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White Paper
Virtual Navigator
Urology
2
TRUS guided biopsy is recognised as the standard technique for randomised sampling
and multiparametric prostate MRI demonstrated the best sensitivity and specificity
among all imaging modalities
Introduction
Virtual Navigator is Esaote’s revolutionary technology for fusion
imaging that allows CT, MR and PET side-by-side with real-time
ultrasound.
Virtual Navigator has all the advantages of different modalities
and provides a real-time, low-cost and radiation-free solution
that aims to guide operators in diagnosis, everyday clinical prac-
tice, interventional procedures, research and teaching.
Increased Insonation Rates
Esaote Virtual Navigator gives operators the option of perform-
ing real-time fusion with multiple second modalities’ imaging,
adding real-time capabilities to ultrasound such as Doppler, CEUS
and Elastosonography.
Virtual Navigator increases your diagnostic confidence in:
-	 Visualising different datasets with Rreal-time multimodality fu-
sion imaging for diagnosis
-	 Planning and taking the best scanning and targeting approach
-	 Guiding the operator during interventional procedures
To test and validate fusion imaging in this area, Esaote Virtual
Navigator system was employed to display ultrasound scans on a
split screen next to matching virtual slices obtained with MRI and
to fuse these images together in real-time thereby offering the
reliability of ultrasound’s high temporal resolution data (Colour/
Power Doppler and Elastosonography) with MRI’s high spatial
resolution data. This system is currently used for urology applica-
tions with promising results, especially in supporting and guiding
biopsy operations and laser thermal ablations in both transper-
ineal and transrectal approaches.
Real-Time Fusion Imaging:
Clinical Solutions for Diagnosis
and Intervention in Urology
Esaote Virtual Navigator can be used to guide countless interven-
tional procedures by simulating the position of therapeutic tools
with respect to the volumetric representation of body’s structure
obtained by a wide range of secondary imaging modalities such
as MRI, CT, PET, 3D Imaging, Doppler, Elastosonography and
Contrast Enhanced Ultrasound.
Prof. Giancarlo Bizzarri, Regina Apostolorum Hospital – Albano Laziale, Rome
TRUS-MRI navigation analysing multiparametric MRI
TRUS-MRI navigation localising and defining the target
Real-time ultrasound and MRI co-registration for improved visibility of lesions
TRUS-MRI navigation systems in a targeted biopsy
Here some highlights of ESAOTE Virtual Navigator using TRUS-
MRI fusion:
-	Reduction of FNR (25-35%) after randomised biopsy (10-12
samples)
-	 Reduction of 2° and 3° biopsies
-	 Better correspondence between actual situation and the Glea-
son score proven in the biopsy
-	 More reliable information for watchful waiting approach
Supporting Different Approaches and
Clinical Needs with Real-time Fusion
Imaging
Esaote Virtual Navigator offers infinite possibilities for patient
monitoring, diagnosis and follow-up and is an excellent solution
for Interventional Radiologists and Urologists in Prostate.
MD Giancarlo Bizzarri, Director of Interventional Radiology Department
Real-time ultrasound and MRI co-registration for improved visibility of lesions
Real-time ultrasound elastosonography and MRI co-registration for improved lesions
characterisation and diagnoses
TRUS-MRI navigation systems in a targeted biopsy
3 Virtual Navigator Urology
The system enables accurate co-registration of real-time TRUS and MRI.
The mean time required for co-registration and target delineation is 4 minutes
Prof. Giancarlo Bizzarri, Regina Apostolorum Hospital – Albano Laziale, Rome
4
Esaote S.p.A.
International Activities: Via di Caciolle 15 - 50127 Florence, Italy - Tel. +39 055 4229 1 - Fax +39 055 4229 208 - international.sales@esaote.com - www.esaote.com
Domestic Activities: Via A. Siffredi, 58 16153 Genoa, Italy, Tel. +39 010 6547 1, Fax +39 010 6547 275, info@esaote.com
Products and technologies included in the document might not yet be released or approved in all countries.
The possibility of more accurate pretreatment staging favours the use of the
watchful approach programs. In this scenario ablation procedures will play an
essential role again
Prof. Giancarlo Bizzarri, Regina Apostolorum Hospital – Albano Laziale, Rome
Different operators perform virtually-guided fusion imaging biop-
sies with different approaches, such transrectal or transperineal.
Virtual Navigator offers the possibility of performing biopsy pro-
cedures using both transrectal (thanks to a dedicated endocavity
probe EC1123 and its fusion tracking device) and transoperineal
approaches, making use of the double transducer probe TRT33.
Dedicated biopsy and ablation kits are available for each probe,
with the possibility of tracking the biopsy needle on the 3D dis-
play or any other external device.
User-Defined Protocol for Biopsy and
Ablation Procedures
A dedicated environment has been developed to assist users dur-
ing cryotherapy, radiofrequency, microwaves and laser ablation
procedures.
Real-time needle guidance with ultrasound and multiparametric mri (T2 and Diffusion)
Virtual Navigator is dedicated to interventional and ablation pro-
cedures:
-	 Manual delineation of lesion margins
-	 Computed calculation of lesion volume
-	 Definition of expected necrotic ellipse
-	 Needle tracking capability for several brands of needle.
Clinical References
1.	 Villa, F. Chiesa, I. Rosenberg, A. Tagliafico, M. Perinetti, A. Del Prato, MRI and ultra-
sound guided prostate biopsy using the fusion imaging technique, ECR 2013
Congress
2.	 P. Colin, S. Mordon, P. Nevoux, M. Feras Marqa,A. Ouzzane, P. Puech, G. Bozzini B. Ler-
oux, A. Villers, N. Betrouni, Focal Laser Ablation of Prostate Cancer: Definition,
Needs, and Future, March 2012,Academic Editor: Eric Barret
3.	 P. Puech, O. Rouvière, R. Renard-Penna, A. Villers, P. Devos, M. Colombel, M. Bitker,
X. Leroy, F. Mège-Lechevallier, E. Comperat, A. Ouzzane, L. Lemaitre, Prostate Can-
cer Diagnosis: Multiparametric MR-targeted Biopsy with Cognitive and
Transrectal US-MR Fusion Guidance versus Systematic Biopsy - Prospective
Multicenter Study, RSNA 2013
4.	 G. Paoletti, M. Silvani, D. Confalone, L. Lodigiani, L. Manzoli, S. D’Onofrio, S. de Beni,
G. Mauri, L. Forzoni, Latest Advancements in Real-time Fusion Imaging for
Prostate, ECR 2015
5.	 Philippe Puech, Genito-urinary Imaging Department of the Lille University Hospital
Centre, Ultrasound-MRI fusion advances prostate therapy, December 2012,
www.healthcare-in-europe.com
6.	 F. Cornud, L. Brolis, N. Barry Delongchamps, D. Portalez, B. Malavaud, R. Renard-Penna,
P. Mozer, TRUS-MRI image registration: a paradigm shift in the diagnosis
of significant prostate cancer, Springer Science+Business Media New York 2013,
Abdom Imaging (2013)
7.	 A. Villa, F. Chiesa, I. Rosenberg,A. Tagliafico, M. Perinetti,A. Del Prato, Mri and ultra-
sound guided prostate biopsy using the fusion imaging technique, ECR 2013
8.	 Anna M. Brown, Osama Elbuluk, Francesca Mertan, Sandeep Sankineni, Daniel J. Mar-
golis, Bradford J. Wood, Peter A. Pinto, Peter L. Choyke, Baris Turkbey, Recent ad-
vances in image-guided targeted prostate biopsy, Abdominal Imaging August
2015
9.	 Geoffrey A. Sonn, Daniel J. Margolis, Leonard S. Marks, Target detection: Magnetic
resonance imaging-ultrasound fusion-guided prostate biopsy, Urol Oncol.
August 2014
10.	Prostate cancer Diagnosis: Multiparametric MR-targeted Biopsy with Cog-
nitive and Transrectal US-MR Fusion Guidance versus Systematic Biopsy -
Prospective Multicenter Study, Genitourinary imaging Radiology,August 2013
11.	Evelyn A. Firle, Stefan Wesarg, Grigorios Karangelis and Christian Dold, Validation of
3D Ultrasound - CT Registration of Prostate images
160000068MAKVer.02

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WP VN urology 160000068 V2 0216 LR

  • 2. 2 TRUS guided biopsy is recognised as the standard technique for randomised sampling and multiparametric prostate MRI demonstrated the best sensitivity and specificity among all imaging modalities Introduction Virtual Navigator is Esaote’s revolutionary technology for fusion imaging that allows CT, MR and PET side-by-side with real-time ultrasound. Virtual Navigator has all the advantages of different modalities and provides a real-time, low-cost and radiation-free solution that aims to guide operators in diagnosis, everyday clinical prac- tice, interventional procedures, research and teaching. Increased Insonation Rates Esaote Virtual Navigator gives operators the option of perform- ing real-time fusion with multiple second modalities’ imaging, adding real-time capabilities to ultrasound such as Doppler, CEUS and Elastosonography. Virtual Navigator increases your diagnostic confidence in: - Visualising different datasets with Rreal-time multimodality fu- sion imaging for diagnosis - Planning and taking the best scanning and targeting approach - Guiding the operator during interventional procedures To test and validate fusion imaging in this area, Esaote Virtual Navigator system was employed to display ultrasound scans on a split screen next to matching virtual slices obtained with MRI and to fuse these images together in real-time thereby offering the reliability of ultrasound’s high temporal resolution data (Colour/ Power Doppler and Elastosonography) with MRI’s high spatial resolution data. This system is currently used for urology applica- tions with promising results, especially in supporting and guiding biopsy operations and laser thermal ablations in both transper- ineal and transrectal approaches. Real-Time Fusion Imaging: Clinical Solutions for Diagnosis and Intervention in Urology Esaote Virtual Navigator can be used to guide countless interven- tional procedures by simulating the position of therapeutic tools with respect to the volumetric representation of body’s structure obtained by a wide range of secondary imaging modalities such as MRI, CT, PET, 3D Imaging, Doppler, Elastosonography and Contrast Enhanced Ultrasound. Prof. Giancarlo Bizzarri, Regina Apostolorum Hospital – Albano Laziale, Rome TRUS-MRI navigation analysing multiparametric MRI TRUS-MRI navigation localising and defining the target Real-time ultrasound and MRI co-registration for improved visibility of lesions
  • 3. TRUS-MRI navigation systems in a targeted biopsy Here some highlights of ESAOTE Virtual Navigator using TRUS- MRI fusion: - Reduction of FNR (25-35%) after randomised biopsy (10-12 samples) - Reduction of 2° and 3° biopsies - Better correspondence between actual situation and the Glea- son score proven in the biopsy - More reliable information for watchful waiting approach Supporting Different Approaches and Clinical Needs with Real-time Fusion Imaging Esaote Virtual Navigator offers infinite possibilities for patient monitoring, diagnosis and follow-up and is an excellent solution for Interventional Radiologists and Urologists in Prostate. MD Giancarlo Bizzarri, Director of Interventional Radiology Department Real-time ultrasound and MRI co-registration for improved visibility of lesions Real-time ultrasound elastosonography and MRI co-registration for improved lesions characterisation and diagnoses TRUS-MRI navigation systems in a targeted biopsy 3 Virtual Navigator Urology The system enables accurate co-registration of real-time TRUS and MRI. The mean time required for co-registration and target delineation is 4 minutes Prof. Giancarlo Bizzarri, Regina Apostolorum Hospital – Albano Laziale, Rome
  • 4. 4 Esaote S.p.A. International Activities: Via di Caciolle 15 - 50127 Florence, Italy - Tel. +39 055 4229 1 - Fax +39 055 4229 208 - international.sales@esaote.com - www.esaote.com Domestic Activities: Via A. Siffredi, 58 16153 Genoa, Italy, Tel. +39 010 6547 1, Fax +39 010 6547 275, info@esaote.com Products and technologies included in the document might not yet be released or approved in all countries. The possibility of more accurate pretreatment staging favours the use of the watchful approach programs. In this scenario ablation procedures will play an essential role again Prof. Giancarlo Bizzarri, Regina Apostolorum Hospital – Albano Laziale, Rome Different operators perform virtually-guided fusion imaging biop- sies with different approaches, such transrectal or transperineal. Virtual Navigator offers the possibility of performing biopsy pro- cedures using both transrectal (thanks to a dedicated endocavity probe EC1123 and its fusion tracking device) and transoperineal approaches, making use of the double transducer probe TRT33. Dedicated biopsy and ablation kits are available for each probe, with the possibility of tracking the biopsy needle on the 3D dis- play or any other external device. User-Defined Protocol for Biopsy and Ablation Procedures A dedicated environment has been developed to assist users dur- ing cryotherapy, radiofrequency, microwaves and laser ablation procedures. Real-time needle guidance with ultrasound and multiparametric mri (T2 and Diffusion) Virtual Navigator is dedicated to interventional and ablation pro- cedures: - Manual delineation of lesion margins - Computed calculation of lesion volume - Definition of expected necrotic ellipse - Needle tracking capability for several brands of needle. Clinical References 1. Villa, F. Chiesa, I. Rosenberg, A. Tagliafico, M. Perinetti, A. Del Prato, MRI and ultra- sound guided prostate biopsy using the fusion imaging technique, ECR 2013 Congress 2. P. Colin, S. Mordon, P. Nevoux, M. Feras Marqa,A. Ouzzane, P. Puech, G. Bozzini B. Ler- oux, A. Villers, N. Betrouni, Focal Laser Ablation of Prostate Cancer: Definition, Needs, and Future, March 2012,Academic Editor: Eric Barret 3. P. Puech, O. Rouvière, R. Renard-Penna, A. Villers, P. Devos, M. Colombel, M. Bitker, X. Leroy, F. Mège-Lechevallier, E. Comperat, A. Ouzzane, L. Lemaitre, Prostate Can- cer Diagnosis: Multiparametric MR-targeted Biopsy with Cognitive and Transrectal US-MR Fusion Guidance versus Systematic Biopsy - Prospective Multicenter Study, RSNA 2013 4. G. Paoletti, M. Silvani, D. Confalone, L. Lodigiani, L. Manzoli, S. D’Onofrio, S. de Beni, G. Mauri, L. Forzoni, Latest Advancements in Real-time Fusion Imaging for Prostate, ECR 2015 5. Philippe Puech, Genito-urinary Imaging Department of the Lille University Hospital Centre, Ultrasound-MRI fusion advances prostate therapy, December 2012, www.healthcare-in-europe.com 6. F. Cornud, L. Brolis, N. Barry Delongchamps, D. Portalez, B. Malavaud, R. Renard-Penna, P. Mozer, TRUS-MRI image registration: a paradigm shift in the diagnosis of significant prostate cancer, Springer Science+Business Media New York 2013, Abdom Imaging (2013) 7. A. Villa, F. Chiesa, I. Rosenberg,A. Tagliafico, M. Perinetti,A. Del Prato, Mri and ultra- sound guided prostate biopsy using the fusion imaging technique, ECR 2013 8. Anna M. Brown, Osama Elbuluk, Francesca Mertan, Sandeep Sankineni, Daniel J. Mar- golis, Bradford J. Wood, Peter A. Pinto, Peter L. Choyke, Baris Turkbey, Recent ad- vances in image-guided targeted prostate biopsy, Abdominal Imaging August 2015 9. Geoffrey A. Sonn, Daniel J. Margolis, Leonard S. Marks, Target detection: Magnetic resonance imaging-ultrasound fusion-guided prostate biopsy, Urol Oncol. August 2014 10. Prostate cancer Diagnosis: Multiparametric MR-targeted Biopsy with Cog- nitive and Transrectal US-MR Fusion Guidance versus Systematic Biopsy - Prospective Multicenter Study, Genitourinary imaging Radiology,August 2013 11. Evelyn A. Firle, Stefan Wesarg, Grigorios Karangelis and Christian Dold, Validation of 3D Ultrasound - CT Registration of Prostate images 160000068MAKVer.02