Diseases Of Breast

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Diseases Of Breast

  1. 1. Diseases of Breast<br />Pathology-B Lab<br />Ravi A Patel<br />
  2. 2. M++<br />Paget disease<br />Fibrocystic change<br />Infiltrating/Invasive ductal carcinoma<br />Fibroadenoma<br />Lipoma<br />
  3. 3. There are 2 types of Breast diseases<br />Invasive(Infiltrating)<br />Invasive ductal carcinoma<br />Medullary carcinoma<br />Colloid carcinoma<br />Tubular carcinoma<br />Other types<br />Non invasive<br />Ductal carcinoma in situ(DCIS – intraductal carcinoma)-includes Paget disease<br />Lobular carcinoma in situ(LCIS)<br />
  4. 4. Paget disease<br />Characterized by extension of ofDuctal carcinoma in situ (DCIS) up to the lactiferous ducts and into the skin of Nipple.<br />Clinical appearance- Unilateral crusting exudate over the nipple and areolar skin.<br />Its a benign breast lesion<br />
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  7. 7. Skin of Areola<br />
  8. 8. PAGET CELLS WITH<br />CLEAR CYTOPLASM AND HYPERCHROMATIC<br />PLEOMORPHIC NUCLEI <br />WHICH ARE INFILTRATING <br />THE DERMIS <br />Atypical lining<br />cells<br />
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  10. 10. Paget cells and Atypical ductal lining cells<br />
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  12. 12. Fibrocystic Change<br />The term change is applied to miscellany changes in the female breast that range from harmless to patterns associated with Breast Carcinoma.<br />Some of these alteration- Stromal fibrosis and micro/macro cyst produce palpable lumps.<br />These changes are the consequence of an exaggeration and distortion of the cystic breast changes that occur normally in menstrual cycle.<br />
  13. 13. There are 2 types<br />Proliferative- Includes atypical duct or ductal epithelial cell hyperplasias.<br />Non proliferative- includes cyst and fibrosis without epithelia hyperplasia..Also known as Simple fibrocystic change.<br /> It is very common(found in 60-80% of women)<br />All these changes tend to rise during the reproductive period of life but may persist after menopause.<br />
  14. 14. * Dilated duct with visible lining epithelial cells-LPO<br />
  15. 15. Numerous<br />Microcysts<br />Produced by <br />The dilated <br />ducts<br />
  16. 16. HPO<br />Observation <br />--- Increased Fibrosis in stroma<br />--- Dilated ducts within fibrosis<br />--- There is no Epithelial <br /> hyperplasia of the ductal<br /> lining cells. If there is <br /> hyperplasia then the <br /> whole lumen gets filled<br /> with heterogenous<br /> cells.<br />---- So we can conclude that<br /> that the slide shown falls <br /> under the most commonly<br /> found Fibrocystic change<br /> that is Non proliferative type..<br />
  17. 17. HPO<br />Non-Proliferative<br />Type of Fibrocystic <br />Change<br />--Fibrosis seen <br />but No Hyperplasia<br />
  18. 18. HPO<br />Fibrosis<br />Dilated ducts<br />
  19. 19. HPO<br />
  20. 20.
  21. 21. Infiltrating/Invasive DuctalCarcinoma<br />Due to abnormally proliferating ductal lining cells, there is invasion of stroma<br />In normal breast tissue<br />Ducts= Stroma<br />Whereas in Infiltrating ductal carcinoma there is very little stroma<br />
  22. 22. Normal Breast tissue is not found<br />HPO<br />Malignant Ductal lining cells<br />Observed to be arranged in <br />sheets<br />Pleomorphism<br />And Hyperchromatic<br /> nuclei Of the ductal<br /> lining cells<br />
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  26. 26. Fibroadenoma<br />Proliferating intralobular stroma pushing the epithelium<br />There are 2 types of fibroadenoma<br />PericanalicularFibroadenoma<br /> In this kind of Fibroadenoma the ductal space are round/oval and fairly regualar<br />2. IntracanalicularFibroadenoma<br /> Over here there is extensive proliferation of surrounding stroma which compresses the ducts giving them irregular/star shape on cross section.<br />
  27. 27. Poliferating Stroma is pushing <br />The ducts leading to their irregular<br />Shape..<br />This signifies of the slide being <br />Intracanalicularfibradenoma<br />Fibroadenoma<br />
  28. 28. Intracanalicular type Pericanalicular type<br />
  29. 29.
  30. 30. Lipoma<br />Lipomas are benign tumours of fat and are most common soft tissue tumour of adulthood.<br />Most are solitary lesions.<br />Most Lipomas are mobile,slowly enlarging painless masses(angiolipoma can present with local pain)<br />Complete excision is usually curative..<br />
  31. 31. Subtypes of Lipoma<br />Conventional- Most common subtype- they are soft, yellow, well encapsulated masses of mature adipocyytes with considerable varying size.<br />Myolipoma<br />Spindle cell<br />Myelolipoma<br />Pleomorphic<br />Angiolipoma(locally painful)<br />
  32. 32. Fat cells are<br />Within a thin fibrous capsule <br />Mature Fat cells with<br />Scanty stroma<br />Remnants<br />Of mammary<br />Gland<br />lobules<br />Lipoma<br />LPO<br />
  33. 33. LPO<br />
  34. 34. HPO<br />Fibrous capsule<br />
  35. 35. HPO<br /> Scanty stroma and <br />Fat cells<br />
  36. 36. Thanking to the entire Universe<br />

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