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Arwa`s seminar on tocos

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a taik in brief about tocotrienols , thier importance and chemical structure by arwa ahmed ali a third year student in food and science technology departement with the sharing of my colleague menna allah ibrahim ghazaly
all the information is obtained from the refrence recommended at the last slide

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Arwa`s seminar on tocos

  1. 1. ARWA AHMED ALI MENNA ALLAH IBRAHIMTOCOTRIENOLS
  2. 2. VE:TOCOTRIENOL AND ITS ISOMERS
  3. 3. WHAT ARE TOCOTRIENOLS • Among the VE compounds tocotrienol exist and possess a unique structure and properties as : antioxidants , anti cancerogenic agents ...etc ( will be discussed in brief) • Tocotrienols have isomers like alpha ,beta, gamma and delta they vary according to : • the strenghth of their properties • And methyl group subistitution on the cromanal ring at ortho or para or meta positions : • Gamma tocotrienol posseses a methyl group at the ortho position and its effective in antioxidation than the other isomers and tocopherols .
  4. 4. TOCOTRIENOL ISOMERS CHEMICAL STRUCTURE
  5. 5. THE BEST SOURCES OF TOCOTRIENOLS
  6. 6. OILY SOURCES FOR TOCOTRIENOLS COCONUT OIL RED PALM OIL RICE-BRAN OIL PALM KERNEL OIL
  7. 7. RED PALM OIL
  8. 8. TOCOTRIENOLS BEST SOURCE •annato
  9. 9. TOCOTRIENOLS VERSUS TOCOPHEROLS • They differ in : • 1-chemical structure • 2-bioavailability • 3-digestion and absorbtion • 4-antioxidative effect
  10. 10. FIRSTLY: CHEMICAL STRUCTURE TOCOTRIENOL • vhave the Unsaturated isoprenoid sidechain possesing double bonds vTheir chemical structure make them more potent than tocopherols in several vitro systems TOCOPHEROL • vhave NO double bonds but saturated phytyl tail Less potent than tocotrienols
  11. 11. COMPARISON TOCOTRIENOL • Chiral centers of tocotrienols prsesnt at c2 where isoprenoid chain binds • Have 2 isomers however it can have 4 geometrical isomers cis/trans at 3' and 7' positions TOCOPHEROL • Have 3 chiral centers • Have 8 isomers
  12. 12. AS SHOWN HERE
  13. 13. ABOUT TOCOTRIENOL ISOMERS In cardio and neuroprotection: Alpha and gamma are more potent than others in rats and humans anti cancer effect (esophagus and prostate and colon cancers )in mouse and human cancer cells in vitro and vivo • Due to their ability to form reactive intermediates that combines DNA beside inhibiting the formation of mutagenic peroxynitriteand nitrosamines that can react with Dna biological molecules **alpha tocotrienols have more molecular weight than gamma ,beta and delta
  14. 14. SECONDELY: DIGESTION AND ABSORBTION • vTocotrienols are poorer and more inferior with regard to tissue retention than alpha tocopherol • They are haif-life in camparison with tocopherols • vTocotrienols penetrate rapidly the skin cells
  15. 15. THIRDLY:ANTIOXIDATIVE EFFECT • vTocotrienols are much better in antioxidation than tocopherol especially alpha tocotrienol WHY? • vDue to its property that can counteract peroxyl and alkoxyl radicals generated during lipid peroxidation so it inhibits continuel hydrogen abstraction thus it inhibits chain propagation step • vThat’s why phospholipids and plasma lipoproteins are not oxidized maintaining good functioning membrane bilayer thanks to tocotrienols role
  16. 16. THIRDLY: BIOAVAILABILITY • Immediately afer oral ingestion tocotrienols are low in bioavailability that’s why its recommended to have a daily intake of its tablets or powder or the oils rich in tocotrienols • Nearly this supplements can overcome • the following demerits of tocotrienols
  17. 17. DEMERITS •tocotrienols v poorly assimilated by digestion vPoorly distributed to tissues in blood vAre rapidly metabolized and eleminated out of the body Low bioavailability
  18. 18. TOCOTRIENOLS BENEFITS
  19. 19. BETTER ANTIOXIDATION • More uniform distribution in the membrane – lipid bilayer Strong disordering of the membrane lipids . Chromanal ring interacts with lipid radicals and prevent continueal oxidation Its effect is in both vivo and vitro systems
  20. 20. PROTEIN OXIDATION • They inhibit oxidation of protein and according to various researches gamma tocotrienols gave better results so they are the strongest inhibitors in this oxidation
  21. 21. ADDITIONAL BENEFITS •vReduces alzheimer`s risk by 55% •vDecrease DNA damage •vAnti cancerogenic properties
  22. 22. FUNCTIONING
  23. 23. HAVE THE ABILITY TO SCAVENGE VARIOUS BIOLOGICALLY RELEVANT FREE RADICALS
  24. 24. INHIBITINH FREE RADICALS
  25. 25. TOCOTRIENOL DIFFICIENCY • it can results in antherosclerosis Due to peroxidation of LDL cholesterol
  26. 26. RECOMMENDED DAILY DOSE •For men 120 mg/kg of body weight the excess dosage causes increasing in liver weights,women 130 mg/kg of body weight •Excess dosage causes reduction in uterus and ovary weights
  27. 27. REFRENCE :
  28. 28. TOCOTRIENOL THANKS YOU

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