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FORMULATIONS   OF  PHARMACEUTICALS AND COSMETICS T.Sudeepthi Final year,B.Pharmacy K.Venkata Ramana Reddy Associate profes...
Formulation of  tablets <ul><li>Active ingredients </li></ul><ul><li>Fillers </li></ul><ul><li>Anti-frictional agents-1-4%...
Film coated tablets <ul><li>API </li></ul><ul><li>Film polymers </li></ul><ul><li>Alloying substances </li></ul><ul><li>Pl...
Dry  syrup <ul><li>API </li></ul><ul><li>Suspending agents </li></ul><ul><li>Sweetners </li></ul><ul><li>Wetting agents </...
Formulation of capsule shell <ul><li>Water-45% </li></ul><ul><li>Plasticizer-0.3-1.8 </li></ul><ul><li>Coloring agent-2% <...
Formulation of empty hard gelatin capsules <ul><li>Gelatin : 80-85%      </li></ul><ul><li>Purified water : 12.5-16%      ...
Formulation of hard gelatin capsules <ul><li>Active ingredients </li></ul><ul><li>Fillers-up to 50% </li></ul><ul><li>Plas...
Formulation of  Soft  gelatin capsules <ul><li>Active ingredients[drug] </li></ul><ul><li>Fillers-up to 50% </li></ul><ul>...
Formulation of ophthalmic ointments <ul><li>Buffering and pH adjustments </li></ul><ul><li>Stabilizers </li></ul><ul><li>a...
Formulation of gels <ul><li>Active ingredient </li></ul><ul><li>Gelling agents-10% </li></ul><ul><li>Surfactants-20-40% </...
Formulation of suppostories <ul><li>Bases </li></ul><ul><li>Surfactants-10% </li></ul><ul><li>Emulsifying agents </li></ul...
Formulation of emulsions <ul><li>Emulsifying agent </li></ul><ul><li>Surfactant-0.05-0.5% </li></ul><ul><li>Anti-foaming a...
Formulation of suspensions <ul><li>Active ingredient </li></ul><ul><li>Wetting agents-0.05-0.5% </li></ul><ul><li>Suspendi...
Parenterals <ul><li>Active ingredient </li></ul><ul><li>Vehicles </li></ul><ul><li>Antioxidants-0.015-0.15% </li></ul><ul>...
Formulation of aerosols <ul><li>Active ingredients-10 </li></ul><ul><li>Propellents-70 </li></ul><ul><li>Dispersing agent ...
Cosmetics
Formulation of lipsticks <ul><li>Wax-20-55% </li></ul><ul><li>Emollients-25-70% </li></ul><ul><li>Pigments-0.5-10% </li></...
Formulation of shaving cream <ul><li>: </li></ul><ul><li>Surfactants-5-20% </li></ul><ul><li>Active agents-0.1-1% </li></u...
<ul><li>Formulation of shampoos </li></ul><ul><li>Anti-dandruff agents </li></ul><ul><li>Surfactants-15-30% </li></ul><ul>...
Formulation of nail polishes <ul><li>Film formers-10-20% </li></ul><ul><li>Resins-2-10% </li></ul><ul><li>Pigments-1-5% </...
FACE POWDER <ul><li>Slipping agents-75% </li></ul><ul><li>Adhesion agents-7.5% </li></ul><ul><li>Absorbent base-1% </li></...
Formulation of toothpaste <ul><li>Abrasives-20-50% </li></ul><ul><li>Surfactants-0.5-2% </li></ul><ul><li>Thickening agent...
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Formulations of pharmaceuticals and cosmetics ppt 1

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Formulations of pharmaceuticals and cosmetics ppt 1

  1. 1. FORMULATIONS OF PHARMACEUTICALS AND COSMETICS T.Sudeepthi Final year,B.Pharmacy K.Venkata Ramana Reddy Associate professor
  2. 2. Formulation of tablets <ul><li>Active ingredients </li></ul><ul><li>Fillers </li></ul><ul><li>Anti-frictional agents-1-4% </li></ul><ul><li>Binders [dry and wet] -1-95% </li></ul><ul><li>Disintegrants-2-20% </li></ul><ul><li>Lubricants-0-10% </li></ul><ul><li>Absorbents </li></ul><ul><li>Glidants-5-10% </li></ul><ul><li>Anti adherants-5-20% </li></ul><ul><li>Dissolution modifiers </li></ul><ul><li>antioxidants </li></ul><ul><li>Colouring agents </li></ul><ul><li>Flavouring agent </li></ul><ul><li>Sweetners </li></ul><ul><li>preservatives </li></ul>
  3. 3. Film coated tablets <ul><li>API </li></ul><ul><li>Film polymers </li></ul><ul><li>Alloying substances </li></ul><ul><li>Plasticizers </li></ul><ul><li>Surfactant </li></ul><ul><li>Opaque and coloring agents </li></ul><ul><li>Sweetening agents </li></ul><ul><li>Flavouring agents </li></ul><ul><li>Glossants </li></ul><ul><li>Volatile solution </li></ul>
  4. 4. Dry syrup <ul><li>API </li></ul><ul><li>Suspending agents </li></ul><ul><li>Sweetners </li></ul><ul><li>Wetting agents </li></ul><ul><li>Buffers </li></ul><ul><li>Flavouring agents </li></ul><ul><li>Coloring agents </li></ul><ul><li>Anti-caking agents </li></ul><ul><li>Preservatives </li></ul>
  5. 5. Formulation of capsule shell <ul><li>Water-45% </li></ul><ul><li>Plasticizer-0.3-1.8 </li></ul><ul><li>Coloring agent-2% </li></ul><ul><li>Chelating agent-qs </li></ul><ul><li>Opacifyng agent-o.5% </li></ul><ul><li>Gelatin-qs </li></ul>
  6. 6. Formulation of empty hard gelatin capsules <ul><li>Gelatin : 80-85%     </li></ul><ul><li>Purified water : 12.5-16%       </li></ul><ul><li>Plasticizer : 0.1%         </li></ul><ul><li>Lubricant : Traces       </li></ul><ul><li>Coloring : < 3.5%   </li></ul><ul><li>Preservative : 0.1%       </li></ul><ul><li>Printing Ink (edible) : Traces </li></ul><ul><li>  </li></ul>
  7. 7. Formulation of hard gelatin capsules <ul><li>Active ingredients </li></ul><ul><li>Fillers-up to 50% </li></ul><ul><li>Plasticizers </li></ul><ul><li>Protective sorbents </li></ul><ul><li>Colorants </li></ul><ul><li>Wetting agents </li></ul><ul><li>Anti-dusting compounds </li></ul><ul><li>Lubricants-0.05-0.75% </li></ul><ul><li>Glidants -<1% </li></ul><ul><li>Disintegrants-2-6% </li></ul><ul><li>Surfactants-0.1-0.5 </li></ul>
  8. 8. Formulation of Soft gelatin capsules <ul><li>Active ingredients[drug] </li></ul><ul><li>Fillers-up to 50% </li></ul><ul><li>Gelatin </li></ul><ul><li>plasticizer-0.4-0.6% </li></ul><ul><li>Dyes,pigments </li></ul><ul><li>Solvent </li></ul><ul><li>Opacifying agents </li></ul><ul><li>Fumaric acid </li></ul><ul><li>Essential oils </li></ul><ul><li>pH adjusting additive-2.5-7.4% </li></ul><ul><li>Flavour </li></ul><ul><li>Anticaking agent </li></ul><ul><li>Humectants </li></ul><ul><li>Suspending agents-5% </li></ul><ul><li>preservative </li></ul>
  9. 9. Formulation of ophthalmic ointments <ul><li>Buffering and pH adjustments </li></ul><ul><li>Stabilizers </li></ul><ul><li>antioxidants </li></ul><ul><li>Surfactants </li></ul><ul><li>Viscosity increasing agents </li></ul><ul><li>Osmolarity adjusting agents-0.25-2.5% </li></ul><ul><li>Vehicles </li></ul><ul><li>Bases </li></ul><ul><li>Colours </li></ul><ul><li>perfumes </li></ul><ul><li>preservatives </li></ul>
  10. 10. Formulation of gels <ul><li>Active ingredient </li></ul><ul><li>Gelling agents-10% </li></ul><ul><li>Surfactants-20-40% </li></ul><ul><li>acrylic polymers </li></ul><ul><li>Humectant-80% </li></ul><ul><li>Hygroscopic substances </li></ul><ul><li>Chelating agents </li></ul><ul><li>Film formers </li></ul><ul><li>Thickening agents </li></ul><ul><li>preservatives </li></ul>
  11. 11. Formulation of suppostories <ul><li>Bases </li></ul><ul><li>Surfactants-10% </li></ul><ul><li>Emulsifying agents </li></ul><ul><li>Hardening agents </li></ul><ul><li>Thickening agents </li></ul><ul><li>melting temperature modulators </li></ul><ul><li>Preservatives </li></ul><ul><li>Antioxidants-0.1% </li></ul><ul><li>Colouring agents </li></ul><ul><li>Absorption promoters[depolymerising enzymes] </li></ul>
  12. 12. Formulation of emulsions <ul><li>Emulsifying agent </li></ul><ul><li>Surfactant-0.05-0.5% </li></ul><ul><li>Anti-foaming agents </li></ul><ul><li>pH adjusting agents-4-10% </li></ul><ul><li>Hydrophilic colloids </li></ul><ul><li>Consistency builders </li></ul><ul><li>Coloring agents </li></ul><ul><li>Antioxidants-0.001-0.1% </li></ul><ul><li>preservatives </li></ul>
  13. 13. Formulation of suspensions <ul><li>Active ingredient </li></ul><ul><li>Wetting agents-0.05-0.5% </li></ul><ul><li>Suspending agents-2-10% </li></ul><ul><li>Dispersants </li></ul><ul><li>Anti-foaming agents </li></ul><ul><li>Flocculating agents-0.01-1% </li></ul><ul><li>Thickening agents-<0.1%->0.1% </li></ul><ul><li>Buffering agents </li></ul><ul><li>Liquid vehicles </li></ul><ul><li>Osmotic agents and stabilizers </li></ul><ul><li>Colouring agents-qs </li></ul><ul><li>Preservatives-0.01-1% </li></ul><ul><li>Flavouring agents-qs </li></ul>
  14. 14. Parenterals <ul><li>Active ingredient </li></ul><ul><li>Vehicles </li></ul><ul><li>Antioxidants-0.015-0.15% </li></ul><ul><li>Surfactant-0.05-0.5% </li></ul><ul><li>Buffering agents-0.8-2% </li></ul><ul><li>Bulking agents </li></ul><ul><li>Tonicity modifying agents -0.5-5.5% </li></ul><ul><li>Wetting agents </li></ul><ul><li>Chelating agents-0.01-0.075% </li></ul><ul><li>Solubilizing agents </li></ul><ul><li>Suspending agents </li></ul><ul><li>Emulsifying agents </li></ul><ul><li>Stabilizers </li></ul><ul><li>Antimicrobial compounds-0.002%-0.5% </li></ul>
  15. 15. Formulation of aerosols <ul><li>Active ingredients-10 </li></ul><ul><li>Propellents-70 </li></ul><ul><li>Dispersing agent or surfactant-5% </li></ul><ul><li>Flavouring agent </li></ul><ul><li>Preservative </li></ul><ul><li>Antioxidant0.01-0.1% </li></ul><ul><li>Cosolvents-12 </li></ul>
  16. 16. Cosmetics
  17. 17. Formulation of lipsticks <ul><li>Wax-20-55% </li></ul><ul><li>Emollients-25-70% </li></ul><ul><li>Pigments-0.5-10% </li></ul><ul><li>Thickeners-0-1% </li></ul><ul><li>Preservatives-0-1% </li></ul><ul><li>Antioxidants-0.05-1% </li></ul><ul><li>Pigments-5-25% </li></ul><ul><li>Uv filters-0-2% </li></ul><ul><li>Flavours-0-1% </li></ul><ul><li>Active agents-0-1% </li></ul>
  18. 18. Formulation of shaving cream <ul><li>: </li></ul><ul><li>Surfactants-5-20% </li></ul><ul><li>Active agents-0.1-1% </li></ul><ul><li>Consistency agents-3-8% </li></ul><ul><li>Neutrilising agents-qs </li></ul><ul><li>Humectants-2-10% </li></ul><ul><li>Diluents-qs </li></ul><ul><li>Emollients-2-5% </li></ul><ul><li>Film formers-0-2% </li></ul><ul><li>Perfume-0.1-1% </li></ul><ul><li>Preservative-0.2-1% </li></ul>
  19. 19. <ul><li>Formulation of shampoos </li></ul><ul><li>Anti-dandruff agents </li></ul><ul><li>Surfactants-15-30% </li></ul><ul><li>Foam stabilizers-1-4% </li></ul><ul><li>Thickening agents-0-5% </li></ul><ul><li>Deionised water-qs </li></ul><ul><li>Humectants-1-5% </li></ul><ul><li>Buffers-qs </li></ul><ul><li>Emollients </li></ul><ul><li>Detergents </li></ul><ul><li>Chelating agents 0-0.025 </li></ul><ul><li>Opacifying agents-0.2-2% </li></ul><ul><li>Perfume-0.5-1% </li></ul><ul><li>Colors-qs </li></ul><ul><li>Conditioning-qs </li></ul><ul><li>Uv.filters-0.01-0.1% </li></ul><ul><li>Preservatives-0.1-1% </li></ul>
  20. 20. Formulation of nail polishes <ul><li>Film formers-10-20% </li></ul><ul><li>Resins-2-10% </li></ul><ul><li>Pigments-1-5% </li></ul><ul><li>Plasticizers-3-10% </li></ul><ul><li>Solvents-30-50% </li></ul><ul><li>Diluents-5-15% </li></ul><ul><li>Thixotropic agents-0-1% </li></ul><ul><li>Uv.filters-0-0.1% </li></ul><ul><li>Preservatives-0.1-1% </li></ul><ul><li>Anti oxidants-0-0.1% </li></ul><ul><li>Pigments-1-5% </li></ul><ul><li>Flavours-0-1% </li></ul><ul><li>Active agents-0-1% </li></ul>
  21. 21. FACE POWDER <ul><li>Slipping agents-75% </li></ul><ul><li>Adhesion agents-7.5% </li></ul><ul><li>Absorbent base-1% </li></ul><ul><li>Fragnance agent-0.15% </li></ul><ul><li>Pigments-3% </li></ul><ul><li>Coloring agents-0.3% </li></ul><ul><li>Flavouring agents </li></ul><ul><li>Opacifyers-10% </li></ul><ul><li>Preservatives-qs </li></ul>
  22. 22. Formulation of toothpaste <ul><li>Abrasives-20-50% </li></ul><ul><li>Surfactants-0.5-2% </li></ul><ul><li>Thickening agents-0-12% </li></ul><ul><li>Humectants-20-40% </li></ul><ul><li>Binders-0.9-2% </li></ul><ul><li>Diluents-qs </li></ul><ul><li>Antimicrobials-0.2-1.5% </li></ul><ul><li>Anticaries-0.2-1.5% </li></ul><ul><li>Sweetners-0.05-0.25% </li></ul><ul><li>Falvours-0.2-2% </li></ul><ul><li>Preservative-0.05-0.2% </li></ul><ul><li>Tartar control-0.5-10% </li></ul>
  23. 23. THANK YOU

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