ADME for the medicinal chemist


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ADME for the medicinal chemist

  1. 1. Overview: The course gives an overview of the ADME process and covers concepts such as solubility, permeability, Pgp, CYP 450’s, Phase 1 & 2 metabolism, glomerular filtration and enteropathic cycling. It demystifies pharmacokinetic terms such as t1/2, clearance and volume of distribution. Interactive workshops place heavy emphasis on the use of current medicinal chemistry literature to solve recurrent ADME issues. Using the ‘succeed through the literature approach’ participants will distil out working solutions to issues such as solubility, oral absorption, CNS penetration and duration of action. SMi MASTERCLASS SERIES 2014 Register online and receive full information on all of SMi’s conferences Alternatively fax your registration to +44 (0) 870 9090 712 or call +44 (0) 870 9090 711 GROUP DISCOUNTS AVAILABLE MC404 2014 5th Central London Hosted by: Corinne Kay, Company Director, Med-Simple ADME for the Medicinal Chemist DEC SMi presents its masterclass on
  2. 2. Register online and receive full information on all of SMi’s conferences Alternatively fax your registration to +44 (0) 870 9090 712 or call +44 (0) 870 9090 711 GROUP DISCOUNTS AVAILABLE ADME for the Medicinal Chemist 08.30 Registration and Coffee 09:15 Aims of Masterclass 09:30 Lecture 1. Digestion 10:10 Round table: Routes of administration 10:30 Lecture 2. Solubility 11:10 Morning Coffee 11:30 Lecture 2. Solubility & Workshop 12:15 Networking Lunch 1:15 Lecture 3. Permeability and P-gp 2:15 Lecture 4. Liver metabolism 3:15 Afternoon Tea 3:30 Lecture 5. Pharmacokinetics 4:00 What have we learned? 4:30 End of Masterclass MASTERCLASS AGENDA About the masterclass leader: Corinne read Organic Chemistry at Lyon University, France (1984). She then joined Roche (1984- 1990) as a medicinal chemist where she was involved in the Trocade as well as the Saquinavir projects. In addition, she played a key role in establishing a Solid Phase Peptide and Oligonucleotide synthesis facility in house. She then Joined Glaxo in 1990, where she has worked on a number of Protease and GPCR drug Discovery projects at various stages of lead discovery and lead optimisation. Corinne then obtained a GlaxoSmithKline sponsored PhD at the University of Cambridge (2000) having worked with Prof S V Ley, FRS on the discovery of novel solid phase amine linkers. She then joined Organon in 2001 where she became responsible for Medicinal Chemistry training of staff and more recently founded Med-Simple, a company specialising in applied Medicinal Chemistry training. She is the author of over 45 publications, book chapters and reviews in these areas. Her research interests include the design of chemical libraries, peptide synthesis, solid phase synthesis and ADME. About Med-Simple Med-Simple was created in 2004 and provides tailor-made medicinal chemistry courses for the pharmaceutical industry. Its trademark ‘Succeed through the literature approach’, as well as innovative teaching methods have placed the company finalist in the 2012 Small Business Award for Innovation. Who should attend this masterclass: Recommended to medicinal chemists who have recently joined the pharmaceutical industry and more experienced medicinal chemists who wish to pull together a range of notions they have picked up in the course of their projects. It is also suited to students & academics who have an interest in current issues in the drug discovery process.
  3. 3. ADME FOR THE MEDICINAL CHEMIST 5th December 2014, Central London 4 WAYS TO REGISTER FAX your booking form to +44 (0) 870 9090 712 PHONE on +44 (0) 870 9090 711 ONLINE If you have any further queries please call the Events Team on tel +44 (0) 870 9090 711 or you can email them at POST your booking form to: Events Team, SMi Group Ltd, 2nd Floor South, Harling House, 47-51 Great Suffolk Street, London, SE1 0BS Payment: If payment is not made at the time of booking, then an invoice will be issued and must be paid immediately and prior to the start of the event. If payment has not been received then credit card details will be requested and payment taken before entry to the event. Bookings made within 7 days of the event require payment on booking. Substitutions/Name Changes: If you are unable to attend you may nominate, in writing, another delegate to take your place at any time prior to the start of the event. Two or more delegates may not ‘share’ a place at an event. Please make separate bookings for each delegate. Cancellation: If you wish to cancel your attendance at an event and you are unable to send a substitute, then we will refund/credit 50% of the due fee less a £50 administration charge, providing that cancellation is made in writing and received at least 28 days prior to the start of the event. Regretfully cancellation after this time cannot be accepted. Alterations: It may become necessary for us to make alterations to the content, speakers, timing, venue or date of the event compared to the advertised programme. Data Protection: The SMi Group gathers personal data in accordance with the UK Data Protection Act 1998 and we may use this to contact you by telephone, fax, post or email to tell you about other products and services. Unless you tick here □ we may also share your data with third parties offering complementary products or services. If you have any queries or want to update any of the data that we hold then please contact our Database Manager databasemanager@smi- or visit our website quoting the URN as detailed above your address on the attached letter. Unique Reference Number Our Reference MC404 Terms and Conditions of Booking DELEGATE DETAILS Please complete fully and clearly in capital letters. Please photocopy for additional delegates. Title: Forename: Surname: Job Title: Department/Division: Company/Organisation: Email: Company VAT Number: Address: Town/City: Post/Zip Code: Country: Direct Tel: Direct Fax: Mobile: Switchboard: Signature: Date: I agree to be bound by SMi's Terms and Conditions of Booking. ACCOUNTS DEPT Title: Forename: Surname: Email: Address (if different from above): Town/City: Post/Zip Code: Country: Direct Tel: Direct Fax: CONFERENCE PRICES VENUE □ Please contact me to book my hotel Alternatively call us on +44 (0) 870 9090 711, email: or fax +44 (0) 870 9090 712 VAT VAT at 20% is charged on the attendance fees for all delegates. Payment must be made to SMi Group Ltd, and received before the event, by one of the following methods quoting reference MC404 and the delegate’s name. Bookings made within 7 days of the event require payment on booking, methods of payment are below. Please indicate method of payment: □ UK BACS Sort Code 300009, Account 00936418 □ Wire Transfer Lloyds TSB Bank Plc, 39 Threadneedle Street, London, EC2R 8AU Swift (BIC): LOYDGB21013, Account 00936418 IBAN GB48 LOYD 3000 0900 9364 18 □ Cheque We can only accept Sterling cheques drawn on a UK bank. □ Credit Card □ Visa □ MasterCard □ American Express All credit card payments will be subject to standard credit card charges. Card No: □□□□ □□□□ □□□□ □□□ □ Valid From □□/□□ Expiry Date □□/□□ CVV Number □□□□ 3 digit security on reverse of card, 4 digits for AMEX card Cardholder’s Name: Signature: Date: I agree to be bound by SMi's Terms and Conditions of Booking. Card Billing Address (If different from above): MASTERCLASS PRICE PAYMENT FUTURE MASTERCLASSES I would like to attend: Fee Total □ Masterclass: £599.00 +VAT £718.80 I would be interested in attending a Masterclass on the following topic or area: