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AMOUD UNIVERSITY
SCHOOL OF DENTISTRY
1ST YEAR STUDENTS
Course Title: DNS6116
Course Code: Genetics
Lecturer: Harun Ismail Warsame(BSc/MPH)
Chapter 5: Modes of Inheritance
Lesson 1
Learning Objectives
1. Define modes of inheritance.
2. Discuss the modes of inheritance.
Mode of Inheritance
Mode of Inheritance is the
manner in which a genetic
trait or disorder is passed
from one generation to the
next.
Categories of modes of
inheritance
Mode of Inheritance includes:
1. Autosomal dominant
2. autosomal recessive
3. X-linked dominant
4. X-linked recessive, and
5. mitochondrial inheritance are
examples.
Each mode of inheritance results in
a characteristic pattern of affected
and unaffected family members.
Autosomal vs X-linked
 Autosomal and X-linked are two types of
inheritance patterns that describe the inheritance
of a particular genetic trait from one generation to
the next.
 The main difference between autosomal and X-
linked is that autosomal inheritance is the
inheritance of traits that are determined by
the genes in the autosome whereas X-linked
inheritance is the inheritance of traits
determined by the genes in one of the sex
chromosomes.
Autosomal Dominant
Autosomal dominant
inheritance is refers to
genetic conditions that occur
when a variant is present in
one copy of a given gene (i.e.,
the person is heterozygous).

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Chapter 5 Modes of Inheritance.pptx

  • 1. AMOUD UNIVERSITY SCHOOL OF DENTISTRY 1ST YEAR STUDENTS Course Title: DNS6116 Course Code: Genetics Lecturer: Harun Ismail Warsame(BSc/MPH)
  • 2. Chapter 5: Modes of Inheritance Lesson 1 Learning Objectives 1. Define modes of inheritance. 2. Discuss the modes of inheritance.
  • 3. Mode of Inheritance Mode of Inheritance is the manner in which a genetic trait or disorder is passed from one generation to the next.
  • 4. Categories of modes of inheritance Mode of Inheritance includes: 1. Autosomal dominant 2. autosomal recessive 3. X-linked dominant 4. X-linked recessive, and 5. mitochondrial inheritance are examples. Each mode of inheritance results in a characteristic pattern of affected and unaffected family members.
  • 5. Autosomal vs X-linked  Autosomal and X-linked are two types of inheritance patterns that describe the inheritance of a particular genetic trait from one generation to the next.  The main difference between autosomal and X- linked is that autosomal inheritance is the inheritance of traits that are determined by the genes in the autosome whereas X-linked inheritance is the inheritance of traits determined by the genes in one of the sex chromosomes.
  • 6. Autosomal Dominant Autosomal dominant inheritance is refers to genetic conditions that occur when a variant is present in one copy of a given gene (i.e., the person is heterozygous).
  • 8. Autosomal Recessive  Autosomal recessive inheritance refers to genetic conditions that occur only when variants are present in both copies of a given gene (i.e., the person is homozygous for a variant, or carries two different variants of the same gene, a state referred to as compound heterozygosity)
  • 10. Mitochondrial  Mitochondria make most of the energy for the cell and have their own genetic material that is different from the genetic material found in the nucleus.  Mitochondrial DNA is the small circular chromosome found inside mitochondria.  The mitochondria, and thus mitochondrial DNA, are passed from
  • 12. X-Linked Dominant  X-linked dominant inheritance refers to genetic conditions associated with variants in genes on the X chromosome.  Example: A single copy of the variant is enough to cause the disease in both males (who have one X chromosome) and females (who have two X chromosomes).  In some conditions, the absence of a functional gene results in the death of affected males.
  • 13. X-Linked Recessive  X-linked recessive inheritance refers to genetic conditions associated with variants in genes on the X chromosome.  Example: A male carrying such a variant will be affected, because he carries only one X chromosome. A female carrying a variant in one gene, with a normal gene on the other X
  • 14. Pedigree The pedigree shows the relationships between family members and indicates which individuals express or silently carry the trait in question.