02 oxi decarboxy-krebcycle

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02 oxi decarboxy-krebcycle

  1. 2. Oxidative Decarboxylation
  2. 3. Oxidative Decarboxylation <ul><li>Pyruvate is converted into acetyl-CoA in order to be brought into the mitochondria. </li></ul>
  3. 4. Oxidative Decarboxylation <ul><li>rxn type: decarboxylation </li></ul><ul><li> redox </li></ul><ul><li> synthesis </li></ul><ul><li>enzyme: decarboxylase </li></ul><ul><li> dehydrogenase </li></ul><ul><li> synthase </li></ul><ul><li>energy: released </li></ul>
  4. 5. Coenzyme A <ul><li>Coenzyme A is a large organic molecule. </li></ul><ul><li>The active functional group is a thiol . </li></ul><ul><li>It is also written as </li></ul><ul><li>CoA- SH . </li></ul>
  5. 6. Oxidative Decarboxylation Summary <ul><li>2 pyruvate  2 acetyl-CoA </li></ul><ul><li>2 CO 2 released </li></ul><ul><li>2 NADH produced </li></ul>
  6. 8. Krebs Cycle
  7. 9. Krebs Cycle Function <ul><li>Krebs cycle is a cyclical process to: </li></ul><ul><li>produce additional CO 2 molecules </li></ul><ul><li>generate more high energy molecules (NADH, FADH 2 and ATP) </li></ul><ul><li>Also known as the citric acid cycle and the tricarboxylic acid cycle ( TCA ). </li></ul>
  8. 10. Krebs Cycle
  9. 11. Krebs Cycle: Step by Step <ul><li>Step 1: </li></ul><ul><li>join 2 carbon molecule with a 4 carbon molecule </li></ul><ul><li>rxn type: synthesis </li></ul><ul><li>enzyme: synthase </li></ul><ul><li>energy: absorbed </li></ul>
  10. 12. Krebs Cycle: Step by Step <ul><li>Step 2: </li></ul><ul><li>rearrangement of atoms with the help of H 2 O </li></ul><ul><li>rxn type: isomerization </li></ul><ul><li>enzyme: isomerase </li></ul><ul><li>energy: equilibrium </li></ul>
  11. 13. Krebs Cycle: Step by Step <ul><li>Step 3: </li></ul><ul><li>synthesis of CO 2 and NADH </li></ul><ul><li>rxn type: decarboxylation </li></ul><ul><li> redox </li></ul><ul><li>enzyme: decarboxylase </li></ul><ul><li> dehydrogenase </li></ul><ul><li>energy: released </li></ul>
  12. 14. Krebs Cycle: Step by Step <ul><li>Step 4: </li></ul><ul><li>CO 2 release and energy molecule formation </li></ul><ul><li>rxn type: decarboxylation </li></ul><ul><li> redox </li></ul><ul><li> synthesis </li></ul><ul><li>enzyme: decarboxylase </li></ul><ul><li> dehydrogenase </li></ul><ul><li>energy: released </li></ul>
  13. 15. Krebs Cycle: Step by Step <ul><li>Step 5: </li></ul><ul><li>ADP phosphorylation to ATP </li></ul><ul><li>rxn type: substrate-level phosphorylation </li></ul><ul><li>cleavage </li></ul><ul><li>enzyme: kinase </li></ul><ul><li> lyase </li></ul><ul><li>energy: released </li></ul>
  14. 16. Krebs Cycle: Step by Step <ul><li>Step 6: </li></ul><ul><li>FADH 2 (energy molecule) formation </li></ul><ul><li>rxn type: redox </li></ul><ul><li>enzyme: dehydrogenase </li></ul><ul><li>energy: released </li></ul>
  15. 17. FAD / FADH 2 <ul><li>FAD – flavin adenine dinucleotide (oxidized form) </li></ul><ul><li>FADH 2 – flavin adenine dinucleotide (reduced form) </li></ul>
  16. 18. Krebs Cycle: Step by Step <ul><li>Step 7: </li></ul><ul><li>rearranging the molecule for the next reaction </li></ul><ul><li>rxn type: hydration </li></ul><ul><li>enzyme: hydrase </li></ul><ul><li>energy: absorbed </li></ul>
  17. 19. Krebs Cycle: Step by Step <ul><li>Step 8: </li></ul><ul><li>energy molecule formation & recreating molecules for Krebs cycle </li></ul><ul><li>rxn type: redox </li></ul><ul><li>enzyme: dehydrogenase </li></ul><ul><li>energy: released </li></ul>
  18. 20. Krebs Cycle Summary <ul><li>two cycles of Krebs for EACH glucose molecule </li></ul><ul><li>acetyl-CoA  oxaloacetate (per cycle) </li></ul><ul><li>2 CO 2 released (per cycle) </li></ul><ul><li>3 NADH produced (per cycle) </li></ul><ul><li>1 FADH 2 produced (per cycle) </li></ul><ul><li>1 ATP produced (per cycle) </li></ul>
  19. 23. Krebs Cycle: Big Picture Perspective <ul><li>Many of the components of Krebs cycle are used in many other types of metabolic processes. </li></ul>

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