Blood cell morphology.ppt

Blood cell morphology
Dr RASHAD S. M. Al-KHWLANY
Normal RBCs
Reticulocyte
Hypochromic RBCs
Hypochromic RBCs
Poikilocytes
Anisocytosis
Spherocytes (Microcyte)
Spherocytes (Microcyte)
Spherocytes (Microcyte)
Macrocyte (Megalocytes)
Macrocyte (Megalocytes)
Elliptocytes (ovalocytes)
Elliptocytes (ovalocytes)
Target cell
Target cell
Tear drop cell (Dacryocytes)
Tear drop cell (Dacryocytes)
Basophilic stippling
Polychromatic erythrocytes
Howell-Jolly bodies
Acanthocytes
Acanthocytes
Burr cells (crenated cells)
Burr cells (crenated cells)
Sickle cells (drepanocytes)
Sickle cells (drepanocytes)
Stomatocytes
Stomatocytes
Rouleaux
Rouleaux
Schizocytes (fragmentocytes)
Schizocytes (fragmentocytes)
Blister Cells
Siderocytes
Erythrocyte recognizable
maturation
WBC Morphology
Blood cell morphology.ppt
The granulocytic maturation series
Myeloblast Promyelocyte Myelocyte Metamyelocyte Band Neutrophil
The maturation sequence
Myeloblast Promyelocyte Myelocyte Metamyelocyte Band Neutrophil
Morphological Maturation for Granulocytes
Examples: N/C ratio
N/C ratio decreases
as cell matures
Myeoblast
Myelocyte
Metamyelocyte Band Neutrophil
Nuclear Shape
The shape of the nucleus may aid in the identification of a cell
From regular round to
irregular in shape as
the cell matures
Myeloblast
Myeloblast
Myeloblast
Myeloblast
Myeloblast and
Polychromatophilic
normoblasts
Myeloblast
Myeloblasts, and Lymphocyte
Myeloblast, band neutrophil
Myeloblasts with few granules,
type 2 and 3
Myeloblasts with Auer rods
These rods are only found in myeloblasts and not in
any other blasts, such as lymphoblast or monoblast
on megakaryoblast
Blood cell morphology.ppt
Auer Rods
Promyelocyte
Promyelocyte
Promyelocyte
Promyelocyte or also called
progranulocyte
Promyelocyte
Myeloblast and Promyelocyte
for comparison
Myeloblast
Promyelocyte
Myelocyte
Myelocyte
Eosino and Neutro myelocytes
Eosino and Neutro Myelocyte
Band neutrophil,
metamyelocyte, neutrophilic
myelocyte
Early Eosino and Neutro
Myelocytes
One Eosinophilic myelocyte (lower left), 1 neutrophilic myelocyte,
1 segmented neutrophil, 1 orthochromic NRBC
Neutrophilic Myelocyte
Neutrophilic Myelocyte
Metamyelocyte
Metamyelocyte
Neutro Metamyelocyte
Eosinophilic Metamyelocyte
Bands or Stabs
Neutro Band
Eosinophilic Band and Neutro Band
Eosinophil
Basophil
Basophil
Basophil
Basophil
Monocyte
Plasma cell
Atypical Lymphocytes
Neutro filaments
Blood cell morphology.ppt
Red arrow = Band neutrophil, Green arrow = Segmented neutrophil, Yellow arrow =
Myeloblast in transition to promyelocyte, Blue arrow = promyelocyte, Black arrows =
Plasma cells.
Eosinophils
Seg.Neutro, Lymphocyte and
monocyte
Immature Mature
Pronormoblast and Myeloblast
‫ا‬ ‫على‬ ‫التعرف‬ ‫في‬ ‫يفيد‬ ‫ان‬ ‫يمكن‬ ‫الستوبالزم‬ ‫لون‬ ‫إذا‬ ،‫المختلفة‬ ‫الخاليا‬ ‫بين‬ ‫الستوبالزم‬ ‫لون‬ ‫يختلف‬ ‫كيف‬ ‫انظر‬
‫المختلفة‬ ‫لخاليا‬
.
‫مختلفة‬ ‫خاليا‬ ‫بين‬ ‫يفرق‬ ‫أو‬ ‫الخلية‬ ‫نفس‬ ‫من‬ ‫المختلفة‬ ‫األطوار‬ ‫بين‬ ‫يفرق‬ ‫أن‬ ‫يمكن‬
.
‫سيت‬ ‫لديها‬ ‫التي‬ ‫الخاليا‬ ‫مثال‬
‫اللون‬ ‫داكن‬ ‫وبالزم‬
‫الصورة‬ ‫هذه‬ ‫في‬ ‫أكثر‬
(
‫ال‬ ‫األسهم‬
‫بيض‬
‫اء‬
)
‫خاليا‬ ‫عليها‬ ‫يطلق‬ ‫والتي‬ ‫متطورة‬ ‫الغير‬ ‫الحمراء‬ ‫للخاليا‬ ‫بصلة‬ ‫تمت‬
‫الـ‬
Pronormoblast
.
‫الـ‬ ‫خلية‬ ‫الى‬ ‫يشير‬ ‫األحمر‬ ‫السهم‬ ‫بينما‬
Myeloblast
Promyelocyte and Polychromatophilic normoblast
Promyelocyte with
azurophilic granules that
also cover the nucleus
Neutrophil
Polychromatophilic
normoblast
Inclusion bodies: Auer rods
Auer Rods (which are
aggregates of
azurophilic granules)
are found only in
Myeloblasts and
promyelocytes
‫الـ‬ ‫شفت‬ ‫علطول‬ ‫يعنى‬Auer Rods ‫على‬ ‫الخلية‬ ‫تشخص‬
‫انها‬Myeloblast ‫عيونك‬ ‫مغمض‬ ‫وأنت‬
.
‫الحالة‬ ‫وتشخص‬
‫انها‬ ‫على‬Acute Myeloblastic Leukemia
(AML)
Auer rod
Auer Rods. Auer rods are rods or spindle-shaped, cytoplasmic
inclusions. They stain red-purple and are 1 to 6 microns long and
less than 1.5 microns thick. They are frequently found in leukemias.
Auer rod
Multiple Auer Rods in Promyelocytes
‫الـ‬
Auer Rods
‫الـ‬ ‫خاليا‬ ‫في‬ ‫توجد‬ ‫وعادة‬ ‫متعددة‬
.Promyelocytes
‫العصي‬ ‫هذي‬ ‫تجد‬ ‫عندما‬
(
Auer Rods
)
‫انها‬ ‫على‬ ‫الحالة‬ ‫تشخص‬
Acute
Myeloblastic Leukemia (AML)
‫انها‬ ‫على‬ ‫تشخص‬ ‫الحالة‬ ‫فان‬ ‫عادة‬ ‫متعددة‬ ‫تجدها‬ ‫عندما‬ ‫ولكن‬
Acute Promyelocytic Leukemia (AML-M3)
‫خلية‬ ‫على‬ ‫ويطلق‬
Promyelocyte
‫بالـ‬ ‫متعددة‬ ‫عصي‬ ‫على‬ ‫تحتوي‬ ‫التي‬
Faggot Cell
Normal Blood Cells
Neutrophils
Band form Neutrophils
• There are smaller
numbers of cells of
neutrophil lineage with
non-segmented nuclei.
They are referred to as
neutrophil band cells or
band forms. They are less
mature than segmented
neutrophils.
• An increased number of
band cells is referred to as
a'left shift'.
Eosinophil
Basophil
Basophils
Granulation and type of granules
Basophil
Seg. Neutrophil
Eosinophil
Normal lumphocytes
Normal monocyte
Monocytes
Platelet aggregates
1 of 105

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Blood cell morphology.ppt