08b growth regulation-2010 update-stacy

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08b growth regulation-2010 update-stacy

  1. 2. Anterior Pituitary <ul><li>responsible for physical growth </li></ul><ul><li>growth hormone ( GH ) – levels dictate amount of growth in developing organism </li></ul><ul><ul><li>peptide hormone </li></ul></ul>
  2. 3. Growth Hormone Regulation hypothalamus growth hormone releasing hormone (GHRH) growth hormone inhibiting hormone (GHIH) anterior pituitary growth hormone (GH) GH half-life is 20 – 30 min
  3. 4. Growth Hormone Effects <ul><li>cartilage & bone – increased length and width of skeleton </li></ul><ul><li>muscle cells – increased cell number ( hyperplasia ) and cell size ( hypertrophy ) </li></ul><ul><li>ribosome function – increased protein production </li></ul><ul><li>fat metabolism – fatty acids as energy source </li></ul>
  4. 5. Growth Hormone Abnormalities <ul><li>Dwarfism </li></ul><ul><li>Gigantism </li></ul><ul><li>Acromegaly </li></ul>
  5. 6. Dwarfism <ul><li>Cause: </li></ul><ul><ul><li>decreased GH secretion during childhood </li></ul></ul><ul><li>Result: </li></ul><ul><ul><li>limited height (4 feet tall) </li></ul></ul><ul><ul><li>normal proportions </li></ul></ul>
  6. 7. Dwarfism
  7. 8. Gigantism <ul><li>Cause: </li></ul><ul><ul><li>increased GH secretion during childhood </li></ul></ul><ul><li>Symptom: </li></ul><ul><ul><li>height much taller than average </li></ul></ul><ul><li>Treatment: </li></ul><ul><ul><li>surgery if hypersecretion due to tumor growth on pituitary </li></ul></ul>
  8. 9. Gigantism Robert Wadlow World’s tallest man at 8 feet 11.1 inches
  9. 10. Size 12 Size 25
  10. 11. Tallest person alive <ul><li>Sultan Kosen, born in Turkey </li></ul><ul><li>8 feet 1 inch </li></ul>http://www.youtube.com/watch?v=ODFHC2XCtjU
  11. 12. Acromegaly <ul><li>Cause: </li></ul><ul><ul><li>increased GH secretion as an adult </li></ul></ul><ul><li>Symptom: </li></ul><ul><ul><li>bone lengthening has stopped </li></ul></ul><ul><ul><ul><li>bone width increases </li></ul></ul></ul><ul><li>Treatment: </li></ul><ul><ul><li>surgery if hypersecretion due to tumor growth on pituitary </li></ul></ul>
  12. 14. Professional Sports

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