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Several sp. of natural parasites of wild
and domestic mammals cause
accidental infection in man.
 Transmitted by blood su...


Following death of worm, chronic
inflammatory reaction occurs around
dead worm and that causes clinical
manifestations.
ETIOLOGIC AGENTS: Brugia pahangi,
Brugia beaveri, Brugia leporis etc.,
 CLINICAL MANIFESTATIONS: Enlarged
lymph nodes.
 ...
DIAGNOSIS: Observation of worm in the
histological section following excision of
infected lymph node.
 TREATMENT: Excisio...
KINGDOM: Animalia
 PHYLUM: Nematoda
 CLASS: Secernentea
 ORDER: Spirurida
 FAMILY: Onchocercidae
 GENUS: Brugia
 SPE...
ETYMOLOGY: Brugia from Dr.Brug and
pahangi from Pahang, Malaysia.
 HISTORY: Discovered by Buckley and
Edeson in 1956 from...
Adult male:17.4-20 mm,
Adult female:38-63 mm.
 Distinguishing feature: spicules shortest
among Brugia sp.(B. pahangi<B. m...
From cats and dogs; in Malaysia.
 Implicated in cases of lymphangitis and
lymphadenitis.
 Pathology restricted to affect...
Worms are often dead and surrounded
by a necrotizing granuloma.
 It is very difficult to differentiate between
B. pahangi...
Parasite of raccoon in North America.
 Mosquitoes may accidentally transmit
the infective stage by feeding on an
infected...
 Differential Diagnosis
Enlarged lymph node
Lymphoma
Lipoma
Papilloma

 If

the worm is dead, it is surrounded by
a ...
Local lymphadenopathy.
 Infected node generally not tender.
 Lesions are non erythematous.
 Most common sites are


G...


But in case of immunodeficient patients,
disease may progress to severe lymph
edema and worm may become patent
and prod...


Typically made by examination of worms
in histological section from surgically
excised lymph node.
Removal of infected lymph node or
lymphatic tissue provide complete cure.
 The only realistic control measure is to
avoid...
THANK YOU
Brugia  pahangi  &  brugia  beaveri
Brugia  pahangi  &  brugia  beaveri
Brugia  pahangi  &  brugia  beaveri
Brugia  pahangi  &  brugia  beaveri
Brugia  pahangi  &  brugia  beaveri
Brugia  pahangi  &  brugia  beaveri
Brugia  pahangi  &  brugia  beaveri
Brugia  pahangi  &  brugia  beaveri
Brugia  pahangi  &  brugia  beaveri
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Brugia pahangi & brugia beaveri

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zoonotic brugian filariasis

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Brugia pahangi & brugia beaveri

  1. 1. Several sp. of natural parasites of wild and domestic mammals cause accidental infection in man.  Transmitted by blood sucking arthropods which feed on both animals and humans( eg: Aedes aegypti mosquito).  Infective larvae develop into adults but do not mature to produce microfilariae. 
  2. 2.  Following death of worm, chronic inflammatory reaction occurs around dead worm and that causes clinical manifestations.
  3. 3. ETIOLOGIC AGENTS: Brugia pahangi, Brugia beaveri, Brugia leporis etc.,  CLINICAL MANIFESTATIONS: Enlarged lymph nodes.  COMPLICATIONS: Typically none.  MODE OF TRANSMISSION: Inoculation of microfilaria from the salivary glands of a mosquito. 
  4. 4. DIAGNOSIS: Observation of worm in the histological section following excision of infected lymph node.  TREATMENT: Excision of infected lymph node.  DRUG OF CHOICE: None.  RESERVOIR HOSTS: Raccoons & rabbits(B. beaveri in North America); cats & dogs(B. pahangi in Malaysia).  CONTROL MEASURES: Take precaution to avoid mosquito bite. 
  5. 5. KINGDOM: Animalia  PHYLUM: Nematoda  CLASS: Secernentea  ORDER: Spirurida  FAMILY: Onchocercidae  GENUS: Brugia  SPECIES: B. pahangi & B. beaveri 
  6. 6. ETYMOLOGY: Brugia from Dr.Brug and pahangi from Pahang, Malaysia.  HISTORY: Discovered by Buckley and Edeson in 1956 from dogs and cats of Malaysia. 
  7. 7. Adult male:17.4-20 mm, Adult female:38-63 mm.  Distinguishing feature: spicules shortest among Brugia sp.(B. pahangi<B. malayi).  Microfilariae: -280 μm(when collected in 2% formalinKnott’s technique), -189 μm(in thick blood smear). 
  8. 8. From cats and dogs; in Malaysia.  Implicated in cases of lymphangitis and lymphadenitis.  Pathology restricted to affected lymph node.  Worms are located in lymph nodes and lymphatic tissue.  Worms are immature and infertile. 
  9. 9. Worms are often dead and surrounded by a necrotizing granuloma.  It is very difficult to differentiate between B. pahangi infection and endemic B. malayi infection because i. ii. Both have same mosquito vectors. Microfilaria of both have similar appearance.
  10. 10. Parasite of raccoon in North America.  Mosquitoes may accidentally transmit the infective stage by feeding on an infected animal and then on a human approximately 2 week later.  Rarely exhibit any symptoms.  Patient presents with a tender mass in the cervical, axillary or inguinal region. 
  11. 11.  Differential Diagnosis Enlarged lymph node Lymphoma Lipoma Papilloma  If the worm is dead, it is surrounded by a granulomatous reaction.  Once the mass is removed no further treatment is required.
  12. 12. Local lymphadenopathy.  Infected node generally not tender.  Lesions are non erythematous.  Most common sites are  Groin(34%) Neck(21%) Axilla(10%)
  13. 13.  But in case of immunodeficient patients, disease may progress to severe lymph edema and worm may become patent and produce microfilaria.
  14. 14.  Typically made by examination of worms in histological section from surgically excised lymph node.
  15. 15. Removal of infected lymph node or lymphatic tissue provide complete cure.  The only realistic control measure is to avoid being bitten by mosquitoes. 
  16. 16. THANK YOU

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