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Golden Rice – Potential And Outlook

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2-3 million die every year because of Vitamin A deficiency, 500.000 people get blind, most of them children. With Golden Rice, a lot of these people could be saved. Learn how and why.

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Golden Rice – Potential And Outlook

  1. 1.  792 million people are malnourished (2000)  10 million children die of malnutrition every year  2-3 million die because of VAD, 500.000 get blind  400 million poor consume mainly rice
  2. 2. Vi t am n A i m t ance i por  Vision  Epithelial growth and repair  Bone growth  Reproduction and embryonic development  Maintenance of the surface linings of the eyes  Epithelial integrity of respiratory, urinary and intestinal tracts  Regulation of adult genes  Immune response
  3. 3. Vi t am n A i pr oduct i on Just middle part missing in endosperm: Phytoene Synthase, Phytoene Desaturase, Zeta-Carotene Desaturase
  4. 4. The const r uc t A lot of work has been done since the intitial idea...
  5. 5. The “best “ const r uct : GR II  Endosperm-specific promotor Glutelin-promotor Gt1p  transit peptide tp to target plastid  Nos-Terminator , terminating synthesis (nopaline synthase)  carotene-desaturase from Erwinia uredovora crtI, catalyzing mutiple steps in carotenoid synthesis  Zea mays phytoene synthase  Maize ubiquitin-promotor ubi1p  phosphomannose-isomerase marker-System „Positech“, avoiding antibiotic-marker  RB and LB: RB, T-DNA right/left border sequence
  6. 6. The new G den R ce ol i  Golden Rice up to 37 µg/g carotenoid of which 31 µg/g is β-carotene (first generation Golden Rice 1.6 µg/g )  $3.00 - 19.40 daly (costs to save one life) – from $200 cost-effective (World bank)  India: 5,000-40,000 children could be saved per year – every 14minutes one life
  7. 7. C i t i ci sm r  Golden Rice could contaminate wild rice forever  better answers to the problem of VAD  Encourages diet based on one food  Designed to help introducing GMOs  Unknown side-effects  Bioavailability, storage effects
  8. 8. M cr onut r i ent s and i B oavai l abl i t y i  Micronutrients can enhance soil quality  Various factors determine availablity  A lot of breeding- potential
  9. 9. St at us and O l ook ut  Introduction to the Philippines by 2012, then Bangladesh  Yield: about 5t - low? Storage – depends on traits Conversion factor – first experiments successfull  GR with additional nutritional traits: vitamin E, iron and zinc, high-quality protein or essential amino acids
  10. 10. Per sonal i zed m ci ne edi  Trend of the future: personalized diets for problematic SNPs  Nutrigenomics: Interaction of dietary components and resulting proteonomic and metabolomic changes  Nutrigenetics: Understanding Gene-based differences in response to dietary components
  11. 11. What shoul d be done  Spread biofortified food to Africa  Adopt regulatory process  Shift public opinion  Focus research and agriculture lesser on profits  Establish not only bio, but also quality
  12. 12. Sour ces  All Slides: Salim Al-Babili and Peter Beyer, „Golden Rice – five years on the road – five years to go?“, Review: Trends in Plant Science, Vol. 10 No. 12 December 2005 Roukayatou Zimmermann, Matin Qaim: „Potential health benefits of Golden Rice – a Philippine case study“ – Food policy 29 (2004) Ross M. Welch, Robin D. Graham: „Breeding for micronutrients in staple food crops from a human nutrition perspective“, Journal of Experimental Botany, Vol. 55, No. 396 Peter Bayer et al.: „Golden Rice: Indroducing the β-Carotene Biosynthesis Pathway into Rice Endosperm by Genetic Engineering to Defeat Vitamin A Defiency“, Symposium The Journal of Nutrition, 2002 American Society for Nutritional Science The Golden Rice project – www.goldenrice.org  Slide 3: http://www.cehjournal.org/extra/40_15_01.html , Photos: Simon Franken, Allen Foster, Donald McLaren & Gordon Johnson Alfred Sommer (ophthalmologist) http://www.jhsph.edu/publichealthnews/press_releases/sommer_vitA.html  Slide 7: DER SPIEGEL 48/2008 http://www.spiegel.de/media/0,4906,19439,00.pdf „Kampagne für gentechnisch veränderten Reis am Scheideweg“ Christoph Then, www.scouting-biotechnology.net, Januar 2009, im Auftrag von foodwatch e. V. http://www.foodwatch.de/e10/e1026/e19431/e23453/GoldenRice_deutsch_final_ger.pdf „All that glitters is not Gold: The false hope of Golden Rice“, Greenpeace, May 2005, http://www.greenpeace.org/raw/content/international/press/reports/ all-that-glitters-is-not-gold.pdf  Slide 8: www.greenpeace.org  Slide 9: http://www.goldenrice.org/Content3-Why/why3_FAQ.html  Slide 11: Rahul Shetty MD, http://open.medicdrive.org/blog/2007/09/26/surfing-the-waves-of-medicine-two-point-oh/  Slide 12: Google Earth, Terrametrics, DigitalGlobe Undata, www.thematicmapping.org

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