Hodgkin's Lymphoma

854 views

Published on

What second-line regimen should we use for recurrent Hodgkin lymphoma prior to stem cell transplant?
Pankaj Malhotra, MD

Published in: Health & Medicine
0 Comments
0 Likes
Statistics
Notes
  • Be the first to comment

  • Be the first to like this

No Downloads
Views
Total views
854
On SlideShare
0
From Embeds
0
Number of Embeds
455
Actions
Shares
0
Downloads
16
Comments
0
Likes
0
Embeds 0
No embeds

No notes for slide

Hodgkin's Lymphoma

  1. 1. What second-line regimen should we use for recurrent Hodgkin lymphoma prior to stem cell transplant? Pankaj Malhotra, MD PGI, Chandigarh, India
  2. 2. Outline of talk • Why auto is better than continuing chemo in relapsed HL? • Results of auto transplant in relapsed HL • Predictors of transplant outcome • Chemotherapy regimens used before transplant • Does any specific chemotherapy regimen make diff in outcome? • Upcoming therapies
  3. 3. Chemotherapy vs Autologous SCT in relapsed HL Results of randomized trials
  4. 4. ABMTR data and multicentric studies data on autologous SCT in relapsed HL
  5. 5. Summary • Autologous stem cell transplantation improves EFS and PFS in relapsed HL Factors predicting poor outcome • B symptoms • Stage IV disease at relapse • Residual disease at the time of transplantation • More than three prior chemotherapies (chemo-resistant disease)
  6. 6. Further predictors of outcome
  7. 7. Regimens used before transplant
  8. 8. Best salvage regimen • Effective/High response rates • Out patient administration • Minimal effect on stem cell mobilisation • Minimal toxicity
  9. 9. 60-88% 17-56% 0-9%
  10. 10. 69-89% 17-60%
  11. 11. Upcoming therapies
  12. 12. Conclusions • ORR of salvage chemotherapy regimens in relapsed refractory HL vary from 60-80% • CR rates vary from 20-40% • Brentuximab as a single agent is able to achieve ORR and CR rates similar to chemotherapy regimens • The available data is thus compelling enough to recommend use of Brentuximab in relapsed refractory HL before auto or allogeneic stem cell transplantation

×