSeverepersistentpersistent• < 2x amonth• > 2x amonth• > oncea week• Frequent• Daily • Frequent• LimitsphysicalactivityFEV1 or PEF• > 80% predicted• Variability < 20%• > 80% predicted• Variability 20-30%• > 60-80%predicted• Variability > 30%• < 60% predicted• Variability > 30%
  13. 13. THANK YOUTHANK YOU

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