Successfully reported this slideshow.
We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. You can change your ad preferences anytime.

Golden Rice – Potential And Outlook


Published on

2-3 million die every year because of Vitamin A deficiency, 500.000 people get blind, most of them children. With Golden Rice, a lot of these people could be saved. Learn how and why.

Published in: Technology, Business
  • how can i download these slides
    Are you sure you want to  Yes  No
    Your message goes here

Golden Rice – Potential And Outlook

  1. 1.  792 million people are malnourished (2000)  10 million children die of malnutrition every year  2-3 million die because of VAD, 500.000 get blind  400 million poor consume mainly rice
  2. 2. Vi t am n A i m t ance i por  Vision  Epithelial growth and repair  Bone growth  Reproduction and embryonic development  Maintenance of the surface linings of the eyes  Epithelial integrity of respiratory, urinary and intestinal tracts  Regulation of adult genes  Immune response
  3. 3. Vi t am n A i pr oduct i on Just middle part missing in endosperm: Phytoene Synthase, Phytoene Desaturase, Zeta-Carotene Desaturase
  4. 4. The const r uc t A lot of work has been done since the intitial idea...
  5. 5. The “best “ const r uct : GR II  Endosperm-specific promotor Glutelin-promotor Gt1p  transit peptide tp to target plastid  Nos-Terminator , terminating synthesis (nopaline synthase)  carotene-desaturase from Erwinia uredovora crtI, catalyzing mutiple steps in carotenoid synthesis  Zea mays phytoene synthase  Maize ubiquitin-promotor ubi1p  phosphomannose-isomerase marker-System „Positech“, avoiding antibiotic-marker  RB and LB: RB, T-DNA right/left border sequence
  6. 6. The new G den R ce ol i  Golden Rice up to 37 µg/g carotenoid of which 31 µg/g is β-carotene (first generation Golden Rice 1.6 µg/g )  $3.00 - 19.40 daly (costs to save one life) – from $200 cost-effective (World bank)  India: 5,000-40,000 children could be saved per year – every 14minutes one life
  7. 7. C i t i ci sm r  Golden Rice could contaminate wild rice forever  better answers to the problem of VAD  Encourages diet based on one food  Designed to help introducing GMOs  Unknown side-effects  Bioavailability, storage effects
  8. 8. M cr onut r i ent s and i B oavai l abl i t y i  Micronutrients can enhance soil quality  Various factors determine availablity  A lot of breeding- potential
  9. 9. St at us and O l ook ut  Introduction to the Philippines by 2012, then Bangladesh  Yield: about 5t - low? Storage – depends on traits Conversion factor – first experiments successfull  GR with additional nutritional traits: vitamin E, iron and zinc, high-quality protein or essential amino acids
  10. 10. Per sonal i zed m ci ne edi  Trend of the future: personalized diets for problematic SNPs  Nutrigenomics: Interaction of dietary components and resulting proteonomic and metabolomic changes  Nutrigenetics: Understanding Gene-based differences in response to dietary components
  11. 11. What shoul d be done  Spread biofortified food to Africa  Adopt regulatory process  Shift public opinion  Focus research and agriculture lesser on profits  Establish not only bio, but also quality
  12. 12. Sour ces  All Slides: Salim Al-Babili and Peter Beyer, „Golden Rice – five years on the road – five years to go?“, Review: Trends in Plant Science, Vol. 10 No. 12 December 2005 Roukayatou Zimmermann, Matin Qaim: „Potential health benefits of Golden Rice – a Philippine case study“ – Food policy 29 (2004) Ross M. Welch, Robin D. Graham: „Breeding for micronutrients in staple food crops from a human nutrition perspective“, Journal of Experimental Botany, Vol. 55, No. 396 Peter Bayer et al.: „Golden Rice: Indroducing the β-Carotene Biosynthesis Pathway into Rice Endosperm by Genetic Engineering to Defeat Vitamin A Defiency“, Symposium The Journal of Nutrition, 2002 American Society for Nutritional Science The Golden Rice project –  Slide 3: , Photos: Simon Franken, Allen Foster, Donald McLaren & Gordon Johnson Alfred Sommer (ophthalmologist)  Slide 7: DER SPIEGEL 48/2008,4906,19439,00.pdf „Kampagne für gentechnisch veränderten Reis am Scheideweg“ Christoph Then,, Januar 2009, im Auftrag von foodwatch e. V. „All that glitters is not Gold: The false hope of Golden Rice“, Greenpeace, May 2005, all-that-glitters-is-not-gold.pdf  Slide 8:  Slide 9:  Slide 11: Rahul Shetty MD,  Slide 12: Google Earth, Terrametrics, DigitalGlobe Undata,